NZ569396A - Use of nitrooxyderivative of drug for the treatment of muscular dystrophies - Google Patents
Use of nitrooxyderivative of drug for the treatment of muscular dystrophiesInfo
- Publication number
- NZ569396A NZ569396A NZ569396A NZ56939607A NZ569396A NZ 569396 A NZ569396 A NZ 569396A NZ 569396 A NZ569396 A NZ 569396A NZ 56939607 A NZ56939607 A NZ 56939607A NZ 569396 A NZ569396 A NZ 569396A
- Authority
- NZ
- New Zealand
- Prior art keywords
- integer
- formula
- april
- recieved iponz
- group
- Prior art date
Links
- 201000006938 muscular dystrophy Diseases 0.000 title claims abstract description 19
- 239000003814 drug Substances 0.000 title claims abstract description 18
- 238000011282 treatment Methods 0.000 title claims abstract description 16
- 229940079593 drug Drugs 0.000 title description 13
- 229910004679 ONO2 Inorganic materials 0.000 claims abstract description 10
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims abstract description 5
- 239000002840 nitric oxide donor Substances 0.000 claims abstract description 5
- 238000002360 preparation method Methods 0.000 claims abstract description 3
- 150000001875 compounds Chemical class 0.000 claims description 17
- -1 [1,1'-biphenyl]4-acetic acid 4-nitrooxybutyl ester Chemical class 0.000 claims description 8
- 229960005205 prednisolone Drugs 0.000 claims description 7
- OIGNJSKKLXVSLS-VWUMJDOOSA-N prednisolone Chemical compound O=C1C=C[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 OIGNJSKKLXVSLS-VWUMJDOOSA-N 0.000 claims description 6
- 101100294106 Caenorhabditis elegans nhr-3 gene Proteins 0.000 claims description 4
- 125000002947 alkylene group Chemical group 0.000 claims description 4
- 125000005843 halogen group Chemical group 0.000 claims description 4
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 4
- 125000001424 substituent group Chemical group 0.000 claims description 4
- 238000012360 testing method Methods 0.000 claims description 4
- 125000000008 (C1-C10) alkyl group Chemical group 0.000 claims description 3
- 125000003031 C5-C7 cycloalkylene group Chemical group 0.000 claims description 3
- 125000000896 monocarboxylic acid group Chemical group 0.000 claims description 3
- 230000036470 plasma concentration Effects 0.000 claims description 2
- 125000002993 cycloalkylene group Chemical group 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 abstract description 3
- 150000002576 ketones Chemical group 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- MWUXSHHQAYIFBG-UHFFFAOYSA-N Nitric oxide Chemical compound O=[N] MWUXSHHQAYIFBG-UHFFFAOYSA-N 0.000 description 30
- 230000000694 effects Effects 0.000 description 8
- 229960001145 deflazacort Drugs 0.000 description 7
- FBHSPRKOSMHSIF-GRMWVWQJSA-N deflazacort Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@@H]2[C@@H]1[C@@H]1C[C@H]3OC(C)=N[C@@]3(C(=O)COC(=O)C)[C@@]1(C)C[C@@H]2O FBHSPRKOSMHSIF-GRMWVWQJSA-N 0.000 description 7
- 210000003205 muscle Anatomy 0.000 description 7
- 241000699670 Mus sp. Species 0.000 description 6
- 241001465754 Metazoa Species 0.000 description 5
- TUZYXOIXSAXUGO-UHFFFAOYSA-N Pravastatin Natural products C1=CC(C)C(CCC(O)CC(O)CC(O)=O)C2C(OC(=O)C(C)CC)CC(O)C=C21 TUZYXOIXSAXUGO-UHFFFAOYSA-N 0.000 description 5
- 239000003246 corticosteroid Substances 0.000 description 5
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- 230000015572 biosynthetic process Effects 0.000 description 4
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- 238000003786 synthesis reaction Methods 0.000 description 4
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- 206010013801 Duchenne Muscular Dystrophy Diseases 0.000 description 3
- 229940121710 HMGCoA reductase inhibitor Drugs 0.000 description 3
- KCWZGJVSDFYRIX-YFKPBYRVSA-N N(gamma)-nitro-L-arginine methyl ester Chemical compound COC(=O)[C@@H](N)CCCN=C(N)N[N+]([O-])=O KCWZGJVSDFYRIX-YFKPBYRVSA-N 0.000 description 3
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 3
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- 102100022745 Laminin subunit alpha-2 Human genes 0.000 description 2
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- 239000003146 anticoagulant agent Substances 0.000 description 2
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- 239000000203 mixture Substances 0.000 description 2
- 201000009340 myotonic dystrophy type 1 Diseases 0.000 description 2
- 208000015122 neurodegenerative disease Diseases 0.000 description 2
- 150000002828 nitro derivatives Chemical class 0.000 description 2
- 239000000041 non-steroidal anti-inflammatory agent Substances 0.000 description 2
- 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 description 2
- 238000007911 parenteral administration Methods 0.000 description 2
- 229960004618 prednisone Drugs 0.000 description 2
- XOFYZVNMUHMLCC-ZPOLXVRWSA-N prednisone Chemical compound O=C1C=C[C@]2(C)[C@H]3C(=O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 XOFYZVNMUHMLCC-ZPOLXVRWSA-N 0.000 description 2
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- 125000006832 (C1-C10) alkylene group Chemical group 0.000 description 1
- IOJUJUOXKXMJNF-UHFFFAOYSA-N 2-acetyloxybenzoic acid [3-(nitrooxymethyl)phenyl] ester Chemical compound CC(=O)OC1=CC=CC=C1C(=O)OC1=CC=CC(CO[N+]([O-])=O)=C1 IOJUJUOXKXMJNF-UHFFFAOYSA-N 0.000 description 1
- 201000001320 Atherosclerosis Diseases 0.000 description 1
- ZNVLSXYRNRZNQE-UHFFFAOYSA-N C1=CN(C=C1)CCCCCCC(=O)OCC2=CC(=CC=C2)CO[N+](=O)[O-] Chemical compound C1=CN(C=C1)CCCCCCC(=O)OCC2=CC(=CC=C2)CO[N+](=O)[O-] ZNVLSXYRNRZNQE-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
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- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
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- A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
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- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
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- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Emergency Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Neurology (AREA)
- Physical Education & Sports Medicine (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US76475506P | 2006-02-03 | 2006-02-03 | |
| PCT/EP2007/050630 WO2007088123A2 (en) | 2006-02-03 | 2007-01-23 | Use of nitrooxyderivative of drug for the treatment of muscular dystrophies |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NZ569396A true NZ569396A (en) | 2011-06-30 |
Family
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Family Applications (1)
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|---|---|---|---|
| NZ569396A NZ569396A (en) | 2006-02-03 | 2007-01-23 | Use of nitrooxyderivative of drug for the treatment of muscular dystrophies |
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| EP (2) | EP1978947B1 (enExample) |
| JP (1) | JP5745210B2 (enExample) |
| KR (1) | KR20080097989A (enExample) |
| CN (1) | CN101378739B (enExample) |
| AU (1) | AU2007211508B2 (enExample) |
| CA (1) | CA2641816C (enExample) |
| DK (1) | DK1978947T3 (enExample) |
| ES (1) | ES2520893T3 (enExample) |
| IL (1) | IL192299A0 (enExample) |
| NZ (1) | NZ569396A (enExample) |
| PL (1) | PL1978947T3 (enExample) |
| PT (1) | PT1978947E (enExample) |
| RU (2) | RU2560144C2 (enExample) |
| SI (1) | SI1978947T1 (enExample) |
| WO (1) | WO2007088123A2 (enExample) |
| ZA (1) | ZA200805716B (enExample) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
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| EP2669269B1 (en) | 2005-05-27 | 2019-05-22 | The University of North Carolina At Chapel Hill | Nitric oxide-releasing particles for nitric oxide therapeutics and biomedical applications |
| CN101534843A (zh) | 2006-08-01 | 2009-09-16 | 普里克萨斯医药股份有限公司 | 泊洛沙姆用于预防和/或治疗心力衰竭的用途 |
| JP2010523612A (ja) * | 2007-04-13 | 2010-07-15 | ニコックス エス エイ | アトルバスタチン４−（ニトロオキシ）ブチルエステルの結晶形態 |
| EP2234625B8 (en) | 2007-12-17 | 2013-10-30 | The Regents of the University of Michigan | Compositions and methods for treating and preventing skeletal muscle deficiencies |
| AU2009231258A1 (en) * | 2008-04-04 | 2009-10-08 | Biomarin Iga Limited | Compounds for treating muscular dystrophy |
| WO2010108843A1 (en) | 2009-03-27 | 2010-09-30 | Nicox S.A. | Use of nitrooxyderivative of paracetamol for the treatment of muscular dystrophies |
| EP2467173B8 (en) | 2009-08-21 | 2019-06-19 | Novan, Inc. | Wound dressings, methods of using the same and methods of forming the same |
| WO2011022652A1 (en) | 2009-08-21 | 2011-02-24 | Novan, Inc. | Topical gels |
| US9023890B2 (en) | 2009-12-02 | 2015-05-05 | The Charlotte-Mecklenburg Hospital Authority | Nitrate esters and their use for the treatment of muscle and muscle related diseases |
| US8591876B2 (en) | 2010-12-15 | 2013-11-26 | Novan, Inc. | Methods of decreasing sebum production in the skin |
| WO2012118819A2 (en) | 2011-02-28 | 2012-09-07 | Novan, Inc. | Nitric oxide-releasing s-nitrosothiol-modified silica particles and methods of making the same |
| US9452117B2 (en) | 2011-06-01 | 2016-09-27 | The Charlotte-Mecklenburg Hospital Authority | Nitrate esters and their use for the treatment of muscle and muscle related diseases |
| US9844599B2 (en) | 2013-01-21 | 2017-12-19 | Apparao Satyam | Nitric oxide releasing produgs of therapeutic agents |
| RU2517259C1 (ru) * | 2013-03-06 | 2014-05-27 | Федеральное государственное бюджетное учреждение науки Государственный научный центр Российской Федерации - Институт медико-биологических проблем Российской академии наук (ГНЦ РФ-ИМБП РАН) | Способ профилактики и снижения деструкции белков скелетных мышц при их атрофии, вызванной гипокинезией и/или гравитационной разгрузкой |
| WO2014169976A1 (en) * | 2013-04-18 | 2014-10-23 | Nicox Science Ireland | Quinone based nitric oxide donating compounds |
| US9974767B2 (en) | 2014-07-14 | 2018-05-22 | University Of Washington | Statins in the treatment of muscular dystrophies and myopathies |
| KR101661332B1 (ko) | 2015-05-28 | 2016-09-29 | (의료)길의료재단 | 글루카곤 유사 펩타이드-1 수용체 항진제를 포함하는 근감소증 치료용 약학 조성물 |
| US10993993B2 (en) | 2015-05-28 | 2021-05-04 | Immunoforge Co., Ltd. | Pharmaceutical composition for treating muscle atrophy or sarcopenia including glucagon-like peptide (GLP-1) or GLP-1 receptor agonist |
| AR111295A1 (es) | 2017-03-20 | 2019-06-26 | Forma Therapeutics Inc | Composiciones de pirrolopirrol como activadores de piruvato quinasa (pkr) |
| CA3090241C (en) | 2018-04-25 | 2023-03-28 | Oncocross Co.,Ltd. | Composition for preventing and treating muscular disease |
| WO2020055186A1 (ko) | 2018-09-14 | 2020-03-19 | 고려대학교 산학협력단 | If1 을 유효성분으로 함유하는 비만 또는 근감소증의 예방 또는 치료용 약학 조성물 |
| WO2020061255A1 (en) | 2018-09-19 | 2020-03-26 | Forma Therapeutics, Inc. | Activating pyruvate kinase r |
| US20200129485A1 (en) | 2018-09-19 | 2020-04-30 | Forma Therapeutics, Inc. | Treating sickle cell disease with a pyruvate kinase r activating compound |
| MX2022003025A (es) | 2019-09-19 | 2022-04-07 | Forma Therapeutics Inc | Activacion de la piruvato cinasa r. |
| US12128035B2 (en) | 2021-03-19 | 2024-10-29 | Novo Nordisk Health Care Ag | Activating pyruvate kinase R |
| KR102329853B1 (ko) | 2021-03-25 | 2021-11-23 | 주식회사 엔테로바이옴 | 아커만시아 뮤시니필라 균주를 포함하는 근위축증 예방 또는 치료용 약학적 조성물 |
| KR102272616B1 (ko) | 2021-03-25 | 2021-07-05 | 주식회사 엔테로바이옴 | 피컬리박테리움 프로스니치 균주를 포함하는 근위축증 예방 또는 치료용 약학적 조성물 |
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| RU2145595C1 (ru) * | 1994-05-10 | 2000-02-20 | Никокс С.А. | Нитроксисоединения и фармацевтическая композиция на их основе, имеющие противовоспалительную, анальгетическую и антитромбоцитарную активности |
| US5583101A (en) * | 1994-07-15 | 1996-12-10 | Harvard College | Use of nitrogen oxide species and adducts to inhibit skeletal muscle contraction |
| IT1288123B1 (it) * | 1996-09-04 | 1998-09-10 | Nicox Sa | Uso di nitroderivati per l'incontinenza urinaria |
| WO2000053191A2 (en) | 1999-03-11 | 2000-09-14 | The University Of Manitoba | Modulation of skeletal muscle precursor cell activation |
| FR2794647A1 (fr) * | 1999-06-11 | 2000-12-15 | Centre Nat Rech Scient | Compositions pharmaceutique comprenant du no ou au moins un compose capable de liberer ou d'induire la formation de no dans les cellules |
| ITMI991517A1 (it) | 1999-07-09 | 2001-01-09 | Nicox Sa | Procedimento per ottenere nitrossimetil fenil esterni di derivati dell'acido salicilico |
| IT1313596B1 (it) * | 1999-08-04 | 2002-09-09 | Nicox Sa | Processo per la preparazione di nitrossialchil esteri del naproxene |
| ITMI20011744A1 (it) * | 2001-08-09 | 2003-02-09 | Nicox Sa | Farmaci per le vasculopatie |
| ITMI20021392A1 (it) * | 2002-06-25 | 2003-12-29 | Nicox Sa | Forme farmaceutiche per la somministrazione orale di farmaci liquidi a temperatura ambiente dotate di migliore biodisponibilita' |
| US7166638B2 (en) * | 2003-05-27 | 2007-01-23 | Nicox S.A. | Statin derivatives |
| WO2005023189A2 (en) * | 2003-09-03 | 2005-03-17 | Pharmacia Corporation | Method of cox-2 selective inhibitor and nitric oxide-donating agent |
| GB0321228D0 (en) * | 2003-09-10 | 2003-10-08 | Inpharmatica Ltd | Modulating cell activity |
| CA2611140C (en) * | 2005-06-09 | 2013-11-19 | University Of Manitoba | Compositions and methods for enhancing nitric oxide delivery |
| EP1983975B1 (en) | 2006-02-03 | 2015-07-29 | Giulio Cossu | Method of treatment for muscular dystrophy |
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2007
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- 2007-01-23 WO PCT/EP2007/050630 patent/WO2007088123A2/en not_active Ceased
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- 2007-01-23 EP EP20140175223 patent/EP2786749A1/en not_active Withdrawn
- 2007-01-23 NZ NZ569396A patent/NZ569396A/en not_active IP Right Cessation
- 2007-01-23 ES ES07712084.8T patent/ES2520893T3/es active Active
- 2007-01-23 DK DK07712084.8T patent/DK1978947T3/da active
- 2007-01-23 KR KR1020087015930A patent/KR20080097989A/ko not_active Ceased
- 2007-01-23 RU RU2008135153/15A patent/RU2429828C2/ru not_active IP Right Cessation
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2008
- 2008-06-19 IL IL192299A patent/IL192299A0/en unknown
- 2008-06-30 ZA ZA200805716A patent/ZA200805716B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP2786749A1 (en) | 2014-10-08 |
| ES2520893T3 (es) | 2014-11-12 |
| DK1978947T3 (da) | 2014-11-03 |
| KR20080097989A (ko) | 2008-11-06 |
| AU2007211508B2 (en) | 2012-08-23 |
| WO2007088123A2 (en) | 2007-08-09 |
| WO2007088123A3 (en) | 2007-09-20 |
| PT1978947E (pt) | 2014-11-03 |
| RU2011118522A (ru) | 2012-11-20 |
| JP5745210B2 (ja) | 2015-07-08 |
| CA2641816C (en) | 2016-01-05 |
| HK1129592A1 (en) | 2009-12-04 |
| CA2641816A1 (en) | 2007-08-09 |
| IL192299A0 (en) | 2009-08-03 |
| AU2007211508A1 (en) | 2007-08-09 |
| US20090093510A1 (en) | 2009-04-09 |
| SI1978947T1 (sl) | 2014-12-31 |
| CN101378739B (zh) | 2014-06-04 |
| RU2008135153A (ru) | 2010-03-10 |
| US8575222B2 (en) | 2013-11-05 |
| EP1978947B1 (en) | 2014-08-13 |
| PL1978947T3 (pl) | 2015-03-31 |
| ZA200805716B (en) | 2009-11-25 |
| RU2429828C2 (ru) | 2011-09-27 |
| EP1978947A2 (en) | 2008-10-15 |
| CN101378739A (zh) | 2009-03-04 |
| JP2009525302A (ja) | 2009-07-09 |
| RU2560144C2 (ru) | 2015-08-20 |
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