IL226112B - Antibodies against met–c - Google Patents

Antibodies against met–c

Info

Publication number
IL226112B
IL226112B IL226112A IL22611213A IL226112B IL 226112 B IL226112 B IL 226112B IL 226112 A IL226112 A IL 226112A IL 22611213 A IL22611213 A IL 22611213A IL 226112 B IL226112 B IL 226112B
Authority
IL
Israel
Prior art keywords
met antibodies
antibodies
met
Prior art date
Application number
IL226112A
Other languages
English (en)
Hebrew (he)
Other versions
IL226112A0 (en
Original Assignee
Argenx B V B A
Argenx Se
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Argenx B V B A, Argenx Se filed Critical Argenx B V B A
Publication of IL226112A0 publication Critical patent/IL226112A0/en
Publication of IL226112B publication Critical patent/IL226112B/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/10Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14Specific host cells or culture conditions, e.g. components, pH or temperature
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/22Immunoglobulins specific features characterized by taxonomic origin from camelids, e.g. camel, llama or dromedary
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/32Immunoglobulins specific features characterized by aspects of specificity or valency specific for a neo-epitope on a complex, e.g. antibody-antigen or ligand-receptor
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55Fab or Fab'
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565Complementarity determining region [CDR]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732Antibody-dependent cellular cytotoxicity [ADCC]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/74Inducing cell proliferation
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
IL226112A 2010-11-03 2013-05-02 Antibodies against met–c IL226112B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US40986610P 2010-11-03 2010-11-03
PCT/EP2011/069369 WO2012059561A1 (en) 2010-11-03 2011-11-03 Anti c-met antibodies

Publications (2)

Publication Number Publication Date
IL226112A0 IL226112A0 (en) 2013-06-27
IL226112B true IL226112B (en) 2019-05-30

Family

ID=44906140

Family Applications (2)

Application Number Title Priority Date Filing Date
IL226112A IL226112B (en) 2010-11-03 2013-05-02 Antibodies against met–c
IL226113A IL226113A0 (en) 2010-11-03 2013-05-02 combinations of met–c antibodies

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL226113A IL226113A0 (en) 2010-11-03 2013-05-02 combinations of met–c antibodies

Country Status (12)

Country Link
US (7) US8637027B2 (cg-RX-API-DMAC7.html)
EP (3) EP2635603B1 (cg-RX-API-DMAC7.html)
JP (3) JP5857060B2 (cg-RX-API-DMAC7.html)
CN (2) CN103562223B (cg-RX-API-DMAC7.html)
AU (3) AU2011325098B2 (cg-RX-API-DMAC7.html)
BR (3) BR122014027420A2 (cg-RX-API-DMAC7.html)
CA (2) CA2816919A1 (cg-RX-API-DMAC7.html)
DK (1) DK2635602T3 (cg-RX-API-DMAC7.html)
ES (1) ES2594493T3 (cg-RX-API-DMAC7.html)
IL (2) IL226112B (cg-RX-API-DMAC7.html)
RU (2) RU2013125457A (cg-RX-API-DMAC7.html)
WO (2) WO2012059562A1 (cg-RX-API-DMAC7.html)

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US8444976B2 (en) 2008-07-02 2013-05-21 Argen-X B.V. Antigen binding polypeptides
EP2143441A1 (en) * 2008-07-08 2010-01-13 Pierre Fabre Medicament Combination of a c-Met antagonist and an aminoheteroaryl compound for the treatment of cancer
US8637027B2 (en) 2010-11-03 2014-01-28 Argen-X B.V. Anti c-Met antibodies
KR20130036993A (ko) * 2011-10-05 2013-04-15 삼성전자주식회사 c-Met의 SEMA 도메인 내의 에피토프에 특이적으로 결합하는 항체
EP2768857B1 (en) * 2011-10-19 2020-01-01 NovImmune SA Methods of purifying antibodies
WO2013064700A2 (en) 2011-11-03 2013-05-10 Argen-X B.V. Chimeric polypeptides and methods of use
WO2013078170A1 (en) 2011-11-21 2013-05-30 Genentech, Inc. Purification of anti-c-met antibodies
US20150147274A1 (en) * 2011-12-02 2015-05-28 Cancer Research Technology Limited Antibodies against hgf - receptor and uses
EP2807189B1 (en) 2012-01-23 2019-03-20 Ablynx N.V. Sequences directed against hepatocyte growth factor (hgf) and polypeptides comprising the same for the treatment of cancers and/or tumors
US9931400B2 (en) 2012-09-12 2018-04-03 Samsung Electronics Co., Ltd. Method of combination therapy for prevention or treatment of c-Met or angiogenesis factor induced diseases
US9168300B2 (en) 2013-03-14 2015-10-27 Oncomed Pharmaceuticals, Inc. MET-binding agents and uses thereof
US9535055B2 (en) * 2013-03-28 2017-01-03 Samsung Electronics Co., Ltd. Marker for determining effects of anti-c-Met antibody and method of determining effects of anti-c-Met antibody using the marker
KR102139607B1 (ko) * 2013-04-01 2020-07-30 삼성전자주식회사 항 c-Met 항체 및 FGFR 저해제를 포함하는 병용 투여용 약학 조성물
EP2786765B1 (en) * 2013-04-01 2018-10-03 Samsung Electronics Co., Ltd. Composition for combination therapy comprising an anti-C-met antibody and a FGFR inhibitor
US10214593B2 (en) 2013-04-02 2019-02-26 Samsung Electronics Co., Ltd. Anti-idiotype antibody against anti-c-MET antibody
KR102060540B1 (ko) * 2013-04-03 2019-12-31 삼성전자주식회사 항 c-Met 항체 및 항 Ang2 항체를 포함하는 병용 투여용 약학 조성물
EP2992019B1 (en) * 2013-04-30 2019-03-06 Agency For Science, Technology And Research Mab 2 anti-met antibody
KR102186363B1 (ko) * 2013-09-06 2020-12-04 삼성전자주식회사 c-Met 저해제 및 베타-카테닌 저해제를 포함하는 병용 투여용 약학 조성물
KR102192591B1 (ko) * 2013-09-09 2020-12-18 삼성전자주식회사 c-Met 저해제 및 c-Myc 저해제를 포함하는 병용 투여용 약학 조성물
JP6667967B2 (ja) * 2014-07-29 2020-03-18 ウェルマーカー バイオ カンパニー リミテッド Met阻害剤に対する感受性予測用の新規なバイオマーカー及びその用途
AU2015316522B2 (en) * 2014-09-16 2021-01-21 Symphogen A/S Anti-met antibodies and compositions
CN107613974B (zh) * 2015-03-16 2021-01-15 塞尔德克斯医疗公司 抗-met抗体及其使用方法
GB201611123D0 (en) * 2016-06-27 2016-08-10 Euremab Srl Anti met antibodiesand uses thereof
US11673971B2 (en) 2016-09-23 2023-06-13 Marengo Therapeutics, Inc. Multispecific antibody molecules comprising lambda and kappa light chains
TWI782930B (zh) 2016-11-16 2022-11-11 美商再生元醫藥公司 抗met抗體,結合met之雙特異性抗原結合分子及其使用方法
US11479612B2 (en) 2017-05-30 2022-10-25 Chong Kun Dang Pharmaceutical Corp. Anti-c-Met antibody and use thereof
WO2018221969A1 (en) * 2017-05-30 2018-12-06 Chong Kun Dang Pharmaceutical Corp. A novel anti-c-met antibody and use thereof
JP7280238B2 (ja) * 2017-07-17 2023-05-23 ヤンセン バイオテツク,インコーポレーテツド フィブロネクチンiii型ドメインに対する抗原結合領域及びその使用方法
CN109771642B (zh) * 2017-11-13 2022-09-20 同济大学苏州研究院 c-MET激动型抗体及其用途
US11591390B2 (en) 2018-09-27 2023-02-28 Celgene Corporation SIRP-α binding proteins and methods of use thereof
PE20211491A1 (es) 2018-09-27 2021-08-11 Celgene Corp PROTEINAS DE FIJACION A SIRPa Y METODOS DE USO DE ESTAS
US11896682B2 (en) 2019-09-16 2024-02-13 Regeneron Pharmaceuticals, Inc. Radiolabeled MET binding proteins for immuno-PET imaging and methods of use thereof
AU2022254291A1 (en) 2021-04-08 2023-10-12 Byondis B.V. Anti-c-met antibodies and antibody-drug conjugates
TW202328188A (zh) * 2021-09-03 2023-07-16 美商Go治療公司 抗醣化-cmet抗體及其用途
TW202500584A (zh) 2023-05-19 2025-01-01 法商施維雅藥廠 抗met抗體、抗體-藥物結合物、組合物及其用途

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US5648273A (en) 1989-12-27 1997-07-15 The United States Of America, As Represented By The Department Of Health And Human Services Hepatic growth factor receptor is the MET proto-oncogene
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US20090068179A1 (en) 2005-11-16 2009-03-12 Fariba Nayeri Methods for Inhibiting Carcinogenesis and/or Metastasis in an Individual with Endogenous C-Met Ligands and Inhibitors
BRPI0707480A8 (pt) 2006-02-06 2022-11-08 Vertical Bio Ag Usos de um anticorpo monoclonal, um fragmento e/ou anticorpo geneticamente engenheirado ou humanizado, de uma seqüência de nucleotídeos e de um vetor, produto, e, método para triar compostos
JP5536445B2 (ja) * 2006-03-30 2014-07-02 ノバルティス アーゲー c−Metの抗体の組成物およびその使用方法
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EP2014681A1 (en) 2007-07-12 2009-01-14 Pierre Fabre Medicament Novel antibodies inhibiting c-met dimerization, and uses thereof
JPWO2009011426A1 (ja) 2007-07-19 2010-09-24 エーザイ・アール・アンド・ディー・マネジメント株式会社 γ−セクレターゼの新規基質c−Metを利用したスクリーニング方法
US7892770B2 (en) 2007-08-24 2011-02-22 Van Andel Research Institute Monoclonal antibody which binds cMet (HGFR) in formalin-fixed and paraffin-embedded tissues and related methods
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WO2010005965A1 (en) 2008-07-08 2010-01-14 Aronchick Craig A Colonic purgative formulations and methods of using the same
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AR074439A1 (es) 2008-12-02 2011-01-19 Pf Medicament Anticuerpo anti-cmet (receptor c-met)
US8545839B2 (en) 2008-12-02 2013-10-01 Pierre Fabre Medicament Anti-c-Met antibody
US8637027B2 (en) 2010-11-03 2014-01-28 Argen-X B.V. Anti c-Met antibodies

Also Published As

Publication number Publication date
CA2816745C (en) 2019-03-12
AU2011325097A1 (en) 2013-05-02
JP2013545455A (ja) 2013-12-26
US9688773B2 (en) 2017-06-27
BR112013010688B1 (pt) 2020-11-17
CA2816919A1 (en) 2012-05-10
US20150376292A1 (en) 2015-12-31
EP2635603B1 (en) 2016-03-23
US9688774B2 (en) 2017-06-27
CN103562223B (zh) 2017-02-22
JP2016034957A (ja) 2016-03-17
RU2608644C2 (ru) 2017-01-23
EP2635602B1 (en) 2016-09-07
BR112013010687A2 (pt) 2016-08-02
AU2011325098B2 (en) 2016-07-14
EP3165538A1 (en) 2017-05-10
US20120156206A1 (en) 2012-06-21
BR112013010688A2 (pt) 2016-08-09
BR122014027420A2 (pt) 2019-08-20
US10676535B2 (en) 2020-06-09
US20150376291A1 (en) 2015-12-31
JP2013545738A (ja) 2013-12-26
US20120148607A1 (en) 2012-06-14
WO2012059562A1 (en) 2012-05-10
US20140205606A1 (en) 2014-07-24
AU2015210420A1 (en) 2015-09-03
AU2015210420B2 (en) 2017-08-03
ES2594493T3 (es) 2016-12-20
AU2011325098A1 (en) 2013-05-09
CN103562223A (zh) 2014-02-05
RU2013125459A (ru) 2014-12-10
CA2816745A1 (en) 2012-05-10
US9631027B2 (en) 2017-04-25
EP2635603A1 (en) 2013-09-11
AU2011325097B2 (en) 2015-05-21
US20170349667A1 (en) 2017-12-07
WO2012059561A1 (en) 2012-05-10
IL226113A0 (en) 2013-06-27
IL226112A0 (en) 2013-06-27
US8637027B2 (en) 2014-01-28
JP5857060B2 (ja) 2016-02-10
CN103764678A (zh) 2014-04-30
EP2635602A1 (en) 2013-09-11
DK2635602T3 (en) 2016-10-10
RU2013125457A (ru) 2014-12-10
US20180215833A1 (en) 2018-08-02
US9884917B2 (en) 2018-02-06

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