JP5746617B2 - キトサン混合物を形成する注入可能なヒドロゲル - Google Patents

キトサン混合物を形成する注入可能なヒドロゲル Download PDF

Info

Publication number
JP5746617B2
JP5746617B2 JP2011513112A JP2011513112A JP5746617B2 JP 5746617 B2 JP5746617 B2 JP 5746617B2 JP 2011513112 A JP2011513112 A JP 2011513112A JP 2011513112 A JP2011513112 A JP 2011513112A JP 5746617 B2 JP5746617 B2 JP 5746617B2
Authority
JP
Japan
Prior art keywords
chitosan
composition
highly
kda
hydrogel
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP2011513112A
Other languages
English (en)
Japanese (ja)
Other versions
JP2011522879A (ja
JP2011522879A5 (enExample
Inventor
ベン−シャロム ノア
ベン−シャロム ノア
ネボ ジヴィ
ネボ ジヴィ
パッチョーニク エイブラハム
パッチョーニク エイブラハム
ロビンドン ドロール
ロビンドン ドロール
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chi2Gel Ltd
Original Assignee
Chi2Gel Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US12/155,916 external-priority patent/US8153612B2/en
Application filed by Chi2Gel Ltd filed Critical Chi2Gel Ltd
Publication of JP2011522879A publication Critical patent/JP2011522879A/ja
Publication of JP2011522879A5 publication Critical patent/JP2011522879A5/ja
Application granted granted Critical
Publication of JP5746617B2 publication Critical patent/JP5746617B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J3/00—Processes of treating or compounding macromolecular substances
    • C08J3/02—Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques
    • C08J3/03—Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques in aqueous media
    • C08J3/075—Macromolecular gels
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
    • A23L29/20—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents
    • A23L29/275—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents of animal origin, e.g. chitin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/04—Dispersions; Emulsions
    • A61K8/042—Gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A61K8/736—Chitin; Chitosan; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0043—Nose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/20—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/52—Hydrogels or hydrocolloids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
    • C08L5/08—Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/91—Injection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2305/00—Characterised by the use of polysaccharides or of their derivatives not provided for in groups C08J2301/00 or C08J2303/00
    • C08J2305/08—Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Dermatology (AREA)
  • Dispersion Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Polymers & Plastics (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • Birds (AREA)
  • Urology & Nephrology (AREA)
  • Organic Chemistry (AREA)
  • Cell Biology (AREA)
  • Reproductive Health (AREA)
  • Botany (AREA)
  • Nutrition Science (AREA)
  • Gynecology & Obstetrics (AREA)
  • Food Science & Technology (AREA)
  • Neurosurgery (AREA)
  • Inorganic Chemistry (AREA)
  • Otolaryngology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Medicinal Preparation (AREA)
  • Materials For Medical Uses (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
JP2011513112A 2008-06-11 2009-06-11 キトサン混合物を形成する注入可能なヒドロゲル Expired - Fee Related JP5746617B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US12/155,916 US8153612B2 (en) 2006-12-11 2008-06-11 Injectable chitosan mixtures forming hydrogels
US12/155,916 2008-06-11
PCT/IL2009/000582 WO2009150651A1 (en) 2008-06-11 2009-06-11 Injectable hydrogel forming chitosan mixtures

Publications (3)

Publication Number Publication Date
JP2011522879A JP2011522879A (ja) 2011-08-04
JP2011522879A5 JP2011522879A5 (enExample) 2012-07-26
JP5746617B2 true JP5746617B2 (ja) 2015-07-08

Family

ID=41092178

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2011513112A Expired - Fee Related JP5746617B2 (ja) 2008-06-11 2009-06-11 キトサン混合物を形成する注入可能なヒドロゲル

Country Status (5)

Country Link
EP (1) EP2294126A1 (enExample)
JP (1) JP5746617B2 (enExample)
AU (1) AU2009258885A1 (enExample)
CA (1) CA2727588A1 (enExample)
WO (1) WO2009150651A1 (enExample)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8716204B2 (en) 2010-07-27 2014-05-06 Zimmer, Inc. Synthetic synovial fluid compositions and methods for making the same
GB201020193D0 (en) * 2010-11-29 2011-01-12 Biotec Pharmacon Asa Glucan compositions
US10064960B2 (en) 2011-11-25 2018-09-04 Danmarks Tekniske Universitet Formulation of solid nano-sized particles in a gel-forming system
FR2983070B1 (fr) * 2011-11-30 2014-04-25 Cytosial Biomedic Solution aqueuse homogene de chitosane injectable
US9999676B2 (en) 2012-11-27 2018-06-19 Utah-Inha Dds & Advanced Therapeutics Research Center Biodegradable microbead comprising anionic polymer for improving adsorptive power to anticancer drugs, and method for preparing same
TWI624270B (zh) 2013-01-17 2018-05-21 財團法人工業技術研究院 藥物組合物
RU2016129138A (ru) * 2013-12-19 2018-01-24 Новартис Аг Системы доставки лекарственных средств
FR3029422B1 (fr) 2014-12-05 2017-01-13 Synolyne Pharma Microbille d'hydrogel
FR3035327B1 (fr) 2015-04-23 2021-07-02 Cytosial Biomedic Solution aqueuse homogene de chitosane ou derive de chitosane injectable presentant un ph proche du ph physiologique
US20190224229A1 (en) * 2016-09-05 2019-07-25 Association For The Advancement Of Tissue Engineering And Cell Based Technologies Kefiran for use in regenerative medicine and/or tissue engineering
FR3057778B1 (fr) * 2016-10-25 2020-05-22 Bioxis Pharmaceuticals Nouvelles compositions actives sur les adipocytes
JP7069494B2 (ja) * 2017-10-02 2022-05-18 花王株式会社 脱アセチル化キチンの製造方法
WO2019242847A1 (en) * 2018-06-19 2019-12-26 Westfälische Wilhelms-Universität Münster Process for the preparation of a non-random chitosan polymer
FR3091995B1 (fr) 2019-01-30 2022-11-11 Bioxis Pharmaceuticals Modelage de Gel de Chitosane
BR112022006344A2 (pt) * 2019-10-03 2023-01-10 Vitruvia Holdings Inc Método de restauração de tecido conjuntivo
CN111388755A (zh) * 2020-03-20 2020-07-10 东华大学 一种可注射型透明质酸/壳聚糖水凝胶及其制备方法
WO2023183769A1 (en) * 2022-03-21 2023-09-28 University Of Washington Chitosan scaffolds and thin films for the expansion of human neural stem cells

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH10309287A (ja) * 1997-05-12 1998-11-24 Matsumoto Shika Univ 骨補填材、及びその製造方法
CA2212300A1 (en) * 1997-08-04 1999-02-04 Abdellatif Chenite In vitro or in vivo gelfying chitosan and therapeutic uses thereof
KR100451399B1 (ko) * 2001-11-02 2004-10-06 주식회사 건풍바이오 키토산의 아세틸화 방법
GB0302738D0 (en) * 2003-02-06 2003-03-12 Advanced Biopolymers As Composition
JP2005132737A (ja) * 2003-10-28 2005-05-26 Kyoko Koto 埋込型製剤の薬物保持担体
EP1730216A1 (en) * 2004-03-22 2006-12-13 Universite De Geneve Pseudo-thermosetting neutralized chitosan composition forming a hydrogel and a process for producing the same
JP5632125B2 (ja) * 2005-06-14 2014-11-26 ジェニス イーエイチエフ．Ｇｅｎｉｓ ｅｈｆ． 部分的脱アセチル化キチン誘導体の組成物
CA2672495C (en) * 2006-12-11 2017-01-17 Chi2Gel Ltd. Novel injectable chitosan mixtures forming hydrogels

Also Published As

Publication number Publication date
JP2011522879A (ja) 2011-08-04
WO2009150651A1 (en) 2009-12-17
EP2294126A1 (en) 2011-03-16
AU2009258885A1 (en) 2009-12-17
WO2009150651A4 (en) 2010-02-18
CA2727588A1 (en) 2009-12-17

Similar Documents

Publication Publication Date Title
JP5746617B2 (ja) キトサン混合物を形成する注入可能なヒドロゲル
EP2121026B1 (en) Novel injectable chitosan mixtures forming hydrogels
US8153612B2 (en) Injectable chitosan mixtures forming hydrogels
US9034348B2 (en) Injectable chitosan mixtures forming hydrogels
Lee et al. Controlled degradation of hydrogels using multi-functional cross-linking molecules
Leone et al. Enriched Gellan Gum hydrogel as visco-supplement
Zhang et al. Synthesis and characterization of a degradable composite agarose/HA hydrogel
Weng et al. Non-cytotoxic, in situ gelable hydrogels composed of N-carboxyethyl chitosan and oxidized dextran
US8481080B2 (en) Method of cross-linking hyaluronic acid with divinulsulfone
CN105142399B (zh) 生物相容的和生物可吸收的衍生的壳聚糖组合物
JP2014521492A (ja) 注入充填剤（フィラー）｛ｉｎｊｅｃｔａｂｌｅｆｉｌｌｅｒ｝
IL193640A (en) Biodegradable foam
CN105451786B (zh) 交联的透明质酸、用于其制备的工艺及其在美学领域中的用途
Giri et al. Polysaccharide Hydrogels for Drug Delivery and Regenerative Medicine
Fakhari Biomedical application of hyaluronic acid nanoparticles
Calles et al. Hyaluronan–itaconic acid–glutaraldehyde films for biomedical applications: preliminary studies
CA2956658C (en) Composition comprising polyglucosamine-glyoxylate solutions mixed with hyaluronan
US10857176B2 (en) Composition comprising polyglucosamine-glyoxylate solutions mixed with hyaluronan
Sudha et al. Advances in guar gum-based materials in biomedical applications with special reference to tissue engineering applications
Nagpal et al. Pharmaceutical applications of gellan gum
KR20240168062A (ko) 생체적합성 고분자와 하이드록시에틸전분을 함유한 파우더형 유착방지제 및 이의 제조방법
CN115806633A (zh) 京尼平交联的pdrn-sacran生物聚合物支架

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20120611

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20120611

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20131025

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20131112

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20140212

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20140219

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20140509

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20140930

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20141211

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20150414

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20150508

R150 Certificate of patent or registration of utility model

Ref document number: 5746617

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

LAPS Cancellation because of no payment of annual fees