JP5762380B2 - 神経刺激を使って不快感を軽減するシステム - Google Patents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N2/00—Magnetotherapy
- A61N2/004—Magnetotherapy specially adapted for a specific therapy
- A61N2/006—Magnetotherapy specially adapted for a specific therapy for magnetic stimulation of nerve tissue
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N2/00—Magnetotherapy
- A61N2/004—Magnetotherapy specially adapted for a specific therapy
- A61N2/008—Magnetotherapy specially adapted for a specific therapy for pain treatment or analgesia
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- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
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Description
1831年、導体に誘導される電場の大きさが、その導体を貫く磁束密度の変化率に比例することをマイケル・ファラデーが発見した。当業者に広く知られているこのファラデーの法則は、Eα=−(dB/dt)と表すことができる。ここで、Eは誘導される電場(ボルト/メートル単位)、dB/dtは磁束密度の時間変化率(テスラ/秒)である。すなわち、導体などの物体中に誘導される電場の大きさは、磁束密度と、磁束密度の時間変化率との2要因により決定される。磁束密度とその微分値が大きいほど、誘導されるピーク電場とその結果生じるピーク電流密度も大きくなる。磁束密度は磁場源からの距離の2乗に反比例して減少するため、導体が磁場源に近づくほど大きくなる。導体がコイルである場合、電場によりコイル内に誘導される電流はコイルの巻き数およびコイルの面積に比例して増加する。
強磁性コアは、例えば経頭蓋磁気刺激(Transcranial Magnetic Stimulation:TMS)、反復経頭蓋磁気刺激(Repetitive TMS:rTMS)、磁気発作治療(Magnetic Seizure Therapy:MST)、末梢神経不快感の軽減などの経皮的磁気刺激を実施する目的で磁場を生成するため使用することができる。上述したように、以下の例でも説明および明瞭化のためTMSおよびrTMSの実施形態に関連して説明しているが、上記のタイプの全てを含め、いかなるタイプの経皮的磁性刺激も、本発明の一実施形態に従った実施が可能である。
上記のとおり、経皮的刺激を使うと、例えば末梢神経など問題のある神経に磁場を直接印加することにより患者の不快感を軽減できる。また上述したように、患者への経皮的刺激は治療のためのものであるが、望ましくない副作用が生じるおそれがあることにも留意すべきである。例えば経頭蓋刺激の場合は、脳神経や三叉神経などには、各々の刺激閾値を越えた磁場が付与される。その結果、患者は、例えば筋肉の痙攣(けいれん)や感覚神経から来る痛みにより不快感を感じる場合がある。このため、治療しない領域(非治療領域)の位置における磁場を低減するよう磁場の照準を合わせることが有益である。
Claims (8)
- 経皮的な磁気刺激を実施するシステムであって、
第1の磁場を生成する第1の磁気刺激装置であって、第1の磁場は第1の位置で磁気刺激を生成するよう適合され、第1の磁気刺激装置は、強磁性コアと該強磁性コアの周りに配置された巻線を有し、第1の位置は治療領域であり、第1の位置における磁気刺激は治療領域についての刺激閾値よりも上であり、
末梢神経に関係する第2の位置を過剰刺激する第2の磁場を生成する第2の磁気刺激装置であって、第2の磁気刺激装置は、磁気刺激に応答する末梢神経の能力を低下させるレートでパルスされるよう適合され、
刺激システムは、
前記第1の磁気刺激装置および前記第2の磁気刺激装置を作動させる1または2以上のパラメータを受信するための刺激コントロールと、
前記刺激コントロールによって受信された1または2以上のパラメータに従って、第1の波形及び第2の波形を生成する少なくとも1つのパルスプログラマと、
第1の波形に従って第1の磁気刺激装置をパルスして第1の位置に磁気刺激を引き起こし、第2の波形に従って第2の磁気刺激装置をパルスして磁気刺激に応答する末梢神経の能力を低下させるよう適合された少なくとも1つの駆動回路とを備えていることを特徴とするシステム。 - 第1の磁気刺激装置および第2の磁気刺激装置は実質的に同時にパルスされることを特徴とする請求項1に記載のシステム。
- 第1の磁気刺激装置および第2の磁気刺激装置は実質的に異なる時間パルスされることを特徴とする請求項1に記載のシステム。
- 第1の波形及び第2の波形は異なる特性を有することを特徴とする請求項1に記載のシステム。
- 第2の磁場は末梢神経を麻痺させるように適合され、それによって、磁気刺激に応答する末梢神経の能力を低下させることを特徴とする請求項1に記載のシステム。
- 第2の磁場は、末梢神経が再分極することを防止することによって磁気刺激に応答する末梢神経の能力を低下させるよう適合されていることを特徴とする請求項1に記載のシステム。
- 第2の磁気刺激装置は、第1の磁気刺激装置に対する第2の磁気刺激装置の配置を調整するよう適合されていることを特徴とする請求項1に記載のシステム。
- 末梢神経は三叉神経であることを特徴とする請求項1に記載のシステム。
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US10/977,734 US7857746B2 (en) | 2004-10-29 | 2004-10-29 | System and method to reduce discomfort using nerve stimulation |
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EP (1) | EP1807154B1 (ja) |
JP (3) | JP2008518677A (ja) |
AU (1) | AU2005302300B2 (ja) |
CA (1) | CA2585842C (ja) |
DK (1) | DK1807154T3 (ja) |
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US7493171B1 (en) * | 2000-11-21 | 2009-02-17 | Boston Scientific Neuromodulation Corp. | Treatment of pathologic craving and aversion syndromes and eating disorders by electrical brain stimulation and/or drug infusion |
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WO2006050279A3 (en) | 2009-04-16 |
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JP2008518677A (ja) | 2008-06-05 |
JP2014166584A (ja) | 2014-09-11 |
EP1807154A4 (en) | 2013-01-09 |
EP1807154A2 (en) | 2007-07-18 |
US7857746B2 (en) | 2010-12-28 |
JP2013046775A (ja) | 2013-03-07 |
EP1807154B1 (en) | 2016-09-28 |
US20060094924A1 (en) | 2006-05-04 |
WO2006050279A2 (en) | 2006-05-11 |
AU2005302300B2 (en) | 2011-06-09 |
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CA2585842C (en) | 2013-12-17 |
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