JP5678089B2 - 安定な脂溶性活性成分粒子 - Google Patents
安定な脂溶性活性成分粒子 Download PDFInfo
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- JP5678089B2 JP5678089B2 JP2012542603A JP2012542603A JP5678089B2 JP 5678089 B2 JP5678089 B2 JP 5678089B2 JP 2012542603 A JP2012542603 A JP 2012542603A JP 2012542603 A JP2012542603 A JP 2012542603A JP 5678089 B2 JP5678089 B2 JP 5678089B2
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- ATGAWOHQWWULNK-UHFFFAOYSA-I pentapotassium;[oxido(phosphonatooxy)phosphoryl] phosphate Chemical compound [K+].[K+].[K+].[K+].[K+].[O-]P([O-])(=O)OP([O-])(=O)OP([O-])([O-])=O ATGAWOHQWWULNK-UHFFFAOYSA-I 0.000 description 1
- HWGNBUXHKFFFIH-UHFFFAOYSA-I pentasodium;[oxido(phosphonatooxy)phosphoryl] phosphate Chemical compound [Na+].[Na+].[Na+].[Na+].[Na+].[O-]P([O-])(=O)OP([O-])(=O)OP([O-])([O-])=O HWGNBUXHKFFFIH-UHFFFAOYSA-I 0.000 description 1
- 239000000467 phytic acid Substances 0.000 description 1
- 229940068041 phytic acid Drugs 0.000 description 1
- 235000002949 phytic acid Nutrition 0.000 description 1
- 235000021118 plant-derived protein Nutrition 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 239000001205 polyphosphate Chemical class 0.000 description 1
- 235000011176 polyphosphates Nutrition 0.000 description 1
- 235000020777 polyunsaturated fatty acids Nutrition 0.000 description 1
- 230000035484 reaction time Effects 0.000 description 1
- 238000006479 redox reaction Methods 0.000 description 1
- 229960002477 riboflavin Drugs 0.000 description 1
- 210000004767 rumen Anatomy 0.000 description 1
- 150000004671 saturated fatty acids Chemical class 0.000 description 1
- 235000003441 saturated fatty acids Nutrition 0.000 description 1
- 150000003342 selenium Chemical class 0.000 description 1
- 239000011669 selenium Substances 0.000 description 1
- 229910052711 selenium Inorganic materials 0.000 description 1
- 238000007873 sieving Methods 0.000 description 1
- UGTZMIPZNRIWHX-UHFFFAOYSA-K sodium trimetaphosphate Chemical compound [Na+].[Na+].[Na+].[O-]P1(=O)OP([O-])(=O)OP([O-])(=O)O1 UGTZMIPZNRIWHX-UHFFFAOYSA-K 0.000 description 1
- 235000019832 sodium triphosphate Nutrition 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 229960003495 thiamine Drugs 0.000 description 1
- 229930003799 tocopherol Natural products 0.000 description 1
- 239000011732 tocopherol Substances 0.000 description 1
- 229960001295 tocopherol Drugs 0.000 description 1
- 235000010384 tocopherol Nutrition 0.000 description 1
- 229940048102 triphosphoric acid Drugs 0.000 description 1
- SUZJDLRVEPUNJG-UHFFFAOYSA-K tripotassium 2,4,6-trioxido-1,3,5,2lambda5,4lambda5,6lambda5-trioxatriphosphinane 2,4,6-trioxide Chemical compound [K+].[K+].[K+].[O-]P1(=O)OP([O-])(=O)OP([O-])(=O)O1 SUZJDLRVEPUNJG-UHFFFAOYSA-K 0.000 description 1
- 238000011144 upstream manufacturing Methods 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- 239000011691 vitamin B1 Substances 0.000 description 1
- 235000019163 vitamin B12 Nutrition 0.000 description 1
- 239000011715 vitamin B12 Substances 0.000 description 1
- 239000011716 vitamin B2 Substances 0.000 description 1
- 239000011726 vitamin B6 Substances 0.000 description 1
- 239000011727 vitamin B9 Substances 0.000 description 1
- 229940011671 vitamin b6 Drugs 0.000 description 1
- 239000000811 xylitol Substances 0.000 description 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
- 235000010447 xylitol Nutrition 0.000 description 1
- 229960002675 xylitol Drugs 0.000 description 1
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 1
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Description
−タンパク質と、糖と、アルカリ金属リン酸塩と、ビタミン(またはカロテノイド)とを含む水性分散体を作る工程、続けての
−特に乾燥により、この分散体を乾燥粉末に変える工程、および次の
−55℃〜180℃、しかし好ましくは85℃〜125℃に含まれる温度で、5分〜3時間、好ましくは6〜25分に含まれる期間にわたってのタンパク質の熱処理にある架橋工程。
a)以下の成分をエマルションの総重量に基づいて以下の重量百分率で含む水中油型エマルションを調製する工程:
−8〜20%、好ましくは10〜15%の少なくとも1種のタンパク質、
−5〜15%、好ましくは8〜12%の少なくとも1種の糖、
−0.5〜3%、好ましくは2〜3%の少なくとも1種の無機塩、
−10〜22%、好ましくは15〜20%の、油状のおよび/または食用油中に溶解した少なくとも1種の脂溶性活性成分、
−qs%の水
b)工程a)の終わりに得られる水中油型エマルションを流体中に分散させることで、実質的に球状に粒子の付形を行う工程、
c)タンパク質を架橋させるための少なくとも1種の薬剤を工程b)の終わりに得られる分散体に添加する工程、
d)活性成分を実質的に球状の粒子の形態で回収する工程。
−リン酸ナトリウム(Na3PO4)、リン酸水素ナトリウム(Na2HPO4)、リン酸二水素ナトリウム(NaH2PO4)、二リン酸二水素ナトリウム、三リン酸ナトリウム、トリメタリン酸ナトリウム(Na3P3O9)、
−リン酸カリウム(K3PO4)、リン酸水素カリウム(K2HPO4)、リン酸二水素カリウム(KH2PO4)、二リン酸二水素カリウム、三リン酸カリウム、トリメタリン酸カリウム(K3P3O9)。
−ビタミン、たとえばビタミンA、ビタミンE、ビタミンD特にビタミンD3、ビタミンK特にビタミンK3、ならびに、
−これらのビタミンの誘導体、たとえばそれらのエステル、特にビタミンAのエステル、たとえばビタミンA酢酸エステル、ビタミンAプロピオン酸エステルもしくはビタミンAパルミチン酸エステル、またはビタミンEの他のエステル、たとえばトコフェリル酢酸エステル、
−カロテノイド、たとえばベータカロテン、リコペン、ビキシン、ゼアキサンチン、シトラナキサンチン、アスタキサンチン、カンタキサンチン、ルテイン、カプサンシン、クリプトキサンチン、ベータ−アポ−8’−カロチノイック酸およびそのエステル、ベータ−アポ−8’−カロテナール、ベータ−アポ−12’−カロテナール、
−多価不飽和脂肪酸、たとえばオメガ三系およびオメガ六系脂肪酸。
i.第1のミキサーにおいて、タンパク質を45℃〜70℃、好ましくは45℃〜55℃に含まれる、より好ましくは50℃の温度の熱水中に溶解させ、これを、たとえば2〜3m/秒の速度でおよび少なくとも20分間にわたって撹拌する。
ii.この第1のミキサーにおいて、糖、無機塩および脂溶性活性成分、ならびに任意に抗酸化剤、さらには上で説明したような成分、たとえば増湿剤、乳化剤、増粘剤から選択される少なくとも1種を油状で添加する。温度は45℃〜70℃、好ましくは45℃〜55℃に含まれる、より好ましくは50℃の温度に常に維持する。これらの種々の成分を添加したら、混合物を、たとえば2〜3m/秒の速度で撹拌し続ける。混合物をかなり均質にするために、撹拌は少なくとも10分間維持する。
−工程c)の終わりにそのようにして得られた活性成分の顆粒を水切りし、
−任意に、前記活性成分の顆粒を抗凝集剤たとえばシリカ、ステアリン酸マグネシウム、またはデンプン、マルトデキストリンもしくはコーンスターチ上に吸収させ、
−前記活性成分の顆粒を流動床上で55℃〜65℃に含まれる温度で、好ましくは60℃で乾燥させ、
これは活性成分の粒子を回収するためのものである。
本発明による方法に従って調製した粒子のプレミックス、すなわち「攻撃的プレミックス」中での安定性の評価
この実験パートによると、「試験した」活性成分は:
−ビタミンA酢酸エステル(パート1)、および次に
−ビタミンAプロピオン酸エステル(パートII)、すなわち、上で説明した産業的プロセス条件に対して敏感であり、さらにはアグレッシブプレミックス中に混合される化合物であった。なお、以下に説明する混合物において、ビタミンは組成物の成分の一部である。実際、プレミックスの組成に関与する全てのビタミン、特には極端な条件にさほど敏感でないそれを本発明による方法に従って調製する必要はなく、これはこのプレミックスの製造コストを抑えるためのものである。
A−ビタミンA酢酸エステル活性成分の調製
試験1〜11の全てについて、ミキサー内で、ゼラチンを2〜3m/秒の速度で撹拌しながら50℃の水中に溶解させ、これを約20分間継続させた。
試験第4〜11についてのみ、NaH2PO4をさらに添加した。
−活性成分、
−抗酸化剤、
−タンパク質、
−糖、
−任意に無機塩。
いわゆる「オリゴポーク」プレミックス、すなわち豚の栄養を目的としたものを、以下の成分(示した百分率はオリゴポークプレミックスの全体の組成に対する重量百分率を表している)を混ぜ合わせて調製した:
−硫酸コバルト:0.39%;
−硫酸銅:10%;
−硫酸鉄:12.5%;
−炭酸鉄:20%;
−ヨウ素酸カルシウム:0.15%;
−酸化マンガン緑:10.7%;
−酸化亜鉛:24.9%;
−セレン誘導体(商標名:SELENIPHOS)0.60%;
qs%の炭酸カルシウム。
以下「複合体」と呼ぶ活性成分の混合物を以下のようにして調製した(量はgで表している):
以下の成分を混ぜ合わせた:
−500i.u/gのビタミンD3:0.400g
−50%のビタミンE:3.840g
−ビタミンB1:0.128g
−ビタミンB2:0.384g
−パントテン酸カルシウム:0.960g
−96%のビタミンK3:0.128g
−ビタミンB6:0.128g
−0.1%のビタミンB12:1.280g
−ナイアシン:1.920g
−ビタミンB9:0.064g
−炭酸カルシウム:3.750g
−ミドリング剤:1.600g
以下の成分(量はgで表している)を混ぜ合わせることによって、アグレッシブプレミックスを調製した:
−オリゴポークプレミックス(上で説明したもの):24,0g
−50%の塩化コリン:38.4g
−硫酸銅:22.4g
−炭酸カルシウム:59.2g
−複合体(上で説明したもの):14.6g
すなわち、総重量が158.6gの混合物であり、これに試験1〜11によって上で調製した0.95gのビタミンA酢酸エスエル粉末を添加した。
−1.2mL/分を送出できるポンプを備えた均一溶媒クロマトグラフ、
−RHEODYNEタイプの注入バルブ、
−UV検出器、
−カラム:Lichrocart 125-4、Lichrosorb Si 60(5μm)、
−移動相:n−ヘキサン(99.5%)/2−プロパノール(0.05%)。
E−活性成分、ビタミンAプロピオン酸エステルの調製:
活性成分であるビタミンAプロピオン酸エステルを、上で説明したビタミンA酢酸エステルと同じように調製した。試験第12〜14の様々な成分の種類および量を以下の表3にまとめてあり、これらを組成物全体に対する重量百分率で表している。
試験第1〜14で得られた粉末(または、言い換えると活性成分の粒子)の安定性を90℃の熱水中で試験した。
以下に、本願の発明の実施態様を付記する。
[1]粒子としての脂溶性活性成分、特に薬用および/または食用の活性成分の調製方法であって、以下の工程を含むことを特徴とする調製方法:
a)水中油型エマルションを調製する工程であって、前記エマルションは以下の成分を該エマルションの総重量に基づいて以下の重量百分率で含む工程:
−8〜20%、好ましくは10〜15%の少なくとも1種のタンパク質、
−5〜15%、好ましくは8〜12%の少なくとも1種の糖、
−0.5〜3%、好ましくは2〜3%の少なくとも1種の無機塩、
−10〜22%、好ましくは15〜20%の、油状のおよび/または食用油中に溶解した少なくとも1種の脂溶性活性成分、
−qs%の水
b)工程a)の終わりに得られる前記水中油型エマルションを流体中に分散させることで、実質的に球状の粒子の付形を行う工程、
c)タンパク質を架橋させるための少なくとも1種の薬剤を工程b)の終わりに得られる分散体に添加する工程、
d)前記活性成分を実質的に球状の粒子の形状で回収する工程。
[2]前記少なくとも1種のタンパク質はゼラチン、カゼインまたはカゼイン塩、ダイズまたはトウモロコシのタンパク質から選択されることを特徴とする[1]に記載の調製方法。
[3]前記少なくとも1種の糖はポリオール、単糖、二糖、グルコースおよびフルクトースシロップならびにマルトデキストリンから選択されることを特徴とする[1]または[2]に記載の調製方法。
[4]前記少なくとも1種の無機塩は一リン酸、二リン酸および三リン酸またはポリリン酸のナトリウム、カリウム、リチウム塩から選択され、好ましくはNaH 2 PO 4 であることを特徴とする[1]〜[3]のいずれかに記載の調製方法。
[5]前記少なくとも1種の活性成分は、ビタミン、たとえばビタミンA、ビタミンE、ビタミンD、ビタミンK、これらのビタミンの誘導体、たとえばそれらのエステル、カロテノイド、たとえばベータカロテン、リコペン、ビキシン、ゼアキサンチン、シトラナキサンチン、アスタキサンチン、カンタキサンチン、ルテイン、カプサンシン、クリプトキサンチン、ベータ−アポ−8’−カロチノイック酸およびそのエステル、ベータ−アポ−8’−カロテナール、ベータ−アポ−12’−カロテナール、多価不飽和脂肪酸、たとえばオメガ三系およびオメガ六系脂肪酸から選択されることを特徴とする[1]〜[4]のいずれかに記載の調製方法。
[6]前記少なくとも1種の活性成分はビタミンA酢酸エステル、ビタミンAプロピオン酸エステル、ビタミンAパルミチン酸エステル、トコフェリル酢酸エステルであることを特徴とする[5]に記載の調製方法。
[7]前記方法の工程a)の前に、前記少なくとも1種の活性成分を食用油、たとえばピーナッツ油、ヒマワリ油、ナタネ油、トウモロコシ油、ダイズ油、パーム油またはタラ肝油中に溶解させることを特徴とする[1]〜[6]のいずれかに記載の調製方法。
[8]前記方法の工程b)において、前記水中油型エマルションを食用油中に溶解させることと、工程c)が、工程b)の終わりに得られる混合物の温度を前記タンパク質の相転移温度未満である冷却温度まで下げて、湿った活性成分の顆粒の前記食用油中での分散体を得ることであり、それに対して前記タンパク質を架橋させるための薬剤をこの冷却温度で添加することとを特徴とする[1]〜[7]のいずれかに記載の調製方法。
[9]前記方法の工程b)において、工程a)の終わりに得られる前記水中油型エマルションをアトマイジングによって空気中に分散させることを特徴とする[1]〜[7]のいずれかに記載の調製方法。
[10]前記タンパク質の架橋剤は、アセトアルデヒド、グルタルアルデヒド、グリオキサールから選択され、好ましくはグルタルアルデヒドであることを特徴とする[1]〜[9]のいずれかに記載の調製方法。
[11]前記方法の工程d)は以下の連続工程にあることを特徴とする[8]に記載の調製方法:
−工程c)の終わりに得られる活性成分の顆粒を水切りし、
−任意に、前記活性成分の顆粒を抗凝集剤上に吸収させ、
−前記活性成分の顆粒を流動床で乾燥させ、活性成分の粒子を得る。
[12]工程d)の終わりに回収される粒子の大きさは50〜630μmに含まれることを特徴とする[1]〜[11]のいずれかに記載の調製方法。
[13][1]〜[12]のいずれかに記載の方法によって得られる、脂溶性の、特に薬用および/または食用の活性成分の粒子。
[14][13]に記載の脂溶性活性成分の粒子を含むプレミックス、特にアグレッシブプレミックス。
[15][13]に記載の脂溶性活性成分の粒子を含有する食料品または飼料。
[16][13]に記載の脂溶性活性成分の粒子を含む食品組成物。
Claims (19)
- 粒子としての脂溶性活性成分の調製方法であって、以下の工程を含むことを特徴とする調製方法:
a)水中油型エマルションを調製する工程であって、前記エマルションは以下の成分を該エマルションの総重量に基づいて以下の重量百分率で含む工程:
−8〜20%の少なくとも1種のタンパク質、
−5〜15%の少なくとも1種の糖、
−0.5〜3%の少なくとも1種の無機塩、
−10〜22%の、油状のおよび/または食用油中に溶解した少なくとも1種の脂溶性活性成分、
b)工程a)の終わりに得られる前記水中油型エマルションを流体中に分散させることで、実質的に球状の粒子の付形を行う工程、
c)タンパク質を架橋させるための少なくとも1種の薬剤を工程b)の終わりに得られる分散体に添加する工程であって、前記タンパク質の架橋剤は、アセトアルデヒド、グルタルアルデヒド、グリオキサールから選択される工程、
d)前記活性成分を実質的に球状の粒子の形状で回収する工程。 - 前記少なくとも1種のタンパク質はゼラチン、カゼインまたはカゼイン塩、ダイズまたはトウモロコシのタンパク質から選択されることを特徴とする請求項1に記載の調製方法。
- 前記少なくとも1種の糖はポリオール、単糖、二糖、グルコースおよびフルクトースシロップならびにマルトデキストリンから選択されることを特徴とする請求項1または2に記載の調製方法。
- 前記少なくとも1種の無機塩は一リン酸、二リン酸および三リン酸またはポリリン酸のナトリウム、カリウム、リチウム塩から選択されることを特徴とする請求項1〜3のいずれか1項に記載の調製方法。
- 前記少なくとも1種の無機塩は、NaH 2 PO 4 であることを特徴とする請求項4に記載の調製方法。
- 前記少なくとも1種の活性成分は、ビタミンA、ビタミンE、ビタミンD、ビタミンK、これらのビタミンの誘導体、カロテノイドおよびそれらのエステル、ベータ−アポ−8’−カロテナール、ベータ−アポ−12’−カロテナール、オメガ三系およびオメガ六系脂肪酸から選択されることを特徴とする請求項1〜5のいずれか1項に記載の調製方法。
- 前記カロテノイドは、ベータカロテン、リコペン、ビキシン、ゼアキサンチン、シトラナキサンチン、アスタキサンチン、カンタキサンチン、ルテイン、カプサンシン、クリプトキサンチン、ベータ−アポ−8’−カロチノイック酸から選択されることを特徴とする請求項6に記載の調製方法。
- 前記少なくとも1種の活性成分はビタミンA酢酸エステル、ビタミンAプロピオン酸エステル、ビタミンAパルミチン酸エステル、トコフェリル酢酸エステルであることを特徴とする請求項6又は7に記載の調製方法。
- 前記方法の工程a)の前に、前記少なくとも1種の活性成分を食用油、たとえばピーナッツ油、ヒマワリ油、ナタネ油、トウモロコシ油、ダイズ油、パーム油またはタラ肝油中に溶解させることを特徴とする請求項1〜8のいずれか1項に記載の調製方法。
- 前記方法の工程b)において、前記水中油型エマルションを食用油中に溶解させることと、工程c)が、工程b)の終わりに得られる混合物の温度を前記タンパク質の相転移温度未満である冷却温度まで下げて、湿った活性成分の顆粒の前記食用油中での分散体を得ることであり、それに対して前記タンパク質を架橋させるための薬剤をこの冷却温度で添加することとを特徴とする請求項1〜9のいずれか1項に記載の調製方法。
- 前記方法の工程b)において、工程a)の終わりに得られる前記水中油型エマルションをアトマイジングによって空気中に分散させることを特徴とする請求項1〜9のいずれか1項に記載の調製方法。
- 前記タンパク質の架橋剤は、グルタルアルデヒドであることを特徴とする請求項1〜11のいずれか1項に記載の調製方法。
- 前記方法の工程d)は以下の連続工程にあることを特徴とする請求項10に記載の調製方法:
−工程c)の終わりに得られる活性成分の顆粒を水切りし、
−前記活性成分の顆粒を流動床で乾燥させ、活性成分の粒子を得る。 - 前記方法の工程d)は以下の連続工程にあることを特徴とする請求項10に記載の調製方法:
−工程c)の終わりに得られる活性成分の顆粒を水切りし、
−前記活性成分の顆粒を抗凝集剤上に吸収させ、
−前記活性成分の顆粒を流動床で乾燥させ、活性成分の粒子を得る。 - 工程d)の終わりに回収される粒子の大きさは50〜630μmに含まれることを特徴とする請求項1〜14のいずれか1項に記載の調製方法。
- 請求項1〜15のいずれか1項に記載の方法によって得られる、脂溶性活性成分の粒子。
- 請求項16に記載の脂溶性活性成分の粒子を含むプレミックス。
- 請求項16に記載の脂溶性活性成分の粒子を含有する食料品または飼料。
- 請求項16に記載の脂溶性活性成分の粒子を含む食品組成物。
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