JP5911066B2 - Dressings and systems for reepithelialization formula wound - Google Patents

Dressings and systems for reepithelialization formula wound Download PDF

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JP5911066B2
JP5911066B2 JP2012526840A JP2012526840A JP5911066B2 JP 5911066 B2 JP5911066 B2 JP 5911066B2 JP 2012526840 A JP2012526840 A JP 2012526840A JP 2012526840 A JP2012526840 A JP 2012526840A JP 5911066 B2 JP5911066 B2 JP 5911066B2
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JP2013502983A (en
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ロック,クリストファー,ブライアン
ロビンソン,ティモシー,マーク
クルサード,リチャード,ダニエル,ジョン
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ケーシーアイ ライセンシング インコーポレイテッド
ケーシーアイ ライセンシング インコーポレイテッド
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00Bandages or dressings; Absorbent pads
    • A61F13/00051Accessories for dressings
    • A61F13/00068Accessories for dressings specially adapted for application or removal of fluid, e.g. irrigation or drainage of wounds, under-pressure wound-therapy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00Bandages or dressings; Absorbent pads
    • A61F13/02Adhesive plasters or dressings
    • A61F13/0203Adhesive plasters or dressings having a fluid handling member
    • A61F13/0213Adhesive plasters or dressings having a fluid handling member the fluid handling member being a layer of hydrocoloid, gel forming material
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00Bandages or dressings; Absorbent pads
    • A61F13/02Adhesive plasters or dressings
    • A61F13/0203Adhesive plasters or dressings having a fluid handling member
    • A61F13/022Adhesive plasters or dressings having a fluid handling member having more than one layer with different fluid handling characteristics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/0023Suction drainage systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/008Drainage tubes; Aspiration tips
    • A61M1/0088Drainage tubes; Aspiration tips with a seal, e.g. to stick around a wound for isolating the treatment area
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00Bandages or dressings; Absorbent pads
    • A61F2013/00089Wound bandages
    • A61F2013/0017Wound bandages possibility of applying fluid
    • A61F2013/00174Wound bandages possibility of applying fluid possibility of applying pressure
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00Bandages or dressings; Absorbent pads
    • A61F2013/00361Plasters
    • A61F2013/00365Plasters use
    • A61F2013/00536Plasters use for draining or irrigating wounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00Bandages or dressings; Absorbent pads
    • A61F2013/00361Plasters
    • A61F2013/00365Plasters use
    • A61F2013/0054Plasters use for deep wounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00Bandages or dressings; Absorbent pads
    • A61F2013/00361Plasters
    • A61F2013/00727Plasters means for wound humidity control
    • A61F2013/00748Plasters means for wound humidity control with hydrocolloids or superabsorbers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00Bandages or dressings; Absorbent pads
    • A61F2013/00361Plasters
    • A61F2013/00855Plasters pervious to air or vapours
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M27/00Drainage appliances for wounds or the like, i.e. wound drains, implanted drains

Description

関連出願 本発明は、2009年8月27日提出の米国暫定出願整理番号61/237,486、名称「Re-Epitherliazation Wound Dressings and Systems」の35USC§119(e)の利益を主張するものであり、これは参照によりすべての目的において組み込まれている。 RELATED APPLICATIONS The present invention claims the benefit of 35USC§119 (e) of the filing on August 27, 2009, US Provisional Application Serial No. 61 / 237,486, entitled "Re-Epitherliazation Wound Dressings and Systems" , which is incorporated for all purposes by reference.

本発明は、一般に医療システムを開示するものであり、より具体的には、ただし限定しないが、上皮再形成式創傷用医療材料およびシステムを開示する。 The present invention is generally disclose a medical system, and more specifically, but not limited to, disclose medical materials and systems for re-epithelialisation formula wound.

創傷治癒の生理学上のプロセスは、同時あるいは連続的に生じる異なるフェーズを含む。 Physiological process of wound healing, including simultaneously or sequentially occurring different phases. 本書において、「または」は相互に排他的である必要はない。 In this book, "or" need not be mutually exclusive. 創傷治癒プロセスの2つのフェーズは、顆粒化(増殖)と、上皮再形成を含む。 Two phases of the wound healing process includes granulation and (proliferation), reepithelialization.

創傷ケアの医療材料、方法、およびシステムの特定の態様における改良は、本書に多様な説明的で非限定的な実施例について図示され記述される。 Medical materials wound care, methods, and improvements in certain aspects of the system are illustrated for non-limiting example and diverse explanatory herein described. 説明的で非限定的な実施例によると、減圧とともに用いられる上皮再形成医療材料において、湿性の組織界面層は、組織の水分バランスを提供するように適合し、複数の孔を有して形成される。 According to the description, non-limiting embodiment, the reepithelialization medical materials for use with reduced pressure, permeability of the tissue interface layer is adapted to provide a water balance of tissue, with a plurality of holes formed It is. マニホルドは、密閉部材と湿性組織界面層の間に配置され、減圧を分配しうる。 Manifold is disposed between the sealing member and the wet tissue interface layer may then distribute the reduced pressure.

別の説明的で非限定的な実施例によると、創傷の上皮再形成を促すシステムは、上皮再形成式創傷用医療材料を含む。 According to non-limiting example, another illustrative system for prompting reepithelialization of wounds include reepithelialization formula wound medical materials. この上皮再形成式創傷用医療材料は、湿性の組織界面層と、マニホルド部材と、密閉部材とを具える.。 The reepithelialization formula wound medical material comprises a tissue interface layer of wet, a manifold member, a sealing member .. 湿性の組織界面層は、組織の水分バランスを提供するように適合し、複数の孔を有して形成される。 Wet tissue interface layer, adapted to provide a moisture balance of the tissue is formed with a plurality of holes. マニホルドは、密閉部材と湿性組織界面層の間に配置され、減圧を分配しうる。 Manifold is disposed between the sealing member and the wet tissue interface layer may then distribute the reduced pressure. システムはさらに、減圧を上皮再形成創傷式創傷用医療材料に減圧を提供するための、減圧コネクタと、減圧送達導管と、減圧源とを具える。 The system further comprises for providing a vacuum reduced pressure to reepithelialization wound type wound medical materials, and vacuum connector, the reduced pressure delivery conduit, and a vacuum source. 減圧送達導管は、減圧源と減圧コネクタを流体結合しうる。 Reduced pressure delivery conduit may fluidly couple the vacuum connector and the reduced pressure source.

別の説明的で非限定的な実施例によると、創傷の上皮再形成を促進する方法が、創傷の近くに上皮再形成用医療材料を展開するステップと、前記上皮再形成用医療材料を減圧供給導管に流体結合するステップと、当該減圧送達導管に減圧をかけるステップとを具える。 According to non-limiting example is another illustrative method of promoting re-epithelialization of the wound, the method comprising deploying the reepithelialization for medical materials near the wound, the re-epithelialization for medical materials vacuo comprising the steps of fluidly coupling the supply conduit, the step of applying a vacuum to the vacuum delivery conduit. この上皮再形成用医療材料は、水分バランスを提供する湿性の組織界面層を具える。 The reepithelialization medical material comprises a tissue interface layer of wet to provide a water balance. 湿性の組織界面層は、第1の面と、第2の組織対向面とを具え、複数の孔が形成されている。 Moist tissue interface layer includes a first surface, comprising a second tissue facing surface, a plurality of holes are formed. 上皮再形成用医療材料はさらに、減圧を分配するマニホルド部材を具える。 Reepithelialization medical material further comprises a manifold member to distribute the reduced pressure. このマニホルド部材は第1の面と、第2の組織対向面とを具える。 The manifold member may comprise a first surface and a second tissue facing surface. 上皮再形成用医療材料はまた、第1の面と第2の組織対向面とを具える密閉部材を具える。 Reepithelialization medical material also comprises a sealing member comprising a first surface and a second tissue facing surface. マニア掘る度部材は、前記密閉部材と湿性の組織界面層との間に配置される。 Mania dig time member is disposed between the sealing member and the permeability of the tissue interface layer.

実施例の他の特徴と利点は、以下の図面と詳細な説明より明らかとなる。 Other features and advantages of embodiments will become apparent from the following drawings and detailed description.

図1は、創傷治療システムの例示的かつ非限定的な実施例の一部が断面となった概略図である。 Figure 1 is a schematic illustrating a part of a cross section of an illustrative, non-limiting examples of wound treatment system. 図2は、減圧をかけていない状態の、図1の創傷治療システムの例示的かつ非限定的な実施例の部分概略図である。 2, the state of not applying a vacuum, is an exemplary and partial schematic view of a non-limiting example of wound treatment system of FIG. 図3は、減圧をかけた状態の、図1の創傷治療システムの例示的かつ非限定的な実施例の部分概略図である。 Figure 3 is a state of applying a vacuum, which is exemplary and partial schematic view of a non-limiting example of wound treatment system of FIG. 図4は、吸収層を追加した、図1の創傷治療システムの例示的かつ非限定的な実施例の部分概略図である。 4 has added absorption layer is an exemplary and partial schematic view of a non-limiting example of wound treatment system of FIG.

例示的かつ非限定的な実施例の以下の詳細な説明において、その一部を形成する添付図面を参照する。 In the following detailed description of illustrative and non-limiting examples, reference is made to the accompanying drawings which form a part hereof. これらの実施例は、当業者が本発明を実施できるのに十分なように説明されており、他の実施例も利用可能であると解され、論理的、構造的、機械的、電気的、および化学的な変更を本発明の範囲を逸脱することなく施すことができる。 These embodiments, those skilled in the art are described as sufficient to practice the invention, is understood as other embodiments are available, logical, structural, mechanical, electrical, and chemical changes may be made without departing from the scope of the present invention. 当業者が本書に記載された実施例を実施するのに不要な詳細を避けるべく、当業者にとって周知な特定の情報を省略することがある。 Those skilled in the art to avoid unnecessary detail for practicing the embodiments described herein, may be omitted specific information known to those skilled in the art. このため、以下の詳細な説明は、限定的な意味で解されてはならず、例示的な実施例の範囲は添付のクレームによってのみ規定される。 Therefore, the following detailed description, be construed in a limiting sense not in the range of illustrative embodiments are defined only by the appended claims.

最初に図1を参照すると、上皮再形成用医療材料102を具える創傷治療システム100の例示的かつ非限定的な実施例が示されている。 Referring initially to FIG. 1, an exemplary, non-limiting examples of wound treatment system 100 comprising reepithelialization medical material 102 is shown. 上皮再形成用医療材料102は、組織部位104、特に創傷106、または創傷部位の治療のために展開されている。 Reepithelialization medical material 102, the tissue site 104, especially developed for the treatment of wounds 106 or wound site. 創傷106は、表皮108を通って皮下組織110へと延在する。 Wound 106 extends through the epidermis 108 and into subcutaneous tissue 110. 組織部位104は、ヒト、動物の体細胞、または、骨組織、脂肪組織、筋肉組織、皮膚組織、血管組織、関節組織、軟骨、健、靱帯を含む他の器官、もしくは他の様々な組織である。 The tissue site 104, human, animal body cells, or bone tissue, adipose tissue, muscle tissue, skin tissue, vascular tissue, joint tissue, cartilage, Ken, other organs, including the ligaments or other in various tissues, is there. 上皮再形成用医療材料102を有する創傷治療システム100は、創傷106の上皮再形成を促し、創傷縁部112の移動(migration)を促進する。 Wound therapy system 100 having reepithelialization for medical materials 102 prompts reepithelialization of the wound 106 to facilitate movement of the wound edges 112 (migration).

深刻な創傷治療の上皮再形成、または上皮形成フェーズは、創傷106の露出(resurfacing)と、創傷縁部112の変化を含む。 Re-epithelialization of serious wound treatment or epithelialization phase, comprises exposure of the wound 106 and (Resurfacing), changes in the wound edge 112. これらのプロセスは患者の身体を外部有機体による侵略から保護するものであり、制限されていない場合に他のフェーズと同時に生じうる。 These processes are intended to protect the patient's body from invasion by external organisms can occur concurrently with other phases if not restricted.

とりわけ、真皮および表皮層からのケラチン生成細胞がある。 Especially, there is keratinocytes from the dermal and epidermal layers. ケラチン生成細胞は毛包の膨らんだ領域に位置する表皮の幹細胞から派生し、その位置から表皮の基底層へと移動する。 Keratinocytes derived from stem cells of the epidermis which is located in the region bulging of the hair follicle, moves from its position to the basal layer of the epidermis. このケラチン生成細胞は増殖し分化して表皮を生成し、これにより表皮を補充する。 The keratinocytes proliferate and differentiate to generate a skin, thereby supplementing the skin. ケラチン生成細胞は空間を再び表面処理するシート上を前進して、、創傷の滲出液といった成長因子から放出されるシグナルに応答する。 Keratinocytes respond to the signal emitted from the growth factors such as exudates ,, wound advanced over the sheet for processing the spatial surface again. この移動により、湿性の創傷環境が創傷縁部112からケラチン生成細胞の移動を互いに向かって早めるか、そうでなくとも促進する。 This movement, moist wound environment advance or towards each other the movement of keratinocytes from the wound edges 112 facilitates not be the case. 創傷治療システム100は、この上皮再形成フェーズまたはプロセスを促進する。 Wound therapy system 100 facilitates the reepithelialization phase or process.

創傷治療システム100は、上皮再形成用医療材料102に付随して、上皮再形成用医療材料102の少なくとも一部に減圧を提供する減圧コネクタ114を具える。 Wound treatment system 100 is associated with re-epithelialization for medical materials 102 comprises a vacuum connector 114 to provide at least a portion to a vacuum of re-epithelialization for medical materials 102. 減圧送達導管116がこの減圧コネクタ114の第1の端部118に流体結合され、第2の端部122で減圧源120に流体結合する。 Reduced pressure delivery conduit 116 is fluidly coupled to the first end 118 of the vacuum connector 114 is fluidly coupled to vacuum source 120 at the second end 122. 1またはそれ以上の装置124が減圧コネクタ114と減圧源120の間の、例えば減圧送達導管116に流体結合されてもよい。 Between one or more devices 124 is reduced-pressure source 120 and vacuum connector 114, for example may be fluidly coupled to the reduced pressure delivery conduit 116.

減圧送達導管116に流体結合される装置124は、例えば、限定しないが、流体リザーバ(または滲出液や他の除去される流体を保持する回収部材)、圧力フィードバック装置、容量検出システム、血液検出システム、感染掲出システム、流量モニタシステム、温度監視システム、または他の装置を含む。 Device 124 that is fluidly coupled to the reduced-pressure delivery conduit 116 may include, for example, without limitation, (collecting member for holding or exudate or other fluid removed) fluid reservoir, a pressure feedback device, volume detection system, blood detection system , including infection posting system, flow monitoring system, temperature monitoring system, or other device.

減圧源120は、創傷治療システム100の一部として、減圧を提供する。 Vacuum source 120, as part of a wound treatment system 100 provides reduced pressure. 本書で「減圧」の用語は、治療される組織部位104の雰囲気圧より低い圧力をいう。 The term "reduced pressure" herein refers to a pressure less than the ambient pressure of the tissue site 104 being treated. 多くの場合、減圧は患者が位置する場所の大気圧より低い。 Often, vacuum is lower than the atmospheric pressure of the location to position the patient. あるいは、減圧は、組織部位104の組織の静水圧より低い。 Alternatively, reduced pressure is lower than the hydrostatic pressure of tissue the tissue site 104. 用語「真空」や「負圧」を組織部位に適用される圧力に関して用いられてもよいが、組織部位にかけられる実際の圧力は、完全真空に関して通常いわれる圧力よりかなり高い。 The term "vacuum" and the "negative pressure" may be used with respect to pressure applied to the tissue site, the actual pressure applied to the tissue site is significantly higher than normal pressures referred for full vacuum. 他に明記しない限り、本書で述べる圧力はゲージ圧である。 Unless otherwise stated, the pressure described herein are gauge pressures.

減圧源120が送達する減圧は、一定であっても変化(パターン化またはランダム)してもよく、連続的でも間欠的に供給されてもよい。 The reduced pressure vacuum source 120 is delivered may vary it is constant (patterned or random) and may be also intermittently supplied continuously. 患者の可動性と容易さを最大限とするために、減圧源120は電池駆動式の減圧発生器である。 In order to maximize the mobility and ease of patient, reduced pressure source 120 is a vacuum generator battery powered. これにより、手術室での適用を促進し、リハビリフェーズにおける患者の可動性および利便性を提供する。 This promotes the application of the operating room and provides mobility and convenience for patients in rehabilitation phase. 他の減圧源を用いてもよく、これには例えばテキサス州サンアントニオのKCIから入手可能なV. It may be other vacuum source, V. available including for example the KCI of San Antonio, TX A. A. C. C. (登録商標)治療ユニットの壁吸引式または機械ユニットなどがある。 And the like (R) therapy unit wall suction or mechanical units.

減圧源120が生成する減圧は、減圧送達導管116または医療用導管または配管を通り、減圧コネクタ114に供給される。 The reduced pressure vacuum source 120 is generated through the reduced-pressure delivery conduit 116 or medical conduit or tubing, is supplied to the vacuum connector 114. 減圧送達導管116と減圧源120の間に疎水性膜フィルタが挿入されてもよい。 Hydrophobic membrane filter may be inserted between the reduced pressure source 120 and reduced pressure delivery conduit 116. 別の例示的で非限定的な実施例では(図示せず)、減圧源が上皮再形成用医療材料102内に組み込まれた例えばマイクロポンプである。 In another illustrative, non-limiting embodiment (not shown), a vacuum source is integrated for example micropump re-epithelialization for medical materials 102.

最初に図1及び図2を参照すると、上皮再形成用医療材料は、複数の層または材料を具える。 Referring initially to FIGS. 1 and 2, a medical material for epithelial remodeling, comprises a plurality of layers or materials. 例えば、上皮再形成用医療材料102は、湿性の組織界面層126と、支持層128と、マニホルド部材130と、密閉部材132とを具える。 For example, reepithelialization medical material 102 comprises a moist tissue interface layer 126, a support layer 128, a manifold member 130, and a sealing member 132. この密閉部材132は、減圧コネクタ114の少なくとも一部が通るコネクタ開口部134を設けて形成されている。 The sealing member 132 is formed by providing at least partially through the connector opening 134 of the vacuum connector 114. 図1の例示的で非限定的な実施例では、減圧コネクタ114の一部が、密閉部材132とマニホルド部材130の間に配置され、一部がコネクタ開口部134を通って延在している。 In the illustrative, non-limiting embodiment of Figure 1, a portion of the vacuum connector 114 is disposed between the sealing member 132 and the manifold member 130, part of which extends through a connector opening 134 . 上皮再形成用医療材料102は、さらなる層を有しても少ない層を有してもよく、これらの層はいくつかの実施例で異なる組み合わせで配置されてもよい。 Reepithelialization medical material 102 may have fewer layers may have additional layers, these layers may be arranged in different combinations in some embodiments.

湿性の組織界面層126は、第1の面136と、第2の組織対向面138とを具える。 Moist tissue interface layer 126 comprises a first surface 136 and a second tissue facing surface 138. 湿性の組織界面層126は、第1の複数の孔140を設けて形成され、これは様々な形であってよい。 Moist tissue interface layer 126 is formed by providing a first plurality of holes 140, which may be a variety of forms. 第1の複数の孔140は、湿性の組織界面層126を貫通する。 A first plurality of holes 140 through the permeability of the tissue interface layer 126. 第1の複数の孔140は、レーザ、パンチ、ドリル、またはキャスティング、または他の様々な技術で形成することができる。 A first plurality of holes 140 may be formed laser, punch, drill or casting or other in various techniques,. 第1の複数の孔140は、均一パターンでもランダムに形成されてよいし、均一あるいは異なる直径を有してもよい。 A first plurality of holes 140, may be formed randomly in homogeneous pattern may have a uniform or different diameters.

例示的で非限定的な実施例において、第1の複数の孔140は均一パターンで形成され、孔の中心141は、近接する孔の中心141から距離142離れている。 In an illustrative, non-limiting embodiment, the first plurality of holes 140 are formed in a uniform pattern, the center 141 of the hole has a distance 142 away from the center 141 of the adjacent hole. いくつかの例示的で非限定的な実施例では、この距離142は約2mm、3mm、4mm、5mm、6mm、7mm、8mm、9mm、10mm、またはそれ以上である。 In non-limiting examples a number of exemplary, this distance 142 is about 2mm, 3mm, 4mm, 5mm, 6mm, 7mm, 8mm, 9mm, 10mm or more. 距離142は、湿性の組織界面層126が所望の液体移動となるよう選択される。 The distance 142, permeability of the tissue interface layer 126 is selected so that a desired liquid transfer. 第1の複数の孔140の直径もまた、減圧がかけられ飽和が生じたとき(少なくとも一部の実施例で)、第1の複数の孔140が硬く崩壊して閉塞しないが、第1の複数の孔140を液体が通過するが気体をほぼ通過させないように制限するよう選択される。 The diameter of the first plurality of holes 140 are also (at least in some embodiments) when the vacuum is applied is saturated occurs, the first plurality of holes 140 are not closed collapsed hard, first Although a plurality of holes 140 is liquid passes is selected to limit so as not to substantially pass through the gas. 別の実施例では、第1の複数の孔140は、減圧の影響下では当該第1の複数の孔140が完全かつ硬く閉じるようなサイズとされる。 In another embodiment, the first plurality of holes 140, under the influence of vacuum the first plurality of holes 140 is complete and hard closing sized.

湿性の組織界面層126は、多数の材料から製造しうる。 Moist tissue interface layer 126 may be prepared from a number of materials. この湿性の組織界面層126は、例えば、ヒドロゲルや親水コロイドなど水ベースの材料でなってもよい。 Tissue interface layer 126 of the wet, for example, be made with water-based materials such as a hydrogel or hydrocolloid. 湿性の組織界面層126を構成する材料は、所望の湿度条件に対する流体バランスまたは平衡を提供する。 The material constituting the permeability of the tissue interface layer 126 provides a fluid balance or equilibrium for the desired humidity conditions. したがって、例えば、この材料は必要なときに水分を提供し(すなわち、組織部位104の乾燥時)、必要なときに水分を吸収する(すなわち、組織部位104に余分な水分が存在する場合や、組織部位104が実質的にぬれている場合)。 Thus, for example, when this material provides moisture when needed (i.e., the dry tissue site 104), which absorbs moisture (i.e., the excess water to the tissue site 104 exists when necessary, If the tissue site 104 is wet substantially). 第2の組織対向面138は、連続気泡発泡体などの微少ストレイン誘導材料(micro-strain inducing material)と比べると比較的平滑な表面を有する。 The second tissue facing surface 138 has a relatively smooth surface as compared with small strain inducing material, such as open-cell foam (micro-strain inducing material). 第2の組織対向面138の比較的平滑な面は、細胞の移動を促進する(または、少なくとも妨げない)。 Relatively smooth surface of the second tissue facing surface 138 facilitates migration of cells (or at least not interfere). 第2の組織対向面138の比較的平滑な面は、局所的な微少ストレインの発生が少ないか全くない。 Relatively smooth surface of the second tissue facing surface 138, or no less localized small strain generation. 湿性の組織界面層126による水分環境、第1の複数の孔140の流体管理、および、第2の組織対向面138の比較的平滑な面は、創傷106の上皮再形成を促進する。 Water Environment by moist tissue interface layer 126, fluid management of the first plurality of holes 140, and a relatively smooth surface of the second tissue facing surface 138 promotes reepithelialization of the wound 106.

別の例示的で非限定的な実施例では、湿性の組織界面層126に別の材料を用いることができ、例えば非常に密集した親水性フォーム(例えば親水性独立気泡フォーム)、フィルムコートされた多孔性不織材料、ヒドロゲル浸漬発泡体、水活性型医療材料(hydroactive dressing material)、または他の材料を用いることができる。 In another illustrative, non-limiting embodiment, it is possible to use another material in moist tissue interface layer 126, for example, very dense hydrophilic foam (e.g. a hydrophilic closed cell foam) was film-coated porous nonwoven materials, hydrogel dipped foam, water activated medical materials (hydroactive dressing material), or other materials can be used. ヒドロゲル浸漬発泡体は、特に深部創傷または複雑な形に適している。 Hydrogel dipped foam is especially suitable for deep wound or complex shapes. 湿性の組織界面層126は、穿孔されるか複数部分にカットされ、湿性の組織界面層126の1またはそれ以上の部分を除去して組織部位104の一部に減圧を提供することができる。 Moist tissue interface layer 126 is cut into a plurality of portions or be perforated, it is possible to provide a vacuum to a portion of the tissue site 104 by removing one or more portions of the permeability of the tissue interface layer 126. 除去された部分に生じた開口部は、創傷106の領域内に設計される場合、滲出が多い創傷を補助するか、粒状化を促進する。 Opening generated in the removed portion, if designed in the region of the wound 106, or to assist the exudate is large wounds, promote granulation.

利用時、湿性の組織界面層126は減圧下で流体を受けると、湿性の組織界面層126が通常膨張する。 When using, the permeability of the tissue interface layer 126 is subjected to fluid under reduced pressure, permeability of the tissue interface layer 126 is typically inflated. 十分な流体により湿性の組織界面層126は飽和する。 Sufficient fluid permeability of the tissue interface layer 126 is saturated. 図3に示すように、第1の複数の孔140は、図2の開位置または状態と比べて、制限された位置または状態に膨張している。 As shown in FIG. 3, the first plurality of holes 140, as compared to an open position or state of FIG. 2, it is expanding the limited position or state. この制限された位置は、湿性の組織界面層126ががほぼ飽和した場合に生じる。 This limited position occurs when saturated moist tissue interface layer 126 Gagahobo. この制限位置では、第1の複数の孔140は、組織部位104から第1の複数の孔140を通すが、第1の複数の孔140を通して減圧をほぼ連絡しない。 In this limit position, the first plurality of holes 140, which pass through a first plurality of holes 140 from the tissue site 104 does not substantially contact the vacuum through a first plurality of holes 140. 上皮再形成用医療材料102の他の部分は、湿性の組織界面層126が飽和したり、ほぼ飽和したら、湿式の組織界面層126の第1の面136から流体を除去する。 Other parts of reepithelialization for medical materials 102, or saturated moist tissue interface layer 126, when substantially saturated, to remove fluid from the first surface 136 of the wet tissue interface layer 126. 滲出液などの幾らかの液体または水分が創傷106に残り、シグナルを提供することにより治癒プロセスを補助する場合がある。 Some liquid or moisture, such as exudate remains on a wound 106, which may aid the healing process by providing a signal.

上皮再形成用医療材料102は、任意の支持層128を具えてもよい。 Reepithelialization medical material 102 may comprise any support layer 128. この支持層128は、第1の面144と、第2の組織対向面146とを具える。 The support layer 128 comprises a first surface 144 and a second tissue facing surface 146. この第2の組織対向面146は、湿性の組織界面層126の第1の面136の近くに配置される。 The second tissue facing surface 146 is disposed near the first surface 136 of the permeability of the tissue interface layer 126. 湿性の組織界面層126および支持層128は、結合されてもよい。 Wet tissue interface layer 126 and support layer 128 may be combined. 本書において「結合」とは、個別の物体を介した結合と、直接結合の双方を含む。 The term "binding" in this document includes a coupling through a separate object, both the direct binding. 「結合」の語は、2またはそれ以上の要素が互いに連続しており、各要素が材料の同じピースでなる場合を含む。 The term "bond", two or more elements are contiguous to each other, including the case where each element is the same piece of material. また、「結合」の語は、化学接合といった化学的なもの、機械的、熱的、または電気的な結合を含む。 Also, the term "bond", chemical ones such chemical bonding, including mechanical, thermal, or electrical coupling. この語「結合」は、様々な既知の技術を含み、限定しないが、溶接(超音波またはRF溶接)、接着、粘着、セメント、または他の技術や装置を含む。 The term "binding" includes a variety of known techniques, but are not limited to, welding (ultrasonic or RF welding), including bonding, adhesive, cement or other techniques or devices. 流体結合手段は、流体が所望の部品または位置の間で連絡するという意味である。 Fluid coupling means is a means that the fluid communication between the desired part or location.

支持層128は任意であるが、湿性の組織界面層126に支持を提供するために追加される。 While the support layer 128 is optional, it is added to provide support to wet the tissue interface layer 126. 図2及び図3を比較すると分かるように、支持層128は第1の複数の孔140の第1の端部148を開位置または設定された直径に保持しつつ、他の部分は制限状態の一部としてさらに制限されている。 As seen by comparing Figures 2 and 3, the support layer 128 while maintaining the first end portion 148 the open position or the set diameter of the first plurality of holes 140, the other part of the restricted state It is further limited as part. 支持層128は、閉塞性のフィルム材料など、様々な材料で構成することができる。 Support layer 128, such as occlusive film material, can be configured in a variety of materials. この支持層128は、例えば、ポリウレタン層、ポリエチレン層、または他の支持材料である。 The support layer 128 may, for example, polyurethane layer, a polyethylene layer or other support materials. 支持層128は、直接的な流体フローを促進し、上述したように、特に第1の複数の孔140に支持を提供する。 Support layer 128 facilitates direct fluid flow, as described above, provides a particularly supported by the first plurality of holes 140. 支持層128は、第2の複数の孔150を設けて構成される。 Support layer 128 is configured to provide a second plurality of holes 150. 第2の複数の孔150は、第1の複数の孔140と整列し、かつ対応している。 A second plurality of holes 150 is aligned with the first plurality of holes 140, and corresponds. 第2の複数の孔150は、第1の複数の孔140と同一または類似の方法で形成することができる。 A second plurality of holes 150 may be formed identical to the first plurality of holes 140 or similar methods.

上皮再形成用医療材料102は、マニホルド部材130を具える。 Reepithelialization medical material 102 comprises a manifold member 130. このマニホルド部材130は、第1の面152と、第2の組織対向面154とを具える。 The manifold member 130 comprises a first surface 152 and a second tissue facing surface 154. マニホルド部材130は、減圧を含む流体を分配する様々な材料で構成することができる。 The manifold member 130 may be configured in a variety of materials for dispensing a fluid comprising a vacuum. 「マニホルド」の語は、一般に組織部位104に減圧をかけ、流体を送達し、または流体を除去するのを補助する実体または構造をいう。 The term "manifold" generally subjected to reduced pressure at a tissue site 104, fluid delivery, or refers to a substance or structure to assist in the removal of fluid. マニホルド部材130は一般に、マニホルド部材130周りの組織部位104に流体を提供および除去する複数の流路または経路を具える。 The manifold member 130 typically includes a plurality of flow channels or pathways to provide and remove fluid to the tissue site 104 surrounding the manifold member 130. 例示的で非限定的な一実施例では、流路または経路は、相互接続され、組織部位104に提供あるいはここから除去される流体の分配を向上する。 In an exemplary non-limiting embodiment, the flow path or paths are interconnected to improve distribution of fluids provided or removed from here to the tissue site 104.

マニホルド部材130は、限定しないが、例えば流路を形成するよう構成された構造要素を有するデバイスを備え、これには例えば流路を具えるか養生により流路が形成される細胞性発泡体、連続気泡発泡体、多孔性組織集合体、液体、ゲル、発泡体が含まれる。 The manifold member 130 include, but are not limited to, for example, a device having a structure structuring element to form a flow path, including cellular foam flow path is formed by curing or comprises a flow path for example, open cell foam, porous tissue assembly includes liquid, gel, foam body. マニホルド部材130は多孔性であってもよく、発泡体、ガーゼ、フェルトマット、または生体適用に特に適した他の材料である。 The manifold member 130 may be a porous, foam, gauze, a felt mat or other material particularly suitable for biological applications. 例示的で非限定的な実施例では、マニホルド部材130は多孔性発泡体であり、複数の相互接続された細胞または孔を具え、これらが流路として作用する。 In the illustrative, non-limiting embodiment, the manifold member 130 is a porous foam, comprising a plurality of interconnected cells or pores, it acts as a flow path. この多孔性発泡体はポリウレタンの、連続気泡性の、網状発泡体であり、例えばテキサス州サンアントニオのKinetic Concepts,Incorporated社が製造するGranuFoam(登録商標)である。 The porous foam of polyurethane, open-cell properties, a reticulated foam, for example, of San Antonio, Texas Kinetic Concepts, Incorporated company producing GranuFoam (R). 他の実施例は、「独立気泡」を具えてもよい。 Other embodiments may comprise a "closed cell". 非限定的な例示では、マニホルド部材130は不織材料でなり、例えばベルギーのLiveltexBVBA社から入手可能な不織材料である。 In a non-limiting example, the manifold member 130 is made of a nonwoven material, for example a non-woven material available from LiveltexBVBA Corporation, Belgium. マニホルド部材130の第2の組織対向面154は、例示的で非限定的な一実施例では支持層128の第1の面144に近接配置され、あるいは、別の例示的で非限定的な実施例では湿性の組織界面層126の第1の面136に隣接している。 The second tissue facing surface 154 of the manifold member 130 is disposed close to the first surface 144 of the support layer 128 is in a non-limiting example is illustrative, or non-limiting another exemplary the example is adjacent to the first surface 136 of the permeability of the tissue interface layer 126.

上皮再形成用医療材料102は、密閉部材132を具える。 Reepithelialization medical material 102 comprises a sealing member 132. この密閉部材132は、第1の面158と、第2の組織対向面160とを具える。 The sealing member 132 comprises a first surface 158 and a second tissue facing surface 160. 密閉部材132は、組織部位104または創傷106の上に閉塞空間を形成する。 Sealing member 132 forms a closed space over the tissue site 104 or wound 106. 第2の組織対向面160は、マニホルド部材130の第1の面152または他の層に近接配置され結合される。 The second tissue facing surface 160 is disposed near the first surface 152 or other layers of the manifold member 130 coupling. 密閉部材132は、液密を提供する様々な材料で構成することができる。 Sealing member 132 may be configured in a variety of materials that provide a fluid-tight. 「液密」または「閉塞」とは、特定の減圧源またはサブシステムを用いた場合に所望の部位で減圧を維持するのに適した密閉をいう。 The "liquid-tight" or "closed" refers to a sealing suitable for maintaining the reduced pressure at a desired site in the case of using a specific reduced-pressure source or subsystem. 密閉部材は、例えば、不透過性または半透過性のエラストマー材料である。 Sealing member, for example, is impermeable or semi-permeable elastomeric material. 「エラストマー」とは、エラストマー特性を有することをいう。 The term "elastomer" refers to having elastomeric properties. エラストマーとは、一般にラバー状特性を有するポリマ材料である。 Elastomer is generally polymeric material having a rubber-like properties. より具体的には、大部分のエラストマーは、100%より大きい究極伸長度と、かなりの弾性量を有する。 More specifically, most elastomers have a greater than 100% ultimate elongation, significant elasticity amount. 材料の弾性度は、材料の弾性変形からの復活能力をいう。 Elasticity of the material, refers to the resurrection capability of elastic deformation of the material. エラストマーの例は、限定しないが、天然ゴム、ポリイソプレン、スチレンブタジエンゴム、クロロプレンゴム、ポリブタジエン、ニトリルゴム、ブチルゴム、エチレンプロピレンゴム、エチレンプロピレンジエンモノマー、クロロスルホン酸ポリエチレン、多硫化物ゴム、ポリウレタン、EVAフィルム、コポリエステル、およびシリコーンを含む。 Examples of elastomers include, but are not limited to, natural rubber, polyisoprene, styrene-butadiene rubber, chloroprene rubber, polybutadiene, nitrile rubber, butyl rubber, ethylene propylene rubber, ethylene propylene diene monomer, chlorosulfonated acid polyethylene, polysulfide rubber, polyurethane, EVA film, co-polyester, and silicones. 密閉部材のさらなる例は、シリコーンドレープ、3M Tegaderm(登録商標)ドレープ、Avery Dennisonから入手可能なアクリルドレープ、または切り込み入りドレープを含む。 Further examples of sealing member comprises a silicone drape, 3M Tegaderm (R) drape, acrylic drape available from Avery Dennison, or cuts containing drape.

図4を参照すると、上皮再形成用医療材料102は、密閉部材132とマニホルド部材130または他の層の間に配置された任意の吸収層162または吸収剤を具える。 Referring to FIG. 4, reepithelialization medical material 102 comprises any absorbent layer 162 or absorbent disposed between the sealing member 132 and the manifold member 130, or other layers. この吸収層162は、第1の面164と、第2の組織対向面166とを具える。 The absorbing layer 162 comprises a first surface 164 and a second tissue facing surface 166. 第1の面164は、密閉部材132の第2の組織対向面160に結合され、吸収層162の第2の組織対向面166はマニホルド部材130の第1の面152に結合される。 The first surface 164 is coupled to the second tissue facing surface 160 of the sealing member 132, the second tissue facing surface 166 of the absorbent layer 162 is coupled to the first surface 152 of the manifold member 130. 吸収層162は、主に流体を保存または保持すべく機能する。 Absorbing layer 162 mainly functions to store or hold fluid. 吸収層162は、超吸収ポリマ(SAP)又は上皮再形成用医療剤路湯102内に流体を保持するのに適した他の材料である。 Absorbing layer 162 is another material suitable for holding fluid to superabsorbent polymer (SAP) or reepithelialization medical agent passage water 102. 吸収層162を構成する材料および厚さは、保持すべき流体の量に基づいて選択される。 Material and thickness constituting the absorbing layer 162 is selected based on the amount of fluid to be retained. 吸収層162は、1またはそれ以上の組成層で構成されてもよい。 Absorbing layer 162 may be composed of one or more composition layers.

運用時、例示的で非限定的な実施例によると、組織部位104および特に創傷106は、上皮再形成用医療材料102を展開することにより創傷治療システム100で治療される。 During operation, by way of non-limiting examples are illustrative, the tissue site 104 and in particular the wound 106 is treated in the wound therapy system 100 by deploying reepithelialization for medical materials 102. 上皮再形成用医療材料102が創傷106および患者の無傷の表皮108に近接配置される。 Reepithelialization medical material 102 is disposed close to the wound 106 and the patient's intact skin 108. 組み入れられてなければ、減圧コネクタ114が減圧を提供すべく上皮再形成用医療剤路湯102に流体結合され、もし展開されていなければ、密閉部材132が上皮再形成用医療材料102の他の部分の上に展開される。 Without being incorporated, in the re-epithelialization medical agent passage yu 102 to vacuum connector 114 is to provide a reduced pressure is fluidly coupled, if it is not expanded, the sealing member 132 is another of reepithelialization for medical materials 102 It is deployed on top of the part. 湿性の組織界面層126の第2の組織対向面138は、このようにして図1に示すように創傷106と無傷の表皮108の一部に近接配置される。 The second tissue facing surface 138 of the permeability of the tissue interface layer 126, in this way is located close to a part of the wound 106 and intact skin 108 as shown in FIG. 第2の組織対向面138は、創傷106および創傷縁部112に湿性の平滑面を向ける。 The second tissue facing surface 138 directs the smooth surface of the wet to the wound 106 and wound edge 112.

組み入れられてなければ、減圧送達導管116が減圧コネクタ114および減圧源120に流体結合される。 Without being incorporated, the reduced pressure delivery conduit 116 is fluidly coupled to a vacuum connector 114 and vacuum source 120. 減圧源120が作動され、これにより減圧が上皮再形成用医療材料102に供給される。 Vacuum source 120 is activated, thereby vacuum is supplied to the re-epithelialization for medical materials 102. 減圧は上皮再形成用医療材料102をその場に保持するのを補助し、上皮再形成用医療材料102からいかなる流体の漏れもないようにし、感染の予防を補助し、流体管理を補助する。 Vacuum will assist in holding the reepithelialization medical material 102 in place, so no leakage of any fluid from re-epithelialization for medical materials 102, to assist in the prevention of infection, to assist fluid management.

一般に、減圧は、上皮再形成用医療材料102に−10乃至−100mmHgの範囲で、より具体的には−25乃至−75mmHgの範囲でかけられる。 Generally, the vacuum is in the range of -10 to -100mmHg in re-epithelialization for medical materials 102 are subjected in the range of -25 to -75mmHg more specifically. 減圧は、流体流を生じるのに適しているが、組織部位104に微少ストレインを実質的に生じさせるほど高くはない。 Decompression is suitable to produce a fluid stream, not as high as substantially produces a slight strain on the tissue site 104. 別の例示的で非限定的な実施例では、減圧は−10mmHg乃至−200mmHgの範囲である。 In another illustrative, non-limiting embodiment, the vacuum is in the range of -10mmHg to -200 mmHg. 別の例示的で非限定的な実施例では、減圧は最初の期間で−100乃至−200mmHgであり、次の期間で−25乃至100mmHgである。 In another illustrative, non-limiting embodiment, a reduced pressure is -100 to -200mmHg in the first period, is -25 to 100mmHg in the next period. 必要に応じて他の変形例も可能である。 Other variations as required are also possible.

上皮再形成用医療材料102に減圧がかけられると、第1の複数の孔140は即座あるいは時間をかけて、開位置(図2)から制限位置または状態(図3)へと飽和する。 When reduced pressure is applied to the re-epithelialization for medical materials 102, the first plurality of holes 140 over real or time, to saturate to the open position limit position or state (FIG. 2) (Figure 3). この制限状態では、第1の複数の孔140は液体を通すが、気体(および気体圧力)を通さなくなる。 In this restricted state, the first plurality of holes 140 pass liquid but not impervious to gas (and gas pressure). 上皮再形成用医療材料102はこれにより、空気圧を連絡させることなく組織部位104に力をかけることができる。 Reepithelialization medical material 102 Thus, a force can be exerted on the tissue site 104 without contact pressure. もし含まれる場合、支持層128が第1の複数の孔140の第1の端部148を実質的に開くか一定の直径に維持する。 When included if the support layer 128 to maintain a constant diameter or opening the first end 148 of the first plurality of holes 140 substantially.

上皮再形成用医療材料102に送達される減圧は、組織部位104から余分な液体を除去するのを補助し、湿性の組織界面層126がほぼ飽和したときに湿性の組織界面層126から液体を除去するのを補助する。 The reduced pressure is delivered to the re-epithelialization medical material 102 assists in removing excess liquid from the tissue site 104, the liquid from the permeability of the tissue interface layer 126 when the permeability of the tissue interface layer 126 is almost saturated to assist in the removal. 湿性の組織界面層126の流体バランスまたは平衡も、組織部位104が乾燥しているときに湿性の組織界面層126が液体を提供し、組織部位104が濡れているときに流体を吸収するのを補助する。 The fluid balance or even equilibrium wet tissue interface layer 126, the permeability of the tissue interface layer 126 when the tissue site 104 is dry to provide a liquid, the to absorb fluid when the tissue site 104 is wet auxiliary to. 湿性の組織界面層126の流体除去は遅く、滲出液が幾らか組織部位104に残るようにして(滲出液を注ぐわけではない)治療プロセスを促進する。 Slow fluid removal of the tissue interface layer 126 of moisture, exudate (not pour exudate) somewhat as remains in the tissue site 104 to facilitate the healing process. 滲出液は、前述のようにケラチン生成細胞を活性化するシグナルを出す(すなわち成長因子から)。 Exudate issues a signal that activates keratinocytes, as described above (i.e., from growth factors).

湿性の組織界面層126はまた、組織部位104に対して比較的平滑な面を提供し、細胞移動を促進する(または、少なくとも妨げない)。 The permeability of the tissue interface layer 126 provides a relatively smooth surface to the tissue site 104 to promote cell movement (or, at least not interfere). 比較的平滑な湿性面を提供するのに加え、湿性の組織界面層126は、成長における粒状化、感染、または頻繁な医療材料の交換を行うことなく、組織部位104に面して長い期間残されてもよい。 In addition to providing a relatively smooth wet surface, wet the tissue interface layer 126, granulation in growth, without infection, or the replacement of frequent medical materials, longer time remaining facing the tissue site 104 it may be.

本発明とその利点を特定の例示的で非限定的な実施例について開示したが、添付の特許請求の範囲に規定された本発明の範囲を逸脱することなく様々な変更、置換、入れ替え、および代替を行うことができると理解されたい。 Although the present invention and its advantages have been disclosed for certain illustrative, non-limiting embodiment, various changes without departing from the scope of the invention as defined in the appended claims, a substituted, replaced, and it is to be understood that it is possible to perform the alternative. 一の実施例に関して説明された特徴は、他の様々な実施例にも適用可能であることを理解されたい。 Described features with respect to one embodiment, it is to be understood that in various other embodiments can be applied.

Claims (18)

  1. 創傷部位を治療すべく減圧を用いる上皮再形成用医療材料において、 In reepithelialization medical materials using vacuum in order to treat a wound site,
    前記創傷部位に近接配置される湿性の組織界面層であって、ヒドロゲルを含み、第1の面と、第2の組織対向面とを具え、当該湿性の組織界面層を通して複数の孔が形成されており、これらの孔がそれぞれ個別に前記湿性の組織界面層の第1の面と第2の組織対向面の間に延在しており、水分が増加すると膨張してこれらの孔が気体の通過を制限する制限位置となる、湿性の組織界面層と、 A wet of the tissue interface layer which is arranged close to the wound site comprises a hydrogel, a first surface and comprising a second tissue facing surface, a plurality of holes through the tissue interface layer of the moisture is formed are, these holes extends between the first surface and the second tissue facing surface of the tissue interface layer of each individual the wet, these holes gas expands with moisture increases the limiting position for limiting the passage of the moist tissue interface layer,
    第1の面と第2の組織対向面とを具え、減圧を分配するマニホルド部材と、 A manifold member comprising a first surface and a second tissue facing surface, distributes the vacuum,
    第1の面と第2の組織対向面とを具える密閉部材とを具え、 Comprising a sealing member comprising a first surface and a second tissue facing surface,
    前記マニホルド部材が前記密閉部材と前記湿性の組織界面層との間に配置されていることを特徴とする上皮再形成用医療材料。 Reepithelialization medical material characterized in that it is disposed between the manifold member is the sealing member and the permeability of the tissue interface layer.
  2. 請求項1に記載の上皮再形成用医療材料において、 In reepithelialization medical material according to claim 1,
    前記湿性の組織界面層が、ヒドロゲル層であることを特徴とする上皮再形成用医療材料。 Tissue interface layer of the moisture is reepithelialization for medical materials, which is a hydrogel layer.
  3. 請求項1に記載の上皮再形成用医療材料において、 In reepithelialization medical material according to claim 1,
    前記湿性の組織界面層が、ヒドロゲルに浸漬した発泡体層であることを特徴とする上皮再形成用医療材料。 Tissue interface layer of the moisture is reepithelialization for medical materials, which is a foam layer which was immersed in the hydrogel.
  4. 請求項1に記載の上皮再形成用医療材料において、 In reepithelialization medical material according to claim 1,
    さらに、第1の面と第2の組織対向面とを具える支持層を具え、当該支持層の第2の組織対向面が、前記マニホルド部材と前記湿性の組織界面層の間に、前記湿性の組織界面層の第1の面に結合されており、前記支持層は複数の孔を有し、当該支持層のそれぞれの孔が前記湿性の組織界面層の孔の1つに対応しており、前記支持層は当該湿性の組織界面層の複数ののうちの1以上の端部を開位置に保持し、前記支持層が閉塞性のフィルム材料でなることを特徴とする上皮再形成用医療材料。 Further, the support layer comprises comprising a first surface and a second tissue facing surface, the second tissue facing surface of the support layer, between the manifold member and the permeability of the tissue interface layer, the moisture tissue first is coupled to the surface of the interface layer, the support layer has a plurality of holes, and each hole of the support layer corresponds to one of the holes in the tissue interface layer of the moisture the support layer retains one or more ends of the plurality of holes of those wet of the tissue interface layer to the open position, re-epithelialization, characterized in that the supporting layer is made of occlusive film material use medical materials.
  5. 請求項1に記載の上皮再形成用医療材料において、 In reepithelialization medical material according to claim 1,
    さらに、第1の面と第2の組織対向面とを具える支持層を具え、当該支持層の第2の組織対向面が、前記湿性の組織界面層の第1の面に結合されており、前記支持層が、前記湿性の組織界面層の複数の孔に対応する複数の孔を有することを特徴とする上皮再形成用医療材料。 Further, the support layer comprises comprising a first surface and a second tissue facing surface, the second tissue facing surface of the support layer is coupled to the first surface of the tissue interface layer of the moisture the support layer, reepithelialization medical material characterized by having a plurality of holes corresponding to the plurality of holes of the permeability of the tissue interface layer.
  6. 請求項1に記載の上皮再形成用医療材料において、 In reepithelialization medical material according to claim 1,
    さらに、前記マニホルド部材と密閉部材の間に配置された吸収層を具えることを特徴とする上皮再形成用医療材料。 Furthermore, reepithelialization medical material characterized in that it comprises an absorbent layer disposed between the manifold member and the sealing member.
  7. 請求項1に記載の上皮再形成用医療材料において、 In reepithelialization medical material according to claim 1,
    さらに、第1の面と第2の組織対向面とを具える支持層であって、前記第2の組織対向面が、前記湿性の組織界面層の第1の面に近接配置されており、前記湿性の組織界面層の複数の孔に対応する複数の孔を有する支持層と、 Furthermore, a support layer comprising a first surface and a second tissue facing surface, the second tissue facing surface, which is disposed close to the first surface of the tissue interface layer of the moisture, a support layer having a plurality of holes corresponding to the plurality of holes of tissue interface layer of the moisture,
    前記マニホルド部材の第1の面と、前記密閉部材の第2の組織対向面との間に配置された吸収層を具えることを特徴とする上皮再形成用医療材料。 The first surface and, reepithelialization medical material characterized in that it comprises an arrangement absorption layer between the second tissue facing surface of the sealing member of the manifold member.
  8. 請求項1に記載の上皮再形成用医療材料において、 In reepithelialization medical material according to claim 1,
    前記湿性の組織界面層の第2の組織対向面は前記創傷に面して配置されるものであり、 The second tissue facing surface of the tissue interface layer of the moisture is intended to be positioned facing the wound,
    前記マニホルドの第2の組織対向面が、前記湿性の組織界面層の第1の面に近接配置され、 The second tissue facing surface of the manifold, disposed near the first surface of the tissue interface layer of the moisture,
    前記密閉部材の第2の組織対向面が、前記マニホルド部材の第1の面に近接配置され、 前記湿性の組織界面層の複数の孔は、 近接する孔の中心から少なくとも1mm離れていることを特徴とする上皮再形成用医療材料。 The second tissue facing surface of the sealing member, the disposed near the first surface of the manifold member, a plurality of holes in the permeability of the tissue interface layer that is at least 1mm away from the center of the adjacent hole reepithelialization medical material characterized.
  9. 創傷の上皮再形成を促進するためのシステムにおいて、当該システムが、創傷の上皮再形成用医療材料を具え、当該創傷の上皮再形成用医療材料が、 A system for promoting re-epithelialization of the wound, the system comprising reepithelialization for medical materials of the wound, re-epithelialization for medical materials of the wound,
    前記創傷に近接配置される湿性の組織界面層であって、ヒドロゲルを含み、第1の面と、第2の組織対向面とを具え、当該湿性の組織界面層を通して複数の孔が形成されており、これらの孔がそれぞれ個別に前記湿性の組織界面層の第1の面と第2の組織対向面の間に延在しており、水分が増加すると膨張してこれらの孔が気体の通過を制限する制限位置となる、湿性の組織界面層と、 A tissue interface layer of moist located proximate to the wound comprises a hydrogel, a first surface and comprising a second tissue facing surface, a plurality of holes are formed through the tissue interface layer of the moisture cage, the passage of these holes are respectively extending between the first surface and the second tissue facing surface of the tissue interface layer of the wet individually, these holes expands with moisture increases the gas the limiting position for limiting a moist tissue interface layer,
    第1の面と第2の組織対向面とを具え、減圧を分配するマニホルド部材と、 A manifold member comprising a first surface and a second tissue facing surface, distributes the vacuum,
    第1の面と第2の組織対向面とを具える密閉部材とを具え、 Comprising a sealing member comprising a first surface and a second tissue facing surface,
    前記マニホルド部材が前記密閉部材と前記湿性の組織界面層との間に配置されており、 Wherein is disposed between the manifold member and said sealing member and said moisture-tissue interface layer,
    前記マニホルド部材に流体結合された減圧源を具えることを特徴とするシステム。 System characterized in that it comprises a reduced pressure source fluidly coupled to the manifold member.
  10. 請求項に記載のシステムにおいて、 The system of claim 9,
    前記湿性の組織界面層が、ヒドロゲル層であることを特徴とするシステム。 System tissue interface layer of the moisture, characterized in that a hydrogel layer.
  11. 請求項に記載のシステムにおいて、 The system of claim 9,
    前記湿性の組織界面層が、ヒドロゲルに浸漬した発泡体層であることを特徴とするシステム。 System wherein the permeability of the tissue interface layer is a foam layer which was immersed in the hydrogel.
  12. 請求項に記載のシステムにおいて、 The system of claim 9,
    さらに、第1の面と第2の組織対向面とを具える支持層を具え、当該支持層の第2の組織対向面が、前記マニホルド部材と前記湿性の組織界面層の間に、前記湿性の組織界面層の第1の面に結合されており、前記支持層は複数の孔を有し、当該支持層のそれぞれの孔が前記湿性の組織界面層の孔の1つに対応しており、前記支持層は当該湿性の組織界面層の複数ののうちの1以上の端部を開位置に保持し、前記支持層が閉塞性のフィルム材料でなることを特徴とするシステム。 Further, the support layer comprises comprising a first surface and a second tissue facing surface, the second tissue facing surface of the support layer, between the manifold member and the permeability of the tissue interface layer, the moisture tissue first is coupled to the surface of the interface layer, the support layer has a plurality of holes, and each hole of the support layer corresponds to one of the holes in the tissue interface layer of the moisture system, wherein the supporting layer is maintained at 1 or more ends of the plurality of holes of those wet of the tissue interface layer to the open position, the support layer is characterized by comprising at occlusive film material.
  13. 請求項に記載のシステムにおいて、 The system of claim 9,
    さらに、第1の面と第2の組織対向面とを具える支持層を具え、当該支持層の第2の組織対向面が、前記湿性の組織界面層の第1の面に結合されており、前記支持層が、前記湿性の組織界面層の複数の孔に対応する複数の孔を有することを特徴とするシステム。 Further, the support layer comprises comprising a first surface and a second tissue facing surface, the second tissue facing surface of the support layer is coupled to the first surface of the tissue interface layer of the moisture , a system wherein the supporting layer is characterized by having a plurality of holes corresponding to the plurality of holes of the permeability of the tissue interface layer.
  14. 請求項に記載のシステムにおいて、 The system of claim 9,
    さらに、前記マニホルド部材と密閉部材の間に配置された吸収層を具えることを特徴とするシステム。 Furthermore, system characterized in that it comprises an absorbent layer disposed between the manifold member and the sealing member.
  15. 請求項に記載のシステムにおいて、 The system of claim 9,
    さらに、第1の面と第2の組織対向面とを具える支持層であって、前記第2の組織対向面が、前記湿性の組織界面層の第1の面に近接配置されており、前記湿性の組織界面層の複数の孔に対応する複数の孔を有する支持層と、 Furthermore, a support layer comprising a first surface and a second tissue facing surface, the second tissue facing surface, which is disposed close to the first surface of the tissue interface layer of the moisture, a support layer having a plurality of holes corresponding to the plurality of holes of tissue interface layer of the moisture,
    前記マニホルド部材の第1の面と、前記密閉部材の第2の組織対向面との間に配置された吸収層を具えることを特徴とするシステム。 System characterized in that it comprises a first surface of said manifold member, the absorbent layer disposed between the second tissue facing surface of the sealing member.
  16. 請求項1に記載の上皮再形成用医療材料において、前記マニホルド部材は網状の連続気泡発泡体を含むことを特徴とする上皮再形成用医療材料。 In reepithelialization medical material according to claim 1, wherein the manifold member is reepithelialization medical material characterized in that it comprises an open cell foam reticulated.
  17. 請求項1に記載の上皮再形成用医療材料において、前記湿性の組織界面層の第2の組織対向面は平滑で、前記創傷部位における微少ストレインを防止するのに適合していることを特徴とする上皮再形成用医療材料。 In reepithelialization medical material according to claim 1, the second tissue facing surface of the tissue interface layer of the moisture is smooth, and characterized in that it is adapted to prevent the small strain in the wound site re-epithelialization for medical materials to be.
  18. 請求項1に記載の上皮再形成用医療材料において、前記上皮再形成用医療材料が、前記創傷部位における微少ストレインを防止するのに適合しており、−25mmHgから−75mmHgの減圧を適用可能であることを特徴とする上皮再形成用医療材料。 In reepithelialization medical material according to claim 1, wherein the reepithelialization medical material being adapted to prevent small strain in the wound site, can be applied vacuum of -75mmHg from -25mmHg reepithelialization medical material characterized in that.
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CA2771522A1 (en) 2011-03-10
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US20140148769A1 (en) 2014-05-29
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AU2010289910A1 (en) 2012-03-08
JP2013502983A (en) 2013-01-31
EP2470135A1 (en) 2012-07-04
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US20110054422A1 (en) 2011-03-03
CA2771522C (en) 2017-07-11

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