JP5784604B2 - Ｊｎｋ阻害剤 - Google Patents
Ｊｎｋ阻害剤 Download PDFInfo
- Publication number
- JP5784604B2 JP5784604B2 JP2012524207A JP2012524207A JP5784604B2 JP 5784604 B2 JP5784604 B2 JP 5784604B2 JP 2012524207 A JP2012524207 A JP 2012524207A JP 2012524207 A JP2012524207 A JP 2012524207A JP 5784604 B2 JP5784604 B2 JP 5784604B2
- Authority
- JP
- Japan
- Prior art keywords
- pyrimidin
- indol
- piperazin
- hydroxy
- oxo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 0 CC(C)(C)OC(N(CC1)CCN1c1cccc2c1cc[n]2C1=NC(C)(C(*2)[C@]2(CC2)CC[C@@]2OC(c2ccccc2)=O)NC=C1)=O Chemical compound CC(C)(C)OC(N(CC1)CCN1c1cccc2c1cc[n]2C1=NC(C)(C(*2)[C@]2(CC2)CC[C@@]2OC(c2ccccc2)=O)NC=C1)=O 0.000 description 4
- DINHEIXRGUYCKE-RQNOJGIXSA-N CN(C)CCN[C@H](CC1)CC[C@@H]1N(Cc1ccccc1)Cc1ccccc1 Chemical compound CN(C)CCN[C@H](CC1)CC[C@@H]1N(Cc1ccccc1)Cc1ccccc1 DINHEIXRGUYCKE-RQNOJGIXSA-N 0.000 description 1
- MUVCGLQGSZIZCQ-UHFFFAOYSA-N CS(C(CC1)CCN1c1cccc2c1cn[n]2-c1nc(S(C)(=O)=O)ncc1)(=O)=O Chemical compound CS(C(CC1)CCN1c1cccc2c1cn[n]2-c1nc(S(C)(=O)=O)ncc1)(=O)=O MUVCGLQGSZIZCQ-UHFFFAOYSA-N 0.000 description 1
- WQBDZDBEWKTDLI-UHFFFAOYSA-N CSc1nccc(-[n]2ncc3c2cccc3N(CC2)CCC2S(C)(=O)=O)n1 Chemical compound CSc1nccc(-[n]2ncc3c2cccc3N(CC2)CCC2S(C)(=O)=O)n1 WQBDZDBEWKTDLI-UHFFFAOYSA-N 0.000 description 1
- OBUVBPQTQKQZAW-WMPKNSHKSA-N O=C(c1ccccc1)O[C@H](CC1)CC[C@H]1N(Cc1ccccc1)Cc1ccccc1 Chemical compound O=C(c1ccccc1)O[C@H](CC1)CC[C@H]1N(Cc1ccccc1)Cc1ccccc1 OBUVBPQTQKQZAW-WMPKNSHKSA-N 0.000 description 1
- WPYMKLBDIGXBTP-UHFFFAOYSA-N OC(c1ccccc1)=O Chemical compound OC(c1ccccc1)=O WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 1
- RWMDJQJCEISWRT-MXVIHJGJSA-N O[C@H](CC1)CC[C@@H]1N(Cc1ccccc1)Cc1ccccc1 Chemical compound O[C@H](CC1)CC[C@@H]1N(Cc1ccccc1)Cc1ccccc1 RWMDJQJCEISWRT-MXVIHJGJSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Rheumatology (AREA)
- Pulmonology (AREA)
- Obesity (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Cardiology (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Vascular Medicine (AREA)
- Oncology (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US23252209P | 2009-08-10 | 2009-08-10 | |
| US61/232,522 | 2009-08-10 | ||
| PCT/EP2010/061476 WO2011018417A1 (en) | 2009-08-10 | 2010-08-06 | Inhibitors of jnk |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013501746A JP2013501746A (ja) | 2013-01-17 |
| JP5784604B2 true JP5784604B2 (ja) | 2015-09-24 |
Family
ID=42710723
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012524207A Expired - Fee Related JP5784604B2 (ja) | 2009-08-10 | 2010-08-06 | Ｊｎｋ阻害剤 |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US8536172B2 (enExample) |
| EP (1) | EP2464640A1 (enExample) |
| JP (1) | JP5784604B2 (enExample) |
| KR (1) | KR101506318B1 (enExample) |
| CN (1) | CN102471319B (enExample) |
| AR (1) | AR077820A1 (enExample) |
| AU (1) | AU2010283769B2 (enExample) |
| BR (1) | BR112012003059A2 (enExample) |
| CA (1) | CA2768749A1 (enExample) |
| IL (1) | IL217756A0 (enExample) |
| IN (1) | IN2012DN01231A (enExample) |
| MX (1) | MX2012001449A (enExample) |
| SG (1) | SG178321A1 (enExample) |
| TW (1) | TW201109336A (enExample) |
| WO (1) | WO2011018417A1 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112012030814A2 (pt) * | 2010-06-04 | 2019-09-24 | Hoffmann La Roche | inibidores de jnk |
| NZ705040A (en) * | 2012-07-20 | 2017-07-28 | Cleave Biosciences Inc | Fused pyrimidines as inhibitors of p97 complex |
| EA201501080A1 (ru) * | 2013-06-26 | 2016-07-29 | Ксижен Инфлемейшн Лтд. | Новое применение обладающих способностью проникать в клетку пептидных ингибиторов пути трансдукции сигнала jnk для лечения различных заболеваний |
| MX358346B (es) * | 2014-04-04 | 2018-08-15 | Syros Pharmaceuticals Inc | Inhibidores de la quinasa dependiente de ciclina 7 (cdk7). |
| ES2985135T3 (es) | 2014-12-18 | 2024-11-04 | Harvard College | Procedimientos para generar células ß derivadas de células madre y usos de las mismas |
| JP2018507900A (ja) * | 2015-03-13 | 2018-03-22 | アッヴィ・インコーポレイテッド | （インダゾール−４−イル）ヘキサヒドロピロロピロロン及び使用方法 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101177729B1 (ko) * | 2006-09-08 | 2012-09-07 | 에프. 호프만-라 로슈 아게 | 벤조트리아졸 키나아제 조절제 |
| BRPI0720003A2 (pt) * | 2006-12-08 | 2018-09-18 | Hoffmann La Roche | pirimidinas substituídas e seu uso como moduladores de jnk |
-
2010
- 2010-08-06 IN IN1231DEN2012 patent/IN2012DN01231A/en unknown
- 2010-08-06 BR BR112012003059A patent/BR112012003059A2/pt not_active IP Right Cessation
- 2010-08-06 AU AU2010283769A patent/AU2010283769B2/en not_active Ceased
- 2010-08-06 WO PCT/EP2010/061476 patent/WO2011018417A1/en not_active Ceased
- 2010-08-06 SG SG2012008819A patent/SG178321A1/en unknown
- 2010-08-06 CN CN201080035300.3A patent/CN102471319B/zh not_active Expired - Fee Related
- 2010-08-06 CA CA2768749A patent/CA2768749A1/en not_active Abandoned
- 2010-08-06 KR KR1020127006275A patent/KR101506318B1/ko not_active Expired - Fee Related
- 2010-08-06 JP JP2012524207A patent/JP5784604B2/ja not_active Expired - Fee Related
- 2010-08-06 MX MX2012001449A patent/MX2012001449A/es active IP Right Grant
- 2010-08-06 EP EP10739948A patent/EP2464640A1/en not_active Withdrawn
- 2010-08-09 TW TW099126517A patent/TW201109336A/zh unknown
- 2010-08-09 AR ARP100102908A patent/AR077820A1/es unknown
- 2010-08-09 US US12/852,540 patent/US8536172B2/en not_active Expired - Fee Related
-
2012
- 2012-01-26 IL IL217756A patent/IL217756A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2010283769A1 (en) | 2012-02-09 |
| AR077820A1 (es) | 2011-09-28 |
| WO2011018417A1 (en) | 2011-02-17 |
| EP2464640A1 (en) | 2012-06-20 |
| US8536172B2 (en) | 2013-09-17 |
| KR101506318B1 (ko) | 2015-03-26 |
| BR112012003059A2 (pt) | 2016-08-02 |
| MX2012001449A (es) | 2012-03-26 |
| SG178321A1 (en) | 2012-03-29 |
| US20110034470A1 (en) | 2011-02-10 |
| CA2768749A1 (en) | 2011-02-17 |
| IN2012DN01231A (enExample) | 2015-05-15 |
| IL217756A0 (en) | 2012-03-29 |
| KR20120055645A (ko) | 2012-05-31 |
| TW201109336A (en) | 2011-03-16 |
| JP2013501746A (ja) | 2013-01-17 |
| AU2010283769B2 (en) | 2015-09-17 |
| CN102471319B (zh) | 2014-06-18 |
| CN102471319A (zh) | 2012-05-23 |
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