JP5723293B2 - 緩衝系を用いた経眼イオントフォレシスの装置および方法 - Google Patents

緩衝系を用いた経眼イオントフォレシスの装置および方法 Download PDF

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Publication number
JP5723293B2
JP5723293B2 JP2011544556A JP2011544556A JP5723293B2 JP 5723293 B2 JP5723293 B2 JP 5723293B2 JP 2011544556 A JP2011544556 A JP 2011544556A JP 2011544556 A JP2011544556 A JP 2011544556A JP 5723293 B2 JP5723293 B2 JP 5723293B2
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layer
therapeutic substance
delivery device
iontophoresis
therapeutic
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Japanese (ja)
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JP2012513875A (ja
JP2012513875A5 (cg-RX-API-DMAC7.html
Inventor
モスレミー・ペイマン
マンゾー・マイケル
シューベルト・ウィリアム
アイソム・ウィリアム
ピエール・ロイ
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Kiora Pharmaceuticals Inc
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EyeGate Pharmaceuticals Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/0008—Introducing ophthalmic products into the ocular cavity or retaining products therein
    • A61F9/0026—Ophthalmic product dispenser attachments to facilitate positioning near the eye
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0408—Use-related aspects
    • A61N1/0428—Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
    • A61N1/0444—Membrane
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/20—Applying electric currents by contact electrodes continuous direct currents
    • A61N1/30—Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
    • A61N1/303—Constructional details
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/325—Applying electric currents by contact electrodes alternating or intermittent currents for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0408—Use-related aspects
    • A61N1/0428—Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
    • A61N1/0448—Drug reservoir

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Ophthalmology & Optometry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Electrotherapy Devices (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
JP2011544556A 2008-12-31 2009-12-28 緩衝系を用いた経眼イオントフォレシスの装置および方法 Active JP5723293B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US14199408P 2008-12-31 2008-12-31
US61/141,994 2008-12-31
US18060209P 2009-05-22 2009-05-22
US61/180,602 2009-05-22
PCT/US2009/069580 WO2010078246A1 (en) 2008-12-31 2009-12-28 System and method for ocular iontophoresis with buffering

Publications (3)

Publication Number Publication Date
JP2012513875A JP2012513875A (ja) 2012-06-21
JP2012513875A5 JP2012513875A5 (cg-RX-API-DMAC7.html) 2013-02-21
JP5723293B2 true JP5723293B2 (ja) 2015-05-27

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JP2011544556A Active JP5723293B2 (ja) 2008-12-31 2009-12-28 緩衝系を用いた経眼イオントフォレシスの装置および方法

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US (2) US9180292B2 (cg-RX-API-DMAC7.html)
EP (1) EP2370155B1 (cg-RX-API-DMAC7.html)
JP (1) JP5723293B2 (cg-RX-API-DMAC7.html)
CN (1) CN102341146B (cg-RX-API-DMAC7.html)
AU (1) AU2009332951B2 (cg-RX-API-DMAC7.html)
CA (1) CA2750149C (cg-RX-API-DMAC7.html)
ES (1) ES2679673T3 (cg-RX-API-DMAC7.html)
IL (1) IL213796A0 (cg-RX-API-DMAC7.html)
MX (1) MX2011006925A (cg-RX-API-DMAC7.html)
WO (1) WO2010078246A1 (cg-RX-API-DMAC7.html)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5723293B2 (ja) * 2008-12-31 2015-05-27 アイゲート・ファーマシューティカルズ・インコーポレーテッドＥｙｅｇａｔｅ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． 緩衝系を用いた経眼イオントフォレシスの装置および方法
EP2663281B1 (en) * 2011-01-12 2016-08-10 Sooft Italia Spa Corneal delivery of cross-linking agents by iontophoresis for the treatment of keratoconus and related ophthalmic compositions
EP2753395B1 (en) * 2011-09-09 2020-07-29 International Scientific Pty Ltd Method and device for delivery of substances
ITVE20130043A1 (it) * 2013-07-31 2015-02-01 I A C E R S R L Dispositivo perfezionato oftalmologico per il trattamento di malattie corneali quali il cheratocono.
ES2672327T3 (es) * 2014-01-27 2018-06-13 Opia Technologies Dispositivo de iontoforesis ocular
MX2017009193A (es) 2015-01-22 2017-12-12 Eyegate Pharmaceuticals Inc Lente de contacto iontoforetica.
US11787783B2 (en) 2016-12-13 2023-10-17 Beta Therapeutics Pty Ltd Heparanase inhibitors and use thereof
WO2018107200A1 (en) 2016-12-13 2018-06-21 Beta Therapeutics Pty Ltd Heparanase inhibitors and use thereof
CN113543753B (zh) * 2019-03-04 2024-04-19 国立大学法人东北大学 眼用医疗器械的水分的吸收或排出方法及眼用医疗器械
IT201900010341A1 (it) 2019-06-27 2020-12-27 Vision Eng Italy Srl Dispositivo, sistema e metodo di trattamento di un tessuto corneale
US20240167531A1 (en) * 2019-11-14 2024-05-23 Siemens Gamesa Renewable Energy A/S Damper for a wind turbine

Family Cites Families (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US551880A (en) 1895-12-24 Theodore b
SU654254A2 (ru) 1977-02-07 1979-03-30 В. Н. Серов Устройство дл лечени глаз
SU995783A1 (ru) 1980-07-21 1983-02-15 Омский Государственный Ордена Трудового Красного Знамени Медицинский Институт Им.М.И.Калинина Устройство дл электрофореза лекарственных веществ в ткани глаза
US4678466A (en) 1981-06-25 1987-07-07 Rosenwald Peter L Internal medication delivery method and vehicle
SU1342500A1 (ru) 1982-03-09 1987-10-07 Омский государственный медицинский институт им.М.И.Калинина Способ лечени глаукомы
US5053000A (en) 1985-11-13 1991-10-01 Imperial Chemical Industries Plc Ocular treatment
US4752285B1 (en) 1986-03-19 1995-08-22 Univ Utah Res Found Methods and apparatus for iontophoresis application of medicaments
IL86076A (en) 1988-04-14 1992-12-01 Inventor S Funding Corp Ltd Transdermal drug delivery device
US4955378A (en) 1988-05-02 1990-09-11 University Of South Florida Apparatus and methods for performing electrofusion at specific anatomical sites
AU5354190A (en) 1989-03-17 1990-10-22 Candela Laser Corporation Non-invasive sclerostomy laser apparatus and method
US5174304A (en) 1990-02-16 1992-12-29 Latina Mark A Electrocycloablation apparatus and method
CA2122150A1 (en) 1991-08-26 1993-03-04 Yie W. Chien Iontotherapeutic device and process
US5533971A (en) 1993-09-03 1996-07-09 Alza Corporation Reduction of skin irritation during electrotransport
US5420109A (en) 1993-11-12 1995-05-30 Houghten Pharmaceuticals, Inc. Cytokine restraining agents
US5472436A (en) 1994-07-26 1995-12-05 Fremstad; Daria A. Ocular appliance for delivering medication
AUPM982694A0 (en) 1994-12-02 1995-01-05 University Of Queensland, The Iontophoresis method and apparatus
US5980497A (en) 1996-03-15 1999-11-09 Yavitz; Edward Q. Membrane shield for eyes
JP3459724B2 (ja) * 1996-03-17 2003-10-27 久光製薬株式会社 イオントフォレーシス用電極デバイス
US5676648A (en) 1996-05-08 1997-10-14 The Aps Organization, Llp Iontophoretic drug delivery apparatus and method for use
JPH1072374A (ja) * 1996-06-20 1998-03-17 Hisamitsu Pharmaceut Co Inc イオントフォレーシス用薬物投与組成物
DE69804921T2 (de) 1997-10-28 2002-11-07 Mecanismos Auxiliares Industriales, S.A. M.A.I.S.A. Anschlusselement für eine Leiterplatte
FR2773320B1 (fr) 1998-01-05 2000-03-03 Optisinvest Dispositif pour le transfert intraoculaire de produits actifs par iontophorese
BR0008123A (pt) 1999-02-10 2001-11-13 Gmp Drug Delivery Inc Dispositivo baseado em emplastro para aumentar aliberação local de um agente de tratamento paradentro de tecidos alvo, e, processo de liberaçãode um agente de tratamento para dentro detecidos alvo de uma vesìcula corporal
TW539564B (en) 1999-05-25 2003-07-01 Iomed Inc Methods and apparatus for ocular iontophoresis
US20030023228A1 (en) * 2001-07-20 2003-01-30 Parkinson Thomas M. Ocular iontophoretic device and method for using the same
FR2830766B1 (fr) 2001-10-12 2004-03-12 Optis France Sa Dispositif de delivrance de medicaments par iontophorese transpalpebrale
KR20050108345A (ko) 2003-01-24 2005-11-16 컨트롤 딜리버리 시스템즈 인코포레이티드 탄산 탈수효소 저해제의 안구 전달을 위한 서방 장치와방법
US20050197618A1 (en) * 2004-03-03 2005-09-08 Iomed, Inc. Improved buffer gel for iontophoresis electrodes
FR2869531B1 (fr) 2004-04-30 2006-07-14 Optis France Sa Sa Dispositif de iontophorese oculaire diminuant les irritations
AU2005247122C1 (en) 2004-04-30 2012-02-02 Eyegate Pharma S.A. Irritation-reducing ocular iontophoretic device
KR20080066712A (ko) * 2005-09-30 2008-07-16 티티아이 엘뷰 가부시키가이샤 관능화된 미세바늘 경피 약물 전달 시스템, 장치 및 방법
US8099162B2 (en) * 2005-11-29 2012-01-17 Eyegate Pharma, S.A.S. Ocular iontophoresis device
US8321008B2 (en) * 2005-11-30 2012-11-27 Nitric Biotherapeutics, Inc. Combination cartridge and device for electrokinetic delivery of medicament to a treatment site
KR20090106492A (ko) 2006-12-01 2009-10-09 티티아이 엘뷰 가부시키가이샤 경피성 전달 장치와 같은 장치에 전력을 제공하거나 제어하기 위한 시스템, 장치, 및 방법
CN101970042A (zh) * 2008-02-25 2011-02-09 眼门药品公司 经由离子电渗法增强递送治疗药物至眼部组织
JP5723293B2 (ja) * 2008-12-31 2015-05-27 アイゲート・ファーマシューティカルズ・インコーポレーテッドＥｙｅｇａｔｅ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． 緩衝系を用いた経眼イオントフォレシスの装置および方法

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Publication number Publication date
CA2750149C (en) 2018-02-27
ES2679673T3 (es) 2018-08-30
CN102341146B (zh) 2015-09-23
US9180292B2 (en) 2015-11-10
EP2370155B1 (en) 2018-07-04
JP2012513875A (ja) 2012-06-21
AU2009332951A1 (en) 2011-07-14
US20110301526A1 (en) 2011-12-08
MX2011006925A (es) 2011-07-28
EP2370155A4 (en) 2012-12-26
WO2010078246A1 (en) 2010-07-08
AU2009332951B2 (en) 2015-06-11
US9539141B2 (en) 2017-01-10
IL213796A0 (en) 2011-07-31
EP2370155A1 (en) 2011-10-05
CA2750149A1 (en) 2010-07-08
US20160120696A1 (en) 2016-05-05
CN102341146A (zh) 2012-02-01

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