JP5931439B2 - トリプタン化合物イオントフォレシス用のポリアミン強化製剤 - Google Patents

トリプタン化合物イオントフォレシス用のポリアミン強化製剤 Download PDF

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Publication number
JP5931439B2
JP5931439B2 JP2011514567A JP2011514567A JP5931439B2 JP 5931439 B2 JP5931439 B2 JP 5931439B2 JP 2011514567 A JP2011514567 A JP 2011514567A JP 2011514567 A JP2011514567 A JP 2011514567A JP 5931439 B2 JP5931439 B2 JP 5931439B2
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JP
Japan
Prior art keywords
patch
transdermal patch
salt
iontophoretic transdermal
sumatriptan
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP2011514567A
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English (en)
Japanese (ja)
Other versions
JP2011524901A (ja
JP2011524901A5 (ru
Inventor
セブリー，テリ，ビー．
ホーストマン，ミヒャエル
サメッティ，モハマッド
Original Assignee
テバ・ファーマシューティカルズ・インターナショナル・ゲー・エム・ベー・ハー
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Publication of JP2011524901A publication Critical patent/JP2011524901A/ja
Publication of JP2011524901A5 publication Critical patent/JP2011524901A5/ja
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0009—Galenical forms characterised by the drug release technique; Application systems commanded by energy involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/20—Applying electric currents by contact electrodes continuous direct currents
    • A61N1/30—Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/20—Applying electric currents by contact electrodes continuous direct currents
    • A61N1/30—Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
    • A61N1/303—Constructional details
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Inorganic Chemistry (AREA)
  • Radiology & Medical Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Dermatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Neurosurgery (AREA)
  • Organic Chemistry (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2011514567A 2008-06-19 2008-10-30 トリプタン化合物イオントフォレシス用のポリアミン強化製剤 Expired - Fee Related JP5931439B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US12/214,555 US8366600B2 (en) 2008-06-19 2008-06-19 Polyamine enhanced formulations for triptan compound iontophoresis
US12/214,555 2008-06-19
PCT/US2008/081837 WO2009154648A1 (en) 2008-06-19 2008-10-30 Polyamine enhanced formulations for triptan compound iontophoresis

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2014147900A Division JP6002179B2 (ja) 2008-06-19 2014-07-18 トリプタン化合物イオントフォレシス用のポリアミン強化製剤

Publications (3)

Publication Number Publication Date
JP2011524901A JP2011524901A (ja) 2011-09-08
JP2011524901A5 JP2011524901A5 (ru) 2011-12-08
JP5931439B2 true JP5931439B2 (ja) 2016-06-08

Family

ID=41431954

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2011514567A Expired - Fee Related JP5931439B2 (ja) 2008-06-19 2008-10-30 トリプタン化合物イオントフォレシス用のポリアミン強化製剤
JP2014147900A Expired - Fee Related JP6002179B2 (ja) 2008-06-19 2014-07-18 トリプタン化合物イオントフォレシス用のポリアミン強化製剤

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2014147900A Expired - Fee Related JP6002179B2 (ja) 2008-06-19 2014-07-18 トリプタン化合物イオントフォレシス用のポリアミン強化製剤

Country Status (12)

Country Link
US (3) US8366600B2 (ru)
EP (1) EP2296597A4 (ru)
JP (2) JP5931439B2 (ru)
CN (2) CN102065807B (ru)
AU (2) AU2008358026B2 (ru)
CA (1) CA2727926A1 (ru)
EA (2) EA023339B1 (ru)
HK (1) HK1201763A1 (ru)
IL (1) IL209755A (ru)
MX (1) MX2010013645A (ru)
WO (1) WO2009154648A1 (ru)
ZA (1) ZA201008859B (ru)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3308777A1 (en) * 2008-06-19 2018-04-18 LTS Lohmann Therapie-Systeme AG Composition for transdermal delivery of cationic active agents
US8845612B2 (en) * 2009-08-10 2014-09-30 Nupathe Inc. Methods for iontophoretically treating nausea and migraine
ES2955255T3 (es) 2016-03-25 2023-11-29 Aminex Therapeutics Inc Poliaminas biodisponibles
WO2018006069A1 (en) 2016-06-30 2018-01-04 Teva Pharmaceuticals International Gmbh Improved formulations for transdermal pharmaceutical systems
BR112020010146A2 (pt) 2017-12-20 2020-10-13 Lts Lohmann Therapie-Systeme Ag composição frigoestável para fornecimento transdérmico iontoforético de um composto de triptano
EP3727330A1 (en) * 2017-12-20 2020-10-28 LTS Lohmann Therapie-Systeme AG Frigostable composition for iontophoretic transdermal delivery of a triptan compound
JP2023545674A (ja) 2020-09-30 2023-10-31 アミネックス セラピューティクス， インコーポレイテッド ポリアミン輸送阻害剤およびｄｆｍｏの配合原薬

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US5605536A (en) 1983-08-18 1997-02-25 Drug Delivery Systems Inc. Transdermal drug applicator and electrodes therefor
US5651768A (en) 1983-08-18 1997-07-29 Drug Delivery Systems, Inc. Transdermal drug applicator and electrodes therefor
US4822802A (en) 1987-02-24 1989-04-18 Alza Corporation Method of fentanly administration for postoperative pain relief
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EP0429842B1 (en) * 1989-10-27 1996-08-28 Korea Research Institute Of Chemical Technology Device for the transdermal administration of protein or peptide drug
US5207752A (en) 1990-03-30 1993-05-04 Alza Corporation Iontophoretic drug delivery system with two-stage delivery profile
DE4014913C2 (de) 1990-05-10 1996-05-15 Lohmann Therapie Syst Lts Miniaturisiertes transdermales therapeutisches System für die Iontophorese
ATE160510T1 (de) 1992-06-02 1997-12-15 Alza Corp Abgabevorrichtung zur elektrischen übertragung von arzneimitteln
US5807571A (en) 1993-05-06 1998-09-15 Lts Lohmann Therapie-Systeme Gmbh Transdermal therapeutic systems for administering indole serotonin agonists
US5458569A (en) 1993-06-08 1995-10-17 Becton Dickinson And Company Wearable iontophoresis system
US5533971A (en) 1993-09-03 1996-07-09 Alza Corporation Reduction of skin irritation during electrotransport
EP0643981B1 (en) * 1993-09-22 2002-01-09 Hisamitsu Pharmaceutical Co., Inc. A matrix for iontophoreses
US5697896A (en) 1994-12-08 1997-12-16 Alza Corporation Electrotransport delivery device
IE960312A1 (en) 1995-06-02 1996-12-11 Alza Corp An electrotransport delivery device with voltage boosting¹circuit
US6425892B2 (en) 1995-06-05 2002-07-30 Alza Corporation Device for transdermal electrotransport delivery of fentanyl and sufentanil
AU699774B2 (en) 1995-06-05 1998-12-17 Alza Corporation Device for transdermal electrotransport delivery of fentanyl and sufentanil
US6216033B1 (en) 1996-05-22 2001-04-10 Alza Corporation Device for transdermal electrotransport delivery of fentanyl and sufentanil
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Also Published As

Publication number Publication date
ZA201008859B (en) 2016-03-30
JP2014237675A (ja) 2014-12-18
AU2008358026B2 (en) 2015-06-18
EP2296597A4 (en) 2013-10-16
CN102065807B (zh) 2014-06-25
HK1201763A1 (en) 2015-09-11
JP2011524901A (ja) 2011-09-08
WO2009154648A1 (en) 2009-12-23
US20130245535A1 (en) 2013-09-19
AU2008358026A1 (en) 2009-12-23
IL209755A0 (en) 2011-02-28
US8366600B2 (en) 2013-02-05
IL209755A (en) 2014-06-30
EA201100055A1 (ru) 2011-08-30
AU2015224400B2 (en) 2017-06-01
AU2015224400A1 (en) 2015-10-29
US20090318847A1 (en) 2009-12-24
CA2727926A1 (en) 2009-12-23
EA201590907A1 (ru) 2016-02-29
MX2010013645A (es) 2011-02-15
JP6002179B2 (ja) 2016-10-05
EP2296597A1 (en) 2011-03-23
EA023339B1 (ru) 2016-05-31
EA026988B1 (ru) 2017-06-30
CN104027885A (zh) 2014-09-10
US20170112779A1 (en) 2017-04-27
CN102065807A (zh) 2011-05-18

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