JP5857060B2 - 抗ｃ−Ｍｅｔ抗体 - Google Patents

抗ｃ−Ｍｅｔ抗体 Download PDF

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JP5857060B2
JP5857060B2 JP2013537138A JP2013537138A JP5857060B2 JP 5857060 B2 JP5857060 B2 JP 5857060B2 JP 2013537138 A JP2013537138 A JP 2013537138A JP 2013537138 A JP2013537138 A JP 2013537138A JP 5857060 B2 JP5857060 B2 JP 5857060B2
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sequence
antibody
human
met
seq
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JP2013545455A (ja
JP2013545455A5 (cg-RX-API-DMAC7.html
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フウルトベルグ アンナ
フウルトベルグ アンナ
サウンデルス ミチャエル
サウンデルス ミチャエル
デ ハアルド ジョハンネス
デ ハアルド ジョハンネス
フェストジェンス エルス
フェストジェンス エルス
デ ジョンゲ ナタルイエ
デ ジョンゲ ナタルイエ
ミクヒエルイ パウルオ
ミクヒエルイ パウルオ
バスイルイクオ クリストイナ
バスイルイクオ クリストイナ
ドレイエル トルステン
ドレイエル トルステン
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アルゲン−エックス エヌ．ブイ．
アルゲン−エックス エヌ．ブイ．
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/22—Immunoglobulins specific features characterized by taxonomic origin from camelids, e.g. camel, llama or dromedary
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/32—Immunoglobulins specific features characterized by aspects of specificity or valency specific for a neo-epitope on a complex, e.g. antibody-antigen or ligand-receptor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/74—Inducing cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2013537138A 2010-11-03 2011-11-03 抗ｃ−Ｍｅｔ抗体 Active JP5857060B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US40986610P 2010-11-03 2010-11-03
US61/409,866 2010-11-03
PCT/EP2011/069369 WO2012059561A1 (en) 2010-11-03 2011-11-03 Anti c-met antibodies

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2015177202A Division JP2016034957A (ja) 2010-11-03 2015-09-09 抗ｃ−Ｍｅｔ抗体

Publications (3)

Publication Number Publication Date
JP2013545455A JP2013545455A (ja) 2013-12-26
JP2013545455A5 JP2013545455A5 (cg-RX-API-DMAC7.html) 2014-12-18
JP5857060B2 true JP5857060B2 (ja) 2016-02-10

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JP2013537138A Active JP5857060B2 (ja) 2010-11-03 2011-11-03 抗ｃ−Ｍｅｔ抗体
JP2013537139A Pending JP2013545738A (ja) 2010-11-03 2011-11-03 ｃ−Ｍｅｔ抗体組合せ
JP2015177202A Pending JP2016034957A (ja) 2010-11-03 2015-09-09 抗ｃ−Ｍｅｔ抗体

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JP2013537139A Pending JP2013545738A (ja) 2010-11-03 2011-11-03 ｃ−Ｍｅｔ抗体組合せ
JP2015177202A Pending JP2016034957A (ja) 2010-11-03 2015-09-09 抗ｃ−Ｍｅｔ抗体

Country Status (12)

Country Link
US (7) US8637027B2 (cg-RX-API-DMAC7.html)
EP (3) EP2635603B1 (cg-RX-API-DMAC7.html)
JP (3) JP5857060B2 (cg-RX-API-DMAC7.html)
CN (2) CN103562223B (cg-RX-API-DMAC7.html)
AU (3) AU2011325098B2 (cg-RX-API-DMAC7.html)
BR (3) BR122014027420A2 (cg-RX-API-DMAC7.html)
CA (2) CA2816919A1 (cg-RX-API-DMAC7.html)
DK (1) DK2635602T3 (cg-RX-API-DMAC7.html)
ES (1) ES2594493T3 (cg-RX-API-DMAC7.html)
IL (2) IL226112B (cg-RX-API-DMAC7.html)
RU (2) RU2013125457A (cg-RX-API-DMAC7.html)
WO (2) WO2012059562A1 (cg-RX-API-DMAC7.html)

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EP2768857B1 (en) * 2011-10-19 2020-01-01 NovImmune SA Methods of purifying antibodies
WO2013064700A2 (en) 2011-11-03 2013-05-10 Argen-X B.V. Chimeric polypeptides and methods of use
WO2013078170A1 (en) 2011-11-21 2013-05-30 Genentech, Inc. Purification of anti-c-met antibodies
US20150147274A1 (en) * 2011-12-02 2015-05-28 Cancer Research Technology Limited Antibodies against hgf - receptor and uses
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CA2816745C (en) 2019-03-12
AU2011325097A1 (en) 2013-05-02
JP2013545455A (ja) 2013-12-26
US9688773B2 (en) 2017-06-27
BR112013010688B1 (pt) 2020-11-17
CA2816919A1 (en) 2012-05-10
US20150376292A1 (en) 2015-12-31
EP2635603B1 (en) 2016-03-23
US9688774B2 (en) 2017-06-27
CN103562223B (zh) 2017-02-22
JP2016034957A (ja) 2016-03-17
RU2608644C2 (ru) 2017-01-23
EP2635602B1 (en) 2016-09-07
BR112013010687A2 (pt) 2016-08-02
AU2011325098B2 (en) 2016-07-14
EP3165538A1 (en) 2017-05-10
US20120156206A1 (en) 2012-06-21
BR112013010688A2 (pt) 2016-08-09
BR122014027420A2 (pt) 2019-08-20
US10676535B2 (en) 2020-06-09
IL226112B (en) 2019-05-30
US20150376291A1 (en) 2015-12-31
JP2013545738A (ja) 2013-12-26
US20120148607A1 (en) 2012-06-14
WO2012059562A1 (en) 2012-05-10
US20140205606A1 (en) 2014-07-24
AU2015210420A1 (en) 2015-09-03
AU2015210420B2 (en) 2017-08-03
ES2594493T3 (es) 2016-12-20
AU2011325098A1 (en) 2013-05-09
CN103562223A (zh) 2014-02-05
RU2013125459A (ru) 2014-12-10
CA2816745A1 (en) 2012-05-10
US9631027B2 (en) 2017-04-25
EP2635603A1 (en) 2013-09-11
AU2011325097B2 (en) 2015-05-21
US20170349667A1 (en) 2017-12-07
WO2012059561A1 (en) 2012-05-10
IL226113A0 (en) 2013-06-27
IL226112A0 (en) 2013-06-27
US8637027B2 (en) 2014-01-28
CN103764678A (zh) 2014-04-30
EP2635602A1 (en) 2013-09-11
DK2635602T3 (en) 2016-10-10
RU2013125457A (ru) 2014-12-10
US20180215833A1 (en) 2018-08-02
US9884917B2 (en) 2018-02-06

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