JP5810157B2 - プロテインキナーゼ阻害剤および処置の方法 - Google Patents

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Publication number

JP5810157B2

JP5810157B2 JP2013516912A JP2013516912A JP5810157B2 JP 5810157 B2 JP5810157 B2 JP 5810157B2 JP 2013516912 A JP2013516912 A JP 2013516912A JP 2013516912 A JP2013516912 A JP 2013516912A JP 5810157 B2 JP5810157 B2 JP 5810157B2

Authority

JP

Japan

Prior art keywords

optionally substituted

alkyl

aryl

heteroaryl

hydrogen

Prior art date

2010-07-09

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Expired - Fee Related

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• 238000011282 treatment Methods 0.000 title claims description 19
• 238000000034 method Methods 0.000 title description 15
• 229940045988 antineoplastic drug protein kinase inhibitors Drugs 0.000 title 1
• 239000003909 protein kinase inhibitor Substances 0.000 title 1
• 150000001875 compounds Chemical class 0.000 claims description 79
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• 125000003107 substituted aryl group Chemical group 0.000 claims description 62
• 229910052739 hydrogen Inorganic materials 0.000 claims description 59
• 239000001257 hydrogen Substances 0.000 claims description 55
• 125000000623 heterocyclic group Chemical group 0.000 claims description 47
• 150000003839 salts Chemical class 0.000 claims description 47
• 150000002431 hydrogen Chemical class 0.000 claims description 32
• 125000000217 alkyl group Chemical group 0.000 claims description 31
• 125000003118 aryl group Chemical group 0.000 claims description 29
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 24
• UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 23
• -1 nitro, cyano, amino Chemical group 0.000 claims description 22
• 125000004093 cyano group Chemical group *C#N 0.000 claims description 18
• 229910052760 oxygen Inorganic materials 0.000 claims description 18
• 125000004953 trihalomethyl group Chemical group 0.000 claims description 18
• 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims description 17
• 125000000753 cycloalkyl group Chemical group 0.000 claims description 16
• 229910052717 sulfur Inorganic materials 0.000 claims description 16
• 206010028980 Neoplasm Diseases 0.000 claims description 15
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• 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 14
• 125000000547 substituted alkyl group Chemical group 0.000 claims description 14
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• 125000000266 alpha-aminoacyl group Chemical group 0.000 claims description 13
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• 125000004104 aryloxy group Chemical group 0.000 claims description 8
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• KYQCOXFCLRTKLS-UHFFFAOYSA-N Pyrazine Chemical compound C1=CN=CC=N1 KYQCOXFCLRTKLS-UHFFFAOYSA-N 0.000 claims description 4
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• OGYGFUAIIOPWQD-UHFFFAOYSA-N 1,3-thiazolidine Chemical compound C1CSCN1 OGYGFUAIIOPWQD-UHFFFAOYSA-N 0.000 claims description 2
• KVGZZAHHUNAVKZ-UHFFFAOYSA-N 1,4-Dioxin Chemical compound O1C=COC=C1 KVGZZAHHUNAVKZ-UHFFFAOYSA-N 0.000 claims description 2
• QWENRTYMTSOGBR-UHFFFAOYSA-N 1H-1,2,3-Triazole Chemical compound C=1C=NNN=1 QWENRTYMTSOGBR-UHFFFAOYSA-N 0.000 claims description 2
• KEQTWHPMSVAFDA-UHFFFAOYSA-N 2,3-dihydro-1h-pyrazole Chemical compound C1NNC=C1 KEQTWHPMSVAFDA-UHFFFAOYSA-N 0.000 claims description 2
• RSEBUVRVKCANEP-UHFFFAOYSA-N 2-pyrroline Chemical compound C1CC=CN1 RSEBUVRVKCANEP-UHFFFAOYSA-N 0.000 claims description 2
• MGADZUXDNSDTHW-UHFFFAOYSA-N 2H-pyran Chemical compound C1OC=CC=C1 MGADZUXDNSDTHW-UHFFFAOYSA-N 0.000 claims description 2
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• YHWMFDLNZGIJSD-UHFFFAOYSA-N 2h-1,4-oxazine Chemical compound C1OC=CN=C1 YHWMFDLNZGIJSD-UHFFFAOYSA-N 0.000 claims description 2
• WIKVRBTVPSOQHJ-UHFFFAOYSA-N 2h-1,5,2-dithiazine Chemical compound C1SNC=CS1 WIKVRBTVPSOQHJ-UHFFFAOYSA-N 0.000 claims description 2
• JVQIKJMSUIMUDI-UHFFFAOYSA-N 3-pyrroline Chemical compound C1NCC=C1 JVQIKJMSUIMUDI-UHFFFAOYSA-N 0.000 claims description 2
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