JP5698658B2 - 置換フェニル基を有する環状化合物 - Google Patents
置換フェニル基を有する環状化合物 Download PDFInfo
- Publication number
- JP5698658B2 JP5698658B2 JP2011508333A JP2011508333A JP5698658B2 JP 5698658 B2 JP5698658 B2 JP 5698658B2 JP 2011508333 A JP2011508333 A JP 2011508333A JP 2011508333 A JP2011508333 A JP 2011508333A JP 5698658 B2 JP5698658 B2 JP 5698658B2
- Authority
- JP
- Japan
- Prior art keywords
- group
- carboxamide
- mmol
- phenyl
- isoquinoline
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
- C07D217/16—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Physical Education & Sports Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2011508333A JP5698658B2 (ja) | 2009-04-06 | 2010-03-29 | 置換フェニル基を有する環状化合物 |
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2009091671 | 2009-04-06 | ||
| JP2009091671 | 2009-04-06 | ||
| JP2011508333A JP5698658B2 (ja) | 2009-04-06 | 2010-03-29 | 置換フェニル基を有する環状化合物 |
| PCT/JP2010/055547 WO2010116915A1 (ja) | 2009-04-06 | 2010-03-29 | 置換フェニル基を有する環状化合物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPWO2010116915A1 JPWO2010116915A1 (ja) | 2012-10-18 |
| JP5698658B2 true JP5698658B2 (ja) | 2015-04-08 |
Family
ID=42936200
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011508333A Expired - Fee Related JP5698658B2 (ja) | 2009-04-06 | 2010-03-29 | 置換フェニル基を有する環状化合物 |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US8410273B2 (pt) |
| EP (1) | EP2418203B1 (pt) |
| JP (1) | JP5698658B2 (pt) |
| KR (1) | KR20120006016A (pt) |
| CN (1) | CN102803223A (pt) |
| AU (1) | AU2010235619A1 (pt) |
| BR (1) | BRPI1013988A2 (pt) |
| CA (1) | CA2758144C (pt) |
| CO (1) | CO6450648A2 (pt) |
| ES (1) | ES2444443T3 (pt) |
| IL (1) | IL215531A0 (pt) |
| MX (1) | MX2011010523A (pt) |
| NZ (1) | NZ596154A (pt) |
| SG (1) | SG175091A1 (pt) |
| TW (1) | TW201040180A (pt) |
| WO (1) | WO2010116915A1 (pt) |
| ZA (1) | ZA201107301B (pt) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8759362B2 (en) * | 2008-10-24 | 2014-06-24 | Purdue Pharma L.P. | Bicycloheteroaryl compounds and their use as TRPV1 ligands |
| EP2903615B1 (en) * | 2012-10-05 | 2021-04-07 | Merck Sharp & Dohme Corp. | 5-pyridin-3-yl-2,3-dihydro-1h-indole derivatives as aldosterone synthase (cyp11b2) inhibitors for the treatment of hypertension |
| EP2922540A1 (en) * | 2012-11-20 | 2015-09-30 | F. Hoffmann-La Roche AG | Substituted 1,6-naphthyridines |
| RU2673549C2 (ru) * | 2013-05-03 | 2018-11-28 | Ф. Хоффманн-Ля Рош Аг | Производные изохинолина, стимулирующие нейрогенез |
| EP3041849A4 (en) | 2013-09-05 | 2017-04-19 | Dow AgroSciences LLC | Methods for producing borylated arenes |
| AR099612A1 (es) | 2014-03-04 | 2016-08-03 | Actelion Pharmaceuticals Ltd | Derivados antibacterianos de 1,2-dihidro-3h-pirrolo[1,2-c]imidazol-3-ona |
| TW201625354A (zh) | 2014-06-16 | 2016-07-16 | 陶氏農業科學公司 | 用於製備氧硼基化芳烴之方法 |
| CN106817900A (zh) * | 2014-07-17 | 2017-06-09 | 默克专利有限公司 | 新颖的萘啶和异喹啉及其作为cdk8/19抑制剂的用途 |
| AU2016217874A1 (en) * | 2015-02-11 | 2017-08-10 | Basilea Pharmaceutica International AG | Substituted mono- and polyazanaphthalene derivatives and their use |
| KR102446408B1 (ko) * | 2015-07-24 | 2022-09-23 | 삼성전자주식회사 | 축합환 화합물 및 이를 포함한 유기 발광 소자 |
| US12281080B2 (en) | 2018-08-21 | 2025-04-22 | University Of South Carolina | Quinoline-based compounds and methods of inhibiting CDK8/19 |
| US11014906B2 (en) | 2018-08-21 | 2021-05-25 | University Of South Carolina | Quinoline-based compounds and methods of inhibiting CDK8/19 |
| AU2019375983A1 (en) | 2018-11-09 | 2021-06-10 | Vivace Therapeutics, Inc. | Bicyclic compounds |
| IL287222B2 (en) | 2019-04-16 | 2025-04-01 | Vivace Therapeutics Inc | Bicyclic compounds |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008509151A (ja) * | 2004-08-03 | 2008-03-27 | セレネックス， インコーポレイテッド | ２，８−二置換ナフチリジン誘導体 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0634169B1 (en) * | 1993-06-29 | 2000-01-05 | Takeda Chemical Industries, Ltd. | Quinoline or quinazoline derivatives and their use in the manufacture of a medicament for the treatment of osteoporosis |
| TW403757B (en) | 1994-12-28 | 2000-09-01 | Takeda Chemical Industries Ltd | Optically active benzothiepin derivative, its preparation and use |
| JPH09188665A (ja) * | 1996-01-05 | 1997-07-22 | Kyorin Pharmaceut Co Ltd | 新規置換ｎ−キノリルアントラニル酸誘導体及びその製造法 |
| EP1481977A4 (en) | 2002-03-01 | 2006-02-01 | Astellas Pharma Inc | NITROGENIC HETEROCYCLIC COMPOUND |
| JP2007131617A (ja) | 2005-10-11 | 2007-05-31 | Sankyo Co Ltd | チエノピリジン誘導体を含有する医薬 |
-
2010
- 2010-03-29 CA CA2758144A patent/CA2758144C/en not_active Expired - Fee Related
- 2010-03-29 ES ES10761614.6T patent/ES2444443T3/es active Active
- 2010-03-29 WO PCT/JP2010/055547 patent/WO2010116915A1/ja not_active Ceased
- 2010-03-29 MX MX2011010523A patent/MX2011010523A/es not_active Application Discontinuation
- 2010-03-29 EP EP10761614.6A patent/EP2418203B1/en not_active Not-in-force
- 2010-03-29 CN CN201080024805XA patent/CN102803223A/zh active Pending
- 2010-03-29 KR KR1020117023380A patent/KR20120006016A/ko not_active Withdrawn
- 2010-03-29 NZ NZ596154A patent/NZ596154A/en not_active IP Right Cessation
- 2010-03-29 JP JP2011508333A patent/JP5698658B2/ja not_active Expired - Fee Related
- 2010-03-29 BR BRPI1013988A patent/BRPI1013988A2/pt not_active IP Right Cessation
- 2010-03-29 AU AU2010235619A patent/AU2010235619A1/en not_active Abandoned
- 2010-03-29 SG SG2011072824A patent/SG175091A1/en unknown
- 2010-04-06 TW TW099110493A patent/TW201040180A/zh unknown
-
2011
- 2011-10-04 IL IL215531A patent/IL215531A0/en unknown
- 2011-10-05 ZA ZA2011/07301A patent/ZA201107301B/en unknown
- 2011-10-05 US US13/253,792 patent/US8410273B2/en not_active Expired - Fee Related
- 2011-10-25 CO CO11143912A patent/CO6450648A2/es not_active Application Discontinuation
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008509151A (ja) * | 2004-08-03 | 2008-03-27 | セレネックス， インコーポレイテッド | ２，８−二置換ナフチリジン誘導体 |
Also Published As
| Publication number | Publication date |
|---|---|
| US8410273B2 (en) | 2013-04-02 |
| CA2758144C (en) | 2014-05-13 |
| US20120040936A1 (en) | 2012-02-16 |
| TW201040180A (en) | 2010-11-16 |
| CN102803223A (zh) | 2012-11-28 |
| SG175091A1 (en) | 2011-11-28 |
| EP2418203A1 (en) | 2012-02-15 |
| CA2758144A1 (en) | 2010-10-14 |
| CO6450648A2 (es) | 2012-05-31 |
| EP2418203B1 (en) | 2013-12-11 |
| NZ596154A (en) | 2013-12-20 |
| JPWO2010116915A1 (ja) | 2012-10-18 |
| EP2418203A4 (en) | 2012-08-15 |
| AU2010235619A1 (en) | 2011-11-10 |
| ZA201107301B (en) | 2012-09-26 |
| MX2011010523A (es) | 2011-10-28 |
| IL215531A0 (en) | 2011-12-29 |
| WO2010116915A1 (ja) | 2010-10-14 |
| ES2444443T3 (es) | 2014-02-25 |
| BRPI1013988A2 (pt) | 2016-04-05 |
| KR20120006016A (ko) | 2012-01-17 |
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