JP5885271B2 - ビマトプロストのエステル誘導体の組成物および方法 - Google Patents
ビマトプロストのエステル誘導体の組成物および方法 Download PDFInfo
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- JP5885271B2 JP5885271B2 JP2013554528A JP2013554528A JP5885271B2 JP 5885271 B2 JP5885271 B2 JP 5885271B2 JP 2013554528 A JP2013554528 A JP 2013554528A JP 2013554528 A JP2013554528 A JP 2013554528A JP 5885271 B2 JP5885271 B2 JP 5885271B2
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- Prior art keywords
- unsubstituted
- substituted
- alkyl
- compound
- bimatoprost
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/32—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
- C07C235/34—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/42—Amides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q7/00—Preparations for affecting hair growth
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
- C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
- C07C405/0041—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing nitrogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Dermatology (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Cosmetics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
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|---|---|---|---|
| US201161442400P | 2011-02-14 | 2011-02-14 | |
| US61/442,400 | 2011-02-14 | ||
| PCT/US2012/024881 WO2012112451A1 (en) | 2011-02-14 | 2012-02-13 | Ester derivatives of bimatoprost compositions and methods |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014513051A JP2014513051A (ja) | 2014-05-29 |
| JP2014513051A5 JP2014513051A5 (enExample) | 2015-04-02 |
| JP5885271B2 true JP5885271B2 (ja) | 2016-03-15 |
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| Application Number | Title | Priority Date | Filing Date |
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| JP2013554528A Expired - Fee Related JP5885271B2 (ja) | 2011-02-14 | 2012-02-13 | ビマトプロストのエステル誘導体の組成物および方法 |
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| Country | Link |
|---|---|
| US (3) | US8865766B2 (enExample) |
| EP (1) | EP2675786B1 (enExample) |
| JP (1) | JP5885271B2 (enExample) |
| KR (1) | KR101935068B1 (enExample) |
| CN (1) | CN103459368B (enExample) |
| AR (1) | AR088774A1 (enExample) |
| AU (1) | AU2012217922B2 (enExample) |
| BR (1) | BR112013020719B1 (enExample) |
| CA (1) | CA2827446C (enExample) |
| RU (1) | RU2599249C2 (enExample) |
| TW (1) | TWI642653B (enExample) |
| WO (1) | WO2012112451A1 (enExample) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2007111806A2 (en) * | 2006-03-23 | 2007-10-04 | Massachusetts Eye And Ear Infirmary | Cyclopentane heptanoic acid compounds for reducing body fat |
| US9149484B2 (en) | 2009-11-09 | 2015-10-06 | Allergan, Inc. | Compositions and methods for stimulating hair growth |
| NZ716349A (en) | 2009-11-09 | 2017-07-28 | Allergan Inc | Compositions and methods for stimulating hair growth |
| CA2824317C (en) | 2011-01-19 | 2014-12-16 | Terakine Therapeutics, Inc. | Uses of certain f-series prostaglandin analogs for treating diabetes and dyslipidemia |
| US8859616B2 (en) * | 2011-01-21 | 2014-10-14 | Allergan, Inc. | Compounds and methods for enhancing hair growth |
| US8426471B1 (en) | 2011-12-19 | 2013-04-23 | Topokine Therapeutics, Inc. | Methods and compositions for reducing body fat and adipocytes |
| US20150119367A1 (en) * | 2012-10-29 | 2015-04-30 | Allergan, Inc. | Phosphate Esters of Bimatoprost and the Prostamides |
| SG11201600237YA (en) | 2012-11-21 | 2016-02-26 | Topokine Therapeutics Inc | Methods and compositions for locally increasing body fat |
| EP2968093A1 (en) * | 2013-03-14 | 2016-01-20 | Allergan, Inc. | Topical compositions comprising bimatoprost and methods for stimulating hair growth therewith |
| NO2753788T3 (enExample) | 2013-05-10 | 2018-06-16 | ||
| US9820993B2 (en) | 2013-05-15 | 2017-11-21 | Topokine Therapeutics, Inc. | Methods and compositions for topical delivery of prostaglandins to subcutaneous fat |
| WO2015200425A1 (en) | 2014-06-27 | 2015-12-30 | Topokine Therapeutics, Inc. | Topical dosage regimen |
| US11478437B2 (en) | 2016-07-05 | 2022-10-25 | Jenivision Inc. | Formulations for hair growth |
| JP7141025B1 (ja) * | 2021-11-11 | 2022-09-22 | エルデシエロ プライベート リミテッド | 化合物、組成物、方法、及び製造方法 |
| WO2026135442A1 (es) * | 2024-12-17 | 2026-06-25 | Centro De Retina Médica Y Quirúrgica, S.C. | Formulación de base lipídica que contiene bimatoprost para incrementar la biodisponibilidad y la expresión de la matriz extracelular y mejorar la supervivencia de las células del folículo |
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| US4911920A (en) | 1986-07-30 | 1990-03-27 | Alcon Laboratories, Inc. | Sustained release, comfort formulation for glaucoma therapy |
| FR2588189B1 (fr) | 1985-10-03 | 1988-12-02 | Merck Sharp & Dohme | Composition pharmaceutique de type a transition de phase liquide-gel |
| DK0495421T3 (da) | 1991-01-15 | 1996-12-09 | Alcon Lab Inc | Anvendelse af carragenaner i topiske ophthalmiske sammensætninger |
| US5212162A (en) | 1991-03-27 | 1993-05-18 | Alcon Laboratories, Inc. | Use of combinations gelling polysaccharides and finely divided drug carrier substrates in topical ophthalmic compositions |
| US5972991A (en) | 1992-09-21 | 1999-10-26 | Allergan | Cyclopentane heptan(ene) oic acid, 2-heteroarylalkenyl derivatives as therapeutic agents |
| US5352708A (en) | 1992-09-21 | 1994-10-04 | Allergan, Inc. | Non-acidic cyclopentane heptanoic acid, 2-cycloalkyl or arylalkyl derivatives as therapeutic agents |
| US5688819A (en) | 1992-09-21 | 1997-11-18 | Allergan | Cyclopentane heptanoic acid, 2-cycloalkyl or arylalkyl derivatives as therapeutic agents |
| US5574066A (en) * | 1992-10-28 | 1996-11-12 | Allergan | Intraocular pressure reducing 15-acyl prostaglandins |
| JP2818381B2 (ja) * | 1994-01-18 | 1998-10-30 | 帝人株式会社 | ７−チアプロスタグランジン類およびその製造法 |
| US6309853B1 (en) | 1994-08-17 | 2001-10-30 | The Rockfeller University | Modulators of body weight, corresponding nucleic acids and proteins, and diagnostic and therapeutic uses thereof |
| JPH10259179A (ja) * | 1996-09-19 | 1998-09-29 | Santen Pharmaceut Co Ltd | 多置換アリールオキシ基を有するプロスタグランジン類およびその用途 |
| US6395787B1 (en) * | 2000-02-08 | 2002-05-28 | Allergan Sales, Inc. | Ocular hypotensive lipids |
| US7351404B2 (en) * | 2002-02-04 | 2008-04-01 | Allergan, Inc. | Method of enhancing hair growth |
| JP5122460B2 (ja) * | 2005-09-16 | 2013-01-16 | アラーガン、インコーポレイテッド | 治療薬の眼内輸送のための組成物および方法 |
| WO2008094659A2 (en) * | 2007-01-31 | 2008-08-07 | Allergan, Inc. | Novel biomaterials for ocular drug delivery and a method for making and using same |
| US7632868B2 (en) * | 2007-10-31 | 2009-12-15 | Meta Cosmetics, Llc | Prostaglandin analog compositions to treat epithelial-related conditions |
| AR076731A1 (es) * | 2008-05-09 | 2011-07-06 | Pfizer | Prostamidas donadoras de oxido nitrico, uso de los mismos y composiciones farmaceuticas |
| NZ716349A (en) | 2009-11-09 | 2017-07-28 | Allergan Inc | Compositions and methods for stimulating hair growth |
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2012
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| TW201247613A (en) | 2012-12-01 |
| KR101935068B1 (ko) | 2019-01-03 |
| JP2014513051A (ja) | 2014-05-29 |
| KR20140015364A (ko) | 2014-02-06 |
| BR112013020719B1 (pt) | 2018-04-17 |
| AU2012217922A1 (en) | 2013-09-05 |
| RU2599249C2 (ru) | 2016-10-10 |
| CA2827446C (en) | 2020-06-23 |
| EP2675786B1 (en) | 2018-12-26 |
| CA2827446A1 (en) | 2012-08-23 |
| AU2012217922B2 (en) | 2017-05-04 |
| BR112013020719A2 (pt) | 2016-08-09 |
| US9499478B2 (en) | 2016-11-22 |
| CN103459368A (zh) | 2013-12-18 |
| EP2675786A1 (en) | 2013-12-25 |
| US20130324606A1 (en) | 2013-12-05 |
| RU2013141849A (ru) | 2015-03-27 |
| WO2012112451A1 (en) | 2012-08-23 |
| US20150005377A1 (en) | 2015-01-01 |
| TWI642653B (zh) | 2018-12-01 |
| CN103459368B (zh) | 2016-06-08 |
| US8865766B2 (en) | 2014-10-21 |
| US20120295972A1 (en) | 2012-11-22 |
| AR088774A1 (es) | 2014-07-10 |
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