JP5859988B2 - 外来遺伝子発現亢進活性を有するｄｎａエレメント - Google Patents

外来遺伝子発現亢進活性を有するｄｎａエレメント Download PDF

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Publication number
JP5859988B2
JP5859988B2 JP2012555988A JP2012555988A JP5859988B2 JP 5859988 B2 JP5859988 B2 JP 5859988B2 JP 2012555988 A JP2012555988 A JP 2012555988A JP 2012555988 A JP2012555988 A JP 2012555988A JP 5859988 B2 JP5859988 B2 JP 5859988B2
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Japan
Prior art keywords
polynucleotide
foreign gene
seq
polynucleotide sequence
sequence
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JP2012555988A
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Japanese (ja)
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JP2013531967A (ja
JP2013531967A5 (enExample
Inventor
大祐 西宮
大祐 西宮
井上　竜也
竜也 井上
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Daiichi Sankyo Co Ltd
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Daiichi Sankyo Co Ltd
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/51—Complete heavy chain or Fd fragment, i.e. VH + CH1
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/515—Complete light chain, i.e. VL + CL
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00—Nucleic acids vectors
    • C12N2800/10—Plasmid DNA
    • C12N2800/106—Plasmid DNA for vertebrates
    • C12N2800/107—Plasmid DNA for vertebrates for mammalian
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/46—Vector systems having a special element relevant for transcription elements influencing chromatin structure, e.g. scaffold/matrix attachment region, methylation free island

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  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2012555988A 2010-07-07 2011-07-06 外来遺伝子発現亢進活性を有するｄｎａエレメント Active JP5859988B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2012555988A JP5859988B2 (ja) 2010-07-07 2011-07-06 外来遺伝子発現亢進活性を有するｄｎａエレメント

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2010154782 2010-07-07
JP2010154782 2010-07-07
JP2012555988A JP5859988B2 (ja) 2010-07-07 2011-07-06 外来遺伝子発現亢進活性を有するｄｎａエレメント
PCT/JP2011/065916 WO2012005378A2 (en) 2010-07-07 2011-07-06 Dna element having the activity of enhancing foreign gene expression

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2015245827A Division JP6039048B2 (ja) 2010-07-07 2015-12-17 外来遺伝子発現亢進活性を有するｄｎａエレメント

Publications (3)

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JP2013531967A JP2013531967A (ja) 2013-08-15
JP2013531967A5 JP2013531967A5 (enExample) 2014-08-14
JP5859988B2 true JP5859988B2 (ja) 2016-02-16

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JP2012555988A Active JP5859988B2 (ja) 2010-07-07 2011-07-06 外来遺伝子発現亢進活性を有するｄｎａエレメント
JP2015245827A Active JP6039048B2 (ja) 2010-07-07 2015-12-17 外来遺伝子発現亢進活性を有するｄｎａエレメント

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Country Status (14)

Country Link
US (3) US9371543B2 (enExample)
EP (3) EP2684961B1 (enExample)
JP (2) JP5859988B2 (enExample)
KR (3) KR101856927B1 (enExample)
CN (3) CN105950621B (enExample)
AU (3) AU2011274864B2 (enExample)
BR (1) BR112012033780A2 (enExample)
CA (2) CA2804381C (enExample)
ES (3) ES2701091T3 (enExample)
IL (1) IL243763A0 (enExample)
RU (1) RU2013104989A (enExample)
SG (4) SG10201505354PA (enExample)
TW (2) TWI507523B (enExample)
WO (1) WO2012005378A2 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016054741A (ja) * 2010-07-07 2016-04-21 第一三共株式会社 外来遺伝子発現亢進活性を有するｄｎａエレメント

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104066839B (zh) 2011-11-28 2018-02-16 第一三共株式会社 衍生自人基因的启动子
CN109790539A (zh) 2016-10-03 2019-05-21 第一三共株式会社 Hspa5基因的启动子
CN107881174B (zh) * 2017-11-22 2022-06-03 张宝会 一种翻译水平基因表达调控的方法及应用
US20230192893A1 (en) * 2020-05-11 2023-06-22 Samsung Bioepis Co., Ltd. Human genome-derived polynucleotide and method for producing polypeptide of interest using same
EP4516902A1 (en) 2022-04-26 2025-03-05 Daiichi Sankyo Company, Limited Promoter of eno1 gene

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5258294A (en) * 1988-02-12 1993-11-02 Commonwealth Scientific And Industrial Research Organisation Bidirectional pox virus promoter element
US20070161003A1 (en) * 2003-09-29 2007-07-12 Morris David W Novel therapeutic targets in cancer
EP2105742A1 (en) * 2008-03-26 2009-09-30 Sanofi-Aventis Use of cathepsin C
JP5344682B2 (ja) * 2008-12-26 2013-11-20 グローブライド株式会社 釣糸ガイド、及び釣糸ガイドの製造方法
ES2701091T3 (es) * 2010-07-07 2019-02-20 Daiichi Sankyo Co Ltd Elemento de ADN que tiene actividad de aumento de expresión de un gen exógeno
CN104066839B (zh) * 2011-11-28 2018-02-16 第一三共株式会社 衍生自人基因的启动子

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016054741A (ja) * 2010-07-07 2016-04-21 第一三共株式会社 外来遺伝子発現亢進活性を有するｄｎａエレメント

Also Published As

Publication number Publication date
KR101833570B1 (ko) 2018-03-02
EP2684961B1 (en) 2016-01-20
TWI507523B (zh) 2015-11-11
US9371543B2 (en) 2016-06-21
KR101920187B1 (ko) 2018-11-19
SG10201505354PA (en) 2015-08-28
IL243763A0 (en) 2016-04-21
WO2012005378A2 (en) 2012-01-12
JP2013531967A (ja) 2013-08-15
CN103865931B (zh) 2018-10-02
SG10201705118RA (en) 2017-07-28
JP2016054741A (ja) 2016-04-21
CA2804381C (en) 2016-03-22
US20160333371A1 (en) 2016-11-17
TW201604280A (zh) 2016-02-01
KR20180021247A (ko) 2018-02-28
EP3026117A1 (en) 2016-06-01
AU2018200686A1 (en) 2018-02-22
AU2018200686B2 (en) 2020-02-13
TW201207103A (en) 2012-02-16
CN105950621B (zh) 2019-07-30
US20190345515A1 (en) 2019-11-14
BR112012033780A2 (pt) 2016-05-31
EP2591113A2 (en) 2013-05-15
CN103080321A (zh) 2013-05-01
EP3026117B1 (en) 2018-09-12
KR20180021246A (ko) 2018-02-28
SG186788A1 (en) 2013-02-28
AU2011274864B2 (en) 2016-10-06
SG2014009187A (en) 2014-04-28
CA2916937A1 (en) 2012-01-12
AU2016203681B2 (en) 2018-04-19
RU2013104989A (ru) 2014-08-20
US20130171694A1 (en) 2013-07-04
CA2804381A1 (en) 2012-01-12
EP2684961A1 (en) 2014-01-15
ES2701091T3 (es) 2019-02-20
CN105950621A (zh) 2016-09-21
AU2011274864A1 (en) 2013-02-07
US11060108B2 (en) 2021-07-13
EP2591113B1 (en) 2016-01-20
ES2564227T3 (es) 2016-03-21
CN103865931A (zh) 2014-06-18
KR20130111514A (ko) 2013-10-10
ES2565428T3 (es) 2016-04-04
KR101856927B1 (ko) 2018-05-10
WO2012005378A3 (en) 2012-04-12
AU2016203681A1 (en) 2016-06-23
JP6039048B2 (ja) 2016-12-07
US10407694B2 (en) 2019-09-10

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