JP5943927B2 - アッセイデバイスにおける試薬貯蔵 - Google Patents

アッセイデバイスにおける試薬貯蔵 Download PDF

Info

Publication number
JP5943927B2
JP5943927B2 JP2013533995A JP2013533995A JP5943927B2 JP 5943927 B2 JP5943927 B2 JP 5943927B2 JP 2013533995 A JP2013533995 A JP 2013533995A JP 2013533995 A JP2013533995 A JP 2013533995A JP 5943927 B2 JP5943927 B2 JP 5943927B2
Authority
JP
Japan
Prior art keywords
reagent
assay
binding
assay plate
analyte
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2013533995A
Other languages
English (en)
Japanese (ja)
Other versions
JP2013539867A (ja
JP2013539867A5 (enExample
Inventor
スディープ・クマー
ジョージ・シーガル
マイケル・ツィオンスキー
Original Assignee
メソ スケール テクノロジーズ エルエルシー
メソ スケール テクノロジーズ エルエルシー
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by メソ スケール テクノロジーズ エルエルシー, メソ スケール テクノロジーズ エルエルシー filed Critical メソ スケール テクノロジーズ エルエルシー
Publication of JP2013539867A publication Critical patent/JP2013539867A/ja
Publication of JP2013539867A5 publication Critical patent/JP2013539867A5/ja
Application granted granted Critical
Publication of JP5943927B2 publication Critical patent/JP5943927B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54386—Analytical elements
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C12Q1/6823—Release of bound markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6832—Enhancement of hybridisation reaction
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/5306—Improving reaction conditions, e.g. reduction of non-specific binding, promotion of specific binding
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2446/00—Magnetic particle immunoreagent carriers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2458/00—Labels used in chemical analysis of biological material
    • G01N2458/30—Electrochemically active labels

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Pathology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
JP2013533995A 2010-10-14 2011-10-13 アッセイデバイスにおける試薬貯蔵 Active JP5943927B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US45511210P 2010-10-14 2010-10-14
US61/455,112 2010-10-14
PCT/US2011/056095 WO2012051386A2 (en) 2010-10-14 2011-10-13 Reagent storage in an assay device

Publications (3)

Publication Number Publication Date
JP2013539867A JP2013539867A (ja) 2013-10-28
JP2013539867A5 JP2013539867A5 (enExample) 2014-11-27
JP5943927B2 true JP5943927B2 (ja) 2016-07-05

Family

ID=45938967

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2013533995A Active JP5943927B2 (ja) 2010-10-14 2011-10-13 アッセイデバイスにおける試薬貯蔵

Country Status (5)

Country Link
US (6) US20120157332A1 (enExample)
EP (3) EP2628004A4 (enExample)
JP (1) JP5943927B2 (enExample)
CA (3) CA3241642A1 (enExample)
WO (1) WO2012051386A2 (enExample)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3241642A1 (en) 2010-10-14 2012-04-19 Meso Scale Technologies, Llc Reagent storage in an assay device
JP2016508727A (ja) * 2013-02-25 2016-03-24 ウェルスタット ダイアグノスティクス，エルエルシー 電気化学発光（ｅｃｌ）検出試薬および酵素活性を測定するための関連の方法
CA2919833A1 (en) 2013-07-30 2015-02-05 President And Fellows Of Harvard College Quantitative dna-based imaging and super-resolution imaging
US20150185213A1 (en) * 2013-12-27 2015-07-02 Mag Array, Inc. Method of internal correction in one chip assay and method for measuring test substance using said method
CA2932943C (en) * 2014-03-11 2023-09-26 President And Fellows Of Harvard College High-throughput and highly multiplexed imaging with programmable nucleic acid probes
WO2017024044A1 (en) * 2015-08-03 2017-02-09 President And Fellows Of Harvard College Enhanced electrochemical detection using nanoparticles and precipitation
SG10202105017QA (en) 2015-08-10 2021-06-29 Essenlix Corp Bio/chemical assay devices and methods for simplified steps, small samples, accelerated speed, and ease-of-use
AU2016323062A1 (en) 2015-09-14 2018-04-12 Essenlix Corp. Device and system for analyzing a sample, particularly blood, as well as methods of using the same
JP6594528B2 (ja) 2015-09-14 2019-10-23 エッセンリックス コーポレーション 蒸気凝縮液、特に呼気凝縮液を採取し分析する装置及びシステム、並びにそれらの使用方法
WO2017196917A1 (en) * 2016-05-11 2017-11-16 Mayo Foundation For Medical Education And Research Hpv screening platform
WO2018065102A1 (en) 2016-10-07 2018-04-12 Boehringer Ingelheim Vetmedica Gmbh Method and analysis system for testing a sample
BR112019007081A2 (pt) * 2016-10-07 2019-07-09 Boehringer Ingelheim Vetmedica Gmbh sistema de análise e método para testagem de uma amostra
DK3523448T3 (da) 2016-10-07 2021-06-28 Boehringer Ingelheim Vetmedica Gmbh Fremgangsmåde og analysesystem til at teste en prøve
TW201832726A (zh) * 2016-11-01 2018-09-16 美商海科生醫有限責任公司 可基於輸入數據建議檢測之免疫檢測系統
US10324041B2 (en) * 2016-12-21 2019-06-18 Abbott Japan Co., Ltd. Optical imaging system using lateral illumination for digital assays
WO2018119318A1 (en) 2016-12-21 2018-06-28 Essenlix Corporation Devices and methods for authenticating a sample and use of the same
WO2018148342A1 (en) 2017-02-07 2018-08-16 Essenlix Corporation Compressed open flow assay and use
WO2018148764A1 (en) 2017-02-08 2018-08-16 Essenlix Corporation Molecular manipulation and assay with controlled temperature
CN111936837B (zh) 2017-02-08 2024-06-07 上海宜晟生物科技有限公司 Qmax测定及应用
CN111316096B (zh) 2017-02-08 2023-08-11 Essenlix公司 生物/化学材料提取和测定
WO2018148609A2 (en) 2017-02-09 2018-08-16 Essenlix Corporation Colorimetric assays
CA3053005A1 (en) 2017-02-08 2018-08-16 Essenlix Corporation Sample collection and handling for delayed analysis
WO2018148607A1 (en) 2017-02-09 2018-08-16 Essenlix Corporation Assay using different spacing heights
CN110998325B (zh) 2017-02-09 2024-08-16 上海宜晟生物科技有限公司 扩增测定
CA3053295A1 (en) 2017-02-15 2018-08-23 Essenlix Corporation Assay with rapid temperature change
JP7107953B2 (ja) 2017-02-16 2022-07-27 エッセンリックス コーポレーション テクスチャ表面を用いたアッセイ
JP7339245B2 (ja) 2017-06-12 2023-09-05 エッセンリックス コーポレーション 均質アッセイ法
US11725227B2 (en) 2017-08-01 2023-08-15 Essenlix Corporation Devices and methods for examining drug effects on microorganisms
US11280706B2 (en) 2017-08-01 2022-03-22 Essenlix Corporation Dilution calibration
CN111492222A (zh) 2017-08-01 2020-08-04 Essenlix公司 样品收集、保持和测定
WO2019075244A1 (en) 2017-10-11 2019-04-18 Essenlix Corporation CONTAINING A LIQUID SAMPLE
US11393561B2 (en) 2017-10-13 2022-07-19 Essenlix Corporation Devices and methods for authenticating a medical test and use of the same
US11237113B2 (en) 2017-10-26 2022-02-01 Essenlix Corporation Rapid pH measurement
US11609224B2 (en) 2017-10-26 2023-03-21 Essenlix Corporation Devices and methods for white blood cell analyses
US10807095B2 (en) 2017-10-26 2020-10-20 Essenlix Corporation Making and tracking assay card
US11648551B2 (en) 2017-12-12 2023-05-16 Essenlix Corporation Sample manipulation and assay with rapid temperature change
US11510608B2 (en) 2017-12-14 2022-11-29 Essenlix Corporation Devices, systems, and methods for monitoring hair
US11156606B2 (en) 2018-01-11 2021-10-26 Essenlix Corporation Homogeneous assay (II)
US11885952B2 (en) 2018-07-30 2024-01-30 Essenlix Corporation Optics, device, and system for assaying and imaging
CN112533701A (zh) * 2019-07-18 2021-03-19 京东方科技集团股份有限公司 微全分析系统及其工作方法、制作方法

Family Cites Families (60)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE388694B (sv) 1975-01-27 1976-10-11 Kabi Ab Sett att pavisa ett antigen exv i prov av kroppvetskor, med utnyttjande av till porost berarmaterial bundna eller adsorberande antikroppar
US4235601A (en) 1979-01-12 1980-11-25 Thyroid Diagnostics, Inc. Test device and method for its use
US4366241A (en) 1980-08-07 1982-12-28 Syva Company Concentrating zone method in heterogeneous immunoassays
US4442204A (en) 1981-04-10 1984-04-10 Miles Laboratories, Inc. Homogeneous specific binding assay device and preformed complex method
US5238808A (en) 1984-10-31 1993-08-24 Igen, Inc. Luminescent metal chelate labels and means for detection
US5310687A (en) 1984-10-31 1994-05-10 Igen, Inc. Luminescent metal chelate labels and means for detection
US6165729A (en) 1986-04-30 2000-12-26 Hyperion Catalysis International, Inc. Electrochemiluminescent reaction utilizing amine-derived reductant
US5591581A (en) 1986-04-30 1997-01-07 Igen, Inc. Electrochemiluminescent rhenium moieties and methods for their use
US5147806A (en) 1988-04-29 1992-09-15 Igen, Inc. Method and apparatus for conducting electrochemiluminescence measurements
JP2606722B2 (ja) * 1988-04-05 1997-05-07 栄治 石川 超高感度抗原物質の測定法
US5236849A (en) 1987-08-11 1993-08-17 Eiji Ishikawa Method of high sensitivity immunoassay
US5308754A (en) 1988-03-21 1994-05-03 Kankare Jouko J Electrogenerated luminescence in solution
US5093268A (en) 1988-04-28 1992-03-03 Igen, Inc. Apparatus for conducting a plurality of simultaneous measurements of electrochemiluminescent phenomena
US5705402A (en) 1988-11-03 1998-01-06 Igen International, Inc. Method and apparatus for magnetic microparticulate based luminescence assay including plurality of magnets
US5324457A (en) 1989-10-02 1994-06-28 Board Of Regents, The University Of Tx System Devices and methods for generating electrogenerated chemiluminescence
US5776672A (en) 1990-09-28 1998-07-07 Kabushiki Kaisha Toshiba Gene detection method
JPH04273065A (ja) * 1991-02-28 1992-09-29 Hitachi Ltd 免疫分析方法およびその分析装置
US5208535A (en) 1990-12-28 1993-05-04 Research Development Corporation Of Japan Mr position detecting device
JPH0534345A (ja) 1991-02-19 1993-02-09 Tdk Corp 化学発光を利用する抗原・抗体の測定方法
ZA929351B (en) 1991-12-11 1993-06-04 Igen Inc Electrochemiluminescent label for DNA assays.
US5541623A (en) 1993-06-02 1996-07-30 Alps Electric (U.S.A.) Inc. Temperature compensated opto-electronic circuit and mouse using same
US5786141A (en) 1994-08-26 1998-07-28 Bard; Allen J. Electrogenerated chemiluminescence labels for analysis and/or referencing
US5707799A (en) 1994-09-30 1998-01-13 Abbott Laboratories Devices and methods utilizing arrays of structures for analyte capture
JPH08178926A (ja) * 1994-10-25 1996-07-12 Sumitomo Pharmaceut Co Ltd イムノアッセイプレートおよびその用途
US5866434A (en) 1994-12-08 1999-02-02 Meso Scale Technology Graphitic nanotubes in luminescence assays
US5641623A (en) 1995-01-04 1997-06-24 Martin; Mark T. Electrochemiluminescence assay
US5643713A (en) 1995-06-07 1997-07-01 Liang; Pam Electrochemiluminescent monitoring of compounds
US6207369B1 (en) 1995-03-10 2001-03-27 Meso Scale Technologies, Llc Multi-array, multi-specific electrochemiluminescence testing
CA2213854C (en) 1995-03-10 2010-08-10 Meso Scale Technologies, Llc Multi-array, multi-specific electrochemiluminescence testing
US6319670B1 (en) 1995-05-09 2001-11-20 Meso Scale Technology Llp Methods and apparatus for improved luminescence assays using microparticles
US5679519A (en) 1995-05-09 1997-10-21 Oprandy; John J. Multi-label complex for enhanced sensitivity in electrochemiluminescence assay
US5589136A (en) 1995-06-20 1996-12-31 Regents Of The University Of California Silicon-based sleeve devices for chemical reactions
EP0852004B1 (en) 1995-10-11 2011-01-19 Luminex Corporation Multiplexed analysis of clinical specimens
GB9606850D0 (en) 1996-04-01 1996-06-05 Univ Liverpool An assay system and novel labelled compounds for use therwith
FR2764381A1 (fr) 1997-06-09 1998-12-11 Univ De Neuchatel Detecteur electrochimioluminescent
US6413783B1 (en) 1997-09-18 2002-07-02 Meso Scale Technologies, Llc Assay sonication apparatus and methodology
US6200531B1 (en) 1998-05-11 2001-03-13 Igen International, Inc. Apparatus for carrying out electrochemiluminescence test measurements
EP0962773A1 (en) 1998-06-03 1999-12-08 Mark Howard Jones Electrochemical based assay processes instrument and labels
GB9815042D0 (en) 1998-07-10 1998-09-09 Imperial College Detector
US6214552B1 (en) 1998-09-17 2001-04-10 Igen International, Inc. Assays for measuring nucleic acid damaging activities
US6136268A (en) 1999-08-17 2000-10-24 Orion Diagnostica Method for luminescence measurements
US20020058329A1 (en) * 2000-02-18 2002-05-16 Sharat Singh Multiple-site reaction device and method
US20030003464A1 (en) * 2000-11-27 2003-01-02 Phan Brigitte C. Dual bead assays including optical biodiscs and methods relating thereto
US20030148335A1 (en) * 2001-10-10 2003-08-07 Li Shen Detecting targets by unique identifier nucleotide tags
EP1585957A2 (en) * 2001-11-27 2005-10-19 Burstein Technologies, Inc. Magneto-optical bio-discs and systems including related methods
US20040009528A1 (en) * 2002-07-11 2004-01-15 Shyh-Yu Shaw Protein chips
US20060211055A1 (en) * 2002-11-12 2006-09-21 Caliper Life Sciences, Inc. Capture and release assay system and method
CA3171720C (en) 2002-12-26 2024-01-09 Meso Scale Technologies, Llc. Methods for conducting electrochemiluminescence measurements
ATE452208T1 (de) * 2004-10-08 2010-01-15 Sysmex Corp Verfahren zum nachweis einer zielsubstanz unter verwendung einer nukleinsäuresonde
US20060263907A1 (en) * 2005-04-29 2006-11-23 Zweig Stephen E Fluorescence lateral flow immunoassay
WO2006132666A1 (en) * 2005-06-06 2006-12-14 Decision Biomarkers, Inc. Assays based on liquid flow over arrays
WO2007002579A2 (en) * 2005-06-23 2007-01-04 Bioveris Corporation Assay cartridges and methods for point of care instruments
CA2616404A1 (en) * 2005-07-26 2007-02-01 Oregon Health & Science University Nanoparticle probes for capture, sorting and placement of targets
KR101489804B1 (ko) * 2005-12-21 2015-02-05 메소 스케일 테크놀러지즈, 엘엘시 분석 시약을 갖는 분석 모듈 및 그것의 제조 및 사용 방법
ES2393758T3 (es) * 2006-03-15 2012-12-27 Micronics, Inc. Ensayos integrados de ácidos nucleicos
WO2008016680A1 (en) * 2006-08-02 2008-02-07 California Institute Of Technology Methods and systems for detecting and/or sorting targets
GB0618966D0 (en) * 2006-09-26 2006-11-08 Iti Scotland Ltd Cartridge system
EP2274443A4 (en) * 2008-04-09 2012-03-28 California Inst Of Techn MUG AND PROCESSES AND SYSTEMS ASSOCIATED WITH DETECTING AND / OR SORTING TARGETS
CA3028780C (en) 2009-12-07 2022-05-31 Meso Scale Technologies, Llc Assay cartridges and methods of using the same
CA3241642A1 (en) 2010-10-14 2012-04-19 Meso Scale Technologies, Llc Reagent storage in an assay device

Also Published As

Publication number Publication date
US20200209234A1 (en) 2020-07-02
US20160349253A1 (en) 2016-12-01
EP2628004A2 (en) 2013-08-21
US20250334571A1 (en) 2025-10-30
JP2013539867A (ja) 2013-10-28
EP4300100A2 (en) 2024-01-03
CA3139049A1 (en) 2012-04-19
CA3241642A1 (en) 2012-04-19
CA3139049C (en) 2024-10-15
US10627399B2 (en) 2020-04-21
US20130316928A1 (en) 2013-11-28
WO2012051386A3 (en) 2012-07-19
CA2814680C (en) 2021-11-16
US12216117B2 (en) 2025-02-04
US11231417B2 (en) 2022-01-25
CA2814680A1 (en) 2012-04-19
EP3644058A1 (en) 2020-04-29
EP2628004A4 (en) 2014-08-20
US9797894B2 (en) 2017-10-24
US20220252590A1 (en) 2022-08-11
WO2012051386A2 (en) 2012-04-19
EP4300100A3 (en) 2024-09-04
US20120157332A1 (en) 2012-06-21

Similar Documents

Publication Publication Date Title
JP5943927B2 (ja) アッセイデバイスにおける試薬貯蔵
US12359264B2 (en) Co-binder assisted assay methods
US20200191779A1 (en) Methods for conducting assays
KR102459433B1 (ko) 다중화 어세이를 수행하기 위한 올리고뉴클레오티드
HK1213048B (en) Improved methods for conducting multiplexed assays

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20141010

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20141010

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20150624

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20150630

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20150929

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20151228

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20160426

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20160524

R150 Certificate of patent or registration of utility model

Ref document number: 5943927

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250