JP5902293B2 - ピラゾロピリダジンおよび網膜変性疾患およびアッシャー症候群に伴う聴覚損失を治療するための方法 - Google Patents

ピラゾロピリダジンおよび網膜変性疾患およびアッシャー症候群に伴う聴覚損失を治療するための方法 Download PDF

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JP5902293B2
JP5902293B2 JP2014508507A JP2014508507A JP5902293B2 JP 5902293 B2 JP5902293 B2 JP 5902293B2 JP 2014508507 A JP2014508507 A JP 2014508507A JP 2014508507 A JP2014508507 A JP 2014508507A JP 5902293 B2 JP5902293 B2 JP 5902293B2
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alkyl
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pharmaceutically acceptable
alkylene
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JP2014515758A (ja
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ブーリ，ローランド・ワーナー
エスミユ，ウイリアム・ラメシユチヤンドラ・クリシユナ
ロツク，クリストフアー・ジエームズ
マラグ，カトリーヌ・フアビエンヌ
オーエンズ，アンドリユー・ペイト
ハート，ウイリアム・エドワード
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
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JP2014508507A 2011-04-25 2012-04-25 ピラゾロピリダジンおよび網膜変性疾患およびアッシャー症候群に伴う聴覚損失を治療するための方法 Active JP5902293B2 (ja)

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US201161478642P 2011-04-25 2011-04-25
US61/478,642 2011-04-25
US201161537908P 2011-09-22 2011-09-22
US61/537,908 2011-09-22
US201161576471P 2011-12-16 2011-12-16
US61/576,471 2011-12-16
PCT/US2012/034959 WO2012148994A1 (en) 2011-04-25 2012-04-25 Pyrazolopyridazines and methods for treating retinal-degenerative diseases and hearing loss associated with usher syndrome

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JP5902293B2 (ja) 2011-04-25 2016-04-13 アッシャー・サード・イニシアティブ・インコーポレイテッド ピラゾロピリダジンおよび網膜変性疾患およびアッシャー症候群に伴う聴覚損失を治療するための方法
US9227976B2 (en) 2012-10-25 2016-01-05 Usher Iii Initiative, Inc. Pyrazolopyridazines and methods for treating retinal-degenerative diseases and hearing loss associated with usher syndrome
JP6290910B2 (ja) * 2012-10-25 2018-03-07 アッシャー・サード・イニシアティブ・インコーポレイテッド ピラゾロピリダジンならびに網膜変性疾患およびアッシャー症候群に伴う聴力損失を処置するための方法
US8765762B2 (en) 2012-10-25 2014-07-01 Usher III, Initiative, Inc. Pyrazolopyridazines and methods for treating retinal-degerative diseases and hearing loss associated with usher syndrome
CA2889494C (en) * 2012-10-25 2018-12-18 Usher Iii Initiative, Inc. Pyrazolopyridazines and methods for treating retinal-degenerative diseases and hearing loss associated with usher syndrome
AU2016274956A1 (en) * 2015-06-11 2017-12-14 Usher Iii Initiative, Inc. Methods of treating or preventing a proteopathy
CN114585434A (zh) * 2019-10-23 2022-06-03 新加坡国立大学 用于合成化合物的方法和系统
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US9227976B2 (en) 2012-10-25 2016-01-05 Usher Iii Initiative, Inc. Pyrazolopyridazines and methods for treating retinal-degenerative diseases and hearing loss associated with usher syndrome
CA2889494C (en) 2012-10-25 2018-12-18 Usher Iii Initiative, Inc. Pyrazolopyridazines and methods for treating retinal-degenerative diseases and hearing loss associated with usher syndrome
AU2016274956A1 (en) 2015-06-11 2017-12-14 Usher Iii Initiative, Inc. Methods of treating or preventing a proteopathy

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ZA201307961B (en) 2015-12-23
JP2016193884A (ja) 2016-11-17
WO2012148994A1 (en) 2012-11-01
US9549910B2 (en) 2017-01-24
IL229023A (en) 2017-07-31
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AU2012249801B2 (en) 2016-05-19
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US20130252936A1 (en) 2013-09-26
PL2701510T3 (pl) 2017-07-31
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US9079909B2 (en) 2015-07-14
IL229023A0 (en) 2013-12-31
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ES2625534T3 (es) 2017-07-19
CA2834049C (en) 2018-05-22
US20160158172A1 (en) 2016-06-09
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US10307422B2 (en) 2019-06-04
HUE032820T2 (en) 2017-11-28

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