JP5844561B2 - 美白用組成物 - Google Patents
美白用組成物 Download PDFInfo
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- JP5844561B2 JP5844561B2 JP2011147556A JP2011147556A JP5844561B2 JP 5844561 B2 JP5844561 B2 JP 5844561B2 JP 2011147556 A JP2011147556 A JP 2011147556A JP 2011147556 A JP2011147556 A JP 2011147556A JP 5844561 B2 JP5844561 B2 JP 5844561B2
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- Prior art keywords
- acid
- extract
- oil
- diethyl ether
- derivatives
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- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
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- 239000001103 potassium chloride Substances 0.000 description 1
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- SUKJFIGYRHOWBL-UHFFFAOYSA-N sodium hypochlorite Chemical compound [Na+].Cl[O-] SUKJFIGYRHOWBL-UHFFFAOYSA-N 0.000 description 1
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- CZDYPVPMEAXLPK-UHFFFAOYSA-N tetramethylsilane Chemical compound C[Si](C)(C)C CZDYPVPMEAXLPK-UHFFFAOYSA-N 0.000 description 1
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- 235000019157 thiamine Nutrition 0.000 description 1
- KYMBYSLLVAOCFI-UHFFFAOYSA-N thiamine Chemical compound CC1=C(CCO)SCN1CC1=CN=C(C)N=C1N KYMBYSLLVAOCFI-UHFFFAOYSA-N 0.000 description 1
- 239000011721 thiamine Substances 0.000 description 1
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Landscapes
- Medicines Containing Plant Substances (AREA)
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Description
詳細には、本発明は、アルカロイドを有効成分とする美白用組成物に関する。
より詳細には、本発明は、カルバゾール型アルカロイドを有効成分とする美白用組成物に関する。
カラピンチャは、カレーリーフ(curry leaf)との別名を有する程、インドから東南アジアにかけて庭などに植えられており、葉をとって各家庭で料理に使われている植物である。
R4、R5、R6、R7およびR8は、互いに独立して、水素原子またはヒドロキシ基もしくはメチル基である]
で表されるカルバゾール型アルカロイド化合物が提供される。
R4、R5、R6、R7およびR8は、互いに独立して、水素原子またはヒドロキシ基もしくはメチル基である]
で表されるカルバゾール型アルカロイド化合物を提供できることを特徴とする。
R6は、水素原子またはヒドロキシ基、メチル基もしくはメトキシ基であり;
R7は、水素原子またはヒドロキシもしくはメトキシ基である]
で表されるカルバゾール型アルカロイド化合物である美白用組成物が提供される。
また、本発明において用いられるカラピンチャの葉部は、採取した新鮮な葉部および乾燥した葉部のいずれをも、そのまままたは細断して用いることができる。
また、カラピンチャの葉部の採集時期としては、特に限定されるものではない。
なお、上記の酢酸水溶液の代わりに、シュウ酸、クエン酸またはコハク酸などの有機酸水溶液を用いることもできる。また、希有機酸水溶液の弱アルカリ性化には28%アンモニア水が用いられる。
抽出材料を振盪下に浸漬する場合には、30分間〜10時間程度行うのが適当であり、非振盪下に浸漬する場合には、1時間〜20日間程度行うのが適当である。
なお、50℃より低い温度や室温で浸漬して抽出することも可能であるが、その場合には、上記の時間よりも長時間浸漬するのが好ましい。
本発明のおけるカラピンチャの葉部の上記位の2%酢酸水溶液抽出混合物から固形物を除去して得られる抽出液を、冷却後28%アンモニア水で弱アルカリ性とし、ジエチルエーテル抽出処理し、得られたジエチルエーテル可溶画分(抽出液)を常法により濃縮してジエチルエーテル抽出エキスが得られる。
したがって、本願発明における抽出物とは、溶媒が完全に留去された抽出エキス、抽出エキスを減圧下に乾固するまで溶媒を留去した抽出物および抽出液を凍結乾燥して得られる凍結乾燥物のいずれをも意味し、該抽出物と抽出エキスは同義である。
精製処理は、吸着クロマトグラフ法、イオン交換クロマトグラフ法、溶媒による分配抽出などを単独または組み合わせて採用することができる。
この際の担体、溶出溶媒などの精製条件は、各種クロマトグラフィーに対応して適宜選択することができる。
各生成段階および各画分は、ドラーゲンドルフ試薬によるアルカロイドの検出方法により、アルカロイドの存在の有無をチェックすることが好ましい。
上記の操作を計3回繰り返し行い、得られたジエチルエーテル抽出液を合わせ、減圧濃縮して、ジエチルエーテル抽出エキスを得た。
その場合の使用量としては、例えば化粧品に用いられる公知の他の添加剤または賦形剤を含む製品中に、例えば0.001重量%〜5重量%の割合で用いることができる。
アボガド油、アーモンド油、ウイキョウ油、エゴマ油、オリーブ油、オレンジ油、オレンジラファー油、ゴマ油、カカオ脂、カミツレ油、カロット油、キューカンバー油、牛脂脂肪酸、ククイナッツ油、サフラワー油、シア脂、液状シア脂、大豆油、ツバキ油、トウモロコシ油、ナタネ油、パーシック油、ヒマシ油、綿実油、落花生油、タートル油、ミンク油、卵黄油、パーム油、パーム核油、モクロウ、ヤシ油、牛脂、豚脂、スクワレン、スクワラン、プリスタンまたはこれら油脂類の水素添加物(硬化油など)。
ミツロウ、カルナバロウ、鯨ロウ、ラノリン、液状ラノリン、還元ラノリン、硬質ラノリン、カンデリラロウ、モンタンロウ、セラックロウ、ライスワックス。
流動パラフィン、ワセリン、パラフィン、オゾケライド、セレシン、マイクロクリスタンワックス。
ラウリン酸、ミリスチン酸、パルミチン酸、ステアリン酸、ベヘン酸、オレイン酸、リノール酸、リノレン酸、ドコサヘキサエン酸、エイコサペンタエン酸、12-ヒドロキシステアリン酸、ウンデシレン酸、トール油、ラノリン脂肪酸などの天然脂肪酸、イソノナン酸、カプロン酸、2-エチルブタン酸、イソペンタン酸、2-メチルペンタン酸、2-エチルヘキサン酸、イソペンタン酸などの合成脂肪酸。
エタノール、イソピロパノール、ラウリルアルコール、セタノール、ステアリルアルコール、オレイルアルコール、ラノリンアルコール、コレステロール、フィトステロール、フェノキシエタノールなどの天然アルコール、2-ヘキシルデカノール、イソステアリルアルコール、2-オクチルドデカノールなどの合成アルコール。
酸化エチレン、エチレングリコール、ジエチレングリコール、トリエチレングリコール、エチレングリコールモノエチルエーテル、エチレングリコールモノブチルエーテル、ジエチレングリコールモノメチルエーテル、ジエチレングリコールモノエチルエーテル、ポリエチレングリコール、酸化プロピレン、プロピレングリコール、ポリプロピレングリコール、1,3-ブチレングリコール、ペンチルグリコール、グリセリン、ペンタエリトリトール、トレイトール、アラビトール、キシリトール、リビトール、ガラクチトール、ソルビトール、マンニトール、ラクチトール、マルチトール。
ミリスチン酸イソプロピル、パルミチン酸イソプロピル、ステアリン酸ブチル、ラウリン酸ヘキシル、ミリスチン酸ミリスチル、オレイン酸オレイル、オレイン酸デシル、ミリスチン酸オクチルドデシル、ジメチルオクタン酸ヘキシルデシル、乳酸セチル、乳酸ミリスチル、フタル酸ジエチル、フタル酸ジブチル、酢酸ラノリン、モノステアリン酸エチレングリコール、モノステアリン酸プロピレングリコール、ジオレイン酸プロピレングリコール。
ステアリン酸アルミニウム、ステアリン酸マグネシウム、ステアリン酸亜鉛、ステアリン酸カルシウム、パルミチン酸亜鉛、ミリスチン酸マグネシウム、ラウリン酸亜鉛、ウンデシレン酸亜鉛。
アラビアゴム、ベンゾインゴム、ダンマルゴム、グアヤク脂、アイルランド苔、カラヤゴム、トラガントゴム、キャロブゴム、クインシード、寒天、カゼイン、乳糖、果糖、ショ糖またはそのエステル、トレハロースまたはその誘導体、デキストリン、ゼラチン、ペクチン、デンプン、カラギーナン、カルボキシメチルキチンまたはキトサン、エチレンオキサイドなどのアルキレン(C2〜C4)オキサイドが付加されたヒドロキシアルキル(C2〜C4)キチンまたはキトサン、低分子キチンまたはキトサン、キトサン塩、硫酸化キチンまたはキトサン、リン酸化キチンまたはキトサン、アルギン酸またはその塩、ヒアルロン酸またはその塩、コンドロイチン硫酸またはその塩、ヘパリン、エチルセルロース、メチルセルロース、カルボキシメチルセルロース、カルボキシエチルセルロース、カルボキシエチルセルロースナトリウム、ヒドロキシエチルセルロース、ヒドロキシプロピルセルロース、ニトロセルロース、結晶セルロース、ポリビニルアルコール、ポリビニルメチルエーテル、ポリビニルピロリドン、ポリビニルメタアクリレート、ポリアクリル酸塩、ポリエチレンオキサイドやポリプロピレンオキサイドなどのポリアルキレンオキサイドまたはその架橋重合物、カルボキシビニルポリマー、ポリエチレンイミン。
アニオン界面活性剤:アルキルカルボン酸塩、アルキルスルホン酸塩、アルキル硫酸エステル塩、アルキルリン酸エステル塩;カチオン界面活性剤:アルキルアミン塩、アルキル四級アンモニウム塩);両性界面活性剤;カルボン酸型両性界面活性剤:アミノ型、ベタイン型;硫酸エステル型両性界面活性剤;スルホン酸型両性界面活性剤;リン酸エステル型両性界面活性剤;非イオン界面活性剤:エーテル型非イオン界面活性剤、エーテルエステル型非イオン界面活性剤、エステル型非イオン界面活性剤、ブロックポリマー型非イオン界面活性剤、含窒素型非イオン界面活性剤;その他の界面活性剤:天然界面活性剤、タンパク質加水分解物の誘導体、高分子界面活性剤、チタン・ケイ素を含む界面活性剤、フッ化炭素系界面活性剤。
)ビタミンA群:レチノール、レチナール(ビタミンA1)、デヒドロレチナール(ビタミンA2)、カロチン、リコピン(プロビタミンA)、ビタミンB群:チアミン塩酸塩、チアミン硫酸塩(ビタミンB1)、リボフラビン(ビタミンB2)、ピリドキシン(ビタミンB6)、シアノコバラミン(ビタミンB12)、葉酸類、ニコチン酸類、パントテン酸類、ビオチン類、コリン、イノシトール類、ビタミンC群:ビタミンC酸またはその誘導体、ビタミンD群:エルゴカルシフェロール(ビタミンD2)、コレカルシフェロール(ビタミンD3)、ジヒドロタキステロール、ビタミンE群:ビタミンEまたはその誘導体、ユビキノン類、ビタミンK群:フィトナジオン(ビタミンK1)、メナキノン(ビタミンK2)、メナジオン(ビタミンK3)、メナジオール(ビタミンK4)、その他、必須脂肪酸(ビタミンF)、カルニチン、フェルラ酸、γ−オリザノール、オロット酸、ビタミンP類(ルチン、エリオシトリン、ヘスペリジン)、ビタミンU。
バリン、ロイシン、イソロイシン、トレオニン、メチオニン、フェニルアラニン、トリプトファン、リジン、グリシン、アラニン、アスパラギン、グルタミン、セリン、システイン、シスチン、チロシン、プロリン、ヒドロキシプロリン、アスパラギン酸、グルタミン酸、ヒドロキシリジン、アルギニン、オルニチン、ヒスチジンなどや、それらの硫酸塩、リン酸塩、硝酸塩、クエン酸塩、或いはピロリドンカルボン酸などのアミノ酸誘導体。
これらは、添加しようとする製品種別、形態に応じて常法的に行われる加工(例えば、粉砕、製粉、洗浄、加水分解、醗酵、精製、圧搾、抽出、分画、ろ過、乾燥、粉末化、造粒、溶解、滅菌、pH調整、脱臭、脱色などを任意に選択、組合わせた処理)を行い、各種の素材から任意に選択して供すれば良い。
原料とする植物(生薬)としては、当業者に公知の生薬または動物由来の材料が用いられる。
海藻類としては、緑藻類、褐藻類、紅藻類、藍藻類、車軸藻類、黄色藻類などが挙げられる。
また、動物系原料由来の素材としては、牛、豚、鶏または魚類のコラーゲン加水(酸、アルカリ、酵素など)分解物や水溶性コラーゲンまたはアシル化コラーゲンなどのコラーゲン誘導体、牛または豚のエラスチンまたはエラスチン加水分解物(酸、アルカリ、酵素など)または水溶性エラスチン誘導体、ケラチンおよびその分解物またはそれらの誘導体、シルク蛋白およびその分解物またはそれらの誘導体、牛乳、カゼインおよびその分解物またはそれらの誘導体、脱脂粉乳およびその分解物またはそれらの誘導体、ラクトフェリンまたはその分解物、鶏卵成分、魚肉分解物、核酸関連物質(リボ核酸、デオキシリボ核酸)が挙げられる。
深層水などの海水類、例えば、海水塩、海水乾燥物、死海または大西洋または太平洋の海より得た無機塩(塩化ナトリウム、塩化マグネシウム、塩化カリウムなど)、海泥または泥(ファンゴ)類、例えば、イタリアファンゴ、ドイツファンゴ、アイフェルファンゴ、フライブルグファンゴなどの各地の海泥または泥(含有成分:二酸化珪素、二酸化チタン、酸化アルミニウム、酸化鉄、酸化マンガン、酸化ナトリウム、酸化カリウム、酸化マグネシウム、酸化カルシウム、酸化ストロンチウム、ナトリウム、カリウム、マグネシウム、カルシウム、クロム、鉄、銅、ニッケル、亜鉛、鉛、マンガン、ヒ素、水)、聖徳石、黒耀石が挙げられる。
酵母代謝物、酵母菌抽出エキス、細菌代謝物、細菌抽出エキス、カビまたは放線菌代謝物、カビまたは放線菌抽出エキス、納豆菌代謝物、納豆抽出エキス、米発酵エキス、米糠(赤糠、白糠)発酵エキス、ユーグレナ抽出物またはその分解物またはそれら水溶性誘導体、トレハロースまたはその誘導体、生乳または脱脂粉乳の乳酸発酵物、マメ科植物の乳酸菌発酵物、ココヤシ属植物の乳酸菌発酵物が挙げられる。
無水ケイ酸、ケイ酸マグネシウム、タルク、カオリン、ベントナイト、マイカ、雲母チタン、オキシ塩化ビスマス、酸化ジルコニウム、酸化マグネシウム、酸化亜鉛、酸化チタン、炭酸カルシウム、炭酸マグネシウム、黄酸化鉄、ベンガラ、黒酸化鉄、グンジョウ、酸化クロム、水酸化クロム、カーボンブラック、カラミンが挙げられる。
ベンゾフェノン誘導体(2-ヒドロキシ-4-メトキシベンゾフェノン、2-ヒドロキシ-4-メトキシベンゾフェノン-5-スルホン酸、2-ヒドロキシ-4-メトキシベンゾフェノン-5-スルホン酸ナトリウム、ジヒドロキシジメトキシベンゾフェノン、ジヒドロキシジメトキシベンゾフェノン−スルホン酸ナトリウム、2,4-ジヒドロキシベンゾフェノン、テトラヒドロキシベンゾフェノンなど)、パラアミノ安息香酸誘導体(パラアミノ安息香酸、パラアミノ安息香酸エチル、パラアミノ安息香酸グリセリル、パラジメチルアミノ安息香酸アミル、パラジメチルアミノ安息香酸オクチルなど)、メトキシ桂皮酸誘導体(パラメトキシ桂皮酸エチル、パラメトキシ桂皮酸イソプロピル、パラメトキシ桂皮酸オクチル、パラメトキシ桂皮酸2-エトキシエチル、パラメトキシ桂皮酸ナトリウム、パラメトキシ桂皮酸カリウム、ジパラメトキシ桂皮酸モノ-2-エチルヘキサン酸グリセリルなど)、サリチル酸誘導体(サリチル酸オクチル、サリチル酸フェニル、サリチル酸ホモメンチル、サリチル酸ジプロピレングリコール、
パラアミノ安息香酸誘導体、サルチル酸誘導体、アントラニル酸誘導体、クマリン誘導体、アミノ酸系化合物、ベンゾトリアゾール誘導体、テトラゾール誘導体、イミダゾリン誘導体、ピリミジン誘導体、ジオキサン誘導体、カンファー誘導体、フラン誘導体、ピロン誘導体、核酸誘導体、アラントイン誘導体、ニコチン酸誘導体、ビタミンCまたはその誘導体(ビタミンCリン酸エステルマグネシウム塩、ビタミンCグルコシドなど)、ビタミンEまたはその誘導体、コウジ酸またはその誘導体、オキシベンゾン、ベンゾフェノン、アルブチン、グアイアズレン、シコニン、バイカリン、バイカレイン、ベルベリン、胎盤エキス、エラグ酸、ルシノールが挙げられる。
ビタミンCまたはその誘導体(ビタミンCリン酸エステルマグネシウム塩、ビタミンCグルコシドなど)、ハイドロキノンまたはその誘導体(ハイドロキノンベンジルエーテルなど)、コウジ酸またはその誘導体、ビタミンEまたはその誘導体、N−アセチルチロシンまたはその誘導体、グルタチオン、過酸化水素、過酸化亜鉛、胎盤エキス、エラグ酸、アルブチン、ルシノール、シルク抽出物、植物エキス(カミツレ、クワ、クチナシ、トウキ、ワレモコウ、クララ、ヨモギ、スイカズラ、キハダ、ドクダミ、マツホド、ハトムギ、オドリコソウ、ホップ、サンザシ、ユーカリ、セイヨウノコギリソウ、アルテア、ケイヒ、マンケイシ、ハマメリス、カラグワまたはヤマグワ、延命草、桔梗、トシシ、続随子、射干、麻黄、センキュウ、ドッカツ、サイコ、ボウフウ、ハマボウフウ、オウゴン、牡丹皮、シャクヤク、ゲンノショウコ、葛根、甘草、五倍子、アロエ、ショウマ、紅花、緑茶、紅茶、阿仙薬)が挙げられる。
フェニル水銀ヘキサクロロフェン、酸化第二水銀、塩化第一水銀、過酸化水素水、過酸化亜鉛、ハイドロキノンまたはその誘導体(ハイドロキノンベンジルエーテル)が挙げられる。
ターンオーバーの促進作用/細胞賦活物質ハイドロキノン、乳酸菌エキス、胎盤エキス、霊芝エキス、ビタミンA、ビタミンE、アラントイン、脾臓エキス、胸腺エキス、酵母エキス、発酵乳エキス、植物エキス(アロエ、オウゴン、スギナ、ゲンチアナ、ゴボウ、シコン、ニンジン、ハマメリス、ホップ、ヨクイニン、オドリコソウ、センブリ、トウキ、トウキンセンカ、アマチャ、オトギリソウ、キュウリ、タチジャコウソウ、マンネンロウ、パセリ)が挙げられる。
コハク酸、アラントイン、塩化亜鉛、硫酸亜鉛、酸化亜鉛、カラミン、パラフェノールスルホン酸亜鉛、硫酸アルミニウムカリウム、レゾルシン、塩化第二鉄、タンニン酸(カテキン化合物を含む)が挙げられる。
SOD、カタラーゼ、グルタチオンパーオキシダーゼが挙げられる。
ビタミンCまたはその塩、ステアリン酸エステル、ビタミンEまたはその誘導体、ノルジヒドログアセレテン酸、ブチルヒドロキシトルエン(BHT)、ブチルヒドロキシアニソール(BHA)、ヒドロキシチロソール、パラヒドロキシアニソール、没食子酸プロピル、セサモール、セサモリン、ゴシポール、プロポリスが挙げられる。
β-カロチン、植物エキス(ゴマ培養細胞、アマチャ、オトギリソウ、ハマメリス、チョウジ、メリッサ、エンメイソウ、シラカバ、サルビア、マンネンロウ、南天実、エイジツ、イチョウ、緑茶)が挙げられる。
イクタモール、インドメタシン、カオリン、サリチル酸、サリチル酸ナトリウム、サリチル酸メチル、アセチルサリチル酸、塩酸ジフェンヒドラミン、d-カンフル、dl-カンフル、ヒドロコルチゾン、グアイアズレン、カマズレン、マレイン酸クロルフェニラミン、グリチルリチン酸またはその塩、グリチルレチン酸またはその塩、甘草エキス、シコンエキス、エイジツエキス、プロポリスが挙げられる。
アクリノール、イオウ、グルコン酸カルシウム、グルコン酸クロルヘキシジン、スルファミン、マーキュロクロム、ラクトフェリンまたはその加水分解物、塩化アルキルジアミノエチルグリシン液、トリクロサン、次亜塩素酸ナトリウム、クロラミンT、サラシ粉、ヨウ素化合物、ヨードホルム、ソルビン酸またはその塩、プロピオン酸またはその塩、サルチル酸、デヒドロ酢酸、パラヒドロキシ安息香酸エステル類、ウンデシレン酸、チアミンラウリル硫酸塩、チアミンラウリル硝酸塩、フェノール、クレゾール、p-クロロフェノール、p-クロロ-m-キシレノール、p-クロロ-m-クレゾール、チモール、フェネチルアルコール、O-フェニルフェノール、イルガサンCH3565、ハロカルバン、ヘキサクロロフェン、クロロヘキシジン、エタノール、メタノール、イソプロピルアルコール、ベンジルアルコール、エチレングリコール、プロピレングリコール、2-フェノキシエタノール、1,2-ペンタンジオール、
グリセリン、プロピレングリコール、1,3-ブチレングリコール、ポリエチレングリコール、トリカプリルカプリン酸グリセリン、グリコール酸(αーヒドロキシ酸)、ヒアルロン酸またはその塩、コンドロイチン硫酸またはその塩、水溶性キチンまたはその誘導体或いはキトサン誘導体、ピロリドンカルボン酸またはその塩、乳酸ナトリウム、尿素、ソルビトール、アミノ酸またはその誘導体(バリン、ロイシン、イソロイシン、トレオニン、メチオニン、フェニルアラニン、トリプトファン、リジン、グリシン、アラニン、アスパラギン、グルタミン、セリン、システイン、シスチン、チロシン、プロリン、ヒドロキシプロリン、アスパラギン酸、グルタミン酸、ヒドロキシリジン、アルギニン、オルニチン、ヒスチジンや、
ジャコウ、シベット、カストリウム、アンバーグリスなどの天然動物性香料、アニス精油、アンゲリカ精油、イランイラン精油、イリス精油、ウイキョウ精油、オレンジ精油、カナンガ精油、カラウェー精油、カルダモン精油、グアヤクウッド精油、クミン精油、黒文字精油、ケイ皮精油、シンナモン精油、ゲラニウム精油、コパイババルサム精油、コリアンデル精油、シソ精油、シダーウッド精油、シトロネラ精油、ジャスミン精油、ジンジャーグラス精油、杉精油、スペアミント精油、西洋ハッカ精油、大茴香精油、チュベローズ精油、丁字精油、橙花精油、冬緑精油、トルーバルサム精油、バチュリー精油、バラ精油、パルマローザ精油、桧精油、ヒバ精油、白檀精油、プチグレン精油、ベイ精油、ベチバ精油、ベルガモット精油、ペルーバルサム精油、ボアドローズ精油、芳樟精油、マンダリン精油、ユーカリ精油、ライム精油、ラベンダー精油、リナロエ精油、レモングラス精油、レモン精油、ローズマリー(マンネンロウ)精油、和種ハッカ精油などの植物性香料、その他合成香料が挙げられる。
着色剤赤キャベツ色素、赤米色素、アカネ色素、アナトー色素、イカスミ色素、ウコン色素、エンジュ色素、オキアミ色素、柿色素、カラメル、金、銀、クチナシ色素、コーン色素、タマネギ色素、タマリンド色素、スピルリナ色素、ソバ全草色素、チェリー色素、海苔色素、ハイビスカス色素、ブドウ果汁色素、マリーゴールド色素、紫イモ色素、紫ヤマイモ色素、ラック色素、ルチンが挙げられる。
その他ホルモン類、金属イオン封鎖剤、pH調整剤、キレート剤、防腐・防バイ剤、清涼剤、安定化剤、乳化剤、動・植物性蛋白質およびその分解物、動・植物性多糖類およびその分解物、動・植物性糖蛋白質およびその分解物、血流促進剤、抗炎症剤・消炎剤・抗アレルギー剤、創傷治療剤、増泡剤、増粘剤、酵素、精製水(電子水、小クラスター化などを含む)、消臭・脱臭剤などが挙げられる。
メラニンを生成するメラノサイトは表皮の基底層全体にわたって認められ、皮膚が日射を受けると、メラノサイトはより多くの色素を作り出し、皮膚は黄褐色または暗褐色になる。メラニンはメラノサイトやメラノーマなどといった特殊な細胞内で合成される色素性のポリマーであり、UVからの保護や色素、毒性のある化合物の吸収などに重要な役割を果たしている。
一方で最近、美白効果を目的にメラニン生成抑制物質の探索が広く行われている。
高分解能質量分析(High resolution FAB-MSおよびEI-MS)ならびに質量分析(FAB-MSおよびEI-MS)は、JEOL JMS-SX 102およびJMS-GCMATE型質量分析装置(日本電子株式会社製)を用いて測定した。
実験で得られた数値は、平均値±標準誤差で表記し、対照群との平均値の有意差の検定にはDunnettの方法を使用し、p値が0.05以下のものを有意とみなした。
理研細胞バンクより分譲されたマウスメラノーマB16-メラノーマ-4A5細胞(RCB0557)を10%ウシ胎児血清(FCS)、100 ユニット/mLペニシリンおよび100 μg/mLストレプトマイシン含有DMEM(4500 mg/L グルコース)培地(Sigma-Aldrich社)で培養(5%CO2、37oC)した。
阻害率(%)= [(A−B)/ A] / (C / 100) × 100
[式中、Aは被験試料未添加(コントロール)の吸光度、Bは被験試料添加の吸光度、Cは細胞生存率を意味する]
B16-メラノーマ-4A5細胞を、10%ウシ胎児血清(FCS)、100ユニット/mLペニシリンおよび100 μg/mLストレプトマイシン含有DMEM(4500 mg/L glucose)培地(Sigma-Aldrich社)で培養(5%CO2、37oC)した。
[式中、Aは被験試料未添加(コントロール)の吸光度を意味し、Bは被験試料添加の吸光度を意味する]
96ウェル マイクロプレート(住友ベークライト社製)に2.5mM L-DOPAリン酸緩衝溶液70 μL/ウェルを分注し、調整した試料溶液(DMSO溶液)20 μLを添加した。次に、終濃度46ユニット/mLチロシナーゼリン酸緩衝溶液120 μLを添加し、酵素反応(室温、5分)を開始した。また、ブランクにはリン酸緩衝溶液を用いた。生成されたメラニンの吸光度をマイクロプレートリーダー(model 550、BIO-RAD社製)にて測定した(測定波長:450 nm、参照波長:655 nm)。
[式中、Aは被験試料未添加(コントロール)の吸光度を意味し、Bは被験試料添加の吸光度を意味する]
カラピンチャの乾燥葉部のジエチルエーテル抽出エキスおよび水溶性画分の調整
スリランカ産カラピンチャの乾燥葉部(500 g)を、2容量%酢酸水溶液(7.5 L)を用いて、80℃で3時間加熱抽出した。抽出混合物を室温に冷却後、ろ過し、濾液を28%アンモニア水(150 mL)で弱アルカリ性とし、同容量のジエチルエーテル(7.5 L)で抽出した。
上記の操作を計3回繰り返し、得られたジエチルエーテル抽出液を合わせ、減圧濃縮してジエチルエーテル抽出エキス2.25 g(収率4.25%)を得た。
また、ジエチルエーテルで分配処理した水溶液を減圧濃縮して水溶性画分として478.75 gを得た。
ジエチルエーテル抽出エキスのメラニン生成抑制試験
今回、カラピンチャの乾燥葉部の前記ジエチルエーテル抽出エキスおよび前記水溶性画分について、マウスメラノーマ由来B16-メラノーマ-4A5細胞におけるメラニン生成抑制作用を検討したので、その結果を以下の表1に示す。
ジエチルエーテル抽出エキスの細胞毒性試験
次に、カラピンチャの乾燥葉部の前記ジエチルエーテル抽出エキスおよび前記水溶性画分について、マウスメラノーマ由来B16-メラノーマ-4A5細胞における細胞増殖に対する阻害効果(生存率)を検討したので、その結果を以下の表2に示す。
スリランカ産カラピンチャの乾燥葉部からの含有成分の抽出および単離
スリランカ産カラピンチャの乾燥葉部(500 g)を、2容量%酢酸水溶液(7.5 L)を用いて、80℃で3時間加熱抽出した。抽出混合物を室温に冷却後、ろ過し、濾液を28%アンモニア水(150 mL)で弱アルカリ性とし、た。ろ別した植物材料については、上記と全く同じ操作をさらに2回繰り返し、中和した溶液を合わせた。
上記の操作を計3回繰り返し、得られたジエチルエーテル抽出液を合わせ、減圧濃縮してジエチルエーテル抽出エキス21.25 g(収率4.25%)を得た。
また、ジエチルエーテルで分配処理した水溶液を減圧濃縮して水溶性画分として478.75 gを得た(以下のチャート1参照)。
カラピナミンA (1) は、正の旋光度 ([α]D 24 +12.4°、MeOH) を示す黄色粉末として得られ、そのEI-MS において分子イオンピークがm/z 333 (M+) に観測され、1は高分解能 EI-MS により分子式 C23H27NO を有する化合物であることが明らかになった。
また、IRスペクトルにおいて水酸基 (3400 cm-1)、芳香環 (1509 cm-1) の存在を示唆する吸収が認められた。
また IR スペクトルにおいて水酸基 (3400 cm-1)、芳香環 (1601、1507 cm-1) の存在を示唆する吸収が認められた。
また IRスペクトルにおいて水酸基(3:3450;4:3450)、芳香環(3:1618、1509;4:1615、1509)の存在を示唆する吸収が認められた。
カラピンチャ葉部含有成分のメラニン生成抑制効果
前記ジエチルエーテル抽出エキスから単離した新規カルバゾール型ルカロイド4種および公知カルバゾール型アルカロイド9種(1〜11、13および14) について、B16-メラノーマ-4A5細胞におけるメラニン生成抑制作用を検討した(表4)。
また、上記のジエチルエーテル抽出エキスに含まれるカルバゾール型アルカロイド化合物の殆どは、上記アルブミンよりも強力なメラニン生成効果を有することが判明した。
マウスメラノーマ細胞における細胞増殖阻害効果
前記ジエチルエーテル抽出エキスから単離した新規カルバゾール型ルカロイド4種および公知カルバゾール型アルカロイド9種(1〜11、13および14) について、B16-メラノーマ-4A5細胞におけるメラニン生成抑制作用を検討した(表6)。
チロシナーゼ阻害活性試験
前記ジエチルエーテル抽出エキスから単離した新規カルバゾール型ルカロイド4種および公知カルバゾール型アルカロイド9種(1〜11、13および14)について、マッシュルーム由来のチロシナーゼに対する阻害活性について検討した(表8)。
上記の実施例8においてジエチルエーテル抽出エキス0.01、0.1、1および5重量%をそれぞれ用いたこと以外は、実施例8と全く同様にして化粧水1kgをそれぞれ調製した。
実施例13
乳液の調製
以下の処方:
上記の実施例13においてジエチルエーテル抽出エキス0.01、0.1、1および5重量%をそれぞれ用いたこと以外は、実施例13と全く同様にして乳液1kgをそれぞれ製造した。
上記の実施例18においてジエチルエーテル抽出エキス0.01、0.1、1および5重量%をそれぞれ用いたこと以外は、実施例18と全く同様にしてクリーム1kgをそれぞれ製造した。
上記の実施例23においてジエチルエーテル抽出エキス0.01、0.1、1および5重量%をそれぞれ用いたこと以外は、実施例23と全く同様にして日焼け止めクリーム1kgをそれぞれ製造した。
上記の実施例28においてジエチルエーテル抽出エキス0.01、0.1、1および5重量%をそれぞれ用いたこと以外は、実施例28と全く同様にしてファンデーション1kgをそれぞれ製造した。
上記の実施例33においてジエチルエーテル抽出エキス0.01、0.1、1および5重量%をそれぞれ用いたこと以外は、実施例33と全く同様にして全身用日焼け止めクリーム1kgをそれぞれ製造した。
Claims (4)
- ミカン科ゲッキツ属カラピンチャ(Murraya koenigii L.)の乾燥葉部の希有機酸水溶液抽出物を、弱アルカリ性とし、ジエチルエーテルで抽出して得られたジエチルエーテル抽出エキスを有効成分とする美白用組成物。
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