JP5899112B2 - 灌流イメージング - Google Patents
灌流イメージング Download PDFInfo
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- JP5899112B2 JP5899112B2 JP2012510387A JP2012510387A JP5899112B2 JP 5899112 B2 JP5899112 B2 JP 5899112B2 JP 2012510387 A JP2012510387 A JP 2012510387A JP 2012510387 A JP2012510387 A JP 2012510387A JP 5899112 B2 JP5899112 B2 JP 5899112B2
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- 230000010412 perfusion Effects 0.000 title claims description 10
- 238000003384 imaging method Methods 0.000 title description 6
- 239000003814 drug Substances 0.000 claims description 53
- 229940079593 drug Drugs 0.000 claims description 53
- 230000005855 radiation Effects 0.000 claims description 22
- 238000000034 method Methods 0.000 claims description 12
- 230000003595 spectral effect Effects 0.000 claims description 9
- 238000000354 decomposition reaction Methods 0.000 claims description 2
- 230000001419 dependent effect Effects 0.000 description 8
- 210000001519 tissue Anatomy 0.000 description 8
- 239000002872 contrast media Substances 0.000 description 5
- 238000001228 spectrum Methods 0.000 description 5
- 230000003727 cerebral blood flow Effects 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 239000003795 chemical substances by application Substances 0.000 description 3
- 238000005259 measurement Methods 0.000 description 3
- 206010061216 Infarction Diseases 0.000 description 2
- 208000006011 Stroke Diseases 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
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- 238000002347 injection Methods 0.000 description 2
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- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 241000648484 Nymphalis l-album Species 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
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- 210000001367 artery Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 230000002490 cerebral effect Effects 0.000 description 1
- 230000003788 cerebral perfusion Effects 0.000 description 1
- 238000002591 computed tomography Methods 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 238000002059 diagnostic imaging Methods 0.000 description 1
- 238000001647 drug administration Methods 0.000 description 1
- 238000000295 emission spectrum Methods 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 230000000302 ischemic effect Effects 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
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- 230000002093 peripheral effect Effects 0.000 description 1
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- ZMRUPTIKESYGQW-UHFFFAOYSA-N propranolol hydrochloride Chemical compound [H+].[Cl-].C1=CC=C2C(OCC(O)CNC(C)C)=CC=CC2=C1 ZMRUPTIKESYGQW-UHFFFAOYSA-N 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 238000011896 sensitive detection Methods 0.000 description 1
Images
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B6/00—Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment
- A61B6/02—Devices for diagnosis sequentially in different planes; Stereoscopic radiation diagnosis
- A61B6/03—Computerised tomographs
- A61B6/032—Transmission computed tomography [CT]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B6/00—Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment
- A61B6/48—Diagnostic techniques
- A61B6/481—Diagnostic techniques involving the use of contrast agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B6/00—Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment
- A61B6/48—Diagnostic techniques
- A61B6/482—Diagnostic techniques involving multiple energy imaging
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B6/00—Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment
- A61B6/50—Clinical applications
- A61B6/504—Clinical applications involving diagnosis of blood vessels, e.g. by angiography
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B6/00—Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment
- A61B6/50—Clinical applications
- A61B6/507—Clinical applications involving determination of haemodynamic parameters, e.g. perfusion CT
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B6/00—Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment
- A61B6/48—Diagnostic techniques
- A61B6/486—Diagnostic techniques involving generating temporal series of image data
Description
Claims (10)
- 第1スペクトルスキャンが第1放射電圧により実行され、第2スペクトルスキャンが前記第1放射電圧と異なる第2放射電圧により実行される少なくとも2つの非薬剤ベースのスペクトルスキャンからのスペクトル分解された投影データに基づき、光電コンポーネントとコンプトンコンポーネントとを決定するステップと、
デコンポーザが、前記スペクトル分解により決定された光電コンポーネントとコンプトンコンポーネントとを利用して、対象物又は被検者の薬剤ベース灌流スキャンによる時系列投影データを少なくとも薬剤ベースコンポーネントに分解するステップを有する方法。 - 前記対象物又は被検者を示す薬剤ベースの体積イメージデータを生成するため、前記薬剤ベースコンポーネントを再構成するステップをさらに有する、請求項1記載の方法。
- 前記薬剤ベースの体積イメージデータは、前記薬剤ベース灌流スキャンによる時系列投影データの定量的な薬剤データを提供する、請求項2記載の方法。
- 前記光電コンポーネントと前記コンプトンコンポーネントとを決定し、その後に前記光電コンポーネントと前記コンプトンコンポーネントとに基づき前記薬剤ベースコンポーネントを決定するステップをさらに有する、請求項1乃至3何れか一項記載の方法。
- 前記光電コンポーネント、前記コンプトンコンポーネント及び前記薬剤ベースコンポーネントを同時に決定するステップをさらに有する、請求項1乃至3何れか一項記載の方法。
- 請求項1乃至5何れか一項記載の方法を実現する投影データデコンポーザであって、前記光電コンポーネントと前記コンプトンコンポーネントとに基づき薬剤ベース灌流スキャンによる時系列投影データから、薬剤ベースの投影データを決定する時系列デコンポーザを有する投影データデコンポーザ。
- 異なる2つの放射電圧により実行される少なくとも2回のデータ取得からの非薬剤ベースの投影データに基づき、前記光電コンポーネントと前記コンプトンコンポーネントとを決定するスペクトルデコンポーザをさらに有する、請求項6記載の投影データデコンポーザ。
- 前記薬剤ベース灌流スキャンによる時系列投影データは、薬剤ベースの体積イメージデータを生成するため再構成される、請求項6又は7記載の投影データデコンポーザ。
- 前記薬剤ベースの体積イメージデータは、定量的な薬剤マップを提供する、請求項8記載の投影データデコンポーザ。
- コンピュータにより実行されると、前記コンピュータに請求項1乃至5何れか一項記載の方法の各ステップを実行させる命令を有するコンピュータ可読記憶媒体。
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US17734809P | 2009-05-12 | 2009-05-12 | |
US61/177,348 | 2009-05-12 | ||
US22111309P | 2009-06-29 | 2009-06-29 | |
US61/221,113 | 2009-06-29 | ||
PCT/IB2010/051541 WO2010131130A1 (en) | 2009-05-12 | 2010-04-09 | Perfusion imaging |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2012526582A JP2012526582A (ja) | 2012-11-01 |
JP5899112B2 true JP5899112B2 (ja) | 2016-04-06 |
Family
ID=42269871
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2012510387A Active JP5899112B2 (ja) | 2009-05-12 | 2010-04-09 | 灌流イメージング |
Country Status (6)
Country | Link |
---|---|
US (1) | US9597042B2 (ja) |
EP (1) | EP2429403B1 (ja) |
JP (1) | JP5899112B2 (ja) |
CN (1) | CN102421369B (ja) |
RU (1) | RU2547995C2 (ja) |
WO (1) | WO2010131130A1 (ja) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103889328B (zh) * | 2011-10-24 | 2017-02-15 | 皇家飞利浦有限公司 | 灌注成像 |
CN104136938B (zh) * | 2012-02-27 | 2016-12-07 | 皇家飞利浦有限公司 | 谱成像 |
US9271688B2 (en) * | 2012-03-28 | 2016-03-01 | General Electric Company | System and method for contrast agent estimation in X-ray imaging |
EP2923332B1 (en) * | 2012-11-26 | 2019-01-16 | Koninklijke Philips N.V. | Projection data de-noising |
CN104287763B (zh) | 2014-09-09 | 2016-08-24 | 沈阳东软医疗系统有限公司 | 一种跟踪扫描中监测区域调整方法及装置 |
JP6873902B2 (ja) * | 2014-12-17 | 2021-05-19 | コーニンクレッカ フィリップス エヌ ヴェKoninklijke Philips N.V. | 血流撮像 |
US10383590B2 (en) * | 2015-09-28 | 2019-08-20 | General Electric Company | Methods and systems for adaptive scan control |
EP3373816B1 (en) * | 2015-11-10 | 2019-03-27 | Koninklijke Philips N.V. | Method of computed tomography imaging |
CN106923856B (zh) * | 2017-04-14 | 2020-05-22 | 郑州大学第一附属医院 | 一种同时实现ct灌注与能谱肝脏扫描的影像处理方法 |
US11399779B2 (en) * | 2018-05-16 | 2022-08-02 | Case Western Reserve University | System-independent quantitative perfusion imaging |
CN112334950A (zh) * | 2018-06-29 | 2021-02-05 | 皇家飞利浦有限公司 | 被配置为从kvp切换多能量采集中生成非谱体积图像数据的成像系统 |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
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RU2202282C2 (ru) * | 2001-01-11 | 2003-04-20 | Научный центр реконструктивной и восстановительной хирургии Восточно-Сибирского научного центра СО РАМН | Способ оценки кровообращения в оперированной селезенке |
US7050529B2 (en) * | 2002-07-23 | 2006-05-23 | Ge Medical Systems Global Technolgy Company, Llc | Methods and apparatus for performing a computed tomography scan |
US7627078B2 (en) * | 2002-11-08 | 2009-12-01 | Ge Medical Systems Global Technology Company, Llc | Methods and apparatus for detecting structural, perfusion, and functional abnormalities |
US6813333B2 (en) * | 2002-11-27 | 2004-11-02 | Ge Medical Systems Global Technology Company, Llc | Methods and apparatus for detecting structural, perfusion, and functional abnormalities |
US7599465B2 (en) * | 2004-11-19 | 2009-10-06 | General Electric Company | Detection of thrombi in CT using energy discrimination |
US7209536B2 (en) * | 2004-11-19 | 2007-04-24 | General Electric Company | CT colonography system |
US7583779B2 (en) * | 2004-11-24 | 2009-09-01 | General Electric Company | System and method for acquisition and reconstruction of contrast-enhanced, artifact-reduced CT images |
US7236559B2 (en) * | 2005-08-17 | 2007-06-26 | General Electric Company | Dual energy scanning protocols for motion mitigation and material differentiation |
CN101495039B (zh) * | 2005-09-22 | 2012-05-30 | 皇家飞利浦电子股份有限公司 | 用于能谱ct的定量物质分解 |
WO2007057841A2 (en) * | 2005-11-18 | 2007-05-24 | Koninklijke Philips Electronics N.V. | Systems and methods using x-ray tube spectra for computed tomography applications |
JP2007175194A (ja) | 2005-12-27 | 2007-07-12 | Natl Inst Of Radiological Sciences | Ct投影データの差分画像再構成方法及び装置 |
JP4575909B2 (ja) * | 2006-11-22 | 2010-11-04 | ジーイー・メディカル・システムズ・グローバル・テクノロジー・カンパニー・エルエルシー | X線断層撮影装置 |
US7813472B2 (en) * | 2006-12-04 | 2010-10-12 | Koninklijke Philips Electronics N.V. | CT imaging system |
JP5107569B2 (ja) | 2006-12-13 | 2012-12-26 | ジーイー・メディカル・システムズ・グローバル・テクノロジー・カンパニー・エルエルシー | X線ct装置 |
US20090052621A1 (en) * | 2007-08-23 | 2009-02-26 | Deborah Joy Walter | Method and apparatus for basis material decomposition with k-edge materials |
JP5588994B2 (ja) * | 2008-11-25 | 2014-09-10 | コーニンクレッカ フィリップス エヌ ヴェ | スペクトルイメージング |
-
2010
- 2010-04-09 CN CN201080020455.XA patent/CN102421369B/zh active Active
- 2010-04-09 US US13/266,556 patent/US9597042B2/en active Active
- 2010-04-09 EP EP10719780.8A patent/EP2429403B1/en active Active
- 2010-04-09 RU RU2011150280/14A patent/RU2547995C2/ru not_active IP Right Cessation
- 2010-04-09 JP JP2012510387A patent/JP5899112B2/ja active Active
- 2010-04-09 WO PCT/IB2010/051541 patent/WO2010131130A1/en active Application Filing
Also Published As
Publication number | Publication date |
---|---|
CN102421369A (zh) | 2012-04-18 |
EP2429403A1 (en) | 2012-03-21 |
RU2547995C2 (ru) | 2015-04-10 |
WO2010131130A1 (en) | 2010-11-18 |
US20120045109A1 (en) | 2012-02-23 |
US9597042B2 (en) | 2017-03-21 |
EP2429403B1 (en) | 2020-12-09 |
CN102421369B (zh) | 2014-07-02 |
JP2012526582A (ja) | 2012-11-01 |
RU2011150280A (ru) | 2013-06-20 |
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