JP5732603B2 - 骨標的アルカリホスファターゼ、キット及びその使用方法 - Google Patents

骨標的アルカリホスファターゼ、キット及びその使用方法 Download PDF

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JP5732603B2
JP5732603B2 JP2010507770A JP2010507770A JP5732603B2 JP 5732603 B2 JP5732603 B2 JP 5732603B2 JP 2010507770 A JP2010507770 A JP 2010507770A JP 2010507770 A JP2010507770 A JP 2010507770A JP 5732603 B2 JP5732603 B2 JP 5732603B2
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alkaline phosphatase
amino acid
sequence
seq
residue
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JP2010526543A (ja
JP2010526543A5 (enExample
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クライン、フィリップ
ボアロー、ガイ
ロワゼル、トーマス、ピー．
レミール、イザベル
レオナルド、ピエール
ヘフト、ロバート
ランディー、ハル
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アレクション ファーマ ホールディング
アレクション ファーマ ホールディング
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y301/00—Hydrolases acting on ester bonds (3.1)
    • C12Y301/03—Phosphoric monoester hydrolases (3.1.3)
    • C12Y301/03001—Alkaline phosphatase (3.1.3.1)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/025—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a parvovirus

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Materials For Medical Uses (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Cereal-Derived Products (AREA)
  • Adornments (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
JP2010507770A 2007-05-11 2008-05-12 骨標的アルカリホスファターゼ、キット及びその使用方法 Active JP5732603B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US91758907P 2007-05-11 2007-05-11
US60/917,589 2007-05-11
PCT/CA2008/000923 WO2008138131A1 (en) 2007-05-11 2008-05-12 Bone targeted alkaline phosphatase, kits and methods of use thereof

Publications (3)

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JP2010526543A JP2010526543A (ja) 2010-08-05
JP2010526543A5 JP2010526543A5 (enExample) 2011-06-30
JP5732603B2 true JP5732603B2 (ja) 2015-06-10

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US (1) US20100297119A1 (enExample)
EP (3) EP2662448B1 (enExample)
JP (1) JP5732603B2 (enExample)
AT (1) ATE536413T1 (enExample)
AU (1) AU2008250945B2 (enExample)
BR (2) BRPI0811198B8 (enExample)
CA (1) CA2687001C (enExample)
CY (1) CY2016005I1 (enExample)
DE (1) DE202008018131U1 (enExample)
DK (3) DK2158319T3 (enExample)
ES (3) ES2380546T3 (enExample)
FR (1) FR16C0007I2 (enExample)
HR (1) HRP20140416T1 (enExample)
HU (2) HUE031655T2 (enExample)
IL (1) IL202057A0 (enExample)
LT (1) LTC2368999I2 (enExample)
LU (1) LU92976I2 (enExample)
ME (1) ME01828B (enExample)
NL (1) NL300798I1 (enExample)
NO (1) NO2016002I2 (enExample)
PL (3) PL2158319T4 (enExample)
PT (3) PT2368999E (enExample)
RS (1) RS53302B (enExample)
SI (2) SI2662448T1 (enExample)
WO (1) WO2008138131A1 (enExample)

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CA2823066A1 (en) 2010-12-27 2012-07-05 Alexion Pharma International Sarl Compositions comprising natriuretic peptides and methods of use thereof
SG11201401605QA (en) * 2011-10-19 2014-09-26 Alexion Pharma Holding Compositions comprising alkaline phosphatase and/or natriuretic peptide and methods of use thereof
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WO2014031646A2 (en) 2012-08-20 2014-02-27 Gliknik Inc. Molecules with antigen binding and polyvalent fc gamma receptor binding activity
PL3097189T3 (pl) 2014-01-24 2018-11-30 Am-Pharma B.V. Chimeryczne białka podobne do alkalicznej fosfatazy
US10822596B2 (en) 2014-07-11 2020-11-03 Alexion Pharmaceuticals, Inc. Compositions and methods for treating craniosynostosis
CA2967851C (en) 2014-12-05 2024-02-27 Alexion Pharmaceuticals, Inc. Treating seizure with recombinant alkaline phosphatase
US10603361B2 (en) 2015-01-28 2020-03-31 Alexion Pharmaceuticals, Inc. Methods of treating a subject with an alkaline phosphatase deficiency
MX394116B (es) 2015-07-24 2025-03-19 Gliknik Inc Proteinas de fusion de fragmentos de proteina humana para crear composiciones de fc de inmunoglobulina multimerizada de forma ordenada con union al complemento aumentada.
RU2745528C2 (ru) * 2015-08-17 2021-03-26 Алексион Фармасьютикалз, Инк. Производство щелочных фосфатаз
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JP7613826B2 (ja) * 2016-04-01 2025-01-15 アレクシオン ファーマシューティカルズ， インコーポレイテッド アルカリホスファターゼによって筋力低下を治療すること
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WO2017171871A1 (en) * 2016-04-01 2017-10-05 Alexion Pharmaceuticals, Inc. Methods for treating hypophosphatasia in adolescents and adults
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WO2018004517A1 (en) 2016-06-27 2018-01-04 Alexion Pharmaceuticals, Inc. Methods for treating hypophosphatasia in children and adolescents
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JP7214962B2 (ja) * 2018-01-17 2023-01-31 東ソー株式会社 アルカリホスファターゼ高発現動物細胞
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Publication number Publication date
HK1162589A1 (en) 2012-08-31
IL202057A0 (en) 2011-08-01
BR122019000505B1 (pt) 2022-01-18
EP2662448A1 (en) 2013-11-13
HUE031655T2 (hu) 2017-07-28
PL2368999T3 (pl) 2014-08-29
BRPI0811198A2 (pt) 2014-10-21
CY2016005I2 (el) 2016-08-31
NL300798I2 (enExample) 2016-03-16
BRPI0811198B1 (pt) 2021-03-09
DE202008018131U1 (de) 2011-12-30
CA2687001A1 (en) 2008-11-20
HK1141047A1 (en) 2010-10-29
PL2662448T3 (pl) 2017-07-31
EP2368999A1 (en) 2011-09-28
NO2016002I1 (no) 2016-02-02
RS53302B (sr) 2014-08-29
DK2368999T3 (da) 2014-05-26
SI2368999T1 (sl) 2014-07-31
WO2008138131A4 (en) 2008-12-31
NO2016002I2 (no) 2016-02-02
WO2008138131A9 (en) 2009-08-06
PL2158319T4 (pl) 2016-04-29
DK2158319T3 (da) 2012-03-19
ME01828B (me) 2014-12-20
NL300798I1 (enExample) 2016-03-16
EP2158319A1 (en) 2010-03-03
ES2471915T3 (es) 2014-06-27
HUS1600005I1 (hu) 2016-02-29
JP2010526543A (ja) 2010-08-05
FR16C0007I1 (enExample) 2016-04-15
HK1191372A1 (en) 2014-07-25
AU2008250945A1 (en) 2008-11-20
BRPI0811198B8 (pt) 2021-05-25
US20100297119A1 (en) 2010-11-25
LTPA2016004I1 (lt) 2016-02-25
EP2158319A4 (en) 2010-07-21
ES2380546T3 (es) 2012-05-16
BR122019000505A2 (pt) 2021-12-14
LU92976I2 (en) 2016-04-11
PL2158319T3 (pl) 2012-05-31
PT2662448T (pt) 2017-03-29
SI2662448T1 (sl) 2017-05-31
DK2662448T3 (en) 2017-03-20
EP2662448B1 (en) 2016-12-21
PT2158319E (pt) 2012-03-06
LTC2368999I2 (lt) 2017-09-25
EP2368999B1 (en) 2014-03-12
ES2619332T3 (es) 2017-06-26
WO2008138131A1 (en) 2008-11-20
PT2368999E (pt) 2014-05-26
AU2008250945A2 (en) 2009-12-24
CA2687001C (en) 2019-02-12
BRPI0811198A8 (pt) 2018-08-14
HRP20140416T1 (hr) 2014-06-20
AU2008250945B2 (en) 2013-12-12
CY2016005I1 (el) 2016-08-31
ATE536413T1 (de) 2011-12-15
FR16C0007I2 (fr) 2017-01-27
EP2158319B1 (en) 2011-12-07

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