JP5756630B2 - インフルエンザ抗原送達用のベクターおよび構築体 - Google Patents
インフルエンザ抗原送達用のベクターおよび構築体 Download PDFInfo
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- JP5756630B2 JP5756630B2 JP2010522440A JP2010522440A JP5756630B2 JP 5756630 B2 JP5756630 B2 JP 5756630B2 JP 2010522440 A JP2010522440 A JP 2010522440A JP 2010522440 A JP2010522440 A JP 2010522440A JP 5756630 B2 JP5756630 B2 JP 5756630B2
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| WO2015143339A2 (en) | 2014-03-21 | 2015-09-24 | University Of Washington | Enhanced influenza hemagglutinin binders |
| WO2015157189A1 (en) * | 2014-04-07 | 2015-10-15 | The Regents Of The University Of California | Vaccines and uses thereof |
| JP6103547B2 (ja) * | 2015-01-09 | 2017-03-29 | 三菱電機株式会社 | 電子基板ユニット |
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| EP3257864A1 (en) * | 2016-06-16 | 2017-12-20 | Université de Strasbourg | Metabolically stable spexin peptide analogs |
| CN119033925A (zh) | 2016-10-05 | 2024-11-29 | Pds生物科技公司 | 新型hpv16非hla限制性t细胞疫苗、组合物及其使用方法 |
| BR112019013402A2 (pt) | 2016-12-28 | 2020-03-03 | Invvax, Inc. | Vacinas de influenza |
| US11517617B2 (en) | 2017-09-08 | 2022-12-06 | The University Of Melbourne | Methods and compositions for preventing influenza infection |
| TW201924722A (zh) | 2017-12-05 | 2019-07-01 | 美商Ｐｄｓ生技公司 | 用於刺激第i型干擾素基因之方法及包含陽離子脂質的組合物 |
| JP2021520414A (ja) * | 2018-04-04 | 2021-08-19 | アルティミューン インコーポレーティッド | Ｔ細胞を誘発するワクチン組成物の組合せ及びその使用 |
| JP7037994B2 (ja) | 2018-04-11 | 2022-03-17 | 株式会社シマノ | 制御装置、人力駆動車、および制御方法 |
| CN110772635B (zh) * | 2019-11-11 | 2023-01-31 | 扬州大学 | 流感病毒小体包被的仿生纳米疫苗及其制备方法 |
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Family Cites Families (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3065141A (en) * | 1960-08-24 | 1962-11-20 | Albert E Gessler | Separation of nucleoproteins and nucleic acids from aqueous protein mixtures |
| GB1193378A (en) | 1967-04-11 | 1970-05-28 | Rand Dev Corp | Cancer Antigen Complexes |
| US3843443A (en) * | 1973-03-30 | 1974-10-22 | J Fishman | Polypeptide materials bound to fluorocarbon polymers |
| US4332787A (en) * | 1980-06-23 | 1982-06-01 | The Massachusetts General Hospital | Assay for beta-adrenergic antagonists and antibody therefor |
| US4689398A (en) * | 1984-06-20 | 1987-08-25 | Ortho Diagnostic Systems Inc. | HTLV test using synthetic peptides |
| US4716102A (en) * | 1984-08-15 | 1987-12-29 | Regents Of The University Of California | Purified AIDS-associated virus ARV-2 |
| EP0252531B1 (de) * | 1986-06-12 | 1992-12-02 | BEHRINGWERKE Aktiengesellschaft | Strukturelles Phosphoprotein (pp 150) des menschlichen Cytomegalovirus, seine Herstellung und Verwendung |
| EP0257758B1 (en) * | 1986-08-07 | 1993-03-10 | Minnesota Mining And Manufacturing Company | Stable biologically active fluorochemical emulsions |
| US4954444A (en) | 1987-03-02 | 1990-09-04 | E. I. Du Pont De Nemours And Company | Enzyme immobilization and bioaffinity separations with perfluorocarbon polymer-based supports |
| US5055562A (en) | 1988-02-01 | 1991-10-08 | Biomira, Inc. | Fluorocarbon chain-containing antigenic conjugates |
| US5021551A (en) * | 1989-01-18 | 1991-06-04 | Washington University | Method of enhancing peptide immunogenicity |
| US5703055A (en) * | 1989-03-21 | 1997-12-30 | Wisconsin Alumni Research Foundation | Generation of antibodies through lipid mediated DNA delivery |
| US6413516B1 (en) * | 1989-03-21 | 2002-07-02 | The Immune Response Corporation | Peptides and methods against psoriasis |
| US5817318A (en) * | 1989-05-03 | 1998-10-06 | Connaught Laboratories Limited | Synthetic peptides for an HIV-1 vaccine |
| CA2080835A1 (en) * | 1990-04-18 | 1991-10-19 | Jan H. Wong | A 35kd tumor associated protein antigen and immune complex |
| AU658836B2 (en) * | 1990-09-25 | 1995-05-04 | Xenova Research Limited | Viral defective vaccine produced by transcomplementing cell line |
| US5871746A (en) * | 1990-12-18 | 1999-02-16 | Institut National De La Sainte Et De La Recherche Medicale (Inserm) | Cytotoxic T lymphocyte-inducing lipopeptides and use as vaccines |
| AU654481B2 (en) * | 1991-03-14 | 1994-11-10 | British Technology Group Usa, Inc. | Recombinant anticoccidial vaccine |
| EP0503203A1 (en) | 1991-03-15 | 1992-09-16 | Merrell Dow Pharmaceuticals Inc. | Novel thrombin inhibitors |
| WO2003040165A2 (en) | 2000-10-19 | 2003-05-15 | Epimmune Inc. | Hla class i and ii binding peptides and their uses |
| IL109664A0 (en) | 1993-05-18 | 1994-08-26 | Rijksuniversiteit | Peptides of human influenza virus for use in human t cell response inducing compositions |
| EP0702563B1 (en) * | 1993-05-27 | 2003-08-06 | EntreMed, Inc. | Compositions and methods for treating cancer and hyperproliferative disorders |
| US7344722B1 (en) * | 1993-06-29 | 2008-03-18 | The Regents Of The University Of Michigan | Cold-adapted influenza virus |
| WO1995029193A2 (en) * | 1994-04-22 | 1995-11-02 | The Government Of The United States Of America Represented By The Secretary, Department Of Health And Human Services | Melanoma antigens |
| GB9420146D0 (en) * | 1994-10-06 | 1994-11-23 | Cancer Res Campaign Tech | Papillomavirus vaccine |
| US6548046B1 (en) * | 1995-06-08 | 2003-04-15 | Barnes-Jewish Hospital | Site specific binding system, imaging compositions and methods |
| US6069232A (en) * | 1995-10-02 | 2000-05-30 | Hoechst Marion Roussel, Inc. | Polyfluoroalkyl tryptophan tripeptide thrombin inhibitors |
| FR2752161B1 (fr) | 1996-08-07 | 1998-09-25 | Atta | Emulsions multiples de type hydrocarbure-dans-eau-dans- fluorocarbone pour le transport de substances medicamenteuses hydrophiles et/ou lipophiles |
| US6884414B1 (en) | 1997-04-30 | 2005-04-26 | Mount Sinai School Of Medicine Of New York University | Recombinant influenza viruses expressing tumor-associated antigens as antitumor agents |
| US6121123A (en) | 1997-09-05 | 2000-09-19 | Advanced Micro Devices, Inc. | Gate pattern formation using a BARC as a hardmask |
| EP1023058A2 (en) | 1997-10-24 | 2000-08-02 | Alliance Pharmaceutical Corp. | Amelioration of ischemic damage using synthetic oxygen carriers |
| CA2323632A1 (en) | 1998-03-13 | 1999-09-16 | Epimmune Inc. | Hla-binding peptides and their uses |
| IL127331A0 (en) * | 1998-11-30 | 1999-09-22 | Yeda Res & Dev | Peptide-based vaccine for influenza |
| EP1189624A4 (en) | 1999-06-29 | 2005-02-23 | Epimmune Inc | Hla binding peptides and their uses |
| FR2806727A1 (fr) | 2000-03-23 | 2001-09-28 | Pf Medicament | Molecule d'interet pharmaceutique comprotant en son extremite n-terminale un acide glutamique ou une glutamine sous forme de sel d'addition d'acide fort physiologiquement acceptable |
| US6676963B1 (en) * | 2000-10-27 | 2004-01-13 | Barnes-Jewish Hospital | Ligand-targeted emulsions carrying bioactive agents |
| RU2218175C2 (ru) * | 2001-03-06 | 2003-12-10 | Научно-исследовательский институт по изучению лепры | Способ стимуляции образования антител при иммунизации лабораторных животных |
| WO2002072627A2 (en) | 2001-03-09 | 2002-09-19 | Callistogen Ag | Induction of anti-tumor cytotoxic t-lymphocytes in humans using peptide epitopes found by computer based algorithms for vaccination |
| JP2006512300A (ja) | 2002-10-03 | 2006-04-13 | エピミューン インコーポレイテッド | Ｈｌａ結合ペプチド及びその使用 |
| US20050013826A1 (en) | 2002-12-20 | 2005-01-20 | Shneider Alexander M. | Vaccine compositions and methods |
| US8592197B2 (en) | 2003-07-11 | 2013-11-26 | Novavax, Inc. | Functional influenza virus-like particles (VLPs) |
| EP1722819B1 (en) | 2004-03-12 | 2007-12-26 | Intercell AG | Method for solubilising peptide mixtures |
| GB0408164D0 (en) * | 2004-04-13 | 2004-05-19 | Immune Targeting Systems Ltd | Antigen delivery vectors and constructs |
| GB0716992D0 (en) | 2007-08-31 | 2007-10-10 | Immune Targeting Systems Its L | Influenza antigen delivery vectors and constructs |
| JP5260962B2 (ja) | 2004-12-30 | 2013-08-14 | インテル・コーポレーション | 複数の命令シーケンサでのスレッド実行に基づく命令セットのためのメカニズム |
| FR2883563B1 (fr) | 2005-03-24 | 2007-06-01 | Ts Pharma Sarl | Nouveaux vecteurs cationiques bolaformes hemifluorocarbones et leurs applications |
| PL2478916T3 (pl) * | 2006-01-27 | 2020-11-16 | Seqirus UK Limited | Szczepionki przeciw grypie zawierające hemaglutyninę i białka macierzy |
| GB0613977D0 (en) | 2006-02-07 | 2006-08-23 | Peptcell Ltd | Peptide sequences and compositions |
| EP1982992B1 (en) * | 2006-02-07 | 2010-10-27 | NEC Corporation | Hla-binding peptide, precursor thereof, dna fragment encoding the same and recombinant vector |
| GB201022147D0 (en) | 2010-12-31 | 2011-02-16 | Immune Targeting Systems Its Ltd | Formulation |
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