JP5782603B2 - 抗菌発泡性石鹸 - Google Patents
抗菌発泡性石鹸 Download PDFInfo
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Description
本発明は、一般的に、皮膚感染症の治療及び予防のための抗菌発泡性組成物に関する。より具体的には、本発明は、メチシリン耐性スタフィロコッカス・アウレウス(Staphylococcus aureus)(MRSA)のような細菌感染症及び薬剤耐性細菌感染症の治療及び予防のためのタイム油を含む局所的抗菌発泡性組成物に関する。
本願は、2008年10月30日に出願された米国仮出願第61/109,721号の優先権を主張し、35 U. S. C. §119(e) の利益を主張する。その開示は、その全体が参考として本明細書に引用されている。
スタフィロコッカス・アウレウスは、単に「スタフ」と通常呼ばれ、おおよそ集団の3分の1の皮膚上又は鼻内に通常見られる細菌株である。スタフ感染症は、米国の皮膚感染症の最も一般的な原因の1つである。ほとんどのスタフ感染症は、軽微であり、抗生物質で処置できる。しかしながら、スタフはまた、皮膚及び柔組織の重大な感染症、血流感染症及び肺炎を引き起こす。
本発明は、MRSAで汚染した表面上のMRSAを殺すためのグリーンかつ環境的に抗菌性の発泡性組成物、及びそれで汚染した表面上のMRSAを殺すための方法を提供する。本発明は多数の方法で実行することができる。
本明細書に記載の発泡性組成物は、環境的にフレンドリーで、汚染された表面上のMRSAを殺すためのグリーン組成物である。発泡性組成物は、主なかつ単一の抗菌剤としての低濃度のタイム油、界面活性剤及び二価の銅イオン源を使用する。泡は、皮膚感染症、特にMRSA感染症を予防又は治療するために使用することができる。皮膚感染の症状は、皮膚の、損傷、ただれ、発疹、膨れ、膿瘍又は亀裂を含み、それらのすべては変色、炎症、腫れ又は疼痛を伴い得る。泡は、該症状の期間を短縮することによって、該症状の重度を減少させることによって、又はその両方によって、感染症を治療することができる。更に、泡は、感染症を治癒し及び/又は感染症の症状をなくすことができる。
(1) 濾過中和:NC懸濁液の1.00 mLアリコートを9 mLの中和ブロスに移し、完全に混合した。コントロール懸濁液 (5.0 mL) をフィルター濃縮し、そのフィルターを試験方法にと同様にして濯いだ。約100 CFU/mLを含む生物懸濁液のアリコート (1.0 mL) をフィルター器具に加え、該器具によって処理した。接種材料集団として使用し処理するように、生物懸濁液のアリコート (1.0 mL) を第2のフィルター器具に加えた。該フィルターは無菌で回収アガープレートに移し、インキュベートした。この試験のコントロールの許容基準は、濾過中和コントロールを必要とし、対応する集団コントロールは結果的に1.0 Log内にあることになる。
(2) 化学的中和:NC懸濁液の1.0 mLアリコートを、9 mLの中和ブロスに移し、完全に混合した。次いで、その中和した試料の1.0 mLアリコートを除き、廃棄した。該中和した試料に、生物懸濁液の1.0 mL(約1000 CFU/mLを含む)を加え、完全に混合した。中和した混合物のアリコート (1.0 mL) を2点で播き、インキュベートした。接種材料集団コントロールは、バターフィールドバッファの9 mLに同一の生物懸濁液の1.0 mLを加え、2点で播き、及びインキュベートすることによって行った。この試験コントロールの許容基準は、化学的中和コントロール、及び1.0 Log内の対応する集団コントロールを必要とする。
この試験条件下で、周囲温度(21℃)で試験した時に、調製物1の発泡性組成物は、15秒曝露後の、コミュニティ獲得メシチリン耐性スタフィロコッカス・アウレウス−CA-MRSA (NRS384) (遺伝子型USA300) 生存数の99.9% (3.735 Log10) 減少、30秒曝露後の99.999% (5.2 Log10) 減少、60秒曝露後の> 99.999% (> 5.8 Log10) 減少、120秒曝露後の> 99.999% (> 5.8 Log10) 減少、及び300秒曝露後の> 99.999% (> 5.8 Log10) 減少を証明した。
この試験条件下で、5%ウシ胎児血清有機質土ロードの存在下で、周囲温度(20℃)で試験した時に、調製物1の発泡性組成物は、15秒曝露後の、スタフィロコッカス・アウレウス−MRSA生存数の99.99% (4.32 Log10) 減少、30秒曝露後の99.999% (5.5 Log10) 減少、60秒曝露後の> 99.999% (> 5.8 Log10) 減少、及び300秒曝露後の> 99.999% (> 5.8 Log10) 減少を証明した。
この試験条件下で、5%ウシ胎児血清有機質土ロードの存在下で、周囲温度(20℃)で試験した時に、調製物3の発泡性組成物は、15秒曝露後の、スタフィロコッカス・アウレウス−MRSA生存数の99.99% (4.84 Log10) 減少、30秒曝露後の> 99.999% (5.8 Log10) 減少、60秒曝露後の> 99.999% (> 5.8 Log10) 減少、及び300秒曝露後の> 99.999% (> 5.8 Log10) 減少を証明した。
この試験条件下で、周囲温度(20℃)で試験した時に、調製物2の発泡性組成物は、30、60、120及び300秒曝露後の、スタフィロコッカス・アウレウス−MRSA生存数の> 99.999% (5.9 Log10) 減少を証明した。
Claims (24)
- MRSAで汚染された表面上のMRSAを殺すための発泡性組成物であって、0.01% w/v〜0.5% w/vのタイム油の抗菌量、チモール結晶、オレガノ油、界面活性剤、及び二価の銅イオン源を含み、該二価の銅イオン源が銅ペプチド複合体である、組成物。
- 前記表面に適用した時に、15秒内で、メチシリン耐性スタフィロコッカス・アウレウス(Staphylococcus aureus)の99.99%超を殺す、請求項1記載の組成物。
- タイム油の抗菌量が、0.01% w/v〜0.2% w/vである、請求項1記載の組成物。
- 前記オレガノ油が0.01 % w/v〜0.2 % w/vの量で存在する、請求項1載の組成物。
- 前記チモール結晶が0.01 % w/v〜0.5 % w/vの量で存在する、請求項1記載の組成物。
- フレグランス、抗酸化剤、湿潤剤、及び補助界面活性剤の少なくとも1つを更に含む、請求項1記載の組成物。
- 前記フレグランスが、ブラッド・オレンジ、バニラ、ラベンダー、ジンジャー、ベルガモット、スペアミント及びライムからなる群より選ばれる、請求項6記載の組成物。
- 前記抗酸化剤が白茶抽出物である、請求項6記載の組成物。
- 前記の銅ペプチド複合体が銅PCAである、請求項1記載の組成物。
- 前記界面活性剤がアニオン性又は非イオン性の界面活性剤である、請求項1記載の組成物。
- 前記界面活性剤が、アルキルポリグルコシド、ラウリル硫酸ナトリウム、及びラウレス硫酸ナトリウムからなる群より選ばれる、請求項1記載の組成物。
- MRSAで汚染された表面上のMRSAを殺すための発泡性組成物であって、
0.016% w/vのタイム油、
0.016% w/vのオレガノ油、
0.032% w/vの植物性チモール結晶、
3.0% v/vのアルキルポリグルコシド界面活性剤、
0.008 % w/vの銅PCA、及び
100%までの水
を含む、組成物。 - 局所的に適用した時に、15秒内に、メチシリン耐性スタフィロコッカス・アウレウス(Staphylococcus aureus)の99.99%超を殺すことができる、請求項12記載の組成物。
- 局所的に適用した時に、15秒内に、メチシリン耐性スタフィロコッカス・アウレウス(Staphylococcus aureus)の99.9%超を殺すことができる、請求項12記載の組成物。
- 白茶、クエン酸、クエン酸ナトリウム、補助界面活性剤、天然保湿剤及びアロエベラの少なくとも1つを更に含む。請求項12記載の組成物。
- MRSAで汚染された非ヒト表面上のMRSAを殺すための方法であって、
0.01% w/v〜0.5% w/vのタイム油の抗菌量、チモール結晶、オレガノ油、界面活性剤、及び銅ペプチド複合体である二価の銅イオン源を含む、発泡性組成物を該表面に適用し;及びメチシリン耐性スタフィロコッカス・アウレウス(Staphylococcus aureus)を殺すために少なくとも15秒間、該組成物に該表面を曝露すること、
を含む、方法。 - 曝露時間が少なくとも5分である、請求項16記載の方法。
- 曝露時間が少なくとも1時間である、請求項16記載の方法。
- 前記発泡性組成物が一日に少なくとも一回適用される、請求項16記載の方法。
- 前記組成物が、15秒内に、メチシリン耐性スタフィロコッカス・アウレウス(Staphylococcus aureus)の99.99%超を殺す、請求項16記載の方法。
- 前記組成物が、15秒内に、メチシリン耐性スタフィロコッカス・アウレウス(Staphylococcus aureus)の99.9%超を殺す、請求項16記載の方法。
- 0.01% w/v〜0.5% w/vのタイム油の抗菌量、チモール結晶、オレガノ油、界面活性剤、及び二価の銅イオン源、並びにディスペンサーを含む、MRSAで汚染された表面上のMRSAを殺すための抗菌性の発泡性組成物を含み、該二価の銅イオン源が銅ペプチド複合体である、キット。
- 前記組成物が、15秒内に、メチシリン耐性スタフィロコッカス・アウレウス(Staphylococcus aureus)の99.99%超を殺す、請求項22記載のキット。
- 前記組成物が、15秒内に、メチシリン耐性スタフィロコッカス・アウレウス(Staphylococcus aureus)の99.9%超を殺す、請求項22記載のキット。
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US10972108P | 2008-10-30 | 2008-10-30 | |
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PCT/US2009/062527 WO2010059366A2 (en) | 2008-10-30 | 2009-10-29 | Antimicrobial foamable soaps |
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SG (1) | SG2014007488A (ja) |
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ZA (1) | ZA201103129B (ja) |
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EP2787826A1 (en) * | 2011-12-06 | 2014-10-15 | Unilever N.V. | Method for disinfecting a surface |
CN102827712B (zh) * | 2012-09-21 | 2014-01-22 | 天津宏竹科技发展有限公司 | 一种天然环保厨房清洁剂及其制作方法 |
JP2014091815A (ja) * | 2012-11-06 | 2014-05-19 | Kao Corp | 洗浄剤組成物 |
US9701886B2 (en) | 2013-03-05 | 2017-07-11 | Halliburton Energy Services, Inc. | Alkyl polyglycoside derivative as biodegradable foaming surfactant for cement |
US10285954B2 (en) | 2013-03-08 | 2019-05-14 | Laboratoire M2 | Topical use of an antimicrobial formulation |
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CN103627545A (zh) * | 2013-11-27 | 2014-03-12 | 许伟 | 一种防虫肥皂 |
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KR102335588B1 (ko) * | 2021-03-23 | 2021-12-06 | 주식회사 케미슈티칼 | 구연산동을 유효성분으로 포함하는 항균성 수분산 조성물 |
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BRPI0920972A2 (pt) | 2016-01-05 |
CN102317429A (zh) | 2012-01-11 |
ZA201103129B (en) | 2012-10-31 |
BRPI0920972A8 (pt) | 2019-02-05 |
CN105112177A (zh) | 2015-12-02 |
SG2014007488A (en) | 2014-04-28 |
IL212612A0 (en) | 2011-07-31 |
CA2742285A1 (en) | 2010-05-27 |
WO2010059366A2 (en) | 2010-05-27 |
AU2009317951A1 (en) | 2010-05-27 |
JP2012507549A (ja) | 2012-03-29 |
KR20110133467A (ko) | 2011-12-12 |
KR101757935B1 (ko) | 2017-07-14 |
EP2350252A2 (en) | 2011-08-03 |
US20110206790A1 (en) | 2011-08-25 |
AU2009317951B2 (en) | 2014-07-31 |
EP2350252A4 (en) | 2013-09-25 |
MX2011004539A (es) | 2011-09-28 |
WO2010059366A3 (en) | 2010-08-05 |
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