JP5765722B2 - マイクロ流路チップ及びそれを用いた気液相分離方法 - Google Patents
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Description
捕集液に可溶性の気体である被検物質を含む試料ガスを導入する試料ガス導入マイクロ流路と、
前記捕集液を導入する捕集液導入マイクロ流路と、
前記試料ガス導入マイクロ流路と前記捕集液導入マイクロ流路との合流部の下流に位置するガス抽出マイクロ流路であって、液相流が前記ガス抽出マイクロ流路の周縁部を流通し、気相流がその内側を流通する二相流が流通するガス抽出マイクロ流路と、
該ガス抽出マイクロ流路の下流端に接続され、その深さが10μm〜100μmであり、前記ガス抽出マイクロ流路の深さよりも浅く、上部が平均孔径0.1μm〜2.0μmの多孔性膜で被覆された気液相分離マイクロ流路と、
該気液相分離マイクロ流路の下流に接続され、該気液相分離マイクロ流路を通過することによって気相流が前記多孔性膜から排出された残りの液相流が流通し、該液相流中に含まれる前記被検物質を測定する被検物質測定マイクロ流路とを具備する、気体被検物質測定用マイクロ流路チップを提供する。
前記捕集液導入マイクロ流路に前記捕集液を導入する工程と、
前記試料ガスと前記捕集液とにより形成される前記二相流を前記ガス抽出マイクロ流路に流通させ、それによって前記試料ガス中の前記被検物質を前記捕集液中に捕集する工程と、
前記二相流を、前記気液相分離マイクロ流路に流通させ、それによって気相流を前記多孔性膜から外部に排出して液相流にする工程と、
得られた液相流中に含まれる前記被検物質を測定する工程とを含む、気体被検物質の測定方法を提供する。
12 マイクロ流路
14 気液相分離マイクロ流路
16 多孔性膜
18 気相流
20 液相流
22 液体に可溶性の気体の被検物質の測定のためのマイクロ流路チップ
24 試料ガス導入マイクロ流路
26 捕集液導入マイクロ流路
28 被検物質
30 被検物質測定マイクロ流路
34 酸化液導入マイクロ流路
36 発色液導入マイクロ流路
図1に示す気液相分離マイクロ流路を有するマイクロ流路チップを作製した。その模式平面図を図4に示す。被検物質測定マイクロ流路30には、酸化液導入マイクロ流路34と発色液導入マイクロ流路36を接続した。図4に示すマイクロ流路チップでは、アンモニアガスを溶解した捕集液を、気液相分離部分を通過させた後、一旦チップの外のチューブ(図4中、実線の矢印)に導き、チップ内の流路に再び導入して発色液及び酸化液と合流させ、それよりも下流のマイクロ流路内で反応させている。なお、図4は、マイクロ流路を形成した基板を示しており、「気液相分離部」として長方形で囲まれている部分にあるマイクロ流路はテフロン(登録商標)膜で被覆される。気液相分離マイクロ流路14の断面は、幅400μm、深さ80μmの半楕円形であり、これ以外のマイクロ流路の断面は、全て幅500μm、深さ150μmの半楕円形であった。ガス抽出マイクロ流路12の長さは、35cm、気液相分離マイクロ流路の長さは1cm、被検物質測定マイクロ流路30の長さは50cmであった。マイクロ流路チップは、図1に基づいて上記した通り、2枚のガラス基板の上面に、それぞれマイクロ流路を形成してこれらのガラス基板を積層することにより作製した。
気液相分離マイクロ流路14に代えて、直径2mmの空気孔をマイクロ流路の上部に設けたこと以外は、実施例1と同様なマイクロ流路チップを作製し、上記と同様に気液相分離の様子を顕微鏡観察した。その結果、気液相分離は、最大で連続8時間しか達成できなかった。また、気液相分離後の液の流れがスムーズでない場合が観察された。
Claims (12)
- 基板内に設けられた気相流と液相流からなる二相流が流通するマイクロ流路と、該マイクロ流路の下流端に接続された、二相流から気相流を排除する気液相分離マイクロ流路であって、その深さが10μm〜100μmであり、前記マイクロ流路の深さよりも浅く、上部が平均孔径0.1μm〜2.0μmの多孔性膜で被覆された気液相分離マイクロ流路とを具備する、液体に可溶性のガスを測定するためのマイクロ流路チップ。
- 前記多孔性膜が疎水性材料から成る請求項1記載のマイクロ流路チップ。
- 前記多孔性膜がポリテトラフロロエチレン膜である請求項2記載のマイクロ流路チップ。
- 前記マイクロ流路の幅が10μm〜600μm、深さが50μm〜200μmである請求項1ないし3のいずれか1項に記載のマイクロ流路チップ。
- 前記気液相分離マイクロ流路の長さが0.5cm〜5cmである請求項1ないし4のいずれか1項に記載のマイクロ流路チップ。
- マイクロ流路内を流通する気相と液相から成る二相流であって液相流が前記マイクロ流路の周縁部を流通し、気相流がその内側を流通する二相流から、気相を排除して液相流にする気液相分離方法であって、請求項1ないし5のいずれか1項に記載のマイクロ流路チップ内の前記マイクロ流路に前記二相流を流通させ、前記気液相分離マイクロ流路に導き、該気液相分離マイクロ流路を流通させ、それによって前記気相流を前記多孔性膜を介して前記気液相分離マイクロ流路から外部に排出することを含む、気液相分離方法。
- 捕集液に可溶性の気体である被検物質を含む試料ガスを導入する試料ガス導入マイクロ流路と、
前記捕集液を導入する捕集液導入マイクロ流路と、
前記試料ガス導入マイクロ流路と前記捕集液導入マイクロ流路との合流部の下流に位置するガス抽出マイクロ流路であって、液相流が前記ガス抽出マイクロ流路の周縁部を流通し、気相流がその内側を流通する二相流が流通するガス抽出マイクロ流路と、
該ガス抽出マイクロ流路の下流端に接続され、その深さが10μm〜100μmであり、前記ガス抽出マイクロ流路の深さよりも浅く、上部が平均孔径0.1μm〜2.0μmの多孔性膜で被覆された気液相分離マイクロ流路と、
該気液相分離マイクロ流路の下流に接続され、該気液相分離マイクロ流路を通過することによって気相流が前記多孔性膜から排出された残りの液相流が流通し、該液相流中に含まれる前記被検物質を測定する被検物質測定マイクロ流路とを具備する、気体被検物質測定用マイクロ流路チップ。 - 前記いずれかのマイクロ流路に合流する少なくとも1つのマイクロ流路であって、前記被検物質の測定に必要な試薬を供給する試薬導入マイクロ流路をさらに具備する請求項7記載のマイクロ流路チップ。
- 請求項7又は8記載のマイクロ流路チップの前記試料ガス導入マイクロ流路に前記試料ガスを導入する工程と、
前記捕集液導入マイクロ流路に前記捕集液を導入する工程と、
前記試料ガスと前記捕集液とにより形成される前記二相流を前記ガス抽出マイクロ流路に流通させ、それによって前記試料ガス中の前記被検物質を前記捕集液中に捕集する工程と、
前記二相流を、前記気液相分離マイクロ流路に流通させ、それによって気相流を前記多孔性膜から外部に排出して液相流にする工程と、
得られた液相流中に含まれる前記被検物質を測定する工程とを含む、気体被検物質の測定方法。 - 前記気体被検物質がアンモニアである請求項9記載の方法。
- 前記マイクロ流路チップが、2個の前記試薬導入マイクロ流路をさらに具備する請求項7記載のマイクロ流路チップであり、一方の試薬導入マイクロ流路から発色液を導入し、もう一方の試薬導入マイクロ流路から酸化液を導入する、請求項10記載の方法。
- アンモニアの測定を、熱レンズ顕微鏡を用いて行う請求項11記載の方法。
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Application Number | Priority Date | Filing Date | Title |
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JP2009086805A JP5765722B2 (ja) | 2009-03-31 | 2009-03-31 | マイクロ流路チップ及びそれを用いた気液相分離方法 |
US13/262,103 US8815604B2 (en) | 2009-03-31 | 2010-03-31 | Microchannel chip and method for gas-liquid phase separation using same |
CN201080024006.2A CN102448602B (zh) | 2009-03-31 | 2010-03-31 | 微流路芯片及使用该微流路芯片的气液相分离方法 |
PCT/JP2010/055797 WO2010113997A1 (ja) | 2009-03-31 | 2010-03-31 | マイクロ流路チップ及びそれを用いた気液相分離方法 |
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Cited By (2)
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KR101768037B1 (ko) * | 2016-07-29 | 2017-08-14 | 한국과학기술원 | 필터 및 믹서를 구비하는 랩온어칩 |
KR101910818B1 (ko) | 2017-06-02 | 2018-10-30 | 대한민국 | 유전자 판독용 랩온어칩 |
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TW201422817A (zh) * | 2012-12-14 | 2014-06-16 | Ardic Instr Co | 生物感測晶片結構 |
WO2015107298A1 (fr) * | 2014-01-14 | 2015-07-23 | Centre National De La Recherche Scientifique (Cnrs) | Dispositif microfluidique pour l'analyse de polluants en écoulement |
US9920315B2 (en) | 2014-10-10 | 2018-03-20 | California Institute Of Technology | Methods and devices for micro-isolation, extraction, and/or analysis of microscale components in an array |
JP6190352B2 (ja) * | 2014-12-19 | 2017-08-30 | 株式会社神戸製鋼所 | 流体流通装置及びその運転方法 |
CN106629928B (zh) * | 2017-01-19 | 2018-10-02 | 中国石油大学(华东) | 一种带有疏水表面过滤壳的气水分离装置及其分离方法 |
EP3606660A4 (en) * | 2017-04-06 | 2021-01-13 | SRI International Inc. | MODULAR SYSTEMS FOR CARRYING OUT CHEMICAL MULTI-STEP REACTIONS AND USING PROCEDURES FOR THEM |
WO2018187717A1 (en) | 2017-04-06 | 2018-10-11 | Sri International | Continuous flow synthesis of ibuprofen |
CN108318394B (zh) * | 2018-05-09 | 2024-04-16 | 南京安控易创计算机科技有限公司 | 一种微流控分选测量可吸入颗粒物的方法及装置 |
KR102185548B1 (ko) * | 2018-12-04 | 2020-12-03 | 한국기계연구원 | 기상시료의 유해인자 포집장치 |
FR3104450B1 (fr) * | 2019-12-17 | 2022-06-03 | Univ Grenoble Alpes | Procédé de dégazage d’un fluide |
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JP2004113874A (ja) * | 2002-09-24 | 2004-04-15 | National Institute Of Advanced Industrial & Technology | マイクロ流路利用反応方法 |
JP4555609B2 (ja) * | 2004-05-21 | 2010-10-06 | 東亜ディーケーケー株式会社 | 気液反応ユニットおよび分析装置 |
JP2006223118A (ja) * | 2005-02-15 | 2006-08-31 | Yamaha Corp | マイクロチップ |
JP4899681B2 (ja) | 2006-07-18 | 2012-03-21 | 富士ゼロックス株式会社 | マイクロ流路デバイス |
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2009
- 2009-03-31 JP JP2009086805A patent/JP5765722B2/ja active Active
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Cited By (2)
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KR101768037B1 (ko) * | 2016-07-29 | 2017-08-14 | 한국과학기술원 | 필터 및 믹서를 구비하는 랩온어칩 |
KR101910818B1 (ko) | 2017-06-02 | 2018-10-30 | 대한민국 | 유전자 판독용 랩온어칩 |
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CN102448602B (zh) | 2014-11-26 |
US8815604B2 (en) | 2014-08-26 |
WO2010113997A1 (ja) | 2010-10-07 |
JP2010234313A (ja) | 2010-10-21 |
US20120164743A1 (en) | 2012-06-28 |
CN102448602A (zh) | 2012-05-09 |
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