JP5739659B2 - Intestinal harmful substance adsorbent and method for producing the same - Google Patents

Description

The invention, together comprising at least one compound selected from the charcoal from planted Monosumi powder and thermosetting resin, the gut adsorbs harmful substances generated by dietary and body are produced in the intestine toxic substances The present invention relates to an adsorbent and a method for producing the same.

Generally, examples EbaUe Monosumi powder and charcoal derived resins, due to the large specific surface area by surface pores, is used as adsorbent in the industrial fields of pharmaceuticals and chemicals, etc.. In addition, charcoal powder , when taken orally or enterally, is a harmful ingredient derived from the intestinal diet, or produced by the intestinal bacteria or the body, such as uremic substances, food poisoning substances, allergens and Demonstrates the action of adsorbing residual agricultural chemicals. By the way, since it is difficult for a patient with kidney disease or liver disease to detoxify or excrete a harmful substance, the harmful substance may cause uremia or impaired consciousness. Charcoal powder is used for symptom improvement such as uremia for patients with kidney disease or liver disease.

From the past, a toxin as spherical special adsorbent activated carbon adsorb, adsorbents, and uremia therapeutic agent as a pharmaceutical which is disclosed in Patent Document 1 (Kremezin (average particle diameter 0.25 to 0.45 mm): Kureha Made). The adsorbent and cremedin of Patent Document 1 are manufactured using a carbon source derived from a synthetic resin as a raw material, and the specific surface area and the like are defined to specific numerical values.

  In the field of food and drink, an adsorbent disclosed in Patent Document 2 and a commercially available activated carbon processed food (Health Carbon: manufactured by MK Corporation) are known. The adsorbent and health carbon of Patent Document 2 can be obtained by coating activated carbon with a gel-like substance composed of alginic acid containing glycerin, etc., then freezing, and then removing glycerin.

Japanese Patent No. 3835698 Japanese Patent No. 3914265

However, the adsorbent and cremedin of Patent Document 1 have a problem that constipation may occur as a side effect. In addition, when taken orally, there is a problem that there is a feeling of discomfort in taking because of the roughness derived from charcoal , and it is painful to keep drinking every day. In addition, when taking as a capsule, it was necessary to take 10 capsules once a day three times. As the required intake increased, more water was consumed, which was a burden for the drinker. In particular, patients with renal insufficiency may have limited water intake due to a decrease in the body's ability to drain water. There was a problem that was not easy.

  The adsorbent and health carbon of Patent Document 2 have reduced the side effects of constipation, but the problem of roughness during use and the need for a large amount of water has not been solved. Moreover, the process which removes glycerol is required and there existed a problem that a manufacturing method was complicated.

The present invention is the combined use of at least one kind and a particular polysaccharide selected from the charcoal from planted Monosumi powder and thermosetting resin is based on the finding that the above problems can be solved . The object of the present invention is to reduce the side effects such as constipation, for example, and to prevent intestinal feeling, for example, a small amount of water can be used, and the intestinal harmful substance adsorbent and the method for producing the same Is to provide.

In order to achieve the above object, the intestinal harmful substance adsorbent according to claim 1 is a jelly-like or gel-like intestinal harmful substance adsorbent, a coconut-derived plant charcoal powder, and locust. It contains at least one polysaccharide selected from bean gum, carrageenan, pectin, polydextrose, agarose, agaropectin and xanthan gum.

The invention described in 請 Motomeko 2, in intestinal toxic substances adsorbing agent according to claim 1, wherein the plant charcoal is characterized by a plant charcoal that has been steam activation process.

The invention described in claim 3 is the intestinal harmful substance adsorbent according to claim 1 or 2 , wherein the polysaccharide contains at least polydextrose.
The invention described in claim 4 is a food or pharmaceutical product for a patient with renal or liver disease, or for detoxification, in the intestinal harmful substance adsorbent according to any one of claims 1 to 3. It is characterized by that.

Invention of Claim 5 is at least 1 type chosen from the water, the vegetable charcoal powder, and the carbon powder derived from a thermosetting resin in the manufacturing method of the intestinal harmful-substance adsorbent which is a jelly-form or a gel-form dosage form, In addition, at least one polysaccharide selected from locust bean gum, carrageenan, pectin, polydextrose, agarose, agaropectin and xanthan gum is mixed, heated and dissolved, and then cooled.

According to the present invention, there are provided an intestinal harmful substance adsorbent that can reduce side effects such as constipation and that is easy to ingest, such as having no rough feeling and requiring a small amount of water, and a method for producing the same. be able to.

Hereinafter, an embodiment in which the intestinal harmful substance adsorbent of the present invention is embodied will be described.
Charcoal used in the present embodiment, the surface has fine pores, adsorption Chakusuru harmful substances in the intestine. Charcoal may be used as a resin raw material derived from plant material or a thermosetting resin, and fired at a high temperature using known methods. As the raw material for the powdered coal, a plant raw material derived from coconut shell is preferably used. Since the coconut shell is a natural product, it is highly safe for application to living bodies. Further, a high adsorption of harmful substances in the intestine.

For example, a known method can be employed to produce plant charcoal powder from coconut shell, which is a plant raw material . Specifically, it is manufactured by heating a plant raw material to, for example, 400 to 700 ° C. in an inert gas atmosphere and removing carbon, hydrogen, oxygen, and the like in the raw material as a part of volatile matter. be able to. It is preferable that the charcoal powder used in the present embodiment is further activated to be activated carbon . In the activation treatment, the plant carbide obtained by the carbonization treatment is reacted at a high temperature of, for example, 600 to 1000 ° C. using an activation gas, chemicals, etc., and the volatile component or organic matter in the carbide is gasified to further develop a fine pore structure. It is a process to make. By the activation treatment, the internal surface area can be enlarged and the adsorption power of the substance can be improved. Examples of the activation gas include water vapor, carbon dioxide gas, and air. As the activation treatment, a method of activation with water vapor is preferable from the viewpoint of application to a living body.

  Examples of the thermosetting resin include phenol resin, furan resin, urea resin, melamine resin, and epoxy resin. An ion exchange resin can be further used as the thermosetting resin. Examples of the ion exchange resin include a copolymer of divinylbenzene and styrene, acrylonitrile, acrylic acid, or methacrylic acid, and has a structure in which an ion exchange group is bonded to a copolymer matrix having a three-dimensional network skeleton. Compounds. The type of ion exchange group is not particularly limited. For example, a strong acid ion exchange resin having a sulfonic acid group, a weak acid ion exchange resin having a carboxylic acid group or a sulfonic acid group, and a strong basic ion exchange having a quaternary ammonium salt Examples include resins, weakly basic ion exchange resins having primary or tertiary amines.

  In order to produce resin charcoal powder from a resin raw material derived from a thermosetting resin, it can be produced using a known method. Specifically, it is manufactured by obtaining each step of carbonization treatment, activation treatment, oxidation treatment and reduction treatment from a thermosetting resin raw material previously formed into a spherical body. The carbonization treatment is a treatment in which a thermosetting resin raw material is heated to, for example, 300 to 1000 ° C. in an inert gas atmosphere, and carbon, hydrogen, oxygen, and the like in the raw material are removed as a part of volatile matter. The activation treatment is performed by reacting the resin carbide obtained by the carbonization treatment at a high temperature of, for example, 700 to 1000 ° C. using an activation gas such as water vapor, carbon dioxide gas, and air to gasify the volatile component or organic matter in the carbide. This process further develops the pore structure. In addition, you may perform preliminary baking before performing an activation process. From the viewpoint of further improving the selective adsorptivity of the activated activated spherical activated carbon, it is further oxidized at a temperature of, for example, 300 to 800 ° C. in an atmosphere containing oxygen and then an atmosphere of an inert gas such as nitrogen. For example, it is preferable to perform a reduction treatment by a heating reaction at a temperature of 800 to 1200 ° C. below.

As the polysaccharides used in the present embodiment, those that exhibit the function of dietary fiber in the digestive organs, for example, the function of regulating the intestines, and have good taste and texture when ingested in a jelly-like or gel state are applied. . Specific examples include locust bean gum, carrageenan, pectin, polydextrose, agarose, agaropectin, and xanthan gum. When agarose and agaropectin are used, agar may be used as a raw material. These polysaccharides relieve constipation symptoms that occur when charcoal powder is ingested and exert an intestinal regulating action. Moreover, since these polysaccharides are water-soluble dietary fibers, when ingested with charcoal powder in a jelly state or a gel state, these polysaccharides relieve discomfort at the time of ingestion such as roughness derived from charcoal powder. Of these polysaccharides, polydextrose is preferred because it is less decomposed by microorganisms in the intestinal tract and can maintain colloid osmotic pressure .

The ingestion form of the intestinal harmful substance adsorbent of the present embodiment is configured as a gel-like or jelly-form preparation in order to reduce the amount of water to be ingested. By setting it as such a structure, it is also possible to eat a gelatinous or jelly-form preparation as it is. Carrageenan, pectin, agarose, and agaropectin are preferably blended in order to form an elastic hard gel. In addition, in order to obtain a gel-like or jelly-form preparation, a known gelling agent may be used in combination with the above-mentioned polysaccharide within the range not inhibiting the effects of the present invention.

The blending amount of charcoal in the intestinal harmful substance adsorbent is preferably 3 to 20% by mass, more preferably 5 to 15% by mass, and still more preferably 8 to 12% by mass. If the blending amount is less than 3% by mass, the water composition ratio increases, so that the water intake may increase with the required amount of charcoal powder . On the other hand, if the blending amount exceeds 20% by mass, the rough feeling derived from charcoal at the time of ingestion may be worrisome.

The blending amount of the polysaccharide in the intestinal harmful substance adsorbent is preferably 10 to 40% by mass, more preferably 15 to 30% by mass, and still more preferably 20 to 28% by mass. If the blending amount is less than 10% by mass, the elasticity of the gel or jelly is lowered, and there is a fear that the rough feeling derived from the charcoal powder at the time of intake. On the other hand, if the blending amount exceeds 40% by mass, the elasticity of the gel or jelly becomes strong, which may make it difficult to ingest.

The blending ratio of charcoal powder and polysaccharide in the intestinal harmful substance adsorbent is not particularly limited, but is preferably 1: 0.5 to 4, more preferably 1: 1 to 3, and more preferably 1: 2-2. .8. By prescribing within this range, it is possible to suppress the roughness derived from charcoal powder and to further improve the texture when ingested.

The method for producing the intestinal harmful substance adsorbent of the present embodiment is not particularly limited. For example, first, charcoal powder , polysaccharide and solvent are mixed, and the polysaccharide is dissolved by heating and poured into a container of a predetermined volume. After that, it can be prepared by cooling at the end. The dissolution temperature is appropriately set depending on the type of polysaccharide. As the solvent, water is preferably used from the viewpoints of solubility and safety.

The intestinal harmful substance adsorbent of the present embodiment has an action of adsorbing and discharging harmful substances in the digestive tract. For example, patients with kidney disease or liver disease have difficulty in detoxifying or excreting toxic substances, and toxic substances may cause uremia and impaired consciousness. The intestinal harmful substance adsorbent of this embodiment can be preferably applied to, for example, patients with kidney disease or liver disease for the improvement or prevention of various symptoms such as uremia.

The intestinal harmful substance adsorbent of the present embodiment can be preferably applied in various fields such as foods and drinks, pharmaceuticals and quasi-drugs for the purpose of adsorbing and discharging harmful substances in the intestine .

When applying the intestinal harmful substance adsorbent of the present embodiment to a food or drink, the intestinal harmful substance adsorbent can be used as the food or drink itself or by blending it with various food materials or beverage materials. As said food-drinks, you may mix | blend gelatinizer containing foodstuffs, saccharides, a fragrance | flavor, a sweetener, fats and oils, a base material, an excipient | filler, a food additive, a subsidiary material, a bulking agent etc. suitably as another component. Examples of the sweetener include sugars having a laxative action such as sorbitol and maltitol, and oligosaccharides having an intestinal action. Oligosaccharides are known to promote the production of short-chain fatty acids by microbial metabolic activity in the large intestine, and to lower the pH of the intestine, thereby improving the intestinal environment and suppressing the production of uremic toxins. By blending an oligosaccharide with the intestinal harmful substance adsorbent of this embodiment, it is expected to promote the effect of reducing the harmful substances in the intestine. Further, as other sweeteners, pruned powder or apple powder, which is expected to exhibit a laxative action, may be used. However, this is not particularly limited to food and drink.

When using intestinal toxic substances adsorbent of the present embodiment as pharmaceuticals, can it to ingested as a gel or jelly-like formulation. If necessary, excipients, bases, emulsifiers, solvents, stabilizers and the like may be blended as additives.

The dose of the intestinal harmful substance adsorbent is appropriately set depending on the health condition of the person taking it, and is not particularly limited. However, from the viewpoint of exerting excellent efficacy, the amount of charcoal powder as an active ingredient is 1 to 10 g. / Day is preferred.

The effects exhibited by this embodiment will be described below.
(1) The intestinal harmful substance adsorbent of the present embodiment contains at least one selected from locust bean gum, carrageenan, pectin, polydextrose, agarose, agaropectin and xanthan gum as a polysaccharide. Therefore, the occurrence of side effects such as constipation when charcoal powder is ingested can be reduced. Moreover, the discomfort at the time of oral ingestion can be eased and intake can be made easy. That is, when the intestinal harmful substance adsorbent is taken orally, discomfort such as roughness derived from charcoal powder can be reduced. In addition, the amount of water to be consumed can be reduced.

(2) It is known that the charcoal powder adsorptivity varies greatly depending on the type of carbonized raw material. Intestinal toxic substances adsorbent of the present embodiment, as a charcoal using the resin charcoal from planted Monosumi powder or thermosetting resin. These charcoal powders act to adsorb harmful components derived from meals in the intestines, or harmful components generated in the intestinal bacteria and the body.

(3) Preferably, as the plant charcoal powder , plant charcoal powder derived from coconut shell is used. Thereby, it can apply with respect to a biological body easily and safely .

(4) Preferably, a charcoal powder subjected to steam activation treatment is used as the charcoal powder. Thereby, the internal surface area of activated carbon can be expanded and the adsorption | suction power of a substance can be improved.
(5) Preferably, the polysaccharide includes at least polydextrose. Thereby, while exhibiting the excellent intestinal regulation action, there is little decomposition | disassembly by the microorganisms of an intestinal tract, and a colloid osmotic pressure can be maintained.

(6) Preferably, intestinal toxic substance-adsorbing agent is applied as foods and drinks for patients with renal disease or liver disease. Therefore, alleviation of various symptoms derived from the disease can be expected for patients with kidney disease or liver disease while suppressing side effects such as constipation. Note that the intestinal harmful substance adsorbent of the present embodiment is not limited to food and drink for patients with kidney disease or liver disease.

(7) The intestinal harmful substance adsorbent of this embodiment can be obtained by mixing water, charcoal powder , and polysaccharides, heating and dissolving, and then cooling. Therefore, the intestinal harmful substance adsorbent can be produced simply and easily.

In addition, you may change the said embodiment as follows.
-The intestinal harmful substance adsorbent of the above embodiment can be applied not only to foods and beverages or medicines taken by humans, but also to feeds, drugs, etc. for domestic animals such as pets and livestock. Also good.

-About the enteric harmful | toxic substance adsorption agent of the said embodiment, the shape of charcoal powder is not specifically limited, For example, a powdery, granular form, and fibrous structure are mentioned. The particle diameter of the charcoal powder is not particularly limited as long as it can be ingested. The average particle size is preferably 1 μm to 1 mm, more preferably 1 μm to 10 μm, and even more preferably 1 μm to 5 μm from the viewpoint of reducing discomfort during ingestion such as roughness and facilitating ingestion. The average particle diameter can be determined from the median diameter obtained from the particle size distribution measured using a laser diffraction / scattering particle size distribution measuring instrument.

In the intestinal harmful substance adsorbent of the above embodiment, in order to produce charcoal powder particles from the raw material, the raw material may be preliminarily formed into particles and then carbonized, and obtained after carbonization. The carbide may be formed into particles by pulverizing.

The intestinal harmful substance adsorbent of the above embodiment is preferably applied to patients with kidney disease or liver disease in order to alleviate various symptoms of the disease. However, the ingestor and the purpose of application are not particularly limited, and may be applied to healthy individuals, for example, for alleviation or detoxification of allergens or other toxic components.

In the intestinal harmful substance adsorbent of the above embodiment, when charcoal powder is used for the treatment of uremia in patients with renal failure, the charcoal powder may be washed to reduce the mineral content in the charcoal powder. preferable.

Examples are given below to describe the above embodiments more specifically, but the present invention is not limited to these examples.
(Example 1)
Made either et coconut shell, steam activation treatment plant charcoal (average particle size 4 [mu] m) 10 parts by mass, locust bean gum 0.28 parts by weight, carrageenan 0.15 parts by mass, pectin 0.1 parts by weight, lactulose Water was added to a blended component consisting of 5 parts by mass, 25 parts by mass of polydextrose, 12.5 parts by mass of reduced maltose starch syrup, and 1 part by mass of acidulant to make the whole mixture 100 parts by mass. Then, the mixture was heated and dissolved at 90 ° C., and then filled into 20 g sachets and cooled to prepare the jelly-like enteric harmful substance adsorbent of Example 1.

(Example 2)
It made either et coconut shell, steam activation treatment plant charcoal (average particle size 4 [mu] m) 10 parts by mass, agar 1 part by weight, lactulose 5 parts polydextrose 25 parts by weight, reduced maltose starch syrup 12.5 parts by weight And the water was added to the compounding component which consists of 1 mass part of acidulants, and the whole mixture was 100 mass parts. Then, the jelly-like intestinal harmful substance adsorbent of Example 2 was prepared by filling a mixture obtained by heating and dissolving the mixture at 90 ° C. into 20 g sachets and cooling.

(Example 3)
Made either et coconut shell, steam activation treatment plant charcoal (average particle size 4 [mu] m) 10 parts by weight, carrageenan 0.44 parts by weight, xanthan gum 0.16 parts by weight, locust bean gum 0.16 parts by weight, lactulose Water was added to a blended component consisting of 5 parts by mass, 25 parts by mass of polydextrose, 12.5 parts by mass of reduced maltose starch syrup, and 1 part by mass of acidulant to make the whole mixture 100 parts by mass. Then, the jelly-like enteric harmful substance adsorbent of Example 3 was prepared by filling a mixture obtained by heating and dissolving the mixture at 90 ° C. into 20 g sachets and cooling.

Example 4
Made either et coconut shell, except for using steam activation treatment plants charcoal (average particle size 15 [mu] m), by manufacturing in the same manner as in Example 1, jelly intestinal toxic substances adsorbent of Example 4 Was prepared.

( Reference Example 5)
Example in place of the end plant charcoal from coconut shells in the same manner as 1, spherical activated carbon prepared using a carbon source derived from a thermosetting resin (trade name Kremezin: Kureha Ltd.) using a reference The jelly-like intestinal harmful substance adsorbent of Example 5 was prepared.

(Comparative Example 1)
First, 750 parts by mass of a 5% aqueous glycerin solution is added to 16 parts by mass of coconut powder derived from coconut husk (average particle size 4 μm) and konjac powder 16 parts by mass, which are steam-activated, and heated at 90 ° C. to dissolve. And cooled to 40 ° C. A solution prepared by dissolving 0.64 parts by mass of calcium oxide in 50 parts by mass of hot water of 40 ° C. is added to this and well stirred. This is placed in a mold and heated to solidify. This was exposed to water to remove glycerin, dried with hot air, and further pulverized to obtain a konjac powder containing 50% vegetable charcoal powder of Comparative Example 1.

(Comparative Example 2)
A capsule-like intestinal harmful substance adsorbent of Comparative Example 2 was produced by filling a No. 1 hard capsule with coconut powder derived from coconut shell subjected to steam activation treatment (average particle size 4 μm). The content of the vegetable charcoal powder in the hard capsule is 400 mg.

(Comparative Example 3 )
The granular material of cremedin was used as the intestinal harmful substance adsorbent of Comparative Example 3 .
(Comparative Example 4 )
The capsule-like intestinal harmful substance adsorbent of Comparative Example 4 was produced by filling granule of cremedin into No. 1 hard capsule. The content of cremedin in the hard capsule is 400 mg.

(Comparative Example 5 )
Comparative Example 5 was an intestinal harmful substance adsorbent made only from plant charcoal powder made from a coconut shell plant and subjected to steam activation treatment.

( Comparative Example 6 )
Commercially available Bincho charcoal powder (without activation treatment) was used as the intestinal harmful substance adsorbent of Comparative Example 6 .

(Comparative Example 7)
A commercially available Bincho charcoal powder subjected to steam activation treatment was used as the intestinal harmful substance adsorbent of Comparative Example 7.
<Test Example 1: Ureotoxin adsorption test>
Using the intestinal harmful substance adsorbents of Examples 1 and 2 , Reference Example 5 and Comparative Examples 3 and 5-7, the adsorptivity to creatinine as uremic toxin was tested.

The test method was a method in which the intestinal harmful substance adsorbent of each example was added to an aqueous solution containing the adsorption object, and the adsorption object remaining in the aqueous solution after being left for a predetermined time was tested.
When using creatinine as an adsorption target, to prepare a creatinine as an aqueous solution of 1 0 mg / dL, respectively 2.5 g / 50 mL Ryokuwae the intestinal toxic substances adsorbent in each example as charcoal to the aqueous solution, 37 ° C. For 3 hours. The absorbance of the supernatant after stirring was measured, and compared with the absorbance when no enteric harmful substance adsorbent was added, the adsorption rate was determined . The results of that shown in Table 1.

As shown in Table 1, it was confirmed that Examples 1 and 2 were excellent in creatinine adsorptivity. In Reference Example 5 in which kremezin was prepared in a jelly form, the adsorption rate of creatinine was inferior compared to Examples 1 and 2.

Than actual in Example 1, 2 results, it that can be better maintain the adsorption of creatinine was confirmed by a combination of specific polysaccharides charcoal and the present invention derived from coconut shells.

<Test Example 2: Test on texture when ingesting intestinal harmful substance adsorbent>
About the intestinal harmful-substance adsorbents of Examples 1 to 4, Reference Example 5 and Comparative Examples 1 to 4, the taste and the rough feeling (texture) when ingested and the amount of water necessary for ingestion are evaluated. did. The intestinal harmful substance adsorbent in each case was evaluated by ingesting 2 g as charcoal (average value of n = 5).

(Taste evaluation)
In the table, ○ indicates that it is easy to eat, Δ indicates that it is slightly difficult to eat, and X indicates that it is very difficult to eat.
(Evaluation of roughness)
In the table, “O” indicates almost no roughness, “Δ” indicates a slight roughness, and “x” indicates a strong roughness.

As shown in Table 2, it was confirmed that the intestinal harmful substance adsorbent of Comparative Example 1, which is a konjac powder containing 50% vegetable charcoal powder, has a poor taste and texture evaluation and a large amount of water required for ingestion. It was done. Moreover, it was confirmed that the amount of water required for ingestion is large in Comparative Example 2 which is a capsule-like material of plant charcoal powder subjected to steam activation treatment. It was confirmed that Comparative Example 3 which is a granule of cremedin has a poor taste and texture and requires a large amount of water for ingestion. It was confirmed that Comparative Example 4, which is a capsule of cremedin, requires a large amount of water for ingestion. In Example 4, since the average particle diameter of the plant charcoal powder was larger than that in Example 1, a slight roughness was felt. Moreover, the reference example 5 which prepared cremedin in the jelly form improved the taste compared with the comparative example 3, and the amount of ingested water decreased significantly. However, with respect to the roughness, although an improvement was recognized as compared with Comparative Example 3, the roughness was still recognized as compared with Example 1.

<Test Example 3: Test on frequency of occurrence of constipation when intestinal harmful substance adsorbent is ingested>
The intestinal harmful substance adsorbents of Example 1 , Reference Example 5 and Comparative Examples 2 and 3 were tested for the frequency of occurrence of constipation when 6 g of charcoal was ingested per day. The intestinal harmful substance adsorbent was ingested once by 20 people, and the number of occurrences of constipation was determined. Regarding the number of occurrences of constipation, the number of occurrences of constipation was counted as constipation when no stool occurred within the next day after ingestion.

It was confirmed that Comparative Example 2 which is a capsule of a vegetable charcoal powder subjected to steam activation treatment and Comparative Example 3 which is a granule of cremedin have a significantly higher frequency of constipation than Example 1. On the other hand, it was confirmed that the side effect of constipation was improved in Reference Example 5 in which cremedin was prepared in a jelly form. It was confirmed that the intestinal harmful substance adsorbent of Example 1 hardly caused constipation side effects.

Next, the technical ideas that can be grasped from the above embodiment and other examples will be described below together with the effects. (I) The intestinal harmful substance adsorbent, wherein the polysaccharide is composed of at least one selected from locust bean gum, carrageenan, pectin, polydextrose, agarose, agaropectin and xanthan gum . According to the configuration or Cal (b), it is not reduced more taste and texture of intestinal toxic substances adsorbent.

(C) The method for producing an adsorbent for intestinal harmful substances, wherein glycerin is not used in the production process. According to the configuration (c), it is not necessary to remove glycerin, and the intestinal harmful substance adsorbent can be easily produced.

Claims (5)

In the intestinal harmful substance adsorbent which is a jelly-like or gel-like dosage form,
A plant charcoal powder derived from coconut shell , and at least one polysaccharide selected from locust bean gum, carrageenan, pectin, polydextrose, agarose, agaropectin and xanthan gum, containing an intestinal harmful substance adsorbent. The intestinal harmful substance adsorbent according to claim 1, wherein the plant charcoal is a plant charcoal powder subjected to steam activation treatment. The intestinal harmful substance adsorbent according to claim 1 or 2 , wherein the polysaccharide contains at least polydextrose. The intestinal harmful substance adsorbent according to any one of claims 1 to 3 , wherein the adsorbent is an intestinal harmful substance adsorbent according to any one of claims 1 to 3 , wherein the adsorbent is a food or medicine for patients with kidney disease or liver disease or for detoxification. In the method for producing an intestinal harmful substance adsorbent which is a jelly-like or gel-like dosage form,
Water, coconut shell-derived plant charcoal powder, and at least one polysaccharide selected from locust bean gum, carrageenan, pectin, polydextrose, agarose, agaropectin and xanthan gum are mixed, heated and dissolved, and then cooled. A method for producing an intestinal harmful substance adsorbent.