JP5954918B2 - 未成熟な単球性樹状細胞の活性化を誘導するための組成物および方法 - Google Patents

未成熟な単球性樹状細胞の活性化を誘導するための組成物および方法 Download PDF

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JP5954918B2
JP5954918B2 JP2008544561A JP2008544561A JP5954918B2 JP 5954918 B2 JP5954918 B2 JP 5954918B2 JP 2008544561 A JP2008544561 A JP 2008544561A JP 2008544561 A JP2008544561 A JP 2008544561A JP 5954918 B2 JP5954918 B2 JP 5954918B2
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オールトン エル． ボイントン，
オールトン エル． ボイントン，
マーニックス エル． ボッシュ，
マーニックス エル． ボッシュ，
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ノースウエスト バイオセラピューティクス， インコーポレイテッド
ノースウエスト バイオセラピューティクス， インコーポレイテッド
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JP2008544561A 2005-12-08 2006-12-08 未成熟な単球性樹状細胞の活性化を誘導するための組成物および方法 Active JP5954918B2 (ja)

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US74888505P 2005-12-08 2005-12-08
US60/748,885 2005-12-08
PCT/US2006/047083 WO2007067782A2 (en) 2005-12-08 2006-12-08 Compositions and methods for inducing the activation of immature monocytic dendritic cells

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JP2013162033A Division JP2013223517A (ja) 2005-12-08 2013-08-05 未成熟な単球性樹状細胞の活性化を誘導するための組成物および方法
JP2016035257A Division JP2016105725A (ja) 2005-12-08 2016-02-26 未成熟な単球性樹状細胞の活性化を誘導するための組成物および方法

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JP2009518045A JP2009518045A (ja) 2009-05-07
JP2009518045A5 JP2009518045A5 (https=) 2012-11-29
JP5954918B2 true JP5954918B2 (ja) 2016-07-20

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JP2008544561A Active JP5954918B2 (ja) 2005-12-08 2006-12-08 未成熟な単球性樹状細胞の活性化を誘導するための組成物および方法
JP2013162033A Pending JP2013223517A (ja) 2005-12-08 2013-08-05 未成熟な単球性樹状細胞の活性化を誘導するための組成物および方法
JP2016035257A Withdrawn JP2016105725A (ja) 2005-12-08 2016-02-26 未成熟な単球性樹状細胞の活性化を誘導するための組成物および方法
JP2017122256A Withdrawn JP2017158595A (ja) 2005-12-08 2017-06-22 未成熟な単球性樹状細胞の活性化を誘導するための組成物および方法
JP2018238996A Withdrawn JP2019062904A (ja) 2005-12-08 2018-12-21 未成熟な単球性樹状細胞の活性化を誘導するための組成物および方法
JP2021000066A Withdrawn JP2021045176A (ja) 2005-12-08 2021-01-04 未成熟な単球性樹状細胞の活性化を誘導するための組成物および方法
JP2023175234A Pending JP2023171524A (ja) 2005-12-08 2023-10-10 未成熟な単球性樹状細胞の活性化を誘導するための組成物および方法

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JP2016035257A Withdrawn JP2016105725A (ja) 2005-12-08 2016-02-26 未成熟な単球性樹状細胞の活性化を誘導するための組成物および方法
JP2017122256A Withdrawn JP2017158595A (ja) 2005-12-08 2017-06-22 未成熟な単球性樹状細胞の活性化を誘導するための組成物および方法
JP2018238996A Withdrawn JP2019062904A (ja) 2005-12-08 2018-12-21 未成熟な単球性樹状細胞の活性化を誘導するための組成物および方法
JP2021000066A Withdrawn JP2021045176A (ja) 2005-12-08 2021-01-04 未成熟な単球性樹状細胞の活性化を誘導するための組成物および方法
JP2023175234A Pending JP2023171524A (ja) 2005-12-08 2023-10-10 未成熟な単球性樹状細胞の活性化を誘導するための組成物および方法

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US (2) US20080254537A1 (https=)
EP (3) EP1957634A4 (https=)
JP (7) JP5954918B2 (https=)
KR (6) KR20080109717A (https=)
CN (2) CN101336291A (https=)
AR (1) AR056851A1 (https=)
AU (1) AU2006321794A1 (https=)
BR (1) BRPI0619499A2 (https=)
CA (1) CA2632263C (https=)
CR (1) CR10048A (https=)
IL (2) IL191930A (https=)
RU (1) RU2008122550A (https=)
TW (1) TW200800252A (https=)
WO (1) WO2007067782A2 (https=)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2950109C (en) 2000-10-27 2019-02-19 John W. Hadden Vaccine immunotherapy for immune suppressed patients
US20070025958A1 (en) 2000-10-27 2007-02-01 Hadden John W Vaccine immunotherapy
ES2430389T3 (es) * 2008-04-14 2013-11-20 Irx Therapeutics, Inc. Procedimiento modificado de fabricación de IRX-2
US8728806B2 (en) 2008-12-06 2014-05-20 The Board Of Regents, The University Of Texas System Methods and compositions related to Th-1 dendritic cells
WO2010115229A1 (en) * 2009-04-09 2010-10-14 The University Of Melbourne Immunogenic composition and uses thereof
MX2011012147A (es) 2009-05-15 2012-06-19 Irx Therapeutics Inc Inmunoterapia de vacuna.
KR101911380B1 (ko) * 2009-07-24 2018-10-25 로드아일랜드하스피틀 아스파라기닐-β-히드록실라제 발현 종양을 위한 수지상 세포 백신
US20120183518A1 (en) * 2009-08-24 2012-07-19 Hong Jiang Assay for determining health of cd8+ t cells
AU2010307075B2 (en) 2009-10-12 2014-12-18 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Granulysin in immunotherapy
CN103097543A (zh) 2009-12-08 2013-05-08 伊尔克斯治疗有限公司 逆转朗格汉斯细胞免疫抑制的方法
US9476029B2 (en) * 2010-11-13 2016-10-25 Lung-Ji Chang Ex vivo development, expansion and in vivo analysis of a novel lineage of dendritic cells
NL2009102C2 (en) * 2012-07-02 2014-01-06 Dcprime B V Method for dc-loading.
TWI503414B (zh) * 2012-07-05 2015-10-11 Fullhope Biomedical Co Ltd 一種製備專一性ｔ細胞之配方、方法及其配方製備方法
US9744193B2 (en) 2012-09-06 2017-08-29 Orbis Health Solutions Llc Tumor lysate loaded particles
AU2020203845C1 (en) * 2012-09-06 2022-08-11 Orbis Health Solutions, Llc Tumor lysate loaded particles
AU2013359392C1 (en) 2012-12-12 2016-12-08 Orbis Health Solutions, Llc Compositions and methods for tissue regeneration
EP2913394B1 (en) * 2012-12-18 2016-06-22 Immunicum AB Co-differentiation and activation of monocytes from allogeneic donors to provide pro-inflammatory dendritic cells
CN112891522A (zh) * 2013-09-05 2021-06-04 奥比思健康解决方案有限责任公司 装载了肿瘤裂解物的微粒
CN103756960A (zh) * 2013-12-04 2014-04-30 深圳市合一康生物科技有限公司 一种高毒性、高增值能力的人d-cik细胞的专用试剂盒
CN103784950A (zh) * 2014-01-22 2014-05-14 北京弘润源生物技术有限公司 乳腺癌特异抗原表位多肽负载的树突状细胞疫苗制备及其试剂盒
WO2015134606A1 (en) 2014-03-05 2015-09-11 Orbis Health Solutions Llc Vaccine delivery systems using yeast cell wall particles
CN103800897B (zh) * 2014-03-12 2017-03-22 李金珍 一种肿瘤特异抗原表位多肽负载的树突状细胞疫苗制备方法及其试剂盒
ES2817325T3 (es) * 2014-06-23 2021-04-07 Jw Creagene Inc Procedimiento de preparación de células dendríticas con aumento de expresión génica específica, y composición para tratar o prevenir enfermedades autoinmunes, conteniendo células dendríticas preparadas utilizando el mismo
WO2016145578A1 (en) 2015-03-13 2016-09-22 Syz Cell Therapy Co. Methods of cancer treatment using activated t cells
JP6980650B2 (ja) * 2015-09-15 2021-12-15 ノースウエスト バイオセラピューティクス，インコーポレイティド 進行したがんを有する被験体のための活性化樹状細胞組成物および免疫療法処置に関する方法
CN105670994A (zh) * 2016-02-28 2016-06-15 深圳爱生再生医学科技有限公司 Dc诱导剂及其应用
CN105647867A (zh) * 2016-02-28 2016-06-08 深圳爱生再生医学科技有限公司 诱导树突状细胞成熟的方法和树突状细胞
JP7185530B2 (ja) 2016-06-13 2022-12-07 トルク セラピューティクス， インコーポレイテッド 免疫細胞機能を促進するための方法および組成物
CN109844100A (zh) * 2016-09-01 2019-06-04 株式会社理研免疫再生医学 制备天然杀伤t(nkt)细胞刺激性树突细胞的方法及制备含有nkt细胞刺激性树突细胞和nkt细胞的细胞组合物的方法
EP3518942A4 (en) * 2016-09-29 2020-05-27 Hadasit Medical Research Services&Development Ltd. DENDRITIC CELL PREPARATIONS, COMPOSITIONS AND METHODS OF USE
JP7285828B2 (ja) 2017-09-05 2023-06-02 トルク セラピューティクス， インコーポレイテッド 治療用タンパク質組成物ならびにその作製および使用方法
CN109957548B (zh) * 2017-12-26 2022-03-18 上海尚泰生物技术有限公司 一种基因修饰的树突状细胞疫苗
JP6881332B2 (ja) * 2018-01-29 2021-06-02 株式会社三洋物産 遊技機
JP6881333B2 (ja) * 2018-01-29 2021-06-02 株式会社三洋物産 遊技機
JP6881331B2 (ja) * 2018-01-29 2021-06-02 株式会社三洋物産 遊技機
WO2019183924A1 (en) 2018-03-30 2019-10-03 Syz Cell Therapy Co. Improved multiple antigen specific cell therapy methods
JP2021533759A (ja) * 2018-08-10 2021-12-09 ユーティレックス カンパニー リミテッド 癌抗原特異的ｃｄ８＋ｔ細胞を調製および凍結保存するための方法
CN110106145B (zh) * 2019-06-12 2021-02-12 蓝莲(杭州)生物科技有限公司 一种未成熟树突状细胞培养液及其未成熟树突状细胞的制备方法
WO2021230704A1 (ko) * 2020-05-15 2021-11-18 서울대학교 산학협력단 지방조직에서 분리된 기질혈관분획의 수지상세포의 활성화 기능을 이용한 면역 반응 증진용 조성물
KR102753583B1 (ko) * 2021-11-11 2025-01-10 의료법인 명지의료재단 Kras 특이적 활성화 t 세포 유도용 항원 조성물
KR102818249B1 (ko) * 2021-11-11 2025-06-10 의료법인 명지의료재단 Kras 특이적 활성화 t 세포 유도용 항원 조성물을 이용한 항원 특이적 t 세포 유도방법

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT633929E (pt) 1992-04-01 2004-07-30 Merix Bioscience Inc Metodo para proliferacao (in vitro) de precursores de celulas dentifricas e sua utilizacao para produzir imunogenios
US5788963A (en) 1995-07-31 1998-08-04 Pacific Northwest Cancer Foundation Isolation and/or preservation of dendritic cells for prostate cancer immunotherapy
US7659119B2 (en) 1996-02-12 2010-02-09 Argos Therapeutics, Inc. Method and compositions for obtaining mature dendritic cells
CA2286819A1 (en) * 1997-04-17 1998-10-22 Flossie Wong-Staal Use of lentiviral vectors for antigen presentation in dendritic cells
US6558951B1 (en) 1999-02-11 2003-05-06 3M Innovative Properties Company Maturation of dendritic cells with immune response modifying compounds
AU2002326463A1 (en) 2001-07-25 2003-02-17 Northwest Biotherapeutics, Inc. Methods and apparatus for enrichment and culture of monocytic dendritic cell precursors
CN1636229B (zh) * 2001-09-06 2012-12-19 西北生物治疗药物公司 引发单核树突细胞和t细胞th-1应答的组合物和方法
WO2004000444A1 (en) 2002-06-19 2003-12-31 Northwest Biotherapeutics, Inc. Tangential flow filtration devices and methods for leukocyte enrichment
AT412145B (de) * 2002-09-13 2004-10-25 Forsch Krebskranke Kinder Verfahren zur herstellung eines zellulären immuntherapeutikums auf basis von il-12-freisetzenden dendritischen zellen
ES2321939T3 (es) * 2003-02-27 2009-06-15 Northwest Biotherapeutics, Inc. Generacion de celulas dendriticas a partir de celulas precursoras dendriticas monociticas con gm-csf en ausencia de citoquinas adicionales.

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US20080254537A1 (en) 2008-10-16
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