JP5732603B2 - 骨標的アルカリホスファターゼ、キット及びその使用方法 - Google Patents

骨標的アルカリホスファターゼ、キット及びその使用方法 Download PDF

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JP5732603B2
JP5732603B2 JP2010507770A JP2010507770A JP5732603B2 JP 5732603 B2 JP5732603 B2 JP 5732603B2 JP 2010507770 A JP2010507770 A JP 2010507770A JP 2010507770 A JP2010507770 A JP 2010507770A JP 5732603 B2 JP5732603 B2 JP 5732603B2
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alkaline phosphatase
amino acid
sequence
seq
residue
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JP2010526543A5 (https=
JP2010526543A (ja
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クライン、フィリップ
ボアロー、ガイ
ロワゼル、トーマス、ピー．
レミール、イザベル
レオナルド、ピエール
ヘフト、ロバート
ランディー、ハル
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アレクション ファーマ ホールディング
アレクション ファーマ ホールディング
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y301/00—Hydrolases acting on ester bonds (3.1)
    • C12Y301/03—Phosphoric monoester hydrolases (3.1.3)
    • C12Y301/03001—Alkaline phosphatase (3.1.3.1)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/025—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a parvovirus

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Materials For Medical Uses (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Adornments (AREA)
  • Cereal-Derived Products (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
JP2010507770A 2007-05-11 2008-05-12 骨標的アルカリホスファターゼ、キット及びその使用方法 Active JP5732603B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US91758907P 2007-05-11 2007-05-11
US60/917,589 2007-05-11
PCT/CA2008/000923 WO2008138131A1 (en) 2007-05-11 2008-05-12 Bone targeted alkaline phosphatase, kits and methods of use thereof

Publications (3)

Publication Number Publication Date
JP2010526543A JP2010526543A (ja) 2010-08-05
JP2010526543A5 JP2010526543A5 (https=) 2011-06-30
JP5732603B2 true JP5732603B2 (ja) 2015-06-10

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JP2010507770A Active JP5732603B2 (ja) 2007-05-11 2008-05-12 骨標的アルカリホスファターゼ、キット及びその使用方法

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US (1) US20100297119A1 (https=)
EP (3) EP2158319B1 (https=)
JP (1) JP5732603B2 (https=)
AT (1) ATE536413T1 (https=)
AU (1) AU2008250945B2 (https=)
BR (2) BR122019000505B1 (https=)
CA (1) CA2687001C (https=)
CY (1) CY2016005I1 (https=)
DE (1) DE202008018131U1 (https=)
DK (3) DK2158319T3 (https=)
ES (3) ES2471915T3 (https=)
FR (1) FR16C0007I2 (https=)
HR (1) HRP20140416T1 (https=)
HU (2) HUE031655T2 (https=)
IL (1) IL202057A0 (https=)
LT (1) LTC2368999I2 (https=)
LU (1) LU92976I2 (https=)
ME (1) ME01828B (https=)
NL (1) NL300798I2 (https=)
NO (1) NO2016002I1 (https=)
PL (3) PL2662448T3 (https=)
PT (3) PT2662448T (https=)
RS (1) RS53302B (https=)
SI (2) SI2368999T1 (https=)
WO (1) WO2008138131A1 (https=)

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WO2012016073A2 (en) 2010-07-28 2012-02-02 Gliknik Inc. Fusion proteins of natural human protein fragments to create orderly multimerized immunoglobulin fc compositions
JP6055779B2 (ja) 2010-12-27 2016-12-27 アレクシオン ファーマシューティカルズ， インコーポレイテッド ナトリウム利尿ペプチドを含む組成物およびその使用方法
CA2852874A1 (en) 2011-10-19 2013-04-25 Alexion Pharma Holding Compositions comprising alkaline phosphatase and/or natriuretic peptide and methods of use thereof
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JP2015527366A (ja) 2012-08-20 2015-09-17 グリックニック インコーポレイテッド 抗原結合および多価ｆｃガンマ受容体結合活性を有する分子
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JP6787894B2 (ja) 2014-12-05 2020-11-18 アレクシオン ファーマシューティカルズ， インコーポレイテッド 組換えアルカリホスファターゼを用いた発作の処置
JP6868561B2 (ja) 2015-01-28 2021-05-12 アレクシオン ファーマシューティカルズ， インコーポレイテッド アルカリホスファターゼ欠損を有する被験者を治療する方法
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LU92976I2 (en) 2016-04-11
FR16C0007I2 (fr) 2017-01-27
DK2662448T3 (en) 2017-03-20
ES2380546T3 (es) 2012-05-16
BRPI0811198A2 (pt) 2014-10-21
AU2008250945A2 (en) 2009-12-24
EP2662448A1 (en) 2013-11-13
HUE031655T2 (hu) 2017-07-28
FR16C0007I1 (https=) 2016-04-15
LTPA2016004I1 (lt) 2016-02-25
DK2368999T3 (da) 2014-05-26
CY2016005I2 (el) 2016-08-31
EP2158319A1 (en) 2010-03-03
EP2158319A4 (en) 2010-07-21
NL300798I1 (https=) 2016-03-16
AU2008250945B2 (en) 2013-12-12
BR122019000505A2 (pt) 2021-12-14
EP2368999A1 (en) 2011-09-28
PL2368999T3 (pl) 2014-08-29
HRP20140416T1 (hr) 2014-06-20
WO2008138131A9 (en) 2009-08-06
PT2662448T (pt) 2017-03-29
PL2158319T3 (pl) 2012-05-31
NO2016002I2 (no) 2016-02-02
CY2016005I1 (el) 2016-08-31
PL2662448T3 (pl) 2017-07-31
HK1141047A1 (en) 2010-10-29
ME01828B (me) 2014-12-20
SI2662448T1 (sl) 2017-05-31
BR122019000505B1 (pt) 2022-01-18
JP2010526543A (ja) 2010-08-05
PL2158319T4 (pl) 2016-04-29
NL300798I2 (https=) 2016-03-16
LTC2368999I2 (lt) 2017-09-25
DE202008018131U1 (de) 2011-12-30
HK1191372A1 (en) 2014-07-25
DK2158319T3 (da) 2012-03-19
PT2158319E (pt) 2012-03-06
AU2008250945A1 (en) 2008-11-20
NO2016002I1 (no) 2016-02-02
CA2687001C (en) 2019-02-12
EP2158319B1 (en) 2011-12-07
HUS1600005I1 (hu) 2016-02-29
RS53302B (sr) 2014-08-29
SI2368999T1 (sl) 2014-07-31
IL202057A0 (en) 2011-08-01
BRPI0811198B8 (pt) 2021-05-25
ES2619332T3 (es) 2017-06-26
ATE536413T1 (de) 2011-12-15
US20100297119A1 (en) 2010-11-25
BRPI0811198A8 (pt) 2018-08-14
BRPI0811198B1 (pt) 2021-03-09
HK1162589A1 (en) 2012-08-31
WO2008138131A1 (en) 2008-11-20
PT2368999E (pt) 2014-05-26
ES2471915T3 (es) 2014-06-27
EP2662448B1 (en) 2016-12-21
EP2368999B1 (en) 2014-03-12
WO2008138131A4 (en) 2008-12-31
CA2687001A1 (en) 2008-11-20

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