JP5932830B2 - 炎症及び疼痛を処置するための３‐メタンスルホニルプロピオニトリル - Google Patents

炎症及び疼痛を処置するための３‐メタンスルホニルプロピオニトリル Download PDF

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JP5932830B2
JP5932830B2 JP2013544685A JP2013544685A JP5932830B2 JP 5932830 B2 JP5932830 B2 JP 5932830B2 JP 2013544685 A JP2013544685 A JP 2013544685A JP 2013544685 A JP2013544685 A JP 2013544685A JP 5932830 B2 JP5932830 B2 JP 5932830B2
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pharmaceutical composition
composition according
pain
inflammation
methanesulfonylpropionitrile
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JP2014503533A (ja
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ピー．セント ローレント ジョセフ
ピー．セント ローレント ジョセフ
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オラテック セラピューティクス リミティド ライアビリティ カンパニー
オラテック セラピューティクス リミティド ライアビリティ カンパニー
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/095—Sulfur, selenium, or tellurium compounds, e.g. thiols
    • A61K31/10—Sulfides; Sulfoxides; Sulfones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/275—Nitriles; Isonitriles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/095—Sulfur, selenium, or tellurium compounds, e.g. thiols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/02—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms of an acyclic and saturated carbon skeleton
    • C07C255/03—Mononitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/26—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C317/28—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to acyclic carbon atoms of the carbon skeleton

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Immunology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Pulmonology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
JP2013544685A 2010-12-15 2011-12-13 炎症及び疼痛を処置するための３‐メタンスルホニルプロピオニトリル Active JP5932830B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US42348510P 2010-12-15 2010-12-15
US61/423,485 2010-12-15
PCT/US2011/064590 WO2012082718A2 (en) 2010-12-15 2011-12-13 3-methanesulfonylpropionitrile for treating inflammation and pain

Publications (3)

Publication Number Publication Date
JP2014503533A JP2014503533A (ja) 2014-02-13
JP2014503533A5 JP2014503533A5 (https=) 2015-01-08
JP5932830B2 true JP5932830B2 (ja) 2016-06-08

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JP2013544685A Active JP5932830B2 (ja) 2010-12-15 2011-12-13 炎症及び疼痛を処置するための３‐メタンスルホニルプロピオニトリル

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US (8) US8476316B2 (https=)
EP (1) EP2651407B1 (https=)
JP (1) JP5932830B2 (https=)
KR (1) KR101849813B1 (https=)
CN (1) CN103260613B (https=)
AU (1) AU2011344030B2 (https=)
BR (1) BR112013014583A2 (https=)
CA (1) CA2820625C (https=)
MX (1) MX2013006708A (https=)
TW (1) TWI522338B (https=)
WO (1) WO2012082718A2 (https=)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6151723B2 (ja) 2012-02-27 2017-06-21 オラテック セラピューティクス リミティド ライアビリティ カンパニー ３−メチルスルホニルプロピオニトリルを調製するプロセス
CA2875052C (en) * 2012-06-05 2020-07-14 Olatec Industries Llc Method for treating skin inflammatory diseases
JP6208751B2 (ja) * 2012-06-05 2017-10-04 オラテック セラピューティクス リミティド ライアビリティ カンパニー 炎症及び疼痛を治療するための医薬組成物
US9481644B2 (en) 2012-06-05 2016-11-01 Olatec Therapeutics Llc Pharmaceutical composition comprising omega-(arylsulfonyl)alkylnitrile
WO2013184703A1 (en) * 2012-06-05 2013-12-12 Olatec Industries Llc Pharmaceutical composition for treating inflammation and pain
JP6228193B2 (ja) 2012-06-11 2017-11-08 オラテック セラピューティクス リミティド ライアビリティ カンパニー 炎症及び疼痛を治療するための化合物
US9114122B2 (en) 2012-06-14 2015-08-25 Olatec Industries Llc Compounds for treating inflammation and pain
WO2013188314A1 (en) * 2012-06-14 2013-12-19 Olatec Industries Llc Compounds for treating inflammation and pain
PL3369435T3 (pl) 2013-07-18 2020-04-30 Xalud Therapeutics, Inc. Kompozycja do leczenia choroby zapalnej stawów
JP6461961B2 (ja) 2013-08-20 2019-01-30 オラテック セラピューティクス リミティド ライアビリティ カンパニー ジエチル（２−シアノエチル）ホスホネートの医薬組成物および使用
WO2015048328A1 (en) * 2013-09-26 2015-04-02 Olatec Industries Llc 3, 4-bis-benzylsulfonylbutanenitrile and its pharmaceutical use
US9440916B2 (en) 2013-09-26 2016-09-13 Olatec Therapeutics Llc 3, 4-bis-benzylsulfonylbutyronitrile and its pharmaceutical use
US9999610B2 (en) 2013-10-01 2018-06-19 Olatec Therapeutics Llc Pharmaceutical use of 3-benzylsulfonylpropionitrile
EP3052475B1 (en) * 2013-10-01 2018-08-08 Olatec Therapeutics LLC Pharmaceutical use of 3-benzylsulfonylpropionitrile
US9522878B2 (en) 2013-10-07 2016-12-20 Olatec Therapeutics Llc 4-methylsulfonyl-2-butenenitrile and its pharmaceutical use
EP3055286A4 (en) * 2013-10-07 2017-05-24 Olatec Therapeutics LLC 4-methylsulfonyl-2-butenenitrile and its pharmaceutical use
WO2015081188A1 (en) * 2013-11-27 2015-06-04 Olatec Industries Llc Pharmaceutical composition comprising omega-(arylsulfonyl)alkylnitrile
EP3468530A4 (en) 2016-06-10 2020-03-11 Clarity Cosmetics Inc. NON-COMEDOGEN FORMULA FOR HAIR AND SCALP CARE AND METHOD FOR USE
ES2970485T3 (es) 2017-01-06 2024-05-29 Olatec Therapeutics Llc Composición farmacéutica para su uso en el tratamiento de enfermedades cardiovasculares
US10273203B2 (en) 2017-04-11 2019-04-30 Olatec Therapeutics Llc Deuterated 3-methanesulfonylpropionitrile
WO2019032672A1 (en) * 2017-08-11 2019-02-14 Olatec Therapeutics Llc METHOD OF TREATING SCHNITZLER SYNDROME
CA3087865A1 (en) 2018-01-31 2019-08-08 Olatec Therapeutics Llc Method for preventing or treating alzheimer's disease
JP7229565B2 (ja) * 2018-03-21 2023-02-28 オラテック セラピューティクス リミティド ライアビリティ カンパニー メラノーマを治療するための方法
WO2020241809A1 (ja) * 2019-05-31 2020-12-03 日本たばこ産業株式会社 幸福感の評価方法及び幸福感を評価するためのデータ取得方法
AU2020296829B2 (en) * 2019-06-17 2026-01-15 Olatec Therapeutics Llc Method for treating asthma
EP4045009A4 (en) 2019-10-14 2023-11-01 Olatec Therapeutics LLC METHOD FOR TREATING BREAST CANCER
WO2022226495A1 (en) * 2021-04-22 2022-10-27 Olatec Therapeutics Llc Method for treating spinal cord injury
CN118436631B (zh) * 2024-05-08 2025-07-01 中国人民解放军军事科学院军事医学研究院 达泮舒腈在预防和/或治疗急性放射性肺损伤中的应用

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3041155A1 (de) * 1980-10-31 1982-06-09 Bayer Ag, 5090 Leverkusen Verfahren zur herstellung von 2,3-dichlor-sulfonyl-acrylnitrilen
JPS58501722A (ja) * 1981-10-16 1983-10-13 アボツト　ラボラトリ−ズ 〔１↓−（２↓−ベンゾオキサゾリル）ヒドラジノ〕アルキルニトリル誘導体
US5175192A (en) * 1984-03-19 1992-12-29 The Rockefeller University Inhibitors of the advanced glycosylation of proteins and methods of use therefor
EP0355049A3 (en) 1988-08-18 1990-06-13 Zeneca Limited Heterocyclic compounds
US5348838A (en) 1991-07-31 1994-09-20 Kabushiki Kaisha Toshiba Photosensitive composition comprising alkali soluble binder and photoacid generator having sulfonyl group
KR100294084B1 (ko) * 1998-06-02 2001-09-22 성재갑 비-스테로이드성소염진통제의경피흡수투여용조성물및이를포함하는경피흡수투여용제형
WO1999039713A1 (en) 1998-02-09 1999-08-12 Chong Kun Dang Pharmaceutical Corp. Piroxicam-containing hydroalcoholic gel composition
US6551615B1 (en) * 2001-10-18 2003-04-22 M/S. Strides Arcolab Limited Dexibuprofen-containing soft gelatin capsules and process for preparing the same
CN1528284A (zh) * 2003-10-06 2004-09-15 南昌弘益科技有限公司 蔊菜素滴丸及其制备方法
US7423064B2 (en) 2004-09-24 2008-09-09 Olatec Industries, Llc Composition for treating bacterial, viral, fungal diseases, inflammation and pain
PT1988779E (pt) * 2006-02-16 2015-09-04 Anacor Pharmaceuticals Inc Moléculas pequenas contendo boro como agentes antiinflamatórios
BRPI0621416A2 (pt) * 2006-03-20 2011-12-06 Olatec Ind Llc composição para o tratamento de doenças bacterianas, virais, fúngicas, inflamação e dor
US20100221337A1 (en) * 2007-02-14 2010-09-02 Logical Therapeutics, Inc. Method of treating arthritis, pain or inflammation with naproxen 2(methanesulfonyl)ethyl ester and an h2 receptor antagonist
KR20150065941A (ko) * 2008-03-06 2015-06-15 아나코르 파마슈티칼스 인코포레이티드 소염제로써 붕소가 함유된 소분자
WO2010018814A1 (ja) 2008-08-12 2010-02-18 宇部興産株式会社 非水電解液及びそれを用いたリチウム電池
AU2010226794A1 (en) * 2009-03-18 2011-10-27 Olatec Industries Llc Compounds for treating inflammation and pain

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Publication number Publication date
US8975297B2 (en) 2015-03-10
CA2820625A1 (en) 2012-06-21
US9492420B2 (en) 2016-11-15
US20130172410A1 (en) 2013-07-04
EP2651407A2 (en) 2013-10-23
KR101849813B1 (ko) 2018-04-17
AU2011344030A1 (en) 2013-07-11
TW201305093A (zh) 2013-02-01
US20190133988A1 (en) 2019-05-09
US10080735B2 (en) 2018-09-25
JP2014503533A (ja) 2014-02-13
US9770428B2 (en) 2017-09-26
CA2820625C (en) 2019-04-02
CN103260613A (zh) 2013-08-21
US20180125807A1 (en) 2018-05-10
CN103260613B (zh) 2015-01-14
MX2013006708A (es) 2013-09-13
EP2651407B1 (en) 2016-12-21
US20200237706A1 (en) 2020-07-30
TWI522338B (zh) 2016-02-21
AU2011344030B2 (en) 2017-03-30
WO2012082718A2 (en) 2012-06-21
US20170119725A1 (en) 2017-05-04
US11229620B2 (en) 2022-01-25
US8476316B2 (en) 2013-07-02
WO2012082718A3 (en) 2012-10-26
US10500184B2 (en) 2019-12-10
US20150231106A1 (en) 2015-08-20
US20120157524A1 (en) 2012-06-21
US20140228433A1 (en) 2014-08-14
US8829046B2 (en) 2014-09-09
BR112013014583A2 (pt) 2016-09-20
EP2651407A4 (en) 2014-06-04
KR20140030122A (ko) 2014-03-11

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