JP5921430B2 - 哺乳類細胞の心臓発生能を決定する方法 - Google Patents
哺乳類細胞の心臓発生能を決定する方法 Download PDFInfo
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- JP5921430B2 JP5921430B2 JP2012512038A JP2012512038A JP5921430B2 JP 5921430 B2 JP5921430 B2 JP 5921430B2 JP 2012512038 A JP2012512038 A JP 2012512038A JP 2012512038 A JP2012512038 A JP 2012512038A JP 5921430 B2 JP5921430 B2 JP 5921430B2
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- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
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- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6881—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for tissue or cell typing, e.g. human leukocyte antigen [HLA] probes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/34—Muscles; Smooth muscle cells; Heart; Cardiac stem cells; Myoblasts; Myocytes; Cardiomyocytes
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0657—Cardiomyocytes; Heart cells
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- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/6851—Quantitative amplification
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- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/105—Insulin-like growth factors [IGF]
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/15—Transforming growth factor beta (TGF-β)
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/155—Bone morphogenic proteins [BMP]; Osteogenins; Osteogenic factor; Bone inducing factor
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/16—Activin; Inhibin; Mullerian inhibiting substance
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/70—Enzymes
- C12N2501/73—Hydrolases (EC 3.)
- C12N2501/734—Proteases (EC 3.4.)
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/999—Small molecules not provided for elsewhere
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- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/13—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells
- C12N2506/1346—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells from mesenchymal stem cells
- C12N2506/1353—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells from mesenchymal stem cells from bone marrow mesenchymal stem cells (BM-MSC)
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- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6804—Nucleic acid analysis using immunogens
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- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/686—Polymerase chain reaction [PCR]
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- C12Q2531/00—Reactions of nucleic acids characterised by
- C12Q2531/10—Reactions of nucleic acids characterised by the purpose being amplify/increase the copy number of target nucleic acid
- C12Q2531/113—PCR
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- C12Q2561/00—Nucleic acid detection characterised by assay method
- C12Q2561/101—Taqman
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- C12Q2561/00—Nucleic acid detection characterised by assay method
- C12Q2561/113—Real time assay
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- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/136—Screening for pharmacological compounds
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- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
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- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/178—Oligonucleotides characterized by their use miRNA, siRNA or ncRNA
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
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- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Cardiology (AREA)
- Developmental Biology & Embryology (AREA)
- Rheumatology (AREA)
- Medicinal Chemistry (AREA)
- Virology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Vascular Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| USPCT/US2009/044751 | 2009-05-20 | ||
| USPCT/US2009/044751 | 2009-05-20 | ||
| PCT/US2010/035616 WO2010135555A1 (en) | 2009-05-20 | 2010-05-20 | Method for determining the cardio-generative potential of mammalian cells |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012527245A JP2012527245A (ja) | 2012-11-08 |
| JP2012527245A5 JP2012527245A5 (enExample) | 2013-07-04 |
| JP5921430B2 true JP5921430B2 (ja) | 2016-05-24 |
Family
ID=42316056
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012512038A Active JP5921430B2 (ja) | 2009-05-20 | 2010-05-20 | 哺乳類細胞の心臓発生能を決定する方法 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20160298086A1 (enExample) |
| EP (2) | EP3524980A1 (enExample) |
| JP (1) | JP5921430B2 (enExample) |
| KR (1) | KR101808349B1 (enExample) |
| CN (1) | CN102498399A (enExample) |
| AU (1) | AU2010249821B2 (enExample) |
| BR (1) | BRPI1010684A2 (enExample) |
| CA (1) | CA2761807C (enExample) |
| IL (1) | IL216368A (enExample) |
| NZ (1) | NZ595919A (enExample) |
| RU (1) | RU2624498C2 (enExample) |
| TW (1) | TWI564558B (enExample) |
| WO (1) | WO2010135555A1 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2532909T3 (es) | 2004-07-30 | 2015-04-01 | Mayo Foundation For Medical Education And Research | Tratamiento de tejido cardiovascular |
| US9765298B2 (en) | 2006-07-24 | 2017-09-19 | Mayo Foundation For Medical Education And Research | Methods and materials for providing cardiac cells |
| WO2009145761A1 (en) | 2008-05-27 | 2009-12-03 | Mayo Foundation For Medical Education And Research | Methods and materials for using cells to treat heart tissue |
| US9453205B2 (en) * | 2009-10-31 | 2016-09-27 | Genesis Technologies Limited | Methods for reprogramming cells and uses thereof |
| AU2010312240B2 (en) * | 2009-10-31 | 2016-12-15 | Genesis Technologies Limited | Methods for reprogramming cells and uses thereof |
| US20140038291A1 (en) | 2009-10-31 | 2014-02-06 | New World Laboratories Inc. | Methods for reprogramming cells and uses thereof |
| US9185690B2 (en) * | 2012-02-29 | 2015-11-10 | Sharp Kabushiki Kaisha | Allocating and determining resources for a device-to-device link |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020061837A1 (en) | 1996-09-05 | 2002-05-23 | Lough John W. | Bone morphogenetic protein and fibroblast growth factor compositions and methods for the induction of cardiogenesis |
| US6324479B1 (en) * | 1998-05-08 | 2001-11-27 | Rosetta Impharmatics, Inc. | Methods of determining protein activity levels using gene expression profiles |
| US6218122B1 (en) * | 1998-06-19 | 2001-04-17 | Rosetta Inpharmatics, Inc. | Methods of monitoring disease states and therapies using gene expression profiles |
| US7547674B2 (en) * | 2001-06-06 | 2009-06-16 | New York Medical College | Methods and compositions for the repair and/or regeneration of damaged myocardium |
| TWI226440B (en) * | 2000-09-08 | 2005-01-11 | Kuo Kwang Biotech Corp | Predicting survival of patients with squamous cell carcinoma |
| IL159580A0 (en) | 2001-07-12 | 2004-06-01 | Geron Corp | Cells of the cardiomyocyte lineage produced from human pluripotent stem cells |
| AU2003220562A1 (en) * | 2002-04-01 | 2003-10-20 | Peter K. Law | Cellular transplantation for heart regeneration |
| WO2004094610A2 (en) * | 2003-04-21 | 2004-11-04 | Baylor College Of Medicine | Wnt as a factor for cardiac myogenesis |
| BRPI0414961A (pt) * | 2003-10-03 | 2006-11-07 | Keiichi Fukuda | processo de indução da diferenciação de células tronco em células do miocárdio |
| DE10347436B4 (de) * | 2003-10-13 | 2007-08-02 | Johann Wolfgang Goethe-Universität Frankfurt am Main | In vitro Verfahren zur Diagnose der kardiovaskulären Funktionalität von Blut-abgeleiteter zirkulierender Vorläuferzellen (BDP) |
| US20070077578A1 (en) * | 2004-03-02 | 2007-04-05 | Primagen Holding B.V. | Diagnosis of (a risk of ) disease and monitoring of therapy |
| US20050277124A1 (en) * | 2004-06-10 | 2005-12-15 | White Steven M | Cardiac conduction system cells and uses thereof |
| WO2007093412A2 (en) * | 2006-02-16 | 2007-08-23 | Fondazione Centro San Raffaele Del Monte Tabor | Skeletal muscle periangioblasts and cardiac mesoangioblasts, method for isolation and uses thereof |
| US9765298B2 (en) * | 2006-07-24 | 2017-09-19 | Mayo Foundation For Medical Education And Research | Methods and materials for providing cardiac cells |
| WO2008054819A2 (en) * | 2006-11-02 | 2008-05-08 | The General Hospital Corporation | Cardiovascular stem cells, methods for stem cell isolation, and uses thereof |
| WO2008060446A2 (en) * | 2006-11-09 | 2008-05-22 | The J. David Gladstone Institutes | Methods for inducing cardiomyogenesis |
| US20110110897A1 (en) * | 2008-01-11 | 2011-05-12 | Schwarz Richard P | Adult Human Cardiac-Derived Progenitor Cells |
| EP2100954A1 (en) * | 2008-03-10 | 2009-09-16 | Assistance Publique - Hopitaux de Paris | Method for generating primate cardiac progenitor cells for clinical use from primate embryonic stem cells, and their applications |
| WO2009145761A1 (en) * | 2008-05-27 | 2009-12-03 | Mayo Foundation For Medical Education And Research | Methods and materials for using cells to treat heart tissue |
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2010
- 2010-05-20 CN CN2010800215516A patent/CN102498399A/zh active Pending
- 2010-05-20 EP EP18208719.7A patent/EP3524980A1/en not_active Withdrawn
- 2010-05-20 WO PCT/US2010/035616 patent/WO2010135555A1/en not_active Ceased
- 2010-05-20 EP EP10721224.3A patent/EP2433125B1/en active Active
- 2010-05-20 KR KR1020117027716A patent/KR101808349B1/ko not_active Expired - Fee Related
- 2010-05-20 AU AU2010249821A patent/AU2010249821B2/en not_active Ceased
- 2010-05-20 BR BRPI1010684A patent/BRPI1010684A2/pt not_active IP Right Cessation
- 2010-05-20 RU RU2011143063A patent/RU2624498C2/ru not_active IP Right Cessation
- 2010-05-20 CA CA2761807A patent/CA2761807C/en not_active Expired - Fee Related
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| KR101808349B1 (ko) | 2017-12-12 |
| IL216368A (en) | 2016-02-29 |
| CN102498399A (zh) | 2012-06-13 |
| CA2761807C (en) | 2018-01-09 |
| RU2011143063A (ru) | 2013-06-27 |
| EP2433125A1 (en) | 2012-03-28 |
| AU2010249821B2 (en) | 2015-07-02 |
| TWI564558B (zh) | 2017-01-01 |
| JP2012527245A (ja) | 2012-11-08 |
| TW201105965A (en) | 2011-02-16 |
| KR20120034624A (ko) | 2012-04-12 |
| RU2624498C2 (ru) | 2017-07-04 |
| NZ595919A (en) | 2014-01-31 |
| US20160298086A1 (en) | 2016-10-13 |
| IL216368A0 (en) | 2012-01-31 |
| CA2761807A1 (en) | 2010-11-25 |
| BRPI1010684A2 (pt) | 2017-07-18 |
| EP2433125B1 (en) | 2018-11-28 |
| EP3524980A1 (en) | 2019-08-14 |
| AU2010249821A1 (en) | 2011-11-17 |
| WO2010135555A1 (en) | 2010-11-25 |
| AU2010249821A8 (en) | 2011-12-08 |
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