JP5827220B2 - 人工多能性幹細胞の樹立効率改善方法 - Google Patents
人工多能性幹細胞の樹立効率改善方法 Download PDFInfo
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- JP5827220B2 JP5827220B2 JP2012513400A JP2012513400A JP5827220B2 JP 5827220 B2 JP5827220 B2 JP 5827220B2 JP 2012513400 A JP2012513400 A JP 2012513400A JP 2012513400 A JP2012513400 A JP 2012513400A JP 5827220 B2 JP5827220 B2 JP 5827220B2
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0696—Artificially induced pluripotent stem cells, e.g. iPS
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
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- C12N2501/604—Klf-4
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/60—Transcription factors
- C12N2501/605—Nanog
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/60—Transcription factors
- C12N2501/606—Transcription factors c-Myc
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/60—Transcription factors
- C12N2501/608—Lin28
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US28232010P | 2010-01-22 | 2010-01-22 | |
| US61/282,320 | 2010-01-22 | ||
| PCT/JP2011/051685 WO2011090221A1 (en) | 2010-01-22 | 2011-01-21 | Method for improving induced pluripotent stem cell generation efficiency |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013517758A JP2013517758A (ja) | 2013-05-20 |
| JP2013517758A5 JP2013517758A5 (enExample) | 2014-03-06 |
| JP5827220B2 true JP5827220B2 (ja) | 2015-12-02 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012513400A Active JP5827220B2 (ja) | 2010-01-22 | 2011-01-21 | 人工多能性幹細胞の樹立効率改善方法 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US9005967B2 (enExample) |
| EP (1) | EP2526189B1 (enExample) |
| JP (1) | JP5827220B2 (enExample) |
| WO (1) | WO2011090221A1 (enExample) |
Families Citing this family (55)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9732319B2 (en) | 2010-12-22 | 2017-08-15 | Fate Therapeutics, Inc. | Cell culture platform for single cell sorting and enhanced reprogramming of iPSCs |
| DK2951290T3 (en) | 2013-02-01 | 2018-01-22 | Us Health | PROCEDURE FOR PREPARING RETINAL PIGMENTAL EPIT (RPE) CELLS FROM INDUCED PLURIPOTENT STEM CELLS (IPSCS) |
| EP3766962B1 (en) | 2013-02-06 | 2025-10-22 | University of Rochester | Induced pluripotent cell-derived oligodendrocyte progenitor cells for the treatment of myelin disorders |
| CN120536341A (zh) * | 2014-03-04 | 2025-08-26 | 菲特治疗公司 | 改良的重编程方法和细胞培养平台 |
| US9724432B2 (en) | 2015-04-30 | 2017-08-08 | University Of Rochester | Non-human mammal model of human degenerative disorder, uses thereof, and method of treating human degenerative disorder |
| CN114807035B (zh) | 2015-09-08 | 2024-02-02 | (由卫生与公众服务部部长代表的)美利坚合众国 | 临床级别视网膜色素上皮细胞的可再现的分化方法 |
| US11162070B2 (en) | 2015-09-08 | 2021-11-02 | FUJIFILM Cellular Dynamics, Inc. | MACS-based purification of stem cell-derived retinal pigment epithelium |
| CN117737124A (zh) | 2015-10-16 | 2024-03-22 | 菲特治疗公司 | 用于诱导和维护基态多能性的平台 |
| WO2017070333A1 (en) | 2015-10-20 | 2017-04-27 | Cellular Dynamics International, Inc. | Multi-lineage hematopoietic precursor cell production by genetic programming |
| AU2017290805B2 (en) | 2016-07-01 | 2023-11-16 | Research Development Foundation | Elimination of proliferating cells from stem cell-derived grafts |
| EP3491134B1 (en) | 2016-08-01 | 2023-10-11 | University of Pittsburgh - of The Commonwealth System of Higher Education | Human induced pluripotent stem cells for high efficiency genetic engineering |
| CA3038690A1 (en) | 2016-10-05 | 2018-04-12 | FUJIFILM Cellular Dynamics, Inc. | Generating mature lineages from induced pluripotent stem cells with mecp2 disruption |
| US11458225B2 (en) | 2016-11-09 | 2022-10-04 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | 3D vascularized human ocular tissue for cell therapy and drug discovery |
| AU2018220843B2 (en) | 2017-02-14 | 2023-09-21 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Methods of engineering human induced pluripotent stem cells to produce liver tissue |
| CN110891967B (zh) | 2017-04-18 | 2025-03-14 | 富士胶片细胞动力公司 | 抗原特异性免疫效应细胞 |
| JP2020517259A (ja) | 2017-04-19 | 2020-06-18 | ボード・オブ・リージエンツ,ザ・ユニバーシテイ・オブ・テキサス・システム | 操作された抗原受容体を発現する免疫細胞 |
| EP3621434B1 (en) | 2017-05-10 | 2026-07-15 | University of Rochester | Glial progenitor cells for use in treating schizophrenia |
| WO2019204817A1 (en) | 2018-04-20 | 2019-10-24 | FUJIFILM Cellular Dynamics, Inc. | Method for differentiation of ocular cells and use thereof |
| CN112566640A (zh) | 2018-06-18 | 2021-03-26 | 罗切斯特大学 | 治疗精神分裂症和其他神经精神病症的方法 |
| US12303549B2 (en) | 2018-06-21 | 2025-05-20 | University Of Rochester | Methods of treating or inhibiting onset of Huntington's disease |
| CN112912492A (zh) * | 2018-07-02 | 2021-06-04 | 林希龙 | 活体外诱导成体干细胞增殖及分化 |
| CA3119041A1 (en) | 2018-11-19 | 2020-05-28 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Biodegradable tissue replacement implant and its use |
| AU2019386140B2 (en) | 2018-11-28 | 2026-05-28 | Board Of Regents, The University Of Texas System | Multiplex genome editing of immune cells to enhance functionality and resistance to suppressive environment |
| EP3886874B1 (en) | 2018-11-29 | 2024-12-11 | Board of Regents, The University of Texas System | Methods for ex vivo expansion of natural killer cells and use thereof |
| AU2019396450B2 (en) | 2018-12-11 | 2025-08-28 | University Of Rochester | Methods of treating schizophrenia and other neuropsychiatric disorders |
| EP3923962A2 (en) | 2019-02-13 | 2021-12-22 | University of Rochester | Gene networks that mediate remyelination of the human brain |
| WO2021092657A1 (en) | 2019-11-13 | 2021-05-20 | Monash University | Methods for reprogramming cells |
| EP4118234A1 (en) | 2020-03-09 | 2023-01-18 | FUJIFILM Corporation | Markers specific for pluripotent stem cells, and methods of using the same |
| IL298254A (en) | 2020-05-29 | 2023-01-01 | Fujifilm Cellular Dynamics Inc | Double layer of retinal pigment epithelium and photoreceptors and their uses |
| KR20230019453A (ko) | 2020-05-29 | 2023-02-08 | 후지필름 셀룰러 다이내믹스, 인코포레이티드 | 망막 색소 상피 세포 및 광수용체의 이중 세포 응집체 및 이의 사용 방법 |
| CA3201499A1 (en) | 2020-11-13 | 2022-05-19 | Catamaran Bio, Inc. | Genetically modified natural killer cells and methods of use thereof |
| JP2023550453A (ja) | 2020-11-18 | 2023-12-01 | 富士フイルム株式会社 | セクレトーム含有組成物の生成、並びにその使用及び分析方法 |
| US12060581B2 (en) | 2020-11-24 | 2024-08-13 | Monash University | Methods and cellular structures |
| AU2021389671A1 (en) | 2020-11-24 | 2023-06-22 | Monash University | Induced stem cells |
| EP4251645A1 (en) | 2020-11-25 | 2023-10-04 | Catamaran Bio, Inc. | Cellular therapeutics engineered with signal modulators and methods of use thereof |
| US20220306991A1 (en) | 2021-03-25 | 2022-09-29 | Bluerock Therapeutics Lp | Methods for obtaining induced pluripotent stem cells |
| WO2022251443A1 (en) | 2021-05-26 | 2022-12-01 | FUJIFILM Cellular Dynamics, Inc. | Methods to prevent rapid silencing of genes in pluripotent stem cells |
| WO2022251499A1 (en) | 2021-05-28 | 2022-12-01 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Methods to generate macular, central and peripheral retinal pigment epithelial cells |
| JP2024520423A (ja) | 2021-05-28 | 2024-05-24 | ザ ユナイテッド ステイツ オブ アメリカ, アズ リプレゼンテッド バイ ザ セクレタリー, デパートメント オブ ヘルス アンド ヒューマン サービシーズ | 弱接着細胞を収容するための二次マトリックスを有する生分解性組織スキャフォールド |
| EP4402249A1 (en) | 2021-09-13 | 2024-07-24 | Fujifilm Cellular Dynamics, Inc. | Methods for the production of committed cardiac progenitor cells |
| US20230241118A1 (en) | 2021-10-20 | 2023-08-03 | University Of Rochester | Rejuvenation treatment of age-related white matter loss |
| CA3235105A1 (en) | 2021-10-20 | 2023-04-27 | Steven A. Goldman | Humanized chimeras for the prospective assessment of glial cell addition or replacement therapy |
| US20230226116A1 (en) | 2021-10-20 | 2023-07-20 | University Of Rochester | Method for rejuvenating glial progenitor cells and rejuvenated glial progenitor cells per se |
| CA3236365A1 (en) | 2021-11-02 | 2023-05-11 | University Of Rochester | Tcf7l2 mediated remyelination in the brain |
| US20250161495A1 (en) | 2022-02-01 | 2025-05-22 | University Of Rochester | Methods of generating a population of neurons from human glial progenitor cells and genetic constructs for carrying out such methods |
| WO2023172514A1 (en) | 2022-03-07 | 2023-09-14 | Catamaran Bio, Inc. | Engineered immune cell therapeutics targeted to her2 and methods of use thereof |
| WO2023215455A1 (en) | 2022-05-05 | 2023-11-09 | University Of Rochester | Dual macroglial-microglial approach towards therapeutic cell replacement in neurodegenerative and neuropsychiatric disease |
| US20240003871A1 (en) | 2022-06-29 | 2024-01-04 | FUJIFILM Cellular Dynamics, Inc. | Ipsc-derived astrocytes and methods of use thereof |
| WO2024073776A1 (en) | 2022-09-30 | 2024-04-04 | FUJIFILM Cellular Dynamics, Inc. | Methods for the production of cardiac fibroblasts |
| EP4658294A2 (en) | 2023-02-02 | 2025-12-10 | University of Rochester | Competitive replacement of glial cells |
| WO2024192329A1 (en) | 2023-03-16 | 2024-09-19 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Methods for producing stable human chondroctyes and their use for promoting cartillage growth and repair |
| WO2025245202A1 (en) | 2024-05-21 | 2025-11-27 | FUJIFILM Cellular Dynamics, Inc. | Particle counting and biomass measurements of aggregated cell compositions |
| US20260146229A1 (en) | 2024-11-27 | 2026-05-28 | Bluerock Therapeutics Lp | Photoreceptor precursor cell (prp) compositions and uses thereof |
| WO2026117659A1 (en) | 2024-11-27 | 2026-06-04 | Bluerock Therapeutics Lp | Methods of treating inherited retinal diseases |
| US20260226420A1 (en) | 2025-01-31 | 2026-08-06 | FUJIFILM Holdings America Corporation | Methods for the production of hepatic stellate cells from human pluripotent stem cells |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4937190A (en) | 1987-10-15 | 1990-06-26 | Wisconsin Alumni Research Foundation | Translation enhancer |
| ES2296413T3 (es) | 1998-06-08 | 2008-04-16 | Osiris Therapeutics, Inc. | Regulacion de la diferenciacion de celulas madre hematopoyeticas por el uso de celulas madre mesenquimaticas humanas. |
| WO2000070070A1 (en) | 1999-05-18 | 2000-11-23 | Dnavec Research Inc. | Paramyxoviridae virus vector defective in envelope gene |
| US6602711B1 (en) | 2000-02-21 | 2003-08-05 | Wisconsin Alumni Research Foundation | Method of making embryoid bodies from primate embryonic stem cells |
| JP3660601B2 (ja) | 2001-03-30 | 2005-06-15 | 独立行政法人科学技術振興機構 | 胚性幹細胞からの神経幹細胞、運動ニューロン及びgaba作動性ニューロンの製造法 |
| JP2004121165A (ja) | 2002-10-07 | 2004-04-22 | Asahi Kasei Corp | 膵幹様細胞の分化誘導方法 |
| US20090227032A1 (en) | 2005-12-13 | 2009-09-10 | Kyoto University | Nuclear reprogramming factor and induced pluripotent stem cells |
| EP2206724A1 (en) | 2005-12-13 | 2010-07-14 | Kyoto University | Nuclear reprogramming factor |
| DK3399025T3 (da) | 2007-03-23 | 2025-06-16 | Wisconsin Alumni Res Found | Omprogrammering af somatiske celler |
| AU2008297024B2 (en) | 2007-10-31 | 2014-08-28 | Kyoto University | Nuclear reprogramming method |
-
2011
- 2011-01-21 US US13/497,044 patent/US9005967B2/en active Active
- 2011-01-21 WO PCT/JP2011/051685 patent/WO2011090221A1/en not_active Ceased
- 2011-01-21 JP JP2012513400A patent/JP5827220B2/ja active Active
- 2011-01-21 EP EP11734826.8A patent/EP2526189B1/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| EP2526189A4 (en) | 2014-03-19 |
| US20120276636A1 (en) | 2012-11-01 |
| JP2013517758A (ja) | 2013-05-20 |
| EP2526189B1 (en) | 2016-10-12 |
| WO2011090221A1 (en) | 2011-07-28 |
| US9005967B2 (en) | 2015-04-14 |
| EP2526189A1 (en) | 2012-11-28 |
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