JP5827220B2 - 人工多能性幹細胞の樹立効率改善方法 - Google Patents
人工多能性幹細胞の樹立効率改善方法 Download PDFInfo
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- JP5827220B2 JP5827220B2 JP2012513400A JP2012513400A JP5827220B2 JP 5827220 B2 JP5827220 B2 JP 5827220B2 JP 2012513400 A JP2012513400 A JP 2012513400A JP 2012513400 A JP2012513400 A JP 2012513400A JP 5827220 B2 JP5827220 B2 JP 5827220B2
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- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0696—Artificially induced pluripotent stem cells, e.g. iPS
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
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- C12N2501/604—Klf-4
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/60—Transcription factors
- C12N2501/605—Nanog
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/60—Transcription factors
- C12N2501/606—Transcription factors c-Myc
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/60—Transcription factors
- C12N2501/608—Lin28
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- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
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- General Engineering & Computer Science (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US28232010P | 2010-01-22 | 2010-01-22 | |
| US61/282,320 | 2010-01-22 | ||
| PCT/JP2011/051685 WO2011090221A1 (en) | 2010-01-22 | 2011-01-21 | Method for improving induced pluripotent stem cell generation efficiency |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013517758A JP2013517758A (ja) | 2013-05-20 |
| JP2013517758A5 JP2013517758A5 (enExample) | 2014-03-06 |
| JP5827220B2 true JP5827220B2 (ja) | 2015-12-02 |
Family
ID=44307020
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012513400A Active JP5827220B2 (ja) | 2010-01-22 | 2011-01-21 | 人工多能性幹細胞の樹立効率改善方法 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US9005967B2 (enExample) |
| EP (1) | EP2526189B1 (enExample) |
| JP (1) | JP5827220B2 (enExample) |
| WO (1) | WO2011090221A1 (enExample) |
Families Citing this family (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20140063501A (ko) | 2010-12-22 | 2014-05-27 | 페이트 세러퓨틱스, 인코포레이티드 | 단세포 분류 및 iPSC의 증강된 재프로그래밍을 위한 세포 배양 플랫폼 |
| DK2951290T3 (en) | 2013-02-01 | 2018-01-22 | Us Health | PROCEDURE FOR PREPARING RETINAL PIGMENTAL EPIT (RPE) CELLS FROM INDUCED PLURIPOTENT STEM CELLS (IPSCS) |
| JP6541577B2 (ja) | 2013-02-06 | 2019-07-10 | ユニバーシティー オブ ロチェスター | ミエリン障害の治療のための誘導多能性細胞由来オリゴデンドロサイト前駆細胞 |
| ES2966757T3 (es) | 2014-03-04 | 2024-04-24 | Fate Therapeutics Inc | Métodos de reprogramación mejorados y plataformas de cultivo celular |
| US9724432B2 (en) | 2015-04-30 | 2017-08-08 | University Of Rochester | Non-human mammal model of human degenerative disorder, uses thereof, and method of treating human degenerative disorder |
| CN108473962B (zh) | 2015-09-08 | 2022-04-26 | (由卫生与公众服务部部长代表的)美利坚合众国 | 临床级别视网膜色素上皮细胞的可再现的分化方法 |
| EP4001402A1 (en) | 2015-09-08 | 2022-05-25 | FUJIFILM Cellular Dynamics, Inc. | Macs-based purification of stem cell-derived retinal pigment epithelium |
| WO2017066634A1 (en) | 2015-10-16 | 2017-04-20 | Fate Therapeutics, Inc. | Platform for the induction & maintenance of ground state pluripotency |
| EP3365433A1 (en) | 2015-10-20 | 2018-08-29 | FUJIFILM Cellular Dynamics, Inc. | Methods for directed differentiation of pluripotent stem cells to immune cells |
| US20180030478A1 (en) | 2016-07-01 | 2018-02-01 | Research Development Foundation | Elimination of proliferating cells from stem cell-derived grafts |
| US11866733B2 (en) | 2016-08-01 | 2024-01-09 | University of Pittsburgh—of the Commonwealth System of Higher Education | Human induced pluripotent stem cells for high efficiency genetic engineering |
| AU2017340634B2 (en) | 2016-10-05 | 2022-06-02 | FUJIFILM Cellular Dynamics, Inc. | Generating mature lineages from induced pluripotent stem cells with MECP2 disruption |
| US11458225B2 (en) | 2016-11-09 | 2022-10-04 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | 3D vascularized human ocular tissue for cell therapy and drug discovery |
| US11530388B2 (en) | 2017-02-14 | 2022-12-20 | University of Pittsburgh—of the Commonwealth System of Higher Education | Methods of engineering human induced pluripotent stem cells to produce liver tissue |
| CA3058779A1 (en) | 2017-04-18 | 2018-10-25 | FUJIFILM Cellular Dynamics, Inc. | Antigen-specific immune effector cells |
| WO2018209022A2 (en) | 2017-05-10 | 2018-11-15 | University Of Rochester | Methods of treating neuropsychiatric disorders |
| CA3097428A1 (en) | 2018-04-20 | 2019-10-24 | FUJIFILM Cellular Dynamics, Inc. | Method for differentiation of ocular cells and use thereof |
| KR102847197B1 (ko) | 2018-06-18 | 2025-08-20 | 유니버시티 오브 로체스터 | 정신분열증 및 다른 신경정신장애를 치료하는 방법 |
| KR20210054502A (ko) | 2018-06-21 | 2021-05-13 | 유니버시티 오브 로체스터 | 헌팅턴병을 치료하거나 이의 발병을 저해하는 방법 |
| JP7718819B2 (ja) * | 2018-07-02 | 2025-08-05 | リン、シー-ラン | 成体幹細胞の拡大と誘導のインビトロでの誘発 |
| SG11202104401RA (en) | 2018-11-19 | 2021-05-28 | The United States Of America As Represented By The Secretary | Biodegradable tissue replacement implant and its use |
| EP3887518A2 (en) | 2018-11-28 | 2021-10-06 | Board of Regents, The University of Texas System | Multiplex genome editing of immune cells to enhance functionality and resistance to suppressive environment |
| US20220033778A1 (en) | 2018-11-29 | 2022-02-03 | Board Of Regents, The University Of Texas System | Methods for ex vivo expansion of natural killer cells and use thereof |
| CN119925614A (zh) | 2018-12-11 | 2025-05-06 | 罗切斯特大学 | 治疗精神分裂症和其他神经精神病症的方法 |
| EP3923962A2 (en) | 2019-02-13 | 2021-12-22 | University of Rochester | Gene networks that mediate remyelination of the human brain |
| WO2021182477A1 (en) | 2020-03-09 | 2021-09-16 | Fujifilm Corporation | Markers specific for pluripotent stem cells, and methods of using the same |
| JP2023536210A (ja) | 2020-05-29 | 2023-08-24 | フジフィルム セルラー ダイナミクス,インコーポレイテッド | 網膜色素上皮及び光受容体の二重層、並びにその使用 |
| BR112022024031A2 (pt) | 2020-05-29 | 2023-01-31 | Fujifilm Cellular Dynamics Inc | Agregados de células duplas de epitélio pigmentado da retina e fotorreceptor, e métodos de uso dos mesmos |
| IL302728A (en) | 2020-11-13 | 2023-07-01 | Catamaran Bio Inc | Genetically modified natural killer cells and methods of use thereof |
| KR20230086785A (ko) | 2020-11-18 | 2023-06-15 | 후지필름 가부시키가이샤 | 분비체-함유 조성물의 생성, 및 이의 사용 및 분석 방법 |
| US12492372B2 (en) | 2020-11-24 | 2025-12-09 | Monash University | Induced stem cells |
| CA3199728A1 (en) | 2020-11-24 | 2022-06-02 | Jose POLO | Methods and cellular structures |
| WO2022115611A1 (en) | 2020-11-25 | 2022-06-02 | Catamaran Bio, Inc. | Cellular therapeutics engineered with signal modulators and methods of use thereof |
| CN117083374A (zh) | 2021-03-25 | 2023-11-17 | 蓝岩治疗有限公司 | 获得诱导多能干细胞的方法 |
| AU2022280051A1 (en) | 2021-05-26 | 2023-11-23 | FUJIFILM Cellular Dynamics, Inc. | Methods to prevent rapid silencing of genes in pluripotent stem cells |
| CA3220433A1 (en) | 2021-05-28 | 2022-12-01 | Arvydas Maminishkis | Biodegradable tissue scaffold with secondary matrix to host weakly adherent cells |
| US20240271089A1 (en) | 2021-05-28 | 2024-08-15 | The U.S.A., As Represented By The Secretary, Department Of Health And Human Services | Methods to generate macular, central and peripheral retinal pigment epithelial cells |
| CN118159646A (zh) | 2021-09-13 | 2024-06-07 | 富士胶片细胞动力公司 | 产生定向心脏祖细胞的方法 |
| WO2023069881A1 (en) | 2021-10-20 | 2023-04-27 | University Of Rochester | Treatment with genetically modified cells, and genetically modified cells per se, with increased competitive advantage and/or decreased competitive disadvantage |
| CA3235105A1 (en) | 2021-10-20 | 2023-04-27 | Steven A. Goldman | Humanized chimeras for the prospective assessment of glial cell addition or replacement therapy |
| CN118525089A (zh) | 2021-10-20 | 2024-08-20 | 罗切斯特大学 | 年龄相关的白质损失的再生治疗 |
| US20230270818A1 (en) | 2021-11-02 | 2023-08-31 | University Of Rochester | Tcf7l2 mediated remyelination in the brain |
| WO2023150557A1 (en) | 2022-02-01 | 2023-08-10 | University Of Rochester | Methods of generating a population of neurons from human glial progenitor cells and genetic constructs for carrying out such methods |
| WO2023172514A1 (en) | 2022-03-07 | 2023-09-14 | Catamaran Bio, Inc. | Engineered immune cell therapeutics targeted to her2 and methods of use thereof |
| US20250276020A1 (en) | 2022-05-05 | 2025-09-04 | University Of Rochester | Dual macroglial-microglial approach towards therapeutic cell replacement in neurodegenerative and neuropsychiatric disease |
| CN119452078A (zh) | 2022-06-29 | 2025-02-14 | 富士胶片控股美国公司 | Ipsc来源的星形胶质细胞及其使用方法 |
| WO2024073776A1 (en) | 2022-09-30 | 2024-04-04 | FUJIFILM Cellular Dynamics, Inc. | Methods for the production of cardiac fibroblasts |
| EP4658294A2 (en) | 2023-02-02 | 2025-12-10 | University of Rochester | Competitive replacement of glial cells |
| WO2024192329A1 (en) | 2023-03-16 | 2024-09-19 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Methods for producing stable human chondroctyes and their use for promoting cartillage growth and repair |
| WO2025245202A1 (en) | 2024-05-21 | 2025-11-27 | FUJIFILM Cellular Dynamics, Inc. | Particle counting and biomass measurements of aggregated cell compositions |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4937190A (en) | 1987-10-15 | 1990-06-26 | Wisconsin Alumni Research Foundation | Translation enhancer |
| PT1084230E (pt) | 1998-06-08 | 2008-01-25 | Osiris Therapeutics Inc | Regulação da diferenciação de células estaminais hematopoiéticas através da utilização de células estaminais mesenquimatosas humanas |
| CA2368948C (en) | 1999-05-18 | 2013-12-24 | Dnavec Research Inc. | Envelope gene-deficient virus vector of paramyxoviridae |
| US6602711B1 (en) | 2000-02-21 | 2003-08-05 | Wisconsin Alumni Research Foundation | Method of making embryoid bodies from primate embryonic stem cells |
| JP3660601B2 (ja) | 2001-03-30 | 2005-06-15 | 独立行政法人科学技術振興機構 | 胚性幹細胞からの神経幹細胞、運動ニューロン及びgaba作動性ニューロンの製造法 |
| JP2004121165A (ja) | 2002-10-07 | 2004-04-22 | Asahi Kasei Corp | 膵幹様細胞の分化誘導方法 |
| WO2007069666A1 (ja) | 2005-12-13 | 2007-06-21 | Kyoto University | 核初期化因子 |
| US20090227032A1 (en) | 2005-12-13 | 2009-09-10 | Kyoto University | Nuclear reprogramming factor and induced pluripotent stem cells |
| SG193652A1 (en) | 2007-03-23 | 2013-10-30 | Wisconsin Alumni Res Found | Somatic cell reprogramming |
| CN101617043B (zh) | 2007-10-31 | 2014-03-12 | 国立大学法人京都大学 | 核重编程方法 |
-
2011
- 2011-01-21 WO PCT/JP2011/051685 patent/WO2011090221A1/en not_active Ceased
- 2011-01-21 US US13/497,044 patent/US9005967B2/en active Active
- 2011-01-21 JP JP2012513400A patent/JP5827220B2/ja active Active
- 2011-01-21 EP EP11734826.8A patent/EP2526189B1/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| JP2013517758A (ja) | 2013-05-20 |
| US20120276636A1 (en) | 2012-11-01 |
| US9005967B2 (en) | 2015-04-14 |
| EP2526189B1 (en) | 2016-10-12 |
| WO2011090221A1 (en) | 2011-07-28 |
| EP2526189A4 (en) | 2014-03-19 |
| EP2526189A1 (en) | 2012-11-28 |
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