JP5965407B2 - 選択的グリコシダーゼ阻害薬およびその使用 - Google Patents
選択的グリコシダーゼ阻害薬およびその使用 Download PDFInfo
- Publication number
- JP5965407B2 JP5965407B2 JP2013537923A JP2013537923A JP5965407B2 JP 5965407 B2 JP5965407 B2 JP 5965407B2 JP 2013537923 A JP2013537923 A JP 2013537923A JP 2013537923 A JP2013537923 A JP 2013537923A JP 5965407 B2 JP5965407 B2 JP 5965407B2
- Authority
- JP
- Japan
- Prior art keywords
- pyrano
- tetrahydro
- thiazole
- diol
- hydroxyethyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 0 C*CCN(C)C1=N[C@]([C@]2OC(C)(C)O[C@@]2[C@]([C@](C)F)O2)[C@]2S1 Chemical compound C*CCN(C)C1=N[C@]([C@]2OC(C)(C)O[C@@]2[C@]([C@](C)F)O2)[C@]2S1 0.000 description 31
- QDORKWXAAZVMDH-CCAMKGBSSA-N CC(O[C@@H](C1)C1([C@H]1OC(C)=O)O[C@@H]2SC(NCCOCc3ccccc3)=N[C@@H]2[C@H]1OC(C)=O)=O Chemical compound CC(O[C@@H](C1)C1([C@H]1OC(C)=O)O[C@@H]2SC(NCCOCc3ccccc3)=N[C@@H]2[C@H]1OC(C)=O)=O QDORKWXAAZVMDH-CCAMKGBSSA-N 0.000 description 1
- MPLAVUDUHFBTSK-MPKFMROPSA-N CC([C@H]([C@H]1O)O[C@@H]2SC(N(C)C)=N[C@@H]2[C@H]1O)F Chemical compound CC([C@H]([C@H]1O)O[C@@H]2SC(N(C)C)=N[C@@H]2[C@H]1O)F MPLAVUDUHFBTSK-MPKFMROPSA-N 0.000 description 1
- KIDCXOLUCOAVCJ-MRKXFKPJSA-N CC([C@H]([C@H]1OCc2ccccc2)O[C@@H]2SC(N(CC=C)Br)=N[C@@H]2[C@H]1OCc1ccccc1)=O Chemical compound CC([C@H]([C@H]1OCc2ccccc2)O[C@@H]2SC(N(CC=C)Br)=N[C@@H]2[C@H]1OCc1ccccc1)=O KIDCXOLUCOAVCJ-MRKXFKPJSA-N 0.000 description 1
- AHTNBLGITOXLQP-MSSAAIDJSA-N CC([C@H]1O[C@@H]2SC(N(C)C)=N[C@@H]2[C@H]2OC(C)(C)O[C@H]12)F Chemical compound CC([C@H]1O[C@@H]2SC(N(C)C)=N[C@@H]2[C@H]2OC(C)(C)O[C@H]12)F AHTNBLGITOXLQP-MSSAAIDJSA-N 0.000 description 1
- FZALPSAVTYVQNP-WIUAJIDSSA-N C[C@@H]([C@@H](C(C)(C1)[C@H]1OC(C)=O)OC(C)=O)[C@H]1N=C(NCCF)S[C@H]1O Chemical compound C[C@@H]([C@@H](C(C)(C1)[C@H]1OC(C)=O)OC(C)=O)[C@H]1N=C(NCCF)S[C@H]1O FZALPSAVTYVQNP-WIUAJIDSSA-N 0.000 description 1
- VGLYZAYRUIIGNC-UHFFFAOYSA-N OC(c1ccccc11)N(CCOCc2ccccc2)C1=O Chemical compound OC(c1ccccc11)N(CCOCc2ccccc2)C1=O VGLYZAYRUIIGNC-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/429—Thiazoles condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H9/00—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical
- C07H9/06—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical the hetero ring containing nitrogen as ring hetero atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Physical Education & Sports Medicine (AREA)
- Dermatology (AREA)
- Urology & Nephrology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Ophthalmology & Optometry (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Transplantation (AREA)
- Epidemiology (AREA)
- Anesthesiology (AREA)
- Diabetes (AREA)
- Vascular Medicine (AREA)
- Biochemistry (AREA)
- Hospice & Palliative Care (AREA)
- Molecular Biology (AREA)
- Psychology (AREA)
- Rheumatology (AREA)
- Biotechnology (AREA)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/CN2010/078528 WO2012061972A1 (en) | 2010-11-08 | 2010-11-08 | Selective glycosidase inhibitors and uses thereof |
| CNPCT/CN2010/078528 | 2010-11-08 | ||
| US41859610P | 2010-12-01 | 2010-12-01 | |
| US61/418,596 | 2010-12-01 | ||
| PCT/CN2011/080691 WO2012062157A1 (en) | 2010-11-08 | 2011-10-12 | Pyrano[3,2-d]thiazol derivatives and uses thereof as selective glycosidase inhibitors |
| CNPCT/CN2011/080691 | 2011-10-12 | ||
| PCT/US2011/059668 WO2012064680A1 (en) | 2010-11-08 | 2011-11-08 | Selective glycosidase inhibitors and uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013541596A JP2013541596A (ja) | 2013-11-14 |
| JP2013541596A5 JP2013541596A5 (https=) | 2014-12-25 |
| JP5965407B2 true JP5965407B2 (ja) | 2016-08-03 |
Family
ID=46051261
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013537923A Expired - Fee Related JP5965407B2 (ja) | 2010-11-08 | 2011-11-08 | 選択的グリコシダーゼ阻害薬およびその使用 |
Country Status (12)
| Country | Link |
|---|---|
| EP (1) | EP2637503B1 (https=) |
| JP (1) | JP5965407B2 (https=) |
| KR (1) | KR101922266B1 (https=) |
| AR (1) | AR083798A1 (https=) |
| AU (2) | AU2011326186A1 (https=) |
| BR (1) | BR112013011441B8 (https=) |
| CA (1) | CA2816798C (https=) |
| ES (1) | ES2600028T3 (https=) |
| MX (1) | MX336611B (https=) |
| RU (1) | RU2592285C2 (https=) |
| TW (1) | TW201249848A (https=) |
| WO (1) | WO2012064680A1 (https=) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2321289A4 (en) | 2008-08-01 | 2011-11-16 | Univ Fraser Simon | SELECTIVE GLYCOSIDASE HEMMER AND ITS USE |
| WO2011140640A1 (en) | 2010-05-11 | 2011-11-17 | Simon Fraser University | Selective glycosidase inhibitors and uses thereof |
| US8933040B2 (en) | 2010-11-08 | 2015-01-13 | Craig A. Coburn | Selective glycosidase inhibitors and uses thereof |
| RU2609210C2 (ru) * | 2010-12-23 | 2017-01-31 | Алектос Терапьютикс Инк. | Селективные ингибиторы гликозидазы и их применение |
| EP2688899B1 (en) | 2011-03-24 | 2017-02-22 | Alectos Therapeutics Inc. | Selective glycosidase inhibitors and uses thereof |
| EP2691407B1 (en) | 2011-03-31 | 2017-02-22 | Alectos Therapeutics Inc. | Selective glycosidase inhibitors and uses thereof |
| US9701693B2 (en) | 2011-06-27 | 2017-07-11 | Alectos Therapeutics Inc. | Selective glycosidase inhibitors and uses thereof |
| EP2726468B1 (en) | 2011-06-27 | 2017-04-12 | Alectos Therapeutics Inc. | Selective glycosidase inhibitors and uses thereof |
| BR112013033098B8 (pt) | 2011-06-27 | 2021-03-23 | Alectos Therapeutics Inc | inibidores de glicosidade seletivos e usos dos mesmos |
| EP2847199B1 (en) * | 2012-05-08 | 2017-10-25 | Merck Sharp & Dohme Corp. | Permeable glycosidase inhibitors and uses thereof |
| EP2890675A4 (en) | 2012-08-31 | 2016-01-13 | Alectos Therapeutics Inc | GLYCOSIDASE INHIBITORS AND USES THEREOF |
| EP2890676B1 (en) | 2012-08-31 | 2018-12-05 | Alectos Therapeutics Inc. | Glycosidase inhibitors and uses thereof |
| KR20150079711A (ko) * | 2012-10-31 | 2015-07-08 | 알렉토스 테라퓨틱스 인크. | 글리코시다아제 저해제 및 이의 용도 |
| WO2014100934A1 (en) * | 2012-12-24 | 2014-07-03 | Merck Sharp & Dohme Corp. | Glycosidase inhibitors and uses thereof |
| RU2748383C1 (ru) * | 2020-10-21 | 2021-05-25 | федеральное государственное автономное образовательное учреждение высшего образования "Казанский (Приволжский) федеральный университет" (ФГАОУ ВО КФУ) | Способ терапии болезни Тея-Сакса и болезни Сандхоффа с помощью генетически модифицированных мезенхимных стволовых клеток человека со сверхэкспрессией β-гексозаминидазы A |
| WO2024083820A1 (en) | 2022-10-18 | 2024-04-25 | Institut National de la Santé et de la Recherche Médicale | Method and composition for determining the level of o-glcnacylation in horses |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SU1441749A1 (ru) * | 1987-03-16 | 1996-01-10 | Институт Тонкой Органической Химии Им.А.Л.Мнджояна | 2-АМИНО-5,5-ДИМЕТИЛ-4,5-ДИГИДРО-7Н-ПИРАНО [4,3-d] ТИАЗОЛ, ОБЛАДАЮЩИЙ ТРАНКВИЛИЗИРУЮЩЕЙ АКТИВНОСТЬЮ |
| CA2599843C (en) | 2005-03-01 | 2013-08-27 | Simon Fraser University | Selective glycosidase inhibitors, methods of making inhibitors, and uses thereof |
| AU2007291870B2 (en) * | 2006-08-31 | 2012-12-06 | Simon Fraser University | Selective glycosidase inhibitors and uses thereof |
| EP2321289A4 (en) | 2008-08-01 | 2011-11-16 | Univ Fraser Simon | SELECTIVE GLYCOSIDASE HEMMER AND ITS USE |
| CA2732335A1 (en) | 2008-08-01 | 2010-02-04 | Simon Fraser University | Selective glycosidase inhibitors and uses thereof |
| CA2737267A1 (en) | 2008-09-16 | 2010-04-08 | Simon Fraser University | Selective glycosidase inhibitors and uses thereof |
| ES2568603T3 (es) * | 2011-08-25 | 2016-05-03 | Merck Patent Gmbh | Pirano[3,2-d][1,3]tiazol como inhibidores de glicosidasas |
-
2011
- 2011-11-07 TW TW100140566A patent/TW201249848A/zh unknown
- 2011-11-08 AR ARP110104166A patent/AR083798A1/es unknown
- 2011-11-08 CA CA2816798A patent/CA2816798C/en active Active
- 2011-11-08 AU AU2011326186A patent/AU2011326186A1/en not_active Abandoned
- 2011-11-08 EP EP11840448.2A patent/EP2637503B1/en active Active
- 2011-11-08 ES ES11840448.2T patent/ES2600028T3/es active Active
- 2011-11-08 RU RU2013126531/04A patent/RU2592285C2/ru active
- 2011-11-08 MX MX2013005118A patent/MX336611B/es unknown
- 2011-11-08 JP JP2013537923A patent/JP5965407B2/ja not_active Expired - Fee Related
- 2011-11-08 KR KR1020137014710A patent/KR101922266B1/ko not_active Expired - Fee Related
- 2011-11-08 BR BR112013011441A patent/BR112013011441B8/pt not_active IP Right Cessation
- 2011-11-08 WO PCT/US2011/059668 patent/WO2012064680A1/en not_active Ceased
-
2016
- 2016-04-07 AU AU2016202186A patent/AU2016202186B2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| RU2013126531A (ru) | 2014-12-20 |
| MX336611B (es) | 2016-01-22 |
| JP2013541596A (ja) | 2013-11-14 |
| TW201249848A (en) | 2012-12-16 |
| AU2011326186A8 (en) | 2013-08-01 |
| ES2600028T3 (es) | 2017-02-06 |
| BR112013011441B1 (pt) | 2021-11-09 |
| EP2637503B1 (en) | 2016-09-14 |
| BR112013011441B8 (pt) | 2023-04-18 |
| CA2816798A1 (en) | 2012-05-18 |
| CA2816798C (en) | 2019-02-26 |
| AU2011326186A1 (en) | 2013-05-23 |
| KR20130129974A (ko) | 2013-11-29 |
| EP2637503A1 (en) | 2013-09-18 |
| BR112013011441A2 (pt) | 2016-07-19 |
| RU2592285C2 (ru) | 2016-07-20 |
| MX2013005118A (es) | 2013-07-29 |
| WO2012064680A1 (en) | 2012-05-18 |
| AU2016202186A1 (en) | 2016-04-28 |
| EP2637503A4 (en) | 2014-04-09 |
| AU2016202186B2 (en) | 2017-10-12 |
| AR083798A1 (es) | 2013-03-20 |
| KR101922266B1 (ko) | 2018-11-26 |
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