JP5852309B2 - 増殖性疾患を治療するためのサパシタビンの使用 - Google Patents
増殖性疾患を治療するためのサパシタビンの使用 Download PDFInfo
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- JP5852309B2 JP5852309B2 JP2010504828A JP2010504828A JP5852309B2 JP 5852309 B2 JP5852309 B2 JP 5852309B2 JP 2010504828 A JP2010504828 A JP 2010504828A JP 2010504828 A JP2010504828 A JP 2010504828A JP 5852309 B2 JP5852309 B2 JP 5852309B2
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- sapacitabine
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
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- A—HUMAN NECESSITIES
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- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
Landscapes
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| GB0723723A GB0723723D0 (en) | 2007-12-04 | 2007-12-04 | Use |
| PCT/GB2008/001424 WO2008132443A1 (en) | 2007-04-25 | 2008-04-24 | Use of sapacitabine to treat proliferative disease |
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| JP2014170018A Expired - Fee Related JP5892565B2 (ja) | 2007-04-25 | 2014-08-25 | 増殖性疾患を治療するためのサパシタビンの使用 |
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| WO2008132443A1 (en) | 2007-04-25 | 2008-11-06 | Cyclacel Limited | Use of sapacitabine to treat proliferative disease |
| US20110065663A1 (en) * | 2008-05-15 | 2011-03-17 | Katholieke Universiteit Leuven, K.U. Leuven R&D | Anti-cancer combination therapy |
| US10226478B2 (en) | 2011-04-14 | 2019-03-12 | Cyclacel Limited | Dosage regimen for sapacitabine and decitabine in combination for treating acute myeloid leukemia |
| EP2874631A1 (en) * | 2012-05-15 | 2015-05-27 | Cyclacel Limited | Dosage regimen for sapacitabine and seliciclib |
| CN105025854A (zh) * | 2013-01-07 | 2015-11-04 | 宾夕法尼亚大学董事会 | 治疗皮肤t细胞淋巴瘤的组合物和方法 |
| WO2021079129A1 (en) | 2019-10-24 | 2021-04-29 | Cyclacel Limited | Dosing regimen |
| US11957701B2 (en) | 2020-07-17 | 2024-04-16 | Delta-Fly Pharma, Inc. | Therapy and new therapeutic agent for blood cancer |
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| US20050014716A1 (en) * | 2003-05-21 | 2005-01-20 | Wang Jin Wei | Pancreatic cancer treatment |
| MX2007007611A (es) * | 2004-12-21 | 2007-09-04 | Schering Corp | Nuevos inhibidores de la farnesil protein-transferasa como agentes antitumorales. |
| SI1849470T2 (sl) * | 2005-01-26 | 2024-05-31 | Taiho Pharmaceutical Co., Ltd. | Zdravilo proti raku, ki vsebuje alfa,alfa,alfa-trifluorotimidin in zaviralec timidin-fosforilaze |
| JP2009504774A (ja) * | 2005-08-18 | 2009-02-05 | メルク エンド カムパニー インコーポレーテッド | 癌を治療するためにｓａｈａ及びターグレチンの併用方法 |
| GB0526419D0 (en) * | 2005-12-23 | 2006-02-08 | Cyclacel Ltd | Formulation |
| GB0609530D0 (en) | 2006-05-12 | 2006-06-21 | Cyclacel Ltd | Combination |
| GB0625283D0 (en) * | 2006-12-19 | 2007-01-24 | Cyclacel Ltd | Combination |
| WO2008132443A1 (en) | 2007-04-25 | 2008-11-06 | Cyclacel Limited | Use of sapacitabine to treat proliferative disease |
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| EP2148676A1 (en) | 2010-02-03 |
| PL2148676T3 (pl) | 2016-12-30 |
| JP2015013877A (ja) | 2015-01-22 |
| JP2010525042A (ja) | 2010-07-22 |
| ES2587381T3 (es) | 2016-10-24 |
| US9675631B2 (en) | 2017-06-13 |
| JP5892565B2 (ja) | 2016-03-23 |
| US20100125084A1 (en) | 2010-05-20 |
| US8536188B2 (en) | 2013-09-17 |
| EP2148676B1 (en) | 2016-05-25 |
| WO2008132443A1 (en) | 2008-11-06 |
| US20140142058A1 (en) | 2014-05-22 |
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