JP5823969B2 - 心臓特異的核酸調節因子ならびにこの方法および使用 - Google Patents

心臓特異的核酸調節因子ならびにこの方法および使用 Download PDF

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JP5823969B2
JP5823969B2 JP2012535849A JP2012535849A JP5823969B2 JP 5823969 B2 JP5823969 B2 JP 5823969B2 JP 2012535849 A JP2012535849 A JP 2012535849A JP 2012535849 A JP2012535849 A JP 2012535849A JP 5823969 B2 JP5823969 B2 JP 5823969B2
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nucleic acid
vector
heart
promoter
seq
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チユア，レイ・キム
フアンデンドリースヘ，テイエリー
デ・ブレゼル，ピーテル
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    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
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    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/42—Vector systems having a special element relevant for transcription being an intron or intervening sequence for splicing and/or stability of RNA
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    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/80—Vector systems having a special element relevant for transcription from vertebrates
    • C12N2830/85—Vector systems having a special element relevant for transcription from vertebrates mammalian

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  • Animal Behavior & Ethology (AREA)
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  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
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JP2012535849A 2009-10-29 2010-10-29 心臓特異的核酸調節因子ならびにこの方法および使用 Expired - Fee Related JP5823969B2 (ja)

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Application Number Priority Date Filing Date Title
EP09174519 2009-10-29
EP09174519.0 2009-10-29
PCT/EP2010/066474 WO2011051450A1 (en) 2009-10-29 2010-10-29 Cardiac-specific nucleic acid regulatory elements and methods and use thereof

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JP2013509168A JP2013509168A (ja) 2013-03-14
JP2013509168A5 JP2013509168A5 (https=) 2013-12-19
JP5823969B2 true JP5823969B2 (ja) 2015-11-25

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US (1) US9353164B2 (https=)
EP (1) EP2494058B1 (https=)
JP (1) JP5823969B2 (https=)
AU (1) AU2010311376B2 (https=)
CA (1) CA2778945A1 (https=)
WO (1) WO2011051450A1 (https=)

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WO2011051450A1 (en) 2009-10-29 2011-05-05 Vib Vzw Cardiac-specific nucleic acid regulatory elements and methods and use thereof
US8859517B2 (en) 2011-08-08 2014-10-14 Fondazione Salvatore Maugeri Clinica Del Lavoro E Della Riabilitazione Method of gene transfer for the treatment of recessive catecholaminergic polymorphic ventricular tachycardia (CPVT)
US20130136729A1 (en) * 2011-11-11 2013-05-30 University of Virginia Patent Foundation, d/b/a University of Virginia Licensing & Ventures Group Compositions and methods for targeting and treating diseases and injuries using adeno-associated virus vectors
WO2014077863A1 (en) * 2012-11-19 2014-05-22 Nature Technology Corporation Replicative minicircle vectors with improved expression
JP6707028B2 (ja) 2013-12-09 2020-06-10 ベイラー カレッジ オブ メディスンＢａｙｌｏｒ Ｃｏｌｌｅｇｅ Ｏｆ Ｍｅｄｉｃｉｎｅ 心筋細胞新生におけるｈｉｐｐｏ及びジストロフィン複合体シグナル伝達
PL3097197T3 (pl) 2014-01-21 2021-06-28 Vrije Universiteit Brussel Mięśniowo-specyficzne elementy regulatorowe kwasów nukleinowych oraz sposoby i ich zastosowanie
US10570183B2 (en) * 2016-04-19 2020-02-25 The Board Of Regents Of The University Of Texas System Use of a small native peptide activator of SERCA pump for treatment of heart failure and other disorders characterized by cytosolic calcium overload
WO2018178067A1 (en) 2017-03-27 2018-10-04 Vrije Universiteit Brussel Diaphragm-specific nucleic acid regulatory elements and methods and use thereof
US20210343368A1 (en) * 2018-09-05 2021-11-04 Max-Delbrück-Centrum Für Molekulare Medizin In Der Helmholtz-Gemeinschaft Method for Engineering Synthetic Cis-Regulatory DNA
JP7529286B2 (ja) 2018-10-26 2024-08-06 フリーイェ・ユニヴェルシテイト・ブリュッセル 肝特異的核酸調節エレメント並びにその方法及び使用
EP4073257A1 (en) * 2019-12-09 2022-10-19 UCL Business Ltd Gene therapy composition and treatment for myh7-linked cardiomyopathy
EP4081643A1 (en) * 2019-12-24 2022-11-02 Asklepios Biopharmaceutical, Inc. Regulatory nucleic acid sequences
EP4087489B1 (en) 2020-01-08 2025-05-14 Vitruvia Holdings Inc. Methods and computing system for processing ultrasound image to determine health of subdermal tissue
JP7744027B2 (ja) 2020-02-18 2025-09-25 フレイエ ユニヴェルシテイト ブリュッセル 核酸調節エレメントの新規な組合せ並びにその方法及び使用
JP2024502257A (ja) * 2020-12-21 2024-01-18 フレイエ ユニヴェルシテイト ブリュッセル 心筋細胞由来核酸調節エレメント並びにその方法及び使用
KR20240032971A (ko) 2021-07-08 2024-03-12 테나야 테라퓨틱스, 인코포레이티드 유전자 요법을 위한 최적화된 발현 카세트
AR126660A1 (es) 2021-07-28 2023-11-01 Univ Brussel Vrije Mejorando la eficacia de la terapia génica dirigida a músculos

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FR2797273B1 (fr) 1999-08-06 2004-01-02 Pasteur Institut Polynucleotides dirigeant l'activation de l'expression d'un gene dans le coeur et ses applications a la therapie genique
JP2003530086A (ja) 2000-01-14 2003-10-14 ベス イスラエル ディーコネス メディカル センター 心臓細胞特異的エンハンサー因子とその使用
ATE373095T1 (de) * 2000-07-14 2007-09-15 Univ Michigan Mutierte muskelspezifische enhancer
US20050004058A1 (en) * 2000-12-07 2005-01-06 Patrick Benoit Sequences upstream of the carp gene, vectors containing them and uses thereof
US7714100B2 (en) * 2004-01-27 2010-05-11 Compugen Ltd Nucleotide and amino acid sequences, and assays and methods of use thereof for diagnosis of cardiac disease
BRPI0513897A (pt) * 2004-07-29 2008-05-20 Stem Cell Innovations Inc diferenciação de células-tronco
US20080081354A1 (en) * 2006-10-02 2008-04-03 Cardiac Pacemakers, Inc. Devices, vectors and methods for inducible ischemia cardioprotection
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WO2011051450A1 (en) 2009-10-29 2011-05-05 Vib Vzw Cardiac-specific nucleic acid regulatory elements and methods and use thereof

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EP2494058B1 (en) 2017-04-05
JP2013509168A (ja) 2013-03-14
EP2494058A1 (en) 2012-09-05
CA2778945A1 (en) 2011-05-05
US9353164B2 (en) 2016-05-31
AU2010311376A1 (en) 2012-05-24
AU2010311376A2 (en) 2012-07-12
WO2011051450A1 (en) 2011-05-05
US20120252882A1 (en) 2012-10-04
AU2010311376B2 (en) 2014-07-03

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