JP5709877B2 - プロセシングされていない及び部分的にプロセシングされたａ型ニューロトキシンを測定するためのシステム - Google Patents

プロセシングされていない及び部分的にプロセシングされたａ型ニューロトキシンを測定するためのシステム Download PDF

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Publication number
JP5709877B2
JP5709877B2 JP2012534647A JP2012534647A JP5709877B2 JP 5709877 B2 JP5709877 B2 JP 5709877B2 JP 2012534647 A JP2012534647 A JP 2012534647A JP 2012534647 A JP2012534647 A JP 2012534647A JP 5709877 B2 JP5709877 B2 JP 5709877B2
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bont
polypeptide
unprocessed
complex
partially processed
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Japanese (ja)
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JP2013508701A (ja
Inventor
ブイ． テイラー，ハロルド
ブイ． テイラー，ハロルド
アイゼレ，カール−ハインツ
ブリュン，コルネリア
Original Assignee
メルツ ファルマ ゲーエムベーハー ウント コンパニー カーゲーアーアー
メルツ ファルマ ゲーエムベーハー ウント コンパニー カーゲーアーアー
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/5308—Immunoassay; Biospecific binding assay; Materials therefor for analytes not provided for elsewhere, e.g. nucleic acids, uric acid, worms, mites
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1267—Gram-positive bacteria
    • C07K16/1282—Clostridium (G)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56911—Bacteria
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/94—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/195—Assays involving biological materials from specific organisms or of a specific nature from bacteria
    • G01N2333/33—Assays involving biological materials from specific organisms or of a specific nature from bacteria from Clostridium (G)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/95—Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
    • G01N2333/964—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue
    • G01N2333/96402—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from non-mammals
    • G01N2333/96405—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from non-mammals in general
    • G01N2333/96408—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from non-mammals in general with EC number
    • G01N2333/96419—Metalloendopeptidases (3.4.24)

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Peptides Or Proteins (AREA)
JP2012534647A 2009-10-21 2010-10-18 プロセシングされていない及び部分的にプロセシングされたａ型ニューロトキシンを測定するためのシステム Expired - Fee Related JP5709877B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US27945309P 2009-10-21 2009-10-21
EP09173612 2009-10-21
EP09173612.4 2009-10-21
US61/279,453 2009-10-21
PCT/EP2010/065618 WO2011048044A1 (en) 2009-10-21 2010-10-18 System for determining unprocessed and partially processed neurotoxin type a

Publications (2)

Publication Number Publication Date
JP2013508701A JP2013508701A (ja) 2013-03-07
JP5709877B2 true JP5709877B2 (ja) 2015-04-30

Family

ID=41466928

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JP2012534647A Expired - Fee Related JP5709877B2 (ja) 2009-10-21 2010-10-18 プロセシングされていない及び部分的にプロセシングされたａ型ニューロトキシンを測定するためのシステム

Country Status (15)

Country Link
US (2) US8841080B2 (enExample)
EP (1) EP2491384B1 (enExample)
JP (1) JP5709877B2 (enExample)
KR (1) KR101788340B1 (enExample)
CN (1) CN102597769B (enExample)
AU (1) AU2010309932B2 (enExample)
BR (1) BR112012009436A2 (enExample)
CA (1) CA2773478C (enExample)
ES (1) ES2449303T3 (enExample)
IL (1) IL218455A (enExample)
IN (1) IN2012DN01954A (enExample)
MX (1) MX2012004454A (enExample)
PT (1) PT2491384E (enExample)
RU (1) RU2545825C9 (enExample)
WO (1) WO2011048044A1 (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1786459B1 (en) * 2004-07-26 2014-02-12 Merz Pharma GmbH & Co. KGaA Therapeutic composition whit a botulinum neurotoxin
RU2549463C1 (ru) * 2013-12-03 2015-04-27 Федеральное бюджетное учреждение науки Государственный научный центр прикладной микробиологии и биотехнологии (ФБУН ГНЦ ПМБ) Способ определения ботулинического нейротоксина типа а на основе иммунодетекции, сопряженной с полимеразной цепной реакцией
GB201407525D0 (en) * 2014-04-29 2014-06-11 Syntaxin Ltd Manufacture of recombinant clostridium botulinum neurotoxins

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000067700A2 (en) 1999-05-12 2000-11-16 United States Army Medical Research & Materiel Cmd Recombinant vaccine against botulinum neurotoxin
WO1999037326A1 (en) * 1998-01-26 1999-07-29 University Of Massachusetts Biologically active hemagglutinin from type a clostridium botulinum and methods of use
US6667158B1 (en) * 1998-12-17 2003-12-23 The United States Of America As Represented By The Secretary Of The Army Antibodies against type a botulinum neurotoxin
US20080171347A1 (en) * 2003-04-11 2008-07-17 Atassi M Zouhair Determining and reducing immunoresistance to botulinum toxin therapy using botulinum toxin a peptides
FR2869908B1 (fr) * 2004-05-05 2006-07-28 Pharmaleads Substrat peptidique reconnu par la toxine botulique de type a, bont/a et son utilisation pour detecter et/ou doser ladite toxine ou des inhibiteurs de son activite
CN100575363C (zh) * 2007-03-07 2009-12-30 中国人民解放军军事医学科学院微生物流行病研究所 人源抗a型肉毒神经毒素基因工程抗体及其制备方法与用途
US7732579B2 (en) * 2007-06-13 2010-06-08 The United States Of America As Represented By The Secretary Of Agriculture High-affinity monoclonal antibodies for botulinum toxin type A
BRPI1008885B1 (pt) * 2009-02-19 2021-09-28 Merz Pharma Gmbh & Co. Kgaa Método para obter uma solução purificada de polipeptídeos de neurotoxina processados e composição
CN101503472B (zh) * 2009-03-17 2011-08-10 中国人民解放军军事医学科学院生物工程研究所 抗a型肉毒毒素的人源性中和抗体及其应用

Also Published As

Publication number Publication date
KR101788340B1 (ko) 2017-10-19
CA2773478A1 (en) 2011-04-28
US9213026B2 (en) 2015-12-15
EP2491384A1 (en) 2012-08-29
RU2545825C2 (ru) 2015-04-10
EP2491384B1 (en) 2013-12-04
BR112012009436A2 (pt) 2017-02-21
IL218455A0 (en) 2012-04-30
JP2013508701A (ja) 2013-03-07
PT2491384E (pt) 2014-02-21
US20120214182A1 (en) 2012-08-23
RU2012120572A (ru) 2013-11-27
CN102597769B (zh) 2014-11-05
RU2545825C9 (ru) 2015-06-20
AU2010309932A1 (en) 2012-04-05
MX2012004454A (es) 2012-05-22
AU2010309932B2 (en) 2015-04-16
US20140349322A1 (en) 2014-11-27
KR20120102639A (ko) 2012-09-18
ES2449303T3 (es) 2014-03-19
IL218455A (en) 2015-10-29
US8841080B2 (en) 2014-09-23
CN102597769A (zh) 2012-07-18
HK1173493A1 (zh) 2013-05-16
WO2011048044A1 (en) 2011-04-28
CA2773478C (en) 2018-07-17
IN2012DN01954A (enExample) 2015-08-21

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