JP5709354B2 - mTOR阻害剤投与によるがん患者の治療 - Google Patents

mTOR阻害剤投与によるがん患者の治療 Download PDF

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Publication number
JP5709354B2
JP5709354B2 JP2008540275A JP2008540275A JP5709354B2 JP 5709354 B2 JP5709354 B2 JP 5709354B2 JP 2008540275 A JP2008540275 A JP 2008540275A JP 2008540275 A JP2008540275 A JP 2008540275A JP 5709354 B2 JP5709354 B2 JP 5709354B2
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cancer
treatment
dose
administered
week
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JP2009515901A5 (enExample
JP2009515901A (ja
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ベドロシアン、カミール・エル
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アリアド・ファーマシューティカルズ・インコーポレイテッド
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50Pyridazines; Hydrogenated pyridazines
    • A61K31/502Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with carbocyclic ring systems, e.g. cinnoline, phthalazine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
JP2008540275A 2005-11-14 2006-11-14 mTOR阻害剤投与によるがん患者の治療 Expired - Fee Related JP5709354B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US73676305P 2005-11-14 2005-11-14
US60/736,763 2005-11-14
PCT/US2006/044146 WO2007059106A2 (en) 2005-11-14 2006-11-14 Administration of mntor inhibitor to treat patients with cancer

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2013191029A Division JP2014012721A (ja) 2005-11-14 2013-09-13 mTOR阻害剤投与によるがん患者の治療

Publications (3)

Publication Number Publication Date
JP2009515901A JP2009515901A (ja) 2009-04-16
JP2009515901A5 JP2009515901A5 (enExample) 2010-01-21
JP5709354B2 true JP5709354B2 (ja) 2015-04-30

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ID=38049229

Family Applications (2)

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JP2008540275A Expired - Fee Related JP5709354B2 (ja) 2005-11-14 2006-11-14 mTOR阻害剤投与によるがん患者の治療
JP2013191029A Pending JP2014012721A (ja) 2005-11-14 2013-09-13 mTOR阻害剤投与によるがん患者の治療

Family Applications After (1)

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JP2013191029A Pending JP2014012721A (ja) 2005-11-14 2013-09-13 mTOR阻害剤投与によるがん患者の治療

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Country Link
US (1) US20070185150A1 (enExample)
EP (2) EP2662082A1 (enExample)
JP (2) JP5709354B2 (enExample)
CN (2) CN102579467A (enExample)
AU (1) AU2006315512B2 (enExample)
CA (1) CA2629714A1 (enExample)
EA (1) EA015922B1 (enExample)
IL (1) IL191356A0 (enExample)
WO (1) WO2007059106A2 (enExample)

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JP6381523B2 (ja) 2012-05-16 2018-08-29 ノバルティス アーゲー Pi−3キナーゼ阻害剤の投与レジメン
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US20160030401A1 (en) 2013-03-13 2016-02-04 The Board Of Regents Of The University Of Texas System Use of mtor inhibitors for prevention of intestinal polyp growth and cancer
CN104721158B (zh) * 2013-12-24 2018-01-30 正大天晴药业集团股份有限公司 一种稳定的依维莫司片剂
DK3089737T3 (da) 2013-12-31 2021-12-13 Rapamycin Holdings Llc Orale rapamycin-nanopartikelpræparater og anvendelse.
US9700544B2 (en) 2013-12-31 2017-07-11 Neal K Vail Oral rapamycin nanoparticle preparations
CN106166296A (zh) * 2016-07-01 2016-11-30 江南大学 一种辅助雷帕霉素治疗多种肿瘤的药物组合物
CN107714719A (zh) * 2017-11-08 2018-02-23 上海市第妇婴保健院 雷帕霉素在制备治疗白细胞介素‑27低表达子宫内膜癌的药物中的应用
CN115135322A (zh) * 2020-02-21 2022-09-30 韩国高等科学技术学院 包含哺乳动物雷帕霉素靶蛋白信号传导抑制剂作为有效成分的用于预防或治疗癌症的药物组合物
CN114767867A (zh) * 2021-12-22 2022-07-22 中山大学孙逸仙纪念医院 一种用于治疗cdk4/6抑制剂耐药后的乳腺癌的药物组合物及其应用

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Also Published As

Publication number Publication date
AU2006315512B2 (en) 2012-11-01
JP2014012721A (ja) 2014-01-23
CN101360495B (zh) 2012-03-14
WO2007059106A3 (en) 2008-06-05
EP2662082A1 (en) 2013-11-13
EP1962839A2 (en) 2008-09-03
IL191356A0 (en) 2009-08-03
EA015922B1 (ru) 2011-12-30
AU2006315512A1 (en) 2007-05-24
JP2009515901A (ja) 2009-04-16
CN101360495A (zh) 2009-02-04
EA200801309A1 (ru) 2008-10-30
CN102579467A (zh) 2012-07-18
US20070185150A1 (en) 2007-08-09
EP1962839A4 (en) 2010-08-25
WO2007059106A2 (en) 2007-05-24
CA2629714A1 (en) 2007-05-24

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