JP5763067B2 - センサーデバイスに関連する改善 - Google Patents
センサーデバイスに関連する改善 Download PDFInfo
- Publication number
- JP5763067B2 JP5763067B2 JP2012522240A JP2012522240A JP5763067B2 JP 5763067 B2 JP5763067 B2 JP 5763067B2 JP 2012522240 A JP2012522240 A JP 2012522240A JP 2012522240 A JP2012522240 A JP 2012522240A JP 5763067 B2 JP5763067 B2 JP 5763067B2
- Authority
- JP
- Japan
- Prior art keywords
- calibration
- electrode
- analyte
- reagent
- film
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 239000003153 chemical reaction reagent Substances 0.000 claims description 387
- 239000012491 analyte Substances 0.000 claims description 365
- 238000005259 measurement Methods 0.000 claims description 228
- 239000012528 membrane Substances 0.000 claims description 163
- 239000012530 fluid Substances 0.000 claims description 104
- 238000000034 method Methods 0.000 claims description 94
- 238000006243 chemical reaction Methods 0.000 claims description 65
- 238000011144 upstream manufacturing Methods 0.000 claims description 32
- 238000004519 manufacturing process Methods 0.000 claims description 27
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 26
- 239000004480 active ingredient Substances 0.000 claims description 20
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 20
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims description 20
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 20
- 239000007788 liquid Substances 0.000 claims description 15
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims description 11
- 229920000642 polymer Polymers 0.000 claims description 11
- 239000004094 surface-active agent Substances 0.000 claims description 11
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 claims description 10
- 244000043261 Hevea brasiliensis Species 0.000 claims description 10
- 239000004354 Hydroxyethyl cellulose Substances 0.000 claims description 10
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 claims description 10
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims description 10
- 229920000881 Modified starch Polymers 0.000 claims description 10
- 239000004368 Modified starch Substances 0.000 claims description 10
- 239000004372 Polyvinyl alcohol Substances 0.000 claims description 10
- 239000004373 Pullulan Substances 0.000 claims description 10
- 229920001218 Pullulan Polymers 0.000 claims description 10
- KXVGTQFNYXBBHD-UHFFFAOYSA-N ethenyl acetate;pyrrolidin-2-one Chemical compound CC(=O)OC=C.O=C1CCCN1 KXVGTQFNYXBBHD-UHFFFAOYSA-N 0.000 claims description 10
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 claims description 10
- 239000001863 hydroxypropyl cellulose Substances 0.000 claims description 10
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims description 10
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims description 10
- 235000019426 modified starch Nutrition 0.000 claims description 10
- 229920003052 natural elastomer Polymers 0.000 claims description 10
- 229920001194 natural rubber Polymers 0.000 claims description 10
- 229920000058 polyacrylate Polymers 0.000 claims description 10
- 229920002451 polyvinyl alcohol Polymers 0.000 claims description 10
- 235000019423 pullulan Nutrition 0.000 claims description 10
- 235000010413 sodium alginate Nutrition 0.000 claims description 10
- 239000000661 sodium alginate Substances 0.000 claims description 10
- 229940005550 sodium alginate Drugs 0.000 claims description 10
- 239000001768 carboxy methyl cellulose Substances 0.000 claims description 9
- 239000004014 plasticizer Substances 0.000 claims description 9
- 239000007884 disintegrant Substances 0.000 claims description 8
- 238000001035 drying Methods 0.000 claims description 8
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 claims description 7
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 claims description 7
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 5
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims description 5
- 239000004386 Erythritol Substances 0.000 claims description 5
- UNXHWFMMPAWVPI-UHFFFAOYSA-N Erythritol Natural products OCC(O)C(O)CO UNXHWFMMPAWVPI-UHFFFAOYSA-N 0.000 claims description 5
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims description 5
- 239000002202 Polyethylene glycol Substances 0.000 claims description 5
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 claims description 5
- 235000019414 erythritol Nutrition 0.000 claims description 5
- UNXHWFMMPAWVPI-ZXZARUISSA-N erythritol Chemical compound OC[C@H](O)[C@H](O)CO UNXHWFMMPAWVPI-ZXZARUISSA-N 0.000 claims description 5
- 229940009714 erythritol Drugs 0.000 claims description 5
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 claims description 5
- 239000008108 microcrystalline cellulose Substances 0.000 claims description 5
- 229940016286 microcrystalline cellulose Drugs 0.000 claims description 5
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims description 5
- 229920001223 polyethylene glycol Polymers 0.000 claims description 5
- 229940080313 sodium starch Drugs 0.000 claims description 5
- 239000000600 sorbitol Substances 0.000 claims description 5
- 229960002920 sorbitol Drugs 0.000 claims description 5
- 235000010356 sorbitol Nutrition 0.000 claims description 5
- 239000000811 xylitol Substances 0.000 claims description 5
- 235000010447 xylitol Nutrition 0.000 claims description 5
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 claims description 5
- 229960002675 xylitol Drugs 0.000 claims description 5
- 229920002785 Croscarmellose sodium Polymers 0.000 claims description 4
- 101000945318 Homo sapiens Calponin-1 Proteins 0.000 claims description 4
- 101000652736 Homo sapiens Transgelin Proteins 0.000 claims description 4
- 102100031013 Transgelin Human genes 0.000 claims description 4
- 229960001681 croscarmellose sodium Drugs 0.000 claims description 4
- 235000010947 crosslinked sodium carboxy methyl cellulose Nutrition 0.000 claims description 4
- JJAHTWIKCUJRDK-UHFFFAOYSA-N succinimidyl 4-(N-maleimidomethyl)cyclohexane-1-carboxylate Chemical compound C1CC(CN2C(C=CC2=O)=O)CCC1C(=O)ON1C(=O)CCC1=O JJAHTWIKCUJRDK-UHFFFAOYSA-N 0.000 claims description 4
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 239000000523 sample Substances 0.000 description 153
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 150
- 239000008103 glucose Substances 0.000 description 150
- 238000012360 testing method Methods 0.000 description 71
- 239000000758 substrate Substances 0.000 description 39
- 238000003556 assay Methods 0.000 description 38
- 238000001514 detection method Methods 0.000 description 38
- 239000000203 mixture Substances 0.000 description 36
- 239000000243 solution Substances 0.000 description 30
- 239000007795 chemical reaction product Substances 0.000 description 27
- 239000012212 insulator Substances 0.000 description 26
- 238000004090 dissolution Methods 0.000 description 25
- 210000004369 blood Anatomy 0.000 description 22
- 239000008280 blood Substances 0.000 description 22
- 238000013461 design Methods 0.000 description 20
- 239000000872 buffer Substances 0.000 description 19
- 230000004044 response Effects 0.000 description 18
- 108090000790 Enzymes Proteins 0.000 description 16
- 102000004190 Enzymes Human genes 0.000 description 16
- 238000010586 diagram Methods 0.000 description 16
- 229940088598 enzyme Drugs 0.000 description 16
- 239000000463 material Substances 0.000 description 14
- 238000010276 construction Methods 0.000 description 11
- 238000012937 correction Methods 0.000 description 11
- 238000009792 diffusion process Methods 0.000 description 11
- 238000009472 formulation Methods 0.000 description 11
- 125000006850 spacer group Chemical group 0.000 description 11
- 239000000047 product Substances 0.000 description 9
- KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 description 8
- 239000000853 adhesive Substances 0.000 description 8
- 230000001070 adhesive effect Effects 0.000 description 8
- 238000002360 preparation method Methods 0.000 description 8
- 238000000151 deposition Methods 0.000 description 7
- 206010012601 diabetes mellitus Diseases 0.000 description 7
- 230000000694 effects Effects 0.000 description 7
- -1 potassium ferricyanide Chemical compound 0.000 description 7
- 230000009471 action Effects 0.000 description 6
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 6
- 230000006870 function Effects 0.000 description 6
- 235000019420 glucose oxidase Nutrition 0.000 description 6
- 238000005534 hematocrit Methods 0.000 description 6
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 6
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 6
- 238000007650 screen-printing Methods 0.000 description 6
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 5
- 108010015776 Glucose oxidase Proteins 0.000 description 5
- 230000015572 biosynthetic process Effects 0.000 description 5
- 230000008859 change Effects 0.000 description 5
- 230000001419 dependent effect Effects 0.000 description 5
- 238000002474 experimental method Methods 0.000 description 5
- 239000004615 ingredient Substances 0.000 description 5
- 230000002452 interceptive effect Effects 0.000 description 5
- 210000002381 plasma Anatomy 0.000 description 5
- 239000000126 substance Substances 0.000 description 5
- 239000004366 Glucose oxidase Substances 0.000 description 4
- 239000004721 Polyphenylene oxide Substances 0.000 description 4
- 238000004458 analytical method Methods 0.000 description 4
- 210000001124 body fluid Anatomy 0.000 description 4
- 230000009089 cytolysis Effects 0.000 description 4
- 210000003743 erythrocyte Anatomy 0.000 description 4
- 229940116332 glucose oxidase Drugs 0.000 description 4
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 4
- 229910052737 gold Inorganic materials 0.000 description 4
- 239000010931 gold Substances 0.000 description 4
- 230000002209 hydrophobic effect Effects 0.000 description 4
- 238000007641 inkjet printing Methods 0.000 description 4
- 239000011159 matrix material Substances 0.000 description 4
- 229910052763 palladium Inorganic materials 0.000 description 4
- 229920000570 polyether Polymers 0.000 description 4
- 229920001296 polysiloxane Polymers 0.000 description 4
- 230000008569 process Effects 0.000 description 4
- 102000004169 proteins and genes Human genes 0.000 description 4
- 108090000623 proteins and genes Proteins 0.000 description 4
- 238000003860 storage Methods 0.000 description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
- 108010050375 Glucose 1-Dehydrogenase Proteins 0.000 description 3
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 3
- LCTONWCANYUPML-UHFFFAOYSA-M Pyruvate Chemical compound CC(=O)C([O-])=O LCTONWCANYUPML-UHFFFAOYSA-M 0.000 description 3
- LEHOTFFKMJEONL-UHFFFAOYSA-N Uric Acid Chemical compound N1C(=O)NC(=O)C2=C1NC(=O)N2 LEHOTFFKMJEONL-UHFFFAOYSA-N 0.000 description 3
- TVWHNULVHGKJHS-UHFFFAOYSA-N Uric acid Natural products N1C(=O)NC(=O)C2NC(=O)NC21 TVWHNULVHGKJHS-UHFFFAOYSA-N 0.000 description 3
- 239000010839 body fluid Substances 0.000 description 3
- 235000012000 cholesterol Nutrition 0.000 description 3
- 230000008021 deposition Effects 0.000 description 3
- 238000003745 diagnosis Methods 0.000 description 3
- 238000000840 electrochemical analysis Methods 0.000 description 3
- 210000003722 extracellular fluid Anatomy 0.000 description 3
- 229910002804 graphite Inorganic materials 0.000 description 3
- 239000010439 graphite Substances 0.000 description 3
- 230000001771 impaired effect Effects 0.000 description 3
- 239000011810 insulating material Substances 0.000 description 3
- 230000003993 interaction Effects 0.000 description 3
- 150000002576 ketones Chemical class 0.000 description 3
- 235000014655 lactic acid Nutrition 0.000 description 3
- 239000004310 lactic acid Substances 0.000 description 3
- 230000004048 modification Effects 0.000 description 3
- 238000012986 modification Methods 0.000 description 3
- 229910052697 platinum Inorganic materials 0.000 description 3
- 210000003296 saliva Anatomy 0.000 description 3
- 229910052708 sodium Inorganic materials 0.000 description 3
- 239000011734 sodium Substances 0.000 description 3
- 230000001052 transient effect Effects 0.000 description 3
- 229940116269 uric acid Drugs 0.000 description 3
- 210000002700 urine Anatomy 0.000 description 3
- 238000012935 Averaging Methods 0.000 description 2
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 2
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 2
- 239000012042 active reagent Substances 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 230000000903 blocking effect Effects 0.000 description 2
- 229910052799 carbon Inorganic materials 0.000 description 2
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 2
- 239000008112 carboxymethyl-cellulose Substances 0.000 description 2
- 239000011248 coating agent Substances 0.000 description 2
- 238000000576 coating method Methods 0.000 description 2
- 239000004020 conductor Substances 0.000 description 2
- 238000006911 enzymatic reaction Methods 0.000 description 2
- YAGKRVSRTSUGEY-UHFFFAOYSA-N ferricyanide Chemical compound [Fe+3].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-] YAGKRVSRTSUGEY-UHFFFAOYSA-N 0.000 description 2
- 238000001914 filtration Methods 0.000 description 2
- 125000002791 glucosyl group Chemical group C1([C@H](O)[C@@H](O)[C@H](O)[C@H](O1)CO)* 0.000 description 2
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 description 2
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 2
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 description 2
- 238000010813 internal standard method Methods 0.000 description 2
- 229920003023 plastic Polymers 0.000 description 2
- 239000004033 plastic Substances 0.000 description 2
- 229920000728 polyester Polymers 0.000 description 2
- 239000000276 potassium ferrocyanide Substances 0.000 description 2
- 238000012545 processing Methods 0.000 description 2
- 230000009467 reduction Effects 0.000 description 2
- 239000012488 sample solution Substances 0.000 description 2
- 229910052710 silicon Inorganic materials 0.000 description 2
- 239000010703 silicon Substances 0.000 description 2
- 229910052709 silver Inorganic materials 0.000 description 2
- 239000004332 silver Substances 0.000 description 2
- 238000004544 sputter deposition Methods 0.000 description 2
- XOGGUFAVLNCTRS-UHFFFAOYSA-N tetrapotassium;iron(2+);hexacyanide Chemical compound [K+].[K+].[K+].[K+].[Fe+2].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-] XOGGUFAVLNCTRS-UHFFFAOYSA-N 0.000 description 2
- 150000003626 triacylglycerols Chemical class 0.000 description 2
- GPRLSGONYQIRFK-MNYXATJNSA-N triton Chemical compound [3H+] GPRLSGONYQIRFK-MNYXATJNSA-N 0.000 description 2
- 201000004569 Blindness Diseases 0.000 description 1
- 206010006326 Breath odour Diseases 0.000 description 1
- RGHNJXZEOKUKBD-UHFFFAOYSA-N D-gluconic acid Natural products OCC(O)C(O)C(O)C(O)C(O)=O RGHNJXZEOKUKBD-UHFFFAOYSA-N 0.000 description 1
- YCKRFDGAMUMZLT-UHFFFAOYSA-N Fluorine atom Chemical compound [F] YCKRFDGAMUMZLT-UHFFFAOYSA-N 0.000 description 1
- RGHNJXZEOKUKBD-SQOUGZDYSA-N Gluconic acid Natural products OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O RGHNJXZEOKUKBD-SQOUGZDYSA-N 0.000 description 1
- 206010018910 Haemolysis Diseases 0.000 description 1
- 229920003091 Methocel™ Polymers 0.000 description 1
- 208000031662 Noncommunicable disease Diseases 0.000 description 1
- 229910021607 Silver chloride Inorganic materials 0.000 description 1
- 229920004890 Triton X-100 Polymers 0.000 description 1
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 description 1
- 229920006243 acrylic copolymer Polymers 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 238000004082 amperometric method Methods 0.000 description 1
- 230000003466 anti-cipated effect Effects 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 238000003491 array Methods 0.000 description 1
- 238000002820 assay format Methods 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 238000003705 background correction Methods 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 210000000601 blood cell Anatomy 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
- 238000005266 casting Methods 0.000 description 1
- 239000007979 citrate buffer Substances 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 239000002274 desiccant Substances 0.000 description 1
- 230000001627 detrimental effect Effects 0.000 description 1
- 238000002405 diagnostic procedure Methods 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000007812 electrochemical assay Methods 0.000 description 1
- 239000012776 electronic material Substances 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 238000005530 etching Methods 0.000 description 1
- 229910052731 fluorine Inorganic materials 0.000 description 1
- 239000011737 fluorine Substances 0.000 description 1
- 238000011010 flushing procedure Methods 0.000 description 1
- 239000000174 gluconic acid Substances 0.000 description 1
- 235000012208 gluconic acid Nutrition 0.000 description 1
- 230000036252 glycation Effects 0.000 description 1
- 238000009499 grossing Methods 0.000 description 1
- 230000008588 hemolysis Effects 0.000 description 1
- 230000036571 hydration Effects 0.000 description 1
- 238000006703 hydration reaction Methods 0.000 description 1
- 230000005660 hydrophilic surface Effects 0.000 description 1
- 230000001788 irregular Effects 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 238000007726 management method Methods 0.000 description 1
- 239000000155 melt Substances 0.000 description 1
- QSHDDOUJBYECFT-UHFFFAOYSA-N mercury Chemical compound [Hg] QSHDDOUJBYECFT-UHFFFAOYSA-N 0.000 description 1
- 229910052753 mercury Inorganic materials 0.000 description 1
- 229920000609 methyl cellulose Polymers 0.000 description 1
- 239000001923 methylcellulose Substances 0.000 description 1
- 238000001000 micrograph Methods 0.000 description 1
- 230000003278 mimic effect Effects 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 208000010125 myocardial infarction Diseases 0.000 description 1
- 230000007830 nerve conduction Effects 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 229920002689 polyvinyl acetate Polymers 0.000 description 1
- 239000011118 polyvinyl acetate Substances 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 238000007639 printing Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- HKZLPVFGJNLROG-UHFFFAOYSA-M silver monochloride Chemical compound [Cl-].[Ag+] HKZLPVFGJNLROG-UHFFFAOYSA-M 0.000 description 1
- 239000008109 sodium starch glycolate Substances 0.000 description 1
- 229920003109 sodium starch glycolate Polymers 0.000 description 1
- 229940079832 sodium starch glycolate Drugs 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 239000004834 spray adhesive Substances 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 230000007480 spreading Effects 0.000 description 1
- 238000003892 spreading Methods 0.000 description 1
- 238000013268 sustained release Methods 0.000 description 1
- 239000012730 sustained-release form Substances 0.000 description 1
- 230000002123 temporal effect Effects 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 1
- 229920003176 water-insoluble polymer Polymers 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/001—Enzyme electrodes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/001—Enzyme electrodes
- C12Q1/005—Enzyme electrodes involving specific analytes or enzymes
- C12Q1/006—Enzyme electrodes involving specific analytes or enzymes for glucose
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Analytical Chemistry (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Emergency Medicine (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0913015.4 | 2009-07-27 | ||
| GB0913015A GB0913015D0 (en) | 2009-07-27 | 2009-07-27 | Reagent formulation |
| GB0916067.2 | 2009-09-12 | ||
| GB0916067A GB0916067D0 (en) | 2009-09-12 | 2009-09-12 | Device with water soluble dry film |
| PCT/GB2010/001420 WO2011012848A1 (en) | 2009-07-27 | 2010-07-26 | Improvements relating to sensor devices |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013500492A JP2013500492A (ja) | 2013-01-07 |
| JP2013500492A5 JP2013500492A5 (enExample) | 2013-09-05 |
| JP5763067B2 true JP5763067B2 (ja) | 2015-08-12 |
Family
ID=42711757
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012522240A Expired - Fee Related JP5763067B2 (ja) | 2009-07-27 | 2010-07-26 | センサーデバイスに関連する改善 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US9868974B2 (enExample) |
| EP (1) | EP2459730B1 (enExample) |
| JP (1) | JP5763067B2 (enExample) |
| CN (1) | CN102471796A (enExample) |
| CA (1) | CA2767950C (enExample) |
| WO (1) | WO2011012848A1 (enExample) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201007711D0 (en) * | 2010-05-07 | 2010-06-23 | Pa Consulting Services | Devices and methods for testing analytes |
| KR101471932B1 (ko) * | 2011-10-06 | 2014-12-11 | 주식회사 인지바이오 | 스크린 프린팅을 이용한 다중 진단 멤브레인 센서의 제조방법 |
| CA2866641C (en) * | 2012-03-09 | 2016-01-26 | Siemens Healthcare Diagnostics Inc. | Calibration method for reagent card analyzers |
| US9164056B2 (en) | 2012-07-27 | 2015-10-20 | Bayer Healthcare Llc | System and method for detecting used and dried sensors |
| US20140186866A1 (en) * | 2012-12-27 | 2014-07-03 | General Electric Company | Glucose Control Test Strip |
| EP2972333B1 (en) * | 2013-03-11 | 2018-09-19 | The University of Toledo | A biosensor device to target analytes in situ, in vivo, and/or in real time, and methods of making and using the same |
| GB2514846B (en) * | 2013-06-07 | 2015-09-30 | Lifescan Scotland Ltd | Electrochemical-based analytical test strip with a soluble electrochemically-active coating opposite a bare electrode |
| US9464994B2 (en) | 2013-07-30 | 2016-10-11 | Clemson University | High sensitivity tunable radio frequency sensors |
| JP6700246B2 (ja) | 2014-07-09 | 2020-05-27 | シーメンス・ヘルスケア・ダイアグノスティックス・インコーポレーテッドＳｉｅｍｅｎｓ Ｈｅａｌｔｈｃａｒｅ Ｄｉａｇｎｏｓｔｉｃｓ Ｉｎｃ． | 少量試料検知装置 |
| CN104597100B (zh) * | 2014-07-24 | 2021-11-05 | 南京工业大学 | 一种检测血清中甘油三酯的方法 |
| CN108463719B (zh) * | 2015-12-28 | 2021-12-21 | 生命扫描苏格兰有限公司 | 具有电极电压感测连接件的基于电化学的分析测试条以及与其一起使用的手持式测试仪 |
| GB2549281A (en) * | 2016-04-11 | 2017-10-18 | Palintest Ltd | Electrochemical sensor |
| TWI589870B (zh) * | 2016-05-05 | 2017-07-01 | Vida Biotechnology Co Ltd | Biological test strip with isolated structure and method of use |
| CN106353387B (zh) * | 2016-08-24 | 2019-11-29 | 三诺生物传感股份有限公司 | 一种电化学测试条及同时检测多种待测物的方法 |
| JP7469881B2 (ja) * | 2016-12-09 | 2024-04-17 | デジタル センシング リミテッド | 電気化学センサおよびその使用方法 |
| US10191044B2 (en) * | 2017-01-04 | 2019-01-29 | David R. Hall | Flushable test strip |
| JP7167824B2 (ja) * | 2019-04-08 | 2022-11-09 | 日本電信電話株式会社 | 発汗分析装置 |
| DE102019120897A1 (de) * | 2019-08-02 | 2021-02-04 | Endress+Hauser Group Services Ag | Mobile Anlage für das Kalibrieren, Verifizieren und/oder Justieren eines Sensors und Verfahren zum Kalibrieren, Verifizieren und/oder Justieren eines Sensors |
| CN110716048B (zh) * | 2019-10-30 | 2021-08-13 | 烟台芥子生物技术有限公司 | 干性免疫比浊试剂及其制备方法和应用 |
| FR3111267B1 (fr) * | 2020-06-12 | 2024-05-10 | Univ Grenoble Alpes | Procede pour determiner une concentration reelle d’un substrat a l’aide d’un ensemble de biocapteurs auto-calibres et dispositif pour la mise en œuvre du procede |
| KR20240035602A (ko) * | 2021-07-22 | 2024-03-15 | 바이오나임 코포레이션 | 마이크로 바이오센서 및 그 센싱 구조 |
| CN114923965B (zh) * | 2022-03-18 | 2023-05-23 | 杭州微策生物技术股份有限公司 | 一种一体式多指标传感器及其制作方法 |
| CN120820615A (zh) * | 2024-04-12 | 2025-10-21 | 南京晶捷生物科技有限公司 | 一种干膜自校准传感装置及其检测离子浓度的方法 |
Family Cites Families (66)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4136145A (en) | 1974-07-05 | 1979-01-23 | Schering Aktiengesellschaft | Medicament carriers in the form of film having active substance incorporated therein |
| US4533629A (en) | 1981-04-17 | 1985-08-06 | Syva Company | Simultaneous calibration heterogeneous immunoassay |
| IL75464A (en) | 1984-06-12 | 1990-08-31 | Orgenics Ltd | Method and apparatus for multi-analyte assay |
| TW203120B (enExample) | 1985-10-04 | 1993-04-01 | Abbott Lab | |
| JPS62231168A (ja) | 1986-03-21 | 1987-10-09 | ハイブリテツク・インコ−ポレイテツド | アナライト−レセプタ−分析用内部標準を設けるための改良法 |
| US4774192A (en) * | 1987-01-28 | 1988-09-27 | Technimed Corporation | A dry reagent delivery system with membrane having porosity gradient |
| ATE124990T1 (de) | 1989-12-15 | 1995-07-15 | Boehringer Mannheim Corp | Redox-vermittlungs-reagenz und biosensor. |
| DK138090D0 (da) | 1990-06-06 | 1990-06-06 | Novo Nordisk As | Diagnostisk analysemetode |
| US5726064A (en) | 1990-11-22 | 1998-03-10 | Applied Research Systems Ars Holding Nv | Method of assay having calibration within the assay |
| US5272191A (en) | 1991-08-21 | 1993-12-21 | Fmc Corporation | Cold water soluble films and film forming compositions |
| US5284140A (en) | 1992-02-11 | 1994-02-08 | Eli Lilly And Company | Acrylic copolymer membranes for biosensors |
| US5393528A (en) | 1992-05-07 | 1995-02-28 | Staab; Robert J. | Dissolvable device for contraception or delivery of medication |
| US5582697A (en) | 1995-03-17 | 1996-12-10 | Matsushita Electric Industrial Co., Ltd. | Biosensor, and a method and a device for quantifying a substrate in a sample liquid using the same |
| AUPN363995A0 (en) | 1995-06-19 | 1995-07-13 | Memtec Limited | Electrochemical cell |
| US5628890A (en) | 1995-09-27 | 1997-05-13 | Medisense, Inc. | Electrochemical sensor |
| AUPN661995A0 (en) | 1995-11-16 | 1995-12-07 | Memtec America Corporation | Electrochemical cell 2 |
| US6241862B1 (en) | 1996-02-14 | 2001-06-05 | Inverness Medical Technology, Inc. | Disposable test strips with integrated reagent/blood separation layer |
| DE19605583A1 (de) * | 1996-02-15 | 1997-08-21 | Bayer Ag | Elektrochemische Sensoren mit verbesserter Selektivität und erhöhter Empfindlichkeit |
| US5753517A (en) | 1996-03-29 | 1998-05-19 | University Of British Columbia | Quantitative immunochromatographic assays |
| US5962215A (en) | 1996-04-05 | 1999-10-05 | Mercury Diagnostics, Inc. | Methods for testing the concentration of an analyte in a body fluid |
| DE19646392A1 (de) | 1996-11-11 | 1998-05-14 | Lohmann Therapie Syst Lts | Zubereitung zur Anwendung in der Mundhöhle mit einer an der Schleimhaut haftklebenden, Pharmazeutika oder Kosmetika zur dosierten Abgabe enthaltenden Schicht |
| JP3460538B2 (ja) | 1997-10-08 | 2003-10-27 | 救急薬品工業株式会社 | 速溶性フィルム製剤 |
| US6153085A (en) | 1998-08-17 | 2000-11-28 | Stat-Chem, Inc. | Information storage and transmittal for medical diagnostic devices |
| US6193873B1 (en) | 1999-06-15 | 2001-02-27 | Lifescan, Inc. | Sample detection to initiate timing of an electrochemical assay |
| EP1394535B1 (en) | 2000-03-28 | 2008-08-27 | Diabetes Diagnostics, Inc. | Meter with rapid response glucose sensor |
| CA2403646A1 (en) | 2000-03-28 | 2001-10-04 | Inverness Medical Technology, Inc. | Continuous process for manufacture of disposable electro-chemical sensor |
| DE10025580A1 (de) | 2000-05-24 | 2001-12-06 | Infineon Technologies Ag | Messverfahren mit Substanzsensoren und Messvorrichtung |
| CN1441902A (zh) | 2000-07-14 | 2003-09-10 | 生命扫描有限公司 | 用于测定化学反应速度的电化学方法 |
| JP2004509739A (ja) | 2000-09-27 | 2004-04-02 | ベリオン インコーポレイテッド | 即時水溶解性カプセルおよびその製法 |
| US6555061B1 (en) | 2000-10-05 | 2003-04-29 | Lifescan, Inc. | Multi-layer reagent test strip |
| US6660292B2 (en) | 2001-06-19 | 2003-12-09 | Hf Flavoring Technology Llp | Rapidly disintegrating flavored film for precooked foods |
| US6419903B1 (en) | 2001-08-20 | 2002-07-16 | Colgate Palmolive Company | Breath freshening film |
| JP4328203B2 (ja) * | 2001-09-17 | 2009-09-09 | ファディア・アクチボラゲット | 多数−スポット検出ゾーンでの多数−分析物アッセイデバイス |
| US20030116447A1 (en) | 2001-11-16 | 2003-06-26 | Surridge Nigel A. | Electrodes, methods, apparatuses comprising micro-electrode arrays |
| US7090764B2 (en) | 2002-01-15 | 2006-08-15 | Agamatrix, Inc. | Method and apparatus for processing electrochemical signals |
| US6946299B2 (en) | 2002-04-25 | 2005-09-20 | Home Diagnostics, Inc. | Systems and methods for blood glucose sensing |
| EP3025703A1 (en) | 2002-06-25 | 2016-06-01 | Wm. Wrigley Jr. Company | Breath freshening and oral cleansing product with magnolia bark extract |
| AU2003278365B2 (en) | 2002-10-30 | 2010-07-01 | Lifescan Scotland Limited | Cooling stations for use in a web printing process for the manufacture of electrochemical sensors |
| US20040115137A1 (en) | 2002-12-17 | 2004-06-17 | Verrall Andrew P. | Water-soluble film for oral administration |
| SI21400A (sl) | 2003-02-12 | 2004-08-31 | LEK farmacevtska družba d.d. | Stabilna farmacevtska oblika z inhibitorjem HMG-CoA reduktaze |
| US7875293B2 (en) | 2003-05-21 | 2011-01-25 | Dexcom, Inc. | Biointerface membranes incorporating bioactive agents |
| US20040238359A1 (en) * | 2003-05-28 | 2004-12-02 | Matsushita Electric Industrial Co., Ltd. | Biosensor |
| JP4334969B2 (ja) | 2003-10-02 | 2009-09-30 | パナソニック株式会社 | 血液成分分析用センサ |
| DE10346863A1 (de) | 2003-10-09 | 2005-05-04 | Roche Diagnostics Gmbh | On-Board-Kontrolle für Analyseelemente |
| US9248146B2 (en) | 2003-10-24 | 2016-02-02 | Adhesives Research, Inc. | Dissolvable adhesive films for delivery of pharmaceutical or cosmetic agents |
| WO2005040228A2 (en) | 2003-10-24 | 2005-05-06 | Adhesives Research, Inc. | Disintegratable films for diagnostic devices |
| FR2862654B1 (fr) | 2003-11-20 | 2006-02-10 | Roquette Freres | Composition amylacee filmogene |
| EP2239566B1 (en) | 2003-12-05 | 2014-04-23 | DexCom, Inc. | Calibration techniques for a continuous analyte sensor |
| BRPI0507376A (pt) | 2004-02-06 | 2007-07-10 | Bayer Healthcare Llc | espécie oxidável como uma referência interna para biossensores e método de uso |
| GB0403369D0 (en) * | 2004-02-16 | 2004-03-17 | Pa Consulting Services | Devices and methods for testing analytes |
| DE602004011688D1 (de) | 2004-03-05 | 2008-03-20 | Egomedical Swiss Ag | Analyttestsystem zur bestimmung der konzentration eines analyten in einer physiologischen flüssigkeit |
| CN1954205A (zh) | 2004-05-14 | 2007-04-25 | 拜尔健康护理有限责任公司 | 生产诊断测试条的方法 |
| US20080286359A1 (en) | 2004-05-24 | 2008-11-20 | Richard John Dansereau | Low Dosage Forms Of Risedronate Or Its Salts |
| CA2475240A1 (en) | 2004-07-20 | 2006-01-20 | Biophys, Inc. | Method and device to measure dynamic internal calibration true dose response curves |
| US20060024835A1 (en) | 2004-07-30 | 2006-02-02 | Matzinger David P | Analytical test strip with control zone |
| MX2007001770A (es) | 2004-08-13 | 2007-08-07 | Egomedical Technologies Ag | Sistema de prueba de analitos para determinar la concentracion de un analito en un fluido fisiologico o acuoso. |
| GB0428130D0 (en) | 2004-12-22 | 2005-01-26 | Oxford Biosensors Ltd | Selective HDL cholesterol assay |
| US20080152761A1 (en) | 2006-12-20 | 2008-06-26 | Shiji Shen | Packaging of Food Products with Pullulan Films |
| GB0617276D0 (en) * | 2006-09-04 | 2006-10-11 | Suresensors | Device |
| ES2748685T3 (es) * | 2006-09-22 | 2020-03-17 | Ascensia Diabetes Care Holdings Ag | Sistema de biosensor que tiene estabilidad y rendimiento de hematocrito potenciados |
| US20090007947A1 (en) * | 2006-12-22 | 2009-01-08 | Angela Spangenberg | Portable weather shielding canopy |
| WO2009018503A1 (en) | 2007-08-02 | 2009-02-05 | Monosol, Llc | Carboxymethyl cellulose-based films, edible food casings made therefrom, and method of using same |
| EP2223104B1 (en) | 2007-12-10 | 2018-08-29 | Ascensia Diabetes Care Holdings AG | Slope-based compensation |
| US8241697B2 (en) * | 2007-12-20 | 2012-08-14 | Abbott Point Of Care Inc. | Formation of immobilized biological layers for sensing |
| US8603768B2 (en) | 2008-01-17 | 2013-12-10 | Lifescan, Inc. | System and method for measuring an analyte in a sample |
| GB201007711D0 (en) | 2010-05-07 | 2010-06-23 | Pa Consulting Services | Devices and methods for testing analytes |
-
2010
- 2010-07-26 EP EP10739971.9A patent/EP2459730B1/en active Active
- 2010-07-26 JP JP2012522240A patent/JP5763067B2/ja not_active Expired - Fee Related
- 2010-07-26 US US13/387,072 patent/US9868974B2/en active Active
- 2010-07-26 CA CA2767950A patent/CA2767950C/en active Active
- 2010-07-26 WO PCT/GB2010/001420 patent/WO2011012848A1/en not_active Ceased
- 2010-07-26 CN CN2010800341985A patent/CN102471796A/zh active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CA2767950A1 (en) | 2011-02-03 |
| CN102471796A (zh) | 2012-05-23 |
| WO2011012848A1 (en) | 2011-02-03 |
| CA2767950C (en) | 2019-11-12 |
| WO2011012848A8 (en) | 2011-03-10 |
| EP2459730A1 (en) | 2012-06-06 |
| EP2459730B1 (en) | 2016-12-07 |
| US20120135509A1 (en) | 2012-05-31 |
| US9868974B2 (en) | 2018-01-16 |
| JP2013500492A (ja) | 2013-01-07 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP5763067B2 (ja) | センサーデバイスに関連する改善 | |
| JP5619665B2 (ja) | 血液成分の測定方法、それに用いるバイオセンサおよび測定装置 | |
| JP4611313B2 (ja) | 電気化学検査ストリップにおける直接的な干渉電流の影響を軽減する方法 | |
| ES2800977T3 (es) | Método para análisis electroquímico rápido | |
| US8038860B2 (en) | Biosensor | |
| TWI513978B (zh) | 檢測試片、檢測裝置及檢測方法 | |
| CN103052881B (zh) | 用于提高对于对照溶液的葡萄糖结果进行温度校正的准确度的系统和方法 | |
| CN101178373B (zh) | 生物传感器 | |
| US20100096276A1 (en) | Multicomponent analysis sensor and method of measuring multiple components | |
| JP2007163499A (ja) | グルコースバイオセンサ及び方法 | |
| CN103328962A (zh) | 用于电化学传感器的提高的稳定性的系统和方法 | |
| US10605758B2 (en) | Devices and methods for testing analytes | |
| CN103454321A (zh) | 生物传感器及其制造方法 | |
| EP1733227A1 (en) | Devices and methods for measuring clinically relevant analytes in fluids | |
| TWI293116B (en) | Biosensor device using bioactive membrane | |
| TW201602574A (zh) | 檢測試片、檢測裝置及檢測方法 | |
| MXPA97010374A (en) | Electroquim biosensor test strip |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20130719 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20130722 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20130827 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20131225 |
|
| A977 | Report on retrieval |
Free format text: JAPANESE INTERMEDIATE CODE: A971007 Effective date: 20131226 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20140313 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20140910 |
|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20141210 |
|
| A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20141217 |
|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20150113 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20150210 |
|
| TRDD | Decision of grant or rejection written | ||
| A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20150603 |
|
| A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20150610 |
|
| R150 | Certificate of patent or registration of utility model |
Ref document number: 5763067 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| S531 | Written request for registration of change of domicile |
Free format text: JAPANESE INTERMEDIATE CODE: R313531 |
|
| R350 | Written notification of registration of transfer |
Free format text: JAPANESE INTERMEDIATE CODE: R350 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| LAPS | Cancellation because of no payment of annual fees |