JP5952302B2 - 眼の治療のための方法及びキット - Google Patents

眼の治療のための方法及びキット Download PDF

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Publication number
JP5952302B2
JP5952302B2 JP2013547630A JP2013547630A JP5952302B2 JP 5952302 B2 JP5952302 B2 JP 5952302B2 JP 2013547630 A JP2013547630 A JP 2013547630A JP 2013547630 A JP2013547630 A JP 2013547630A JP 5952302 B2 JP5952302 B2 JP 5952302B2
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abrasive
oil
eyelid
eye
isoprenoid
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Japanese (ja)
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JP2014501281A (ja
JP2014501281A5 (cg-RX-API-DMAC7.html
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ニチャミン、ルイス・ディー
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/0008—Introducing ophthalmic products into the ocular cavity or retaining products therein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/61—Myrtaceae (Myrtle family), e.g. teatree or eucalyptus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/82—Theaceae (Tea family), e.g. camellia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/04—Artificial tears; Irrigation solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/14—Ectoparasiticides, e.g. scabicides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M2037/0007—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin having means for enhancing the permeation of substances through the epidermis, e.g. using suction or depression, electric or magnetic fields, sound waves or chemical agents

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Ophthalmology & Optometry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Mycology (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Medical Informatics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Rheumatology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Cosmetics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
JP2013547630A 2010-12-29 2011-12-28 眼の治療のための方法及びキット Active JP5952302B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201061428043P 2010-12-29 2010-12-29
US61/428,043 2010-12-29
PCT/US2011/067479 WO2012092320A2 (en) 2010-12-29 2011-12-28 Eye treatment

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2016115049A Division JP6182643B2 (ja) 2010-12-29 2016-06-09 眼の治療のための方法及びキット

Publications (3)

Publication Number Publication Date
JP2014501281A JP2014501281A (ja) 2014-01-20
JP2014501281A5 JP2014501281A5 (cg-RX-API-DMAC7.html) 2015-01-22
JP5952302B2 true JP5952302B2 (ja) 2016-07-13

Family

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Family Applications (2)

Application Number Title Priority Date Filing Date
JP2013547630A Active JP5952302B2 (ja) 2010-12-29 2011-12-28 眼の治療のための方法及びキット
JP2016115049A Active JP6182643B2 (ja) 2010-12-29 2016-06-09 眼の治療のための方法及びキット

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2016115049A Active JP6182643B2 (ja) 2010-12-29 2016-06-09 眼の治療のための方法及びキット

Country Status (3)

Country Link
US (3) US20130331768A1 (cg-RX-API-DMAC7.html)
JP (2) JP5952302B2 (cg-RX-API-DMAC7.html)
WO (1) WO2012092320A2 (cg-RX-API-DMAC7.html)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9622911B2 (en) 2010-09-30 2017-04-18 Cxl Ophthalmics, Llc Ophthalmic treatment device, system, and method of use
JP5952302B2 (ja) 2010-12-29 2016-07-13 ニチャミン、ルイス・ディー 眼の治療のための方法及びキット
EP2830637B1 (en) 2012-03-29 2024-08-21 Epion Therapeutics, Inc. Compositions and methods for treating or preventing diseases associated with oxidative stress
EP2830627B1 (en) 2012-03-29 2024-05-01 Epion Therapeutics, Inc. Ocular treatment solutions, delivery devices and delivery augmentation methods
CA2873219C (en) * 2012-07-24 2019-04-02 Blephex, Llc Device for treating an ocular disorder
US9039718B2 (en) 2012-07-24 2015-05-26 Blephex, Llc Method and device for treating an ocular disorder
USD732163S1 (en) 2013-07-24 2015-06-16 Blephex, Llc Instrument for treating an ocular disorder
US20230181459A1 (en) * 2013-07-29 2023-06-15 Attillaps Holdings Inc. Treatment of ophthalmological conditions with acetylcholinesterase inhibitors
US20150125813A1 (en) * 2013-11-05 2015-05-07 Dentek Oral Care, Inc. Topical Anesthetic Applicator, and Method for Numbing a Dental Area
US10314763B2 (en) 2013-12-31 2019-06-11 Teeny Clean, Llc Eyelid care appliance
US20150216722A1 (en) * 2014-02-06 2015-08-06 John R. CHOATE Method and apparatus for ultrasonic eye cleaner
US20210259917A1 (en) * 2014-05-09 2021-08-26 Ocusoft, Inc. Applicators, compositions and methods for cleansing an ocular area
EP3406229B1 (en) * 2014-05-12 2025-08-20 Epion Therapeutics, Inc. Ophthalmic treatment solution delivery devices and delivery augmentation methods
AU2015267211A1 (en) * 2014-05-28 2017-01-12 Lunovus, Llc Ocular eyelid scrub composition for the treatment of Demodex blepharitis
US20170232024A1 (en) 2014-08-04 2017-08-17 Jerry Tan Eye Surgery Pte Ltd Pharmaceutical compositions for demodex related blepharitis and eyelid crusting
US9463201B2 (en) 2014-10-19 2016-10-11 M.G. Therapeutics Ltd Compositions and methods for the treatment of meibomian gland dysfunction
US10357526B2 (en) * 2014-12-30 2019-07-23 Procaps Sa Compositions for the treatment of infections caused by mite Demodex spp
CN104998149A (zh) * 2015-08-19 2015-10-28 张强 一种用于治疗睫缘炎的中药
EP3313413B1 (en) 2015-09-28 2024-12-04 Azura Ophthalmics Ltd Thiol and disulfide-containing agents for increasing meibomian gland lipid secretion
MA44676A (fr) 2016-04-14 2019-02-20 Azura Ophthalmics Ltd Compositions de disulfure de sélénium destinées à être utilisées dans le traitement du dysfonctionnement de la glande de meibomius
JP2019524892A (ja) 2016-08-19 2019-09-05 アクリビスタ エルエルシーＡｋｒｉｖｉｓｔａ，Ｌｌｃ ドライアイ症候群を診断及び治療する方法ならびにヒト眼を治療するための組成物
US12233017B2 (en) 2016-10-14 2025-02-25 Olympic Ophthalmics, Inc. Quiet handheld devices and methods for treatment of disorders
CN114376961A (zh) 2017-08-18 2022-04-22 阿克里维斯塔有限责任公司 诊断和治疗干眼综合症的方法和用于治疗人类眼睛的组合物
CN111655241B (zh) 2017-12-15 2024-10-15 塔苏斯制药有限公司 用于治疗睑炎的异恶唑啉驱虫剂制剂和方法
US11147735B2 (en) 2018-02-26 2021-10-19 Olympic Ophthalmics, Inc. Therapeutic handheld devices for disorders
US10898370B2 (en) 2018-05-21 2021-01-26 Thomas Conti Eyelid cleaning tool
US10730901B2 (en) * 2018-07-27 2020-08-04 Aperta Biosciences, Llc Spinosyn formulations for treatment of demodex-induced ocular and facial conditions
US12502377B2 (en) 2019-04-04 2025-12-23 Tarsus Pharmaceuticals, Inc. Method of eradicating ticks that attach to humans using lotilaner formulations
JP2019142943A (ja) * 2019-04-26 2019-08-29 プロキャプス ソシエダ アノニマ ニキビダニ属種（ｄｅｍｏｄｅｘ ｓｐｐ）のダニによって引き起こされる感染症を、治療するための組成物（ｃｏｍｐｏｓｉｔｉｏｎｓ ｆｏｒ ｔｈｅ ｔｒｅａｔｍｅｎｔ ｏｆ ｉｎｆｅｃｔｉｏｎｓ ｃａｕｓｅｄ ｂｙ ｍｉｔｅ ｄｅｍｏｄｅｘ ｓｐｐ）
CN115279458A (zh) 2020-01-10 2022-11-01 阿祖拉眼科有限公司 组合物和敏感性说明
JP2021004248A (ja) * 2020-09-14 2021-01-14 ダイヤー, ゴードン, ウェーンDYER, Gordon, Wayne キャシーバクスター状態を損なうための方法
IT202000021634A1 (it) * 2020-09-16 2020-12-16 Prete Antonio Del Dispositivo per la somministrazione di una soluzione con iodiopovidone per la prevenzione delle infezioni dell'occhio
CN113876807B (zh) * 2021-10-18 2023-10-27 物生生物科技(北京)有限公司 用于治疗眼部疾病的喷雾剂组合物及其应用
CN118593452A (zh) * 2024-05-22 2024-09-06 深圳市储康科技研发有限公司 一种具有眼部保健功效的复合理疗片及其制备方法

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4778457A (en) * 1986-11-06 1988-10-18 York Kenneth K Disposable applicator
CA2096505C (en) * 1992-05-21 1999-09-21 Robert Stanley Lee Exfoliant composition
EP1109563A4 (en) * 1998-08-04 2009-07-22 Madash Llp HEAT-SENSITIVE HYDROGELS WITH MODIFIED TERMINATION
US6836695B1 (en) * 1998-08-17 2004-12-28 Soft Sight Inc. Automatically generating embroidery designs from a scanned image
US6582442B2 (en) 2000-02-28 2003-06-24 Dynatronics Corporation Method and system for performing microabrasion
EP1219254A1 (fr) 2000-12-28 2002-07-03 Gabriel Bernaz Dispositif de dermabrasion
US20050037034A1 (en) 2003-05-05 2005-02-17 Rhoades Dean L. Method, apparatus, and composition for treating acne
EP1670435A2 (en) * 2003-08-04 2006-06-21 Foamix Ltd. Foam carrier containing amphiphilic copolymeric gelling agent
US7211070B2 (en) 2003-12-01 2007-05-01 Abraham Ebbie Soroudi Device and method for exothermic treatment of eyelid diseases
US20050220742A1 (en) * 2004-03-31 2005-10-06 Breen Ed V Compositions and methods for maintaining eyelid hygiene
CA2603235A1 (en) * 2005-03-28 2006-10-05 Bioresponse, Llc Diindolylmethane-based compositions and methods of use thereof for promoting oral mucosal and bone health
WO2006119174A1 (en) 2005-04-30 2006-11-09 Ocular Surface Center, P.A. Method for treating ocular demodex
FR2891460B1 (fr) 2005-09-30 2010-07-30 Galderma Sa Utilisation d'au moins un compose de la famille des avermectines pour le traitement des pathologies ophtalmiques dues au demodex folliculorum.
US20130184693A1 (en) * 2006-02-17 2013-07-18 Joseph Neev Device and method for treating medical, skin, and hair disorders with energy
US20070243275A1 (en) * 2006-04-13 2007-10-18 Gilbard Jeffrey P Methods and compositions for the treatment of infection or infectious colonization of the eyelid, ocular surface, skin or ear
US20080032605A1 (en) * 2006-08-04 2008-02-07 Chan Tracy L Abrasive lubricating wipes
US7951387B2 (en) * 2006-11-03 2011-05-31 Ocusoft, Inc. Eyelid scrub composition
US8202853B2 (en) 2006-11-03 2012-06-19 Ocusoft, Inc. Convenience kit for eyelid treatment
EP2073794A2 (en) * 2006-11-14 2009-07-01 Foamix Ltd. Stable non-alcoholic foamable pharmaceutical emulsion compositions with an unctuous emollient and their uses
JP2008133197A (ja) * 2006-11-27 2008-06-12 Sanyo Chem Ind Ltd 洗浄剤組成物
US20080166307A1 (en) * 2007-01-10 2008-07-10 Jose Eder Fontana Oral Care Compositions Comprising a Hippophae Extract
US8128968B2 (en) * 2007-08-29 2012-03-06 Tissuetech, Inc. Compositions and methods for treating Demodex infestations
US20090138026A1 (en) 2007-11-26 2009-05-28 Yueh-Chin Wu Water dermabrasion and skincare device and method thereof
CA2726836C (en) * 2008-06-26 2019-06-18 Anterios, Inc. Use of nanoemulsions in the manufacture of a medicament for treating skin disorders
US20100129465A1 (en) * 2008-07-03 2010-05-27 Roger Blotsky Methods and Compositions Related to Acne Treatment
EP2400841A1 (en) * 2009-02-25 2012-01-04 Georgia Health Sciences University Research Institute, Inc. Oral care compositions for treating xerostomia
NO2424374T3 (cg-RX-API-DMAC7.html) * 2009-05-01 2018-06-16
US20120014883A1 (en) * 2010-07-19 2012-01-19 Douglas Craig Scott Compositions Comprising Derivatives Of Essential Oil Compounds And Use In Personal Care Products
JP5952302B2 (ja) * 2010-12-29 2016-07-13 ニチャミン、ルイス・ディー 眼の治療のための方法及びキット
US9095566B1 (en) * 2013-06-28 2015-08-04 Edward Quicksilver Yavitz Eyelash and eyelid margin infections

Also Published As

Publication number Publication date
WO2012092320A2 (en) 2012-07-05
US9788994B2 (en) 2017-10-17
US20160235585A1 (en) 2016-08-18
JP2014501281A (ja) 2014-01-20
JP6182643B2 (ja) 2017-08-16
JP2016155877A (ja) 2016-09-01
US20180000640A1 (en) 2018-01-04
WO2012092320A3 (en) 2012-09-27
US20130331768A1 (en) 2013-12-12

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