JP5752683B2 - 薬剤の共送達のためのカニューレアセンブリ - Google Patents
薬剤の共送達のためのカニューレアセンブリ Download PDFInfo
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- JP5752683B2 JP5752683B2 JP2012516738A JP2012516738A JP5752683B2 JP 5752683 B2 JP5752683 B2 JP 5752683B2 JP 2012516738 A JP2012516738 A JP 2012516738A JP 2012516738 A JP2012516738 A JP 2012516738A JP 5752683 B2 JP5752683 B2 JP 5752683B2
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- drug
- cannula
- formulation
- needle assembly
- injection device
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
- A61M5/2448—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic comprising means for injection of two or more media, e.g. by mixing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
- A61M5/329—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles characterised by features of the needle shaft
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
- A61M5/3293—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles characterised by features of the needle hub
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
- A61M5/3294—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles comprising means for injection of two or more media, e.g. by mixing
Landscapes
- Health & Medical Sciences (AREA)
- Vascular Medicine (AREA)
- Engineering & Computer Science (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
- Materials For Medical Uses (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US22043809P | 2009-06-25 | 2009-06-25 | |
| US61/220,438 | 2009-06-25 | ||
| EP09010325 | 2009-08-11 | ||
| EP09010325.0 | 2009-08-11 | ||
| PCT/EP2010/058984 WO2010149734A1 (en) | 2009-06-25 | 2010-06-24 | Cannula assembly for co-delivery of medicaments |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012530578A JP2012530578A (ja) | 2012-12-06 |
| JP2012530578A5 JP2012530578A5 (https=) | 2013-08-08 |
| JP5752683B2 true JP5752683B2 (ja) | 2015-07-22 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| JP2012516738A Expired - Fee Related JP5752683B2 (ja) | 2009-06-25 | 2010-06-24 | 薬剤の共送達のためのカニューレアセンブリ |
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| EP (1) | EP2445544A1 (https=) |
| JP (1) | JP5752683B2 (https=) |
| CA (1) | CA2764418A1 (https=) |
| WO (1) | WO2010149734A1 (https=) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006083876A2 (en) | 2005-02-01 | 2006-08-10 | Intelliject, Llc | Devices, systems, and methods for medicament delivery |
| US20070202186A1 (en) | 2006-02-22 | 2007-08-30 | Iscience Interventional Corporation | Apparatus and formulations for suprachoroidal drug delivery |
| US8197435B2 (en) | 2006-05-02 | 2012-06-12 | Emory University | Methods and devices for drug delivery to ocular tissue using microneedle |
| WO2012011909A1 (en) | 2010-07-22 | 2012-01-26 | Becton, Dickinson And Company | Needle assembly for mixing of substances |
| CN103140252A (zh) * | 2010-09-27 | 2013-06-05 | 泰尔茂株式会社 | 带针医疗器具 |
| US20120271272A1 (en) | 2010-10-15 | 2012-10-25 | Iscience Interventional Corporation | Device for ocular access |
| US9084849B2 (en) | 2011-01-26 | 2015-07-21 | Kaleo, Inc. | Medicament delivery devices for administration of a medicament within a prefilled syringe |
| US9272093B2 (en) | 2011-02-09 | 2016-03-01 | Sanofi-Aventis Deutschland Gmbh | Dual drug pen-injection device with micro-reservoirs carrying secondary drug for emergency injection |
| EP2750741A1 (en) | 2011-08-30 | 2014-07-09 | Novo Nordisk A/S | Arrangement for sequential delivery of fluid volumes |
| US10052435B2 (en) | 2012-01-31 | 2018-08-21 | Precifiex SA | Skin-attachable miniature drug injection device with remote activation capability and dry drug carrier within injection needle |
| US9522235B2 (en) | 2012-05-22 | 2016-12-20 | Kaleo, Inc. | Devices and methods for delivering medicaments from a multi-chamber container |
| EP2916827B1 (en) | 2012-11-08 | 2020-06-10 | Clearside Biomedical Inc. | Methods for the treatment of ocular disease in human subjects |
| WO2014100097A1 (en) * | 2012-12-19 | 2014-06-26 | Allergan, Inc. | Syringe assembly |
| WO2014169081A2 (en) * | 2013-04-09 | 2014-10-16 | Biodel, Inc. | Methods and devices for point of use mixing of pharmaceutical formulations |
| SG10201702674PA (en) | 2013-05-03 | 2017-06-29 | Clearside Biomedical Inc | Apparatus and methods for ocular injection |
| EP3003454B1 (en) | 2013-06-03 | 2020-01-08 | Clearside Biomedical, Inc. | Apparatus for drug delivery using multiple reservoirs |
| DE102013112856A1 (de) | 2013-11-21 | 2015-05-21 | fzmb GmbH, Forschungszentrum für Medizintechnik und Biotechnologie | Verfahren und Vorrichtung zum Lagern und Rekonstituieren von getrockneten Wirkstoffen |
| CN105792868B (zh) | 2013-12-06 | 2022-05-31 | 豪夫迈·罗氏有限公司 | 用于低体积药物递送的设备和方法 |
| RU2710491C2 (ru) | 2014-06-20 | 2019-12-26 | Клиасайд Байомедикал, Инк. | Устройство для инъекции лекарственного средства в глазную ткань и способ инъекции лекарственного средства в глазную ткань |
| NO20140798A1 (no) * | 2014-06-23 | 2015-12-24 | Dyreidentitet As | Apparat til injeksjon av ampuller |
| US9517307B2 (en) | 2014-07-18 | 2016-12-13 | Kaleo, Inc. | Devices and methods for delivering opioid antagonists including formulations for naloxone |
| USD750223S1 (en) | 2014-10-14 | 2016-02-23 | Clearside Biomedical, Inc. | Medical injector for ocular injection |
| EP3274021B1 (en) | 2015-03-24 | 2024-02-14 | Kaleo, Inc. | Devices and methods for delivering a lyophilized medicament |
| WO2016172281A1 (en) * | 2015-04-22 | 2016-10-27 | Medtronic, Inc. | Shaped lead introducer for epidural space |
| AU2016286525A1 (en) | 2015-07-02 | 2018-02-15 | Marc Andrew Koska | Single use delivery device prefilled with a reconstitutable agent |
| WO2017139375A1 (en) | 2016-02-10 | 2017-08-17 | Clearside Biomedical, Inc. | Ocular injection kit, packaging, and methods of use |
| MX2018012967A (es) | 2016-04-25 | 2019-03-06 | Koska Family Ltd | Sistema de suministro medico. |
| CA3062845A1 (en) | 2016-05-02 | 2017-11-09 | Clearside Biomedical, Inc. | Systems and methods for ocular drug delivery |
| EP3496680B1 (en) | 2016-08-12 | 2024-10-02 | Clearside Biomedical, Inc. | Device for adjusting the insertion depth of a needle for medicament delivery |
| WO2018204515A1 (en) | 2017-05-02 | 2018-11-08 | Georgia Tech Research Corporation | Targeted drug delivery methods using a microneedle |
| KR102639913B1 (ko) | 2017-11-17 | 2024-02-23 | 코스카 패밀리 리미티드 | 유체 전달 매니폴드를 위한 시스템 및 방법 |
| US12544511B2 (en) | 2018-06-20 | 2026-02-10 | Koska Family Limited | Systems and methods for pre-filled dual-chamber medical agent delivery |
| USD1052082S1 (en) | 2020-06-01 | 2024-11-19 | Koska Family Limited | Sealed fluid container |
| USD992110S1 (en) | 2021-08-10 | 2023-07-11 | Koska Family Limited | Sealed fluid container |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2210910A5 (en) | 1972-12-15 | 1974-07-12 | Lablabo | Dispenser for two part liquid compns - with one liquid contained in tube applicable to mouth of second liquid dispenser |
| US4197846A (en) * | 1974-10-09 | 1980-04-15 | Louis Bucalo | Method for structure for situating in a living body agents for treating the body |
| FR2604363A1 (fr) * | 1986-09-30 | 1988-04-01 | Merieux Inst | Dispositif d'injection de substances, notamment medicamenteuses |
| US5395319A (en) * | 1991-03-06 | 1995-03-07 | Suddeutsche Feinmechanik Gmbh | Needle for inserting an object into the body |
| US5330426A (en) * | 1992-08-13 | 1994-07-19 | Science Incorporated | Mixing and delivery syringe assembly |
| FR2775436A1 (fr) | 1998-02-27 | 1999-09-03 | Alain Monfreux | Dispositif pour l'administration parenterale d'une composition sous forme d'une mousse |
| US6862470B2 (en) * | 1999-02-02 | 2005-03-01 | Senorx, Inc. | Cavity-filling biopsy site markers |
| AU2997500A (en) * | 1999-02-16 | 2000-09-04 | Prismedical Corporation | Single dose delivery device |
| US20030006159A1 (en) | 1999-09-01 | 2003-01-09 | Jorgen Thorball | Additive tube for enteral nutrition apparatus |
| US7481826B2 (en) * | 2003-09-30 | 2009-01-27 | Ethicon, Inc. | Fluid emitting suture needle |
| EP1727578A4 (en) | 2004-03-10 | 2009-01-07 | Rxtrocar Ltd | TROCAR CANNULA COMPLEX, CANNULA, AND METHOD FOR DISTRIBUTING BIOLOGICALLY ACTIVE AGENTS IN MINIMAL-INVASIVE SURGERY |
| CA2609810C (en) * | 2005-06-06 | 2012-05-22 | Camurus Ab | Glp-1 analogue formulations |
-
2010
- 2010-06-24 JP JP2012516738A patent/JP5752683B2/ja not_active Expired - Fee Related
- 2010-06-24 CA CA2764418A patent/CA2764418A1/en not_active Abandoned
- 2010-06-24 US US13/379,592 patent/US8795226B2/en not_active Expired - Fee Related
- 2010-06-24 EP EP10724876A patent/EP2445544A1/en not_active Withdrawn
- 2010-06-24 WO PCT/EP2010/058984 patent/WO2010149734A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| US8795226B2 (en) | 2014-08-05 |
| US20120197210A1 (en) | 2012-08-02 |
| EP2445544A1 (en) | 2012-05-02 |
| WO2010149734A1 (en) | 2010-12-29 |
| JP2012530578A (ja) | 2012-12-06 |
| CA2764418A1 (en) | 2010-12-29 |
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