JP5700243B2 - 虚血性疾患および脳変性疾患の予防および治療のためのイネ科植物(Gramineaeplant)からのでんぷんまたは食物繊維を含む組成物 - Google Patents
虚血性疾患および脳変性疾患の予防および治療のためのイネ科植物(Gramineaeplant)からのでんぷんまたは食物繊維を含む組成物 Download PDFInfo
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- YIBXWXOYFGZLRU-UHFFFAOYSA-N syringic aldehyde Natural products CC12CCC(C3(CCC(=O)C(C)(C)C3CC=3)C)C=3C1(C)CCC2C1COC(C)(C)C(O)C(O)C1 YIBXWXOYFGZLRU-UHFFFAOYSA-N 0.000 description 1
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- DPJRMOMPQZCRJU-UHFFFAOYSA-M thiamine hydrochloride Chemical compound Cl.[Cl-].CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N DPJRMOMPQZCRJU-UHFFFAOYSA-M 0.000 description 1
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- 230000001052 transient effect Effects 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
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- 229910052722 tritium Inorganic materials 0.000 description 1
- WKOLLVMJNQIZCI-UHFFFAOYSA-N vanillic acid Chemical compound COC1=CC(C(O)=O)=CC=C1O WKOLLVMJNQIZCI-UHFFFAOYSA-N 0.000 description 1
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- BPICBUSOMSTKRF-UHFFFAOYSA-N xylazine Chemical compound CC1=CC=CC(C)=C1NC1=NCCCS1 BPICBUSOMSTKRF-UHFFFAOYSA-N 0.000 description 1
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Images
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/716—Glucans
- A61K31/718—Starch or degraded starch, e.g. amylose, amylopectin
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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Description
動物の疾患モデルを用いてでんぷんまたは総食物繊維がまた虚血性疾患および脳変性疾患の改善および治療において有効性を有することを調査し、確認して本発明を完成した。
hexastichon ASCH.、malt、Avena sativa、Zea mays L.、Sorghum bicolor MOENCH、Coix lacryma−jobi var.mayuen STAPF、Panicum miliaceυm L.、Setaria italica Beauvなどのイネ科植物(Gramineae plants )またはジャガイモから精製された総食物繊維、好適には、Triticum aestivum L.、Secale cereale L.、Hordeum vulgare var.hexastichon ASCH.、Zea mays L.またはOryza sativa L.から精製された総食物繊維、より好適にはアラビノキシラン、ベータグルカンおよびアラビノガラクタンを相対重量%で5〜20: 1: 1−10含むTriticum aestivum L.から精製された総食物繊維、更により好適には、50,000から400,000ダルトンの範囲の分子量を有するアラビノキシランおよびベータグルカンからなるTriticum aestivum L.から精製された総食物繊維である。
(参考実施例1)
(参考実施例2)
動物は,実験の前10分間手で触れられた。
実施例1において調製したHY6228の10gを500mlの瓶に注ぎ、それにMES/TRIS緩衝溶液(それぞれ0.05M、pH8.0、24°C)400mlを加えた。溶液を完全に混合し、ついでそれにアルファアミラーゼ70マイクロリッター(23mg/ml Termamyl、930U/mg、24°C)を加え、水浴中で80°Cで35分間反応させた。反応後、溶液を60°Cに冷却し、それにプロテアーゼ (−350U/ml Megazyme Cat.No.E−BSPRT)1000マイクロリッターを加え、水浴中で60°Cで30分間反応させた。該溶液を3M酢酸でpH4.3に調製し、それにアミログルコシダーゼ(3300U/ml、Megazyme.Cat.No.E−AMGDF)の2000マイクロリッターを加え、水浴中で60°Cで30分間反応させた。
(実験的実施例1)
t<ii7>図2aに示すように、200マイクログラム/mlを超すSR、HY6228A、SWおよびHY6228d、400マイクログラム/mlを超すHY6228、SCおよびHY6228F、および800マイクログラム/mlを超すSSが、それぞれ、細胞生存率を改善した。
(実験的実施例2)
(実験的実施例3)
(実験的実施例4)
(実験的実施例5)
虚血指数(%)=A/Bx100
A:大脳半球の梗塞容積(mm3)
B:大脳半球の容積(mm3)
(実験的実施例6)
(実験的実施例7)
粉末の調製
ラクトース100mg
タルク10mg
粉末の調製は、上記成分を混合し、シールした包を充填して調製された。
錠剤の調製
コーンでんぷん100mg
ラクトース100mg
ステアリン酸マグネシウム2mg
錠剤の調製は、上記成分を混合し、錠剤化して調製された。
カプセルの調製
コーンでんぷん100mg
ラクトース100mg
ステアリン酸マグネシウム2mg
カプセルの調製は、上記成分を混合し、通常のゼラチンの調製方法によってゼラチンカプセルを充填して調製された。
注射剤の調製
注射剤用蒸留水の至適量
pH調整剤の至適量
注射剤の調製は、活性成分を溶解し、pHを約7.5に調整しついですべての成分を2mlのアンプルに充填し、通常の注射剤調製方法によって滅菌して調製された。
液体の調製
異性化糖10g
マニトール5g
蒸留水の至適量
液体の調製は、活性成分を溶解し、すべての成分を充填し通常の液体の調製方法によって滅菌して調製された。
健康食品の調製
ビタミン混合物の至適量
ビタミンA酢酸塩70マイクログラム
ビタミンE 1.0mg
ビタミンBl 0.13mg
ビタミンB2 0.15mg
ビタミンB6 0.5mg
ビタミンB12 0.2マイクログラム
ビタミンC10mg
ビオチン10マイクログラム
ニコチン酸アミド1.7mg
葉酸50マイクログラム
パントテン酸カルシウム0.5mg
ミネラル混合物至適量
硫酸鉄1.75mg
酸化亜塩0.82mg
炭酸マグネシウム25.3mg
一カリウムリン酸塩15mg
二カリウムリン酸塩55mg
クエン酸カリウム90mg
炭酸カルシウム100mg
塩化マグネシウム24.8mg
上述のビタミンおよびミネラル混合物は、多様に変化し得る。このような変化は本発明の精神と範囲を逸脱するものと見なされない。
健康飲料の調製
クエン酸1000mg
オリゴ糖100g
アプリコット濃縮物2g
タウリン1g
蒸留水900ml
健康飲料の調製は、活性成分を溶解し、混合し、85°Cで1時間攪拌し、ろ過し、ついですべての成分を1000mlのアンプルに充填し、通常の健康飲料調製方法によって滅菌し調製された。
本発明でんぷんまたは総食物繊維は、それぞれの細胞が虚血状態下で、またはベータ−アミロイドおよび6−ヒドロキシドパミンの存在下で培養された場合、細胞生存率を改善し、また心筋梗塞、脳梗塞および血管性痴呆を予防および治療し、または記憶障害を軽減したが、これらはすべてそれぞれの動物モデルとしてラットを用いて証明された。従って、本発明のでんぷんまたは総食物繊維は、虚血性疾患または脳変性疾患の予防および治療のための治療薬または健康食品として用いられ得る。
Claims (7)
- 脳変性疾患の予防または治療、あるいは虚血性疾患の治療のための活性成分として、分離されたアラビノキシラン、分離されたアラビノースおよび分離されたキシロースからなる群から選ばれる少なくとも1つの成分を含む医薬組成物。
- 前記虚血性疾患が、心筋梗塞、脳梗塞、虚血性急性腎不全、虚血性急性肝不全、糖尿病性足潰瘍、糖尿病性腎症、または外科手術の副作用や臓器組織傷害に起因する虚血性疾患である、請求項1に記載の医薬組成物。
- 外科手術の副作用に由来する前記虚血性疾患が、心不全、虚血性腎不全、虚血性肝不全または虚血性脳卒中から選ばれる、請求項2に記載の医薬組成物。
- 前記臓器組織傷害が臓器手術または移植または事故によって切断された体の部分の再結合により生じ、そのいずれもが虚血再灌流を伴う、請求項2に記載の医薬組成物。
- 前記臓器が、腎臓、肝臓、すい臓、肺または心臓から選ばれる、請求項4に記載の医薬組成物。
- 前記脳変性疾患が、アルツハイマー病、血管性痴呆、パーキンソン病、筋萎縮性側索硬化症、ハンチントン病、ピック病、クロイツェルヤコブ病または脊髄傷害から選ばれる、請求項1に記載の医薬組成物。
- 前記活性成分が、Triticum aestivum L.、Triticum levis semen、Secale cerealeL.、Oryzasativa L.(コメ)、Hordeum vulgare var.hexastichon ASCH.、malt、Avena sativa、Zeamays L.、Sorghum bicolor MOENCH、Coix lacryma−jobi var.mayuen STAPF、Panicum miliaceum L.または、Setaria italica Beauv.から選ばれるイネ科植物(Gramineaeplant)から精製される、請求項1に記載の医薬組成物。
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