KR101849813B1 - 염증 및 통증 치료용 3-메탄술포닐프로피오니트릴 - Google Patents

염증 및 통증 치료용 3-메탄술포닐프로피오니트릴 Download PDF

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KR101849813B1
KR101849813B1 KR1020137018100A KR20137018100A KR101849813B1 KR 101849813 B1 KR101849813 B1 KR 101849813B1 KR 1020137018100 A KR1020137018100 A KR 1020137018100A KR 20137018100 A KR20137018100 A KR 20137018100A KR 101849813 B1 KR101849813 B1 KR 101849813B1
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pharmaceutical composition
pain
methanesulfonylpropionitrile
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pharmaceutically acceptable
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KR20140030122A (ko
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로렌 조셉 피 세인트
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오라텍 세라퓨틱스 엘엘씨
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/095—Sulfur, selenium, or tellurium compounds, e.g. thiols
    • A61K31/10—Sulfides; Sulfoxides; Sulfones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/275—Nitriles; Isonitriles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/095—Sulfur, selenium, or tellurium compounds, e.g. thiols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/02—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms of an acyclic and saturated carbon skeleton
    • C07C255/03—Mononitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/26—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C317/28—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to acyclic carbon atoms of the carbon skeleton

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Immunology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Pulmonology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
KR1020137018100A 2010-12-15 2011-12-13 염증 및 통증 치료용 3-메탄술포닐프로피오니트릴 Active KR101849813B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US42348510P 2010-12-15 2010-12-15
US61/423,485 2010-12-15
PCT/US2011/064590 WO2012082718A2 (en) 2010-12-15 2011-12-13 3-methanesulfonylpropionitrile for treating inflammation and pain

Publications (2)

Publication Number Publication Date
KR20140030122A KR20140030122A (ko) 2014-03-11
KR101849813B1 true KR101849813B1 (ko) 2018-04-17

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KR1020137018100A Active KR101849813B1 (ko) 2010-12-15 2011-12-13 염증 및 통증 치료용 3-메탄술포닐프로피오니트릴

Country Status (11)

Country Link
US (8) US8476316B2 (https=)
EP (1) EP2651407B1 (https=)
JP (1) JP5932830B2 (https=)
KR (1) KR101849813B1 (https=)
CN (1) CN103260613B (https=)
AU (1) AU2011344030B2 (https=)
BR (1) BR112013014583A2 (https=)
CA (1) CA2820625C (https=)
MX (1) MX2013006708A (https=)
TW (1) TWI522338B (https=)
WO (1) WO2012082718A2 (https=)

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CA2875052C (en) * 2012-06-05 2020-07-14 Olatec Industries Llc Method for treating skin inflammatory diseases
JP6208751B2 (ja) * 2012-06-05 2017-10-04 オラテック セラピューティクス リミティド ライアビリティ カンパニー 炎症及び疼痛を治療するための医薬組成物
US9481644B2 (en) 2012-06-05 2016-11-01 Olatec Therapeutics Llc Pharmaceutical composition comprising omega-(arylsulfonyl)alkylnitrile
WO2013184703A1 (en) * 2012-06-05 2013-12-12 Olatec Industries Llc Pharmaceutical composition for treating inflammation and pain
JP6228193B2 (ja) 2012-06-11 2017-11-08 オラテック セラピューティクス リミティド ライアビリティ カンパニー 炎症及び疼痛を治療するための化合物
US9114122B2 (en) 2012-06-14 2015-08-25 Olatec Industries Llc Compounds for treating inflammation and pain
WO2013188314A1 (en) * 2012-06-14 2013-12-19 Olatec Industries Llc Compounds for treating inflammation and pain
PL3369435T3 (pl) 2013-07-18 2020-04-30 Xalud Therapeutics, Inc. Kompozycja do leczenia choroby zapalnej stawów
JP6461961B2 (ja) 2013-08-20 2019-01-30 オラテック セラピューティクス リミティド ライアビリティ カンパニー ジエチル（２−シアノエチル）ホスホネートの医薬組成物および使用
WO2015048328A1 (en) * 2013-09-26 2015-04-02 Olatec Industries Llc 3, 4-bis-benzylsulfonylbutanenitrile and its pharmaceutical use
US9440916B2 (en) 2013-09-26 2016-09-13 Olatec Therapeutics Llc 3, 4-bis-benzylsulfonylbutyronitrile and its pharmaceutical use
US9999610B2 (en) 2013-10-01 2018-06-19 Olatec Therapeutics Llc Pharmaceutical use of 3-benzylsulfonylpropionitrile
EP3052475B1 (en) * 2013-10-01 2018-08-08 Olatec Therapeutics LLC Pharmaceutical use of 3-benzylsulfonylpropionitrile
US9522878B2 (en) 2013-10-07 2016-12-20 Olatec Therapeutics Llc 4-methylsulfonyl-2-butenenitrile and its pharmaceutical use
EP3055286A4 (en) * 2013-10-07 2017-05-24 Olatec Therapeutics LLC 4-methylsulfonyl-2-butenenitrile and its pharmaceutical use
WO2015081188A1 (en) * 2013-11-27 2015-06-04 Olatec Industries Llc Pharmaceutical composition comprising omega-(arylsulfonyl)alkylnitrile
EP3468530A4 (en) 2016-06-10 2020-03-11 Clarity Cosmetics Inc. NON-COMEDOGEN FORMULA FOR HAIR AND SCALP CARE AND METHOD FOR USE
ES2970485T3 (es) 2017-01-06 2024-05-29 Olatec Therapeutics Llc Composición farmacéutica para su uso en el tratamiento de enfermedades cardiovasculares
US10273203B2 (en) 2017-04-11 2019-04-30 Olatec Therapeutics Llc Deuterated 3-methanesulfonylpropionitrile
WO2019032672A1 (en) * 2017-08-11 2019-02-14 Olatec Therapeutics Llc METHOD OF TREATING SCHNITZLER SYNDROME
CA3087865A1 (en) 2018-01-31 2019-08-08 Olatec Therapeutics Llc Method for preventing or treating alzheimer's disease
JP7229565B2 (ja) * 2018-03-21 2023-02-28 オラテック セラピューティクス リミティド ライアビリティ カンパニー メラノーマを治療するための方法
WO2020241809A1 (ja) * 2019-05-31 2020-12-03 日本たばこ産業株式会社 幸福感の評価方法及び幸福感を評価するためのデータ取得方法
AU2020296829B2 (en) * 2019-06-17 2026-01-15 Olatec Therapeutics Llc Method for treating asthma
EP4045009A4 (en) 2019-10-14 2023-11-01 Olatec Therapeutics LLC METHOD FOR TREATING BREAST CANCER
WO2022226495A1 (en) * 2021-04-22 2022-10-27 Olatec Therapeutics Llc Method for treating spinal cord injury
CN118436631B (zh) * 2024-05-08 2025-07-01 中国人民解放军军事科学院军事医学研究院 达泮舒腈在预防和/或治疗急性放射性肺损伤中的应用

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JP2002516879A (ja) 1998-06-02 2002-06-11 エルジ ケミカル リミテッド 非ステロイド性消炎鎮痛剤の経皮投与用組成物
US20060069160A1 (en) 2004-09-24 2006-03-30 Christopher Torrence Composition for treating bacterial, viral, fungal diseases, inflammation and pain
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US8975297B2 (en) 2015-03-10
CA2820625A1 (en) 2012-06-21
US9492420B2 (en) 2016-11-15
US20130172410A1 (en) 2013-07-04
JP5932830B2 (ja) 2016-06-08
EP2651407A2 (en) 2013-10-23
AU2011344030A1 (en) 2013-07-11
TW201305093A (zh) 2013-02-01
US20190133988A1 (en) 2019-05-09
US10080735B2 (en) 2018-09-25
JP2014503533A (ja) 2014-02-13
US9770428B2 (en) 2017-09-26
CA2820625C (en) 2019-04-02
CN103260613A (zh) 2013-08-21
US20180125807A1 (en) 2018-05-10
CN103260613B (zh) 2015-01-14
MX2013006708A (es) 2013-09-13
EP2651407B1 (en) 2016-12-21
US20200237706A1 (en) 2020-07-30
TWI522338B (zh) 2016-02-21
AU2011344030B2 (en) 2017-03-30
WO2012082718A2 (en) 2012-06-21
US20170119725A1 (en) 2017-05-04
US11229620B2 (en) 2022-01-25
US8476316B2 (en) 2013-07-02
WO2012082718A3 (en) 2012-10-26
US10500184B2 (en) 2019-12-10
US20150231106A1 (en) 2015-08-20
US20120157524A1 (en) 2012-06-21
US20140228433A1 (en) 2014-08-14
US8829046B2 (en) 2014-09-09
BR112013014583A2 (pt) 2016-09-20
EP2651407A4 (en) 2014-06-04
KR20140030122A (ko) 2014-03-11

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