JP5745210B2 - 筋ジストロフィーの治療用薬剤のニトロオキシ誘導体の使用 - Google Patents
筋ジストロフィーの治療用薬剤のニトロオキシ誘導体の使用 Download PDFInfo
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- JP5745210B2 JP5745210B2 JP2008552778A JP2008552778A JP5745210B2 JP 5745210 B2 JP5745210 B2 JP 5745210B2 JP 2008552778 A JP2008552778 A JP 2008552778A JP 2008552778 A JP2008552778 A JP 2008552778A JP 5745210 B2 JP5745210 B2 JP 5745210B2
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- muscular dystrophy
- muscle
- compound
- treatment
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
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- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
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- Organic Chemistry (AREA)
- Emergency Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Neurology (AREA)
- Physical Education & Sports Medicine (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
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| PCT/EP2007/050630 WO2007088123A2 (en) | 2006-02-03 | 2007-01-23 | Use of nitrooxyderivative of drug for the treatment of muscular dystrophies |
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| CN (1) | CN101378739B (enExample) |
| AU (1) | AU2007211508B2 (enExample) |
| CA (1) | CA2641816C (enExample) |
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| EP2669269B1 (en) | 2005-05-27 | 2019-05-22 | The University of North Carolina At Chapel Hill | Nitric oxide-releasing particles for nitric oxide therapeutics and biomedical applications |
| CN101534843A (zh) | 2006-08-01 | 2009-09-16 | 普里克萨斯医药股份有限公司 | 泊洛沙姆用于预防和/或治疗心力衰竭的用途 |
| JP2010523612A (ja) * | 2007-04-13 | 2010-07-15 | ニコックス エス エイ | アトルバスタチン４−（ニトロオキシ）ブチルエステルの結晶形態 |
| EP2234625B8 (en) | 2007-12-17 | 2013-10-30 | The Regents of the University of Michigan | Compositions and methods for treating and preventing skeletal muscle deficiencies |
| AU2009231258A1 (en) * | 2008-04-04 | 2009-10-08 | Biomarin Iga Limited | Compounds for treating muscular dystrophy |
| WO2010108843A1 (en) | 2009-03-27 | 2010-09-30 | Nicox S.A. | Use of nitrooxyderivative of paracetamol for the treatment of muscular dystrophies |
| EP2467173B8 (en) | 2009-08-21 | 2019-06-19 | Novan, Inc. | Wound dressings, methods of using the same and methods of forming the same |
| WO2011022652A1 (en) | 2009-08-21 | 2011-02-24 | Novan, Inc. | Topical gels |
| US9023890B2 (en) | 2009-12-02 | 2015-05-05 | The Charlotte-Mecklenburg Hospital Authority | Nitrate esters and their use for the treatment of muscle and muscle related diseases |
| US8591876B2 (en) | 2010-12-15 | 2013-11-26 | Novan, Inc. | Methods of decreasing sebum production in the skin |
| WO2012118819A2 (en) | 2011-02-28 | 2012-09-07 | Novan, Inc. | Nitric oxide-releasing s-nitrosothiol-modified silica particles and methods of making the same |
| US9452117B2 (en) | 2011-06-01 | 2016-09-27 | The Charlotte-Mecklenburg Hospital Authority | Nitrate esters and their use for the treatment of muscle and muscle related diseases |
| US9844599B2 (en) | 2013-01-21 | 2017-12-19 | Apparao Satyam | Nitric oxide releasing produgs of therapeutic agents |
| RU2517259C1 (ru) * | 2013-03-06 | 2014-05-27 | Федеральное государственное бюджетное учреждение науки Государственный научный центр Российской Федерации - Институт медико-биологических проблем Российской академии наук (ГНЦ РФ-ИМБП РАН) | Способ профилактики и снижения деструкции белков скелетных мышц при их атрофии, вызванной гипокинезией и/или гравитационной разгрузкой |
| WO2014169976A1 (en) * | 2013-04-18 | 2014-10-23 | Nicox Science Ireland | Quinone based nitric oxide donating compounds |
| US9974767B2 (en) | 2014-07-14 | 2018-05-22 | University Of Washington | Statins in the treatment of muscular dystrophies and myopathies |
| KR101661332B1 (ko) | 2015-05-28 | 2016-09-29 | (의료)길의료재단 | 글루카곤 유사 펩타이드-1 수용체 항진제를 포함하는 근감소증 치료용 약학 조성물 |
| US10993993B2 (en) | 2015-05-28 | 2021-05-04 | Immunoforge Co., Ltd. | Pharmaceutical composition for treating muscle atrophy or sarcopenia including glucagon-like peptide (GLP-1) or GLP-1 receptor agonist |
| AR111295A1 (es) | 2017-03-20 | 2019-06-26 | Forma Therapeutics Inc | Composiciones de pirrolopirrol como activadores de piruvato quinasa (pkr) |
| CA3090241C (en) | 2018-04-25 | 2023-03-28 | Oncocross Co.,Ltd. | Composition for preventing and treating muscular disease |
| WO2020055186A1 (ko) | 2018-09-14 | 2020-03-19 | 고려대학교 산학협력단 | If1 을 유효성분으로 함유하는 비만 또는 근감소증의 예방 또는 치료용 약학 조성물 |
| WO2020061255A1 (en) | 2018-09-19 | 2020-03-26 | Forma Therapeutics, Inc. | Activating pyruvate kinase r |
| US20200129485A1 (en) | 2018-09-19 | 2020-04-30 | Forma Therapeutics, Inc. | Treating sickle cell disease with a pyruvate kinase r activating compound |
| MX2022003025A (es) | 2019-09-19 | 2022-04-07 | Forma Therapeutics Inc | Activacion de la piruvato cinasa r. |
| US12128035B2 (en) | 2021-03-19 | 2024-10-29 | Novo Nordisk Health Care Ag | Activating pyruvate kinase R |
| KR102329853B1 (ko) | 2021-03-25 | 2021-11-23 | 주식회사 엔테로바이옴 | 아커만시아 뮤시니필라 균주를 포함하는 근위축증 예방 또는 치료용 약학적 조성물 |
| KR102272616B1 (ko) | 2021-03-25 | 2021-07-05 | 주식회사 엔테로바이옴 | 피컬리박테리움 프로스니치 균주를 포함하는 근위축증 예방 또는 치료용 약학적 조성물 |
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| RU2145595C1 (ru) * | 1994-05-10 | 2000-02-20 | Никокс С.А. | Нитроксисоединения и фармацевтическая композиция на их основе, имеющие противовоспалительную, анальгетическую и антитромбоцитарную активности |
| US5583101A (en) * | 1994-07-15 | 1996-12-10 | Harvard College | Use of nitrogen oxide species and adducts to inhibit skeletal muscle contraction |
| IT1288123B1 (it) * | 1996-09-04 | 1998-09-10 | Nicox Sa | Uso di nitroderivati per l'incontinenza urinaria |
| WO2000053191A2 (en) | 1999-03-11 | 2000-09-14 | The University Of Manitoba | Modulation of skeletal muscle precursor cell activation |
| FR2794647A1 (fr) * | 1999-06-11 | 2000-12-15 | Centre Nat Rech Scient | Compositions pharmaceutique comprenant du no ou au moins un compose capable de liberer ou d'induire la formation de no dans les cellules |
| ITMI991517A1 (it) | 1999-07-09 | 2001-01-09 | Nicox Sa | Procedimento per ottenere nitrossimetil fenil esterni di derivati dell'acido salicilico |
| IT1313596B1 (it) * | 1999-08-04 | 2002-09-09 | Nicox Sa | Processo per la preparazione di nitrossialchil esteri del naproxene |
| ITMI20011744A1 (it) * | 2001-08-09 | 2003-02-09 | Nicox Sa | Farmaci per le vasculopatie |
| ITMI20021392A1 (it) * | 2002-06-25 | 2003-12-29 | Nicox Sa | Forme farmaceutiche per la somministrazione orale di farmaci liquidi a temperatura ambiente dotate di migliore biodisponibilita' |
| US7166638B2 (en) * | 2003-05-27 | 2007-01-23 | Nicox S.A. | Statin derivatives |
| WO2005023189A2 (en) * | 2003-09-03 | 2005-03-17 | Pharmacia Corporation | Method of cox-2 selective inhibitor and nitric oxide-donating agent |
| GB0321228D0 (en) * | 2003-09-10 | 2003-10-08 | Inpharmatica Ltd | Modulating cell activity |
| CA2611140C (en) * | 2005-06-09 | 2013-11-19 | University Of Manitoba | Compositions and methods for enhancing nitric oxide delivery |
| EP1983975B1 (en) | 2006-02-03 | 2015-07-29 | Giulio Cossu | Method of treatment for muscular dystrophy |
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Also Published As
| Publication number | Publication date |
|---|---|
| NZ569396A (en) | 2011-06-30 |
| EP2786749A1 (en) | 2014-10-08 |
| ES2520893T3 (es) | 2014-11-12 |
| DK1978947T3 (da) | 2014-11-03 |
| KR20080097989A (ko) | 2008-11-06 |
| AU2007211508B2 (en) | 2012-08-23 |
| WO2007088123A2 (en) | 2007-08-09 |
| WO2007088123A3 (en) | 2007-09-20 |
| PT1978947E (pt) | 2014-11-03 |
| RU2011118522A (ru) | 2012-11-20 |
| CA2641816C (en) | 2016-01-05 |
| HK1129592A1 (en) | 2009-12-04 |
| CA2641816A1 (en) | 2007-08-09 |
| IL192299A0 (en) | 2009-08-03 |
| AU2007211508A1 (en) | 2007-08-09 |
| US20090093510A1 (en) | 2009-04-09 |
| SI1978947T1 (sl) | 2014-12-31 |
| CN101378739B (zh) | 2014-06-04 |
| RU2008135153A (ru) | 2010-03-10 |
| US8575222B2 (en) | 2013-11-05 |
| EP1978947B1 (en) | 2014-08-13 |
| PL1978947T3 (pl) | 2015-03-31 |
| ZA200805716B (en) | 2009-11-25 |
| RU2429828C2 (ru) | 2011-09-27 |
| EP1978947A2 (en) | 2008-10-15 |
| CN101378739A (zh) | 2009-03-04 |
| JP2009525302A (ja) | 2009-07-09 |
| RU2560144C2 (ru) | 2015-08-20 |
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