CN103239478A - Calcium carbonate milk composition freeze-dried orally disintegrating tablets, and preparation method thereof - Google Patents
Calcium carbonate milk composition freeze-dried orally disintegrating tablets, and preparation method thereof Download PDFInfo
- Publication number
- CN103239478A CN103239478A CN2012100253928A CN201210025392A CN103239478A CN 103239478 A CN103239478 A CN 103239478A CN 2012100253928 A CN2012100253928 A CN 2012100253928A CN 201210025392 A CN201210025392 A CN 201210025392A CN 103239478 A CN103239478 A CN 103239478A
- Authority
- CN
- China
- Prior art keywords
- calcium carbonate
- freeze
- orally disintegrating
- milk composition
- disintegrating tablet
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
The invention provides a calcium carbonate milk composition, comprising 0.2%-0.8% by weight of calcium carbonate, 1.3%-2.4% by weight of mannitol, 2%-4% by weight of gelatin, 90%-97% by weight of milk powder, 0.1% -0.15% by weight of sucralose. The invention also provides calcium carbonate milk freeze-dried orally disintegrating tablets prepared by the above composition. The freeze-dried orally disintegrating tablets are simple in components, can be taken without water and mastication, can be disintegrated within 2 seconds in a human oral cavity, have few residues in intestinal tracts, can be absorbed completely, have good mouthfeel and are very suitable for being taken by infants.
Description
Technical field
The present invention relates to a kind of calcium carbonate milk composition, more specifically, relate to a kind of calcium carbonate milk composition freeze-dry orally disintegrating tablet and preparation method thereof.
Background technology
Calcium is the inorganic matter of in-vivo content maximum, for keeping human nerve, and muscle, skeletal system, cell membrane and capillary permeability normal function institute are essential.Calcium ion is the important activator of many enzymatic reactions, is essential to many physiological process, as the neural impulse transmission, and the contraction of smooth muscle and skeletal muscle, renal function, breathing and blood coagulation etc.Calcium carbonate is white crystalline or graininess powder.Water insoluble.Molecular formula: CaCO3, molecular mass: 100.09.As medicine, can reduce capillary permeability, increase density, keep NE neural and muscle, strengthen myocardial contraction, and help sclerotin to form.Be applicable to irritated illness, as urticaria; Eczema; Skin pruritus; Contact dermatitis, and serum sickness; Vasodilation is as auxiliary treatment.Be applicable to that also tic and magnesium that blood calcium is crossed due to low poisons.Also be used for prevention and treatment calcium deficiency etc.Also as food additive and nutritional supplement.Be used in particular for child, anemia of pregnant woman and the old people usefulness of replenishing the calcium.
Present calcium carbonate dosage form commonly used: ordinary tablet, chewable tablet, effervescent tablet, dispersible tablet, granule, syrup, drop, oral liquid, oral cavity disintegration tablet (pressing manufacturing) etc.Wherein oral formulations needs with water delivery service or slice, thin piece hardness very big more, this patient for dysphagia or water intaking inconvenience takes and has certain difficulty, particularly very inconvenient for children taking, the calcium carbonate oral cavity disintegration tablet of selling on the market is with multiple adjuvant and disintegrating agent, utilizes the compacting of traditional tablet machine to form, 30 seconds of the minimum needs of its disintegration time in human oral cavity, and in the mouth grains of sand sense is arranged, the child also is not suitable for, Given this, proposes the present invention.
Summary of the invention
An object of the present invention is to provide a kind of calcium carbonate milk composition, this milk composition composition is simple: main constituent is calcium carbonate, also includes nutrient (milk powder), skeleton agent (mannitol), forming agent (gelatin), correctives (sucralose).
Another object of the present invention provides a kind of calcium carbonate milk composition freeze-dry orally disintegrating tablet that contains above-mentioned calcium carbonate milk composition.This freeze-dry orally disintegrating tablet component is simple, need not water when taking, and need not to chew, and disintegration time was no more than for 2 seconds in human oral cavity, and intestinal is residual few, absorbs fully, and mouthfeel is good, is particularly suitable for infant taking.
A further object of the present invention provides a kind of preparation method of calcium carbonate milk composition freeze-dry orally disintegrating tablet, and this method preparation condition gentleness is easy to control, is fit to industrialized great production.
A kind of calcium carbonate milk composition, this milk composition comprises following composition:
Described milk composition preferably includes following composition:
A kind of calcium carbonate milk composition freeze-dry orally disintegrating tablet that contains above-mentioned calcium carbonate milk composition, it is prepared from by following composition:
Described calcium carbonate milk composition freeze-dry orally disintegrating tablet, it preferably is prepared from by following composition:
Described calcium carbonate milk composition freeze-dry orally disintegrating tablet specification is calcic 9mg/ sheet.For realizing a further object of the present invention, a kind of preparation method of calcium carbonate milk composition freeze-dry orally disintegrating tablet adopts following technical scheme:
A) milk powder, mannitol, the sucralose of recipe quantity is dissolved in the purified water of 70%-80% of prescription water total amount, under stirring, is heated to 40 ℃, slowly add the calcium carbonate of recipe quantity;
B) gelatin with recipe quantity is dissolved in the purified water of prescription water consumption 20%-30%, is heated to dissolving fully;
C) merge two kinds of solution of above-mentioned a, b and stirring;
D) according to calcium carbonate milk composition freeze-dry orally disintegrating tablet specification, after determining loading amount, solution after merging is filled in the vessel by the loading amount branch, and put into freeze drying box, medicinal liquid is carried out freezing (cryogenic temperature is-20 ℃--50 ℃), evacuation drying (baking temperature is at+5 ℃-+20 ℃, and vacuum is 0.1 handkerchief-20 handkerchief), the control moisture is no more than 1.0%;
E) treat calcium carbonate milk composition freeze-dry orally disintegrating tablet drying after, in freeze drying box, seal;
F) medicament that freezes is taken out freeze drying box and carry out finished product packing.
Disintegration rate for calcium carbonate milk composition freeze-dry orally disintegrating tablet checks result such as following table according to inspection technique disintegration (two appendix x of Chinese Pharmacopoeia version in 2010 A):
Dosage equates, the disintegration time of different Antacids
The calcium carbonate oral cavity disintegration tablet made than calcium carbonate ordinary tablet, traditional pressing of the disintegration rate of calcium carbonate milk composition freeze-dry orally disintegrating tablet of the present invention is fast as can be seen from above experimental result, and this dosage form has following advantage:
First disintegrate is rapid.Calcium carbonate milk composition freeze-dry orally disintegrating tablet of the present invention is disintegrate rapidly in 2 seconds in mouth, is beneficial to the rapid stripping of medicine, shortens dissolution time, accelerates to absorb.
Second drug absorption is abundant.Calcium carbonate milk composition freeze-dry orally disintegrating tablet of the present invention is disintegrate fully in the oral cavity, makes the absorption of medicine more abundant.
The 3rd taking convenience, mouthfeel is good.Calcium carbonate milk composition freeze-dry orally disintegrating tablet of the present invention needn't be used water delivery service, and saliva can make its complete disintegrate, and no foreign body sensation in mouthful is owing to wherein add the sweet compliance that is conducive to children taking of suitable correctives cool taste flavor.Compare with liquid preparation and dosage advantage accurately arranged.
The selected adjuvant of calcium carbonate milk composition freeze-dry orally disintegrating tablet all is the adjuvants that are suitable for this tablet of preparation.Because calcium carbonate milk composition freeze-dry orally disintegrating tablet of the present invention is main in order to satisfy child's medication demand, has added nutrient milk powder and correctives sucralose in prescription.The sucralose sweet feel is very near sucrose, and is very stable, safe to heat, acid, alkali.Simultaneously, sucralose is not utilized by the dental caries pathogenic bacteria, can reduce pathogenic bacteria in the oral cavity, and the acid amount of generation and streptococcus cell effectively play the dental caries effect in the adhesion of dental surface, useful especially teenager teeth health; The sucralose good stability can long term storage, and can not be damaged in freezing dry process, is fit to industrial applications.
The specific embodiment
Embodiment 1
Prescription: 1000 amounts
Milk powder with recipe quantity, mannitol, sucralose is dissolved in the purified water of 70%-80% of prescription water total amount, under stirring, be heated to 40 ℃, the calcium carbonate that slowly adds recipe quantity, gelatin with recipe quantity is dissolved in the purified water of prescription water consumption 20% in addition, be heated to dissolving fully, merge above-mentioned two kinds of solution and stir, according to calcium carbonate milk composition freeze-dry orally disintegrating tablet specification, after determining loading amount, the medicinal liquid after merging is filled in the vessel by the loading amount branch, and puts into freeze drying box, carry out freezing to medicinal liquid, after treating calcium carbonate milk composition freeze-dry orally disintegrating tablet drying, in freeze drying box, seal, take out the back packing.
Embodiment 2
Prescription: 1000 amounts
Milk powder with recipe quantity, mannitol, sucralose is dissolved in the purified water of 70%-80% of prescription water total amount, under stirring, be heated to 40 ℃, the calcium carbonate that slowly adds recipe quantity, gelatin with recipe quantity is dissolved in the purified water of prescription water consumption 20% in addition, be heated to dissolving fully, merge above-mentioned two kinds of solution and stir, according to calcium carbonate milk composition freeze-dry orally disintegrating tablet specification, after determining loading amount, the medicinal liquid after merging is filled in the vessel by the loading amount branch, and puts into freeze drying box, carry out freezing to medicinal liquid, after treating calcium carbonate milk composition freeze-dry orally disintegrating tablet drying, in freeze drying box, seal, take out the back packing.
Embodiment 3
Prescription: 1000 amounts
Milk powder with recipe quantity, mannitol, sucralose is dissolved in the purified water of 70%-80% of prescription water total amount, under stirring, be heated to 40 ℃, the calcium carbonate that slowly adds recipe quantity, gelatin with recipe quantity is dissolved in the purified water of prescription water consumption 20% in addition, be heated to dissolving fully, merge above-mentioned two kinds of solution and stir, according to calcium carbonate milk composition freeze-dry orally disintegrating tablet specification, after determining loading amount, the medicinal liquid after merging is filled in the vessel by the loading amount branch, and puts into freeze drying box, carry out freezing to medicinal liquid, after treating calcium carbonate milk composition freeze-dry orally disintegrating tablet drying, in freeze drying box, seal, take out the back packing.
Claims (6)
1. calcium carbonate milk composition, this milk composition comprises following composition:
。
2. according to claim 1, the calcium carbonate milk composition is characterized in that, described milk composition comprises following composition:
3. calcium carbonate milk composition freeze-dry orally disintegrating tablet that contains claim 1 or 2 described calcium carbonate milk compositions.
4. calcium carbonate milk composition freeze-dry orally disintegrating tablet according to claim 3.It is prepared from by following composition:
。
5. calcium carbonate milk composition freeze-dry orally disintegrating tablet according to claim 3, it is prepared from by following composition:
6. according to the described calcium carbonate milk composition of claim 4-5 freeze-dry orally disintegrating tablet, it is characterized in that the preparation method of said composition freeze-dry orally disintegrating tablet:
A) milk powder, mannitol, the sucralose of recipe quantity is dissolved in the purified water of 70%-80% of prescription water total amount, under stirring, is heated to 40 ℃, slowly add the calcium carbonate of recipe quantity;
B) gelatin with recipe quantity is dissolved in the purified water of prescription water consumption 20%-30%, is heated to dissolving fully;
C) merge two kinds of solution of above-mentioned a, b and stirring;
D) according to calcium carbonate milk composition freeze-dry orally disintegrating tablet specification, after determining loading amount, solution after merging is filled in the vessel by the loading amount branch, and put into freeze drying box, medicinal liquid is carried out freezing (cryogenic temperature is-20 ℃--50 ℃), evacuation drying (baking temperature is at+5 ℃-+20 ℃, and vacuum is 0.1 handkerchief-20 handkerchief), the control moisture is no more than 1.0%;
E) treat calcium carbonate milk composition freeze-dry orally disintegrating tablet drying after, in freeze drying box, seal;
F) medicament that freezes is taken out freeze drying box and carry out finished product packing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012100253928A CN103239478A (en) | 2012-02-02 | 2012-02-02 | Calcium carbonate milk composition freeze-dried orally disintegrating tablets, and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012100253928A CN103239478A (en) | 2012-02-02 | 2012-02-02 | Calcium carbonate milk composition freeze-dried orally disintegrating tablets, and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN103239478A true CN103239478A (en) | 2013-08-14 |
Family
ID=48919583
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2012100253928A Pending CN103239478A (en) | 2012-02-02 | 2012-02-02 | Calcium carbonate milk composition freeze-dried orally disintegrating tablets, and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103239478A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106259891A (en) * | 2015-05-28 | 2017-01-04 | 上海旺旺食品集团有限公司 | A kind of probiotic bacteria buccal tablet and preparation method thereof |
| CN109730972A (en) * | 2019-03-07 | 2019-05-10 | 北京中医药大学 | A kind of Europe Lee calcium tablet and preparation method thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1689649A (en) * | 2004-04-30 | 2005-11-02 | 量子高科（北京）研究院有限公司 | Oral cavity quick dissolving preparation and production method thereof |
| CN101700122A (en) * | 2009-08-18 | 2010-05-05 | 吉林大学 | Formula and preparation method of phosvitin phosphoeptide milk flavor calcium tablet |
| CN102160648A (en) * | 2011-03-11 | 2011-08-24 | 陕西科技大学 | Rapidly disintegrating calcium tablets and preparation method thereof |
-
2012
- 2012-02-02 CN CN2012100253928A patent/CN103239478A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1689649A (en) * | 2004-04-30 | 2005-11-02 | 量子高科（北京）研究院有限公司 | Oral cavity quick dissolving preparation and production method thereof |
| CN101700122A (en) * | 2009-08-18 | 2010-05-05 | 吉林大学 | Formula and preparation method of phosvitin phosphoeptide milk flavor calcium tablet |
| CN102160648A (en) * | 2011-03-11 | 2011-08-24 | 陕西科技大学 | Rapidly disintegrating calcium tablets and preparation method thereof |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106259891A (en) * | 2015-05-28 | 2017-01-04 | 上海旺旺食品集团有限公司 | A kind of probiotic bacteria buccal tablet and preparation method thereof |
| CN109730972A (en) * | 2019-03-07 | 2019-05-10 | 北京中医药大学 | A kind of Europe Lee calcium tablet and preparation method thereof |
| CN109730972B (en) * | 2019-03-07 | 2021-04-27 | 北京中医药大学 | Prunus humilis calcium tablet and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN106420643B (en) | A kind of chewable tablets and preparation method thereof containing vitamine C sodium | |
| CN103751327A (en) | Zinc gluconate VC (Vitamin C) effervescent tablet | |
| CN102579378B (en) | Child cefdinir composition freeze-dried oral disintegrating tablet and preparation method thereof | |
| JP5739659B2 (en) | Intestinal harmful substance adsorbent and method for producing the same | |
| CN103750310A (en) | Plant-sourced calcium capable of supplementing calcium and promoting calcium absorption and preparation method thereof | |
| CN102631336B (en) | Freeze-drying orally disintegrating tablet with vitamin K1 composition for infants and preparation method for freeze-drying orally disintegrating tablet | |
| CN105381019A (en) | Effervescent tablet with internal-fire clearing function and preparation method thereof | |
| CN101716180B (en) | Combined medicament for supplementing zinc and calcium and preparation method thereof | |
| CN102772383A (en) | Azithromycin composition freeze-dried orally disintegrating tablet and preparation method thereof | |
| CN106343463A (en) | Royal jelly and beeswax lozenge and preparation method thereof | |
| CN102600119B (en) | Pediatric acetaminophen composition | |
| CN103239478A (en) | Calcium carbonate milk composition freeze-dried orally disintegrating tablets, and preparation method thereof | |
| CN102525978B (en) | Children amoxicillin-potassium clavulanate composition | |
| CN103284963A (en) | Children calcium gluconate-milk composition freeze-dried oral disintegrating tablet and preparation method thereof | |
| CN102525979B (en) | Infant ibuprofen composition | |
| WO2016086557A1 (en) | Vitamin d calcium composition chewing tablet and preparation method thereof | |
| CN102784119A (en) | Roxithromycin composition freeze-dried orally disintegrating tablets and preparation method thereof | |
| CN102614212B (en) | Freeze-dried orally disintegrating tablets of pediatric ribavirin composition, and preparation method thereof | |
| CN102784118A (en) | Fosfomycin calcium composition freeze-dried orally disintegrating tablets and preparation method thereof | |
| CN102940610A (en) | Vitamin B6 composition freeze-drying orally disintegrating tablets and preparation method thereof | |
| CN103284964A (en) | Children zinc gluconate-milk composition freeze-dried oral disintegrating tablet and preparation method thereof | |
| JP2007314560A (en) | Agent for keeping oxidative metabolism caused by exercise | |
| CN107951034B (en) | Effervescent vitamin preparation and its preparing process | |
| CN102784121A (en) | Levofloxacin composition freeze-dried orally disintegrating tablets and preparation method thereof | |
| CN102648899B (en) | Child cefalexin composition |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20130814 |