JP5902478B2 - 血清中のBLyS/APRILヘテロ三量体レベルおよび診断方法における使用 - Google Patents

血清中のBLyS/APRILヘテロ三量体レベルおよび診断方法における使用 Download PDF

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JP5902478B2
JP5902478B2 JP2011507535A JP2011507535A JP5902478B2 JP 5902478 B2 JP5902478 B2 JP 5902478B2 JP 2011507535 A JP2011507535 A JP 2011507535A JP 2011507535 A JP2011507535 A JP 2011507535A JP 5902478 B2 JP5902478 B2 JP 5902478B2
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blys
april
antibody
levels
antagonist
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JP2011523037A (ja
JP2011523037A5 (enExample
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アール. ディロン,ステイシー
アール. ディロン,ステイシー
ジェイ. ハーダー,ブランドン
ジェイ. ハーダー,ブランドン
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ザイモジェネティクス, インコーポレイテッド
ザイモジェネティクス, インコーポレイテッド
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    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
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    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/564Immunoassay; Biospecific binding assay; Materials therefor for pre-existing immune complex or autoimmune disease, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9
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    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
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JP2011507535A 2008-05-01 2009-04-20 血清中のBLyS/APRILヘテロ三量体レベルおよび診断方法における使用 Active JP5902478B2 (ja)

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Application Number Priority Date Filing Date Title
US4970608P 2008-05-01 2008-05-01
US61/049,706 2008-05-01
PCT/US2009/041089 WO2009134633A1 (en) 2008-05-01 2009-04-20 Levels of blys/april heterotrimers in serum and use in diagnostic methods

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JP2011523037A JP2011523037A (ja) 2011-08-04
JP2011523037A5 JP2011523037A5 (enExample) 2014-04-03
JP5902478B2 true JP5902478B2 (ja) 2016-04-13

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US (2) US20090274711A1 (enExample)
EP (1) EP2291657B1 (enExample)
JP (1) JP5902478B2 (enExample)
AU (1) AU2009241442B2 (enExample)
CA (1) CA2720651C (enExample)
DK (1) DK2291657T3 (enExample)
ES (1) ES2578526T3 (enExample)
HU (1) HUE028784T2 (enExample)
PL (1) PL2291657T3 (enExample)
PT (1) PT2291657T (enExample)
SI (1) SI2291657T1 (enExample)
WO (1) WO2009134633A1 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8003335B2 (en) 2008-04-30 2011-08-23 Universite Paris-SUD11 Levels of APRIL in serum and use in diagnostic methods
EP2825191B1 (en) * 2012-03-16 2019-08-28 University Health Network Soluble toso protein and its use in treating autoimmune disorders
HRP20231578T1 (hr) 2015-11-25 2024-03-15 Visterra, Inc. Molekule protutijela na april i njihove uporabe
CN115812077A (zh) 2020-05-08 2023-03-17 高山免疫科学股份有限公司 April和baff抑制性免疫调节蛋白及其使用方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10041402A1 (de) 2000-08-23 2002-03-14 Morphochem Ag Neue Verbindungen, die Faktor Xa-Aktivität inhibieren
EP2275449B1 (en) 2000-06-16 2016-09-28 Human Genome Sciences, Inc. Antibodies that immunospecifically bind to BLyS
DK1436003T3 (da) * 2001-05-24 2010-03-15 Zymogenetics Inc TACI-immunoglobulin-fusionsproteiner
JP2004537290A (ja) * 2001-05-24 2004-12-16 ヒューマン ジノーム サイエンシーズ, インコーポレイテッド 腫瘍壊死因子δ(APRIL)に対する抗体
WO2003040307A2 (en) * 2001-07-27 2003-05-15 Human Genome Sciences, Inc. Heteromultimeric tnf ligand family members
US7825089B2 (en) 2001-10-24 2010-11-02 National Jewish Health Three-dimensional structures of TALL-1 and its cognate receptors and modified proteins and methods related thereto
EP2272868B1 (en) 2003-06-05 2015-03-04 Genentech, Inc. Combination therapy for B cell disorders
US7655439B2 (en) * 2005-09-09 2010-02-02 Zymogenetics, Inc. Trimerizing polypeptides
EA015860B1 (ru) * 2005-10-13 2011-12-30 Хьюман Дженом Сайенсиз, Инк. Способы лечения аутоиммунных заболеваний при использовании антагониста нейтрокина-альфа
MY150687A (en) * 2006-07-21 2014-02-28 Femalon S P R L Assay and kit for predicting implantation success in assisted fertilisation
US8003335B2 (en) 2008-04-30 2011-08-23 Universite Paris-SUD11 Levels of APRIL in serum and use in diagnostic methods

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SI2291657T1 (sl) 2016-09-30
AU2009241442B2 (en) 2014-11-27
US20130330339A1 (en) 2013-12-12
CA2720651C (en) 2020-03-10
AU2009241442A1 (en) 2009-11-05
HUE028784T2 (en) 2017-01-30
EP2291657A1 (en) 2011-03-09
PT2291657T (pt) 2016-07-08
JP2011523037A (ja) 2011-08-04
EP2291657B1 (en) 2016-04-13
PL2291657T3 (pl) 2016-09-30
WO2009134633A1 (en) 2009-11-05
US9146242B2 (en) 2015-09-29
CA2720651A1 (en) 2009-11-05
DK2291657T3 (en) 2016-07-25
ES2578526T3 (es) 2016-07-27
US20090274711A1 (en) 2009-11-05

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