CN102579467A - 雷帕霉素衍生物在治疗癌症中的用途 - Google Patents
雷帕霉素衍生物在治疗癌症中的用途 Download PDFInfo
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
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- A—HUMAN NECESSITIES
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
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- General Health & Medical Sciences (AREA)
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106166296A (zh) * | 2016-07-01 | 2016-11-30 | 江南大学 | 一种辅助雷帕霉素治疗多种肿瘤的药物组合物 |
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| WO2008016633A2 (en) * | 2006-08-02 | 2008-02-07 | Ariad Gene Therapeutics, Inc. | Combination therapy |
| CA2669415A1 (en) * | 2006-11-14 | 2008-05-22 | Ariad Pharmaceuticals, Inc. | Solid dosage form comprising ap23573 |
| AU2009225434B2 (en) | 2008-03-21 | 2014-05-22 | The University Of Chicago | Treatment with opioid antagonists and mTOR inhibitors |
| CN102292078A (zh) | 2008-11-11 | 2011-12-21 | 得克萨斯大学体系董事会 | 哺乳动物雷帕霉素靶蛋白的抑制 |
| AU2010236825A1 (en) | 2009-04-16 | 2011-09-15 | Merck Sharp & Dohme Corp. | Compositions and methods for treating cancer |
| US8911766B2 (en) * | 2009-06-26 | 2014-12-16 | Abbott Cardiovascular Systems Inc. | Drug delivery compositions including nanoshells for triggered drug release |
| US10485792B2 (en) | 2009-08-26 | 2019-11-26 | Hadasit Medical Research Services & Development Limited | Sustained release delivery systems for the prevention and treatment of head and neck cancers |
| US9283211B1 (en) | 2009-11-11 | 2016-03-15 | Rapamycin Holdings, Llc | Oral rapamycin preparation and use for stomatitis |
| EP2558092B1 (en) * | 2010-04-13 | 2018-06-27 | Novartis AG | Combination comprising a cyclin dependent kinase 4 or cyclin dependent kinase 6 (cdk4/6) inhibitor and an mtor inhibitor for treating cancer |
| JP2012061053A (ja) | 2010-09-14 | 2012-03-29 | Yuuki Kitaoka | 投薬装置、投薬装置の作動方法及び投薬方法 |
| AR083267A1 (es) * | 2010-10-04 | 2013-02-13 | Novartis Ag | Combinaciones farmaceuticas |
| PH12013502077A1 (en) * | 2011-04-25 | 2013-12-16 | Novartis Ag | Combination of a phosphatidylinositol-3-kinase (pi3k) inhibitor and a mtor inhibitor |
| CN104093398B (zh) * | 2011-12-02 | 2017-03-15 | 西格诺药品有限公司 | 7‑(6‑(2‑羟基丙烷‑2‑基)吡啶‑3‑基)‑1‑((反式)‑4‑甲氧基环己基)‑3,4‑二氢吡嗪并[2,3‑b]吡嗪‑2(1h)‑酮、其固体形式的药物组合物及其使用方法 |
| SG10201608469RA (en) * | 2012-05-16 | 2016-11-29 | Novartis Ag | Dosage regimen for a pi-3 kinase inhibitor |
| EP2919759A4 (en) * | 2012-11-14 | 2016-07-20 | Ohio State Innovation Foundation | MATERIALS AND METHODS FOR THE TREATMENT OF GLIOBLASTOMES |
| DK2968281T3 (da) | 2013-03-13 | 2020-11-02 | Univ Texas | Mtor-hæmmere til forebyggelse af vækst af tarmpolyp |
| CN104721158B (zh) * | 2013-12-24 | 2018-01-30 | 正大天晴药业集团股份有限公司 | 一种稳定的依维莫司片剂 |
| CA2933908C (en) | 2013-12-31 | 2024-01-30 | Rapamycin Holdings, Llc | Oral rapamycin nanoparticle preparations and use |
| US9700544B2 (en) | 2013-12-31 | 2017-07-11 | Neal K Vail | Oral rapamycin nanoparticle preparations |
| CN107714719A (zh) * | 2017-11-08 | 2018-02-23 | 上海市第妇婴保健院 | 雷帕霉素在制备治疗白细胞介素‑27低表达子宫内膜癌的药物中的应用 |
| US20230346762A1 (en) * | 2020-02-21 | 2023-11-02 | Korea Advanced Institute Of Science And Technology | Pharmaceutical composition for preventing or treating cancer, containing mtor-signaling inhibitor as active ingredient |
| CN114767867A (zh) * | 2021-12-22 | 2022-07-22 | 中山大学孙逸仙纪念医院 | 一种用于治疗cdk4/6抑制剂耐药后的乳腺癌的药物组合物及其应用 |
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| US20060183766A1 (en) * | 2005-02-15 | 2006-08-17 | Wyeth | Orally bioavailable CCI-779 formulations |
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- 2006-11-14 CN CN2006800510347A patent/CN101360495B/zh not_active Expired - Fee Related
- 2006-11-14 EA EA200801309A patent/EA015922B1/ru not_active IP Right Cessation
- 2006-11-14 WO PCT/US2006/044146 patent/WO2007059106A2/en not_active Ceased
- 2006-11-14 JP JP2008540275A patent/JP5709354B2/ja not_active Expired - Fee Related
- 2006-11-14 EP EP13179744.1A patent/EP2662082A1/en not_active Withdrawn
- 2006-11-14 AU AU2006315512A patent/AU2006315512B2/en not_active Ceased
- 2006-11-14 EP EP06844354A patent/EP1962839A4/en not_active Withdrawn
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| WO2006039414A2 (en) * | 2004-09-30 | 2006-04-13 | Ariad Gene Therapeutics, Inc. | Treatment method |
| US20060183766A1 (en) * | 2005-02-15 | 2006-08-17 | Wyeth | Orally bioavailable CCI-779 formulations |
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| CN106166296A (zh) * | 2016-07-01 | 2016-11-30 | 江南大学 | 一种辅助雷帕霉素治疗多种肿瘤的药物组合物 |
Also Published As
| Publication number | Publication date |
|---|---|
| CN101360495A (zh) | 2009-02-04 |
| AU2006315512A1 (en) | 2007-05-24 |
| JP5709354B2 (ja) | 2015-04-30 |
| US20070185150A1 (en) | 2007-08-09 |
| JP2009515901A (ja) | 2009-04-16 |
| CN101360495B (zh) | 2012-03-14 |
| EA200801309A1 (ru) | 2008-10-30 |
| EP2662082A1 (en) | 2013-11-13 |
| AU2006315512B2 (en) | 2012-11-01 |
| EA015922B1 (ru) | 2011-12-30 |
| CA2629714A1 (en) | 2007-05-24 |
| IL191356A0 (en) | 2009-08-03 |
| WO2007059106A3 (en) | 2008-06-05 |
| EP1962839A2 (en) | 2008-09-03 |
| WO2007059106A2 (en) | 2007-05-24 |
| JP2014012721A (ja) | 2014-01-23 |
| EP1962839A4 (en) | 2010-08-25 |
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