JP5672880B2 - イプリフラボン可溶化組成物 - Google Patents
イプリフラボン可溶化組成物 Download PDFInfo
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- JP5672880B2 JP5672880B2 JP2010205331A JP2010205331A JP5672880B2 JP 5672880 B2 JP5672880 B2 JP 5672880B2 JP 2010205331 A JP2010205331 A JP 2010205331A JP 2010205331 A JP2010205331 A JP 2010205331A JP 5672880 B2 JP5672880 B2 JP 5672880B2
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- Prior art keywords
- ipriflavone
- oil
- solubilized composition
- quasi
- composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- SFBODOKJTYAUCM-UHFFFAOYSA-N Ipriflavone Chemical compound C=1C(OC(C)C)=CC=C(C2=O)C=1OC=C2C1=CC=CC=C1 SFBODOKJTYAUCM-UHFFFAOYSA-N 0.000 title claims description 43
- 229960005431 ipriflavone Drugs 0.000 title claims description 43
- 239000000203 mixture Substances 0.000 title claims description 29
- 239000003814 drug Substances 0.000 claims description 23
- 239000003921 oil Substances 0.000 claims description 17
- 235000019198 oils Nutrition 0.000 claims description 17
- 229940079593 drug Drugs 0.000 claims description 13
- -1 cyclic monoterpene derivative Chemical class 0.000 claims description 12
- NFLGAXVYCFJBMK-UHFFFAOYSA-N Menthone Chemical compound CC(C)C1CCC(C)CC1=O NFLGAXVYCFJBMK-UHFFFAOYSA-N 0.000 claims description 11
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims description 10
- 239000002537 cosmetic Substances 0.000 claims description 10
- NFLGAXVYCFJBMK-RKDXNWHRSA-N (+)-isomenthone Natural products CC(C)[C@H]1CC[C@@H](C)CC1=O NFLGAXVYCFJBMK-RKDXNWHRSA-N 0.000 claims description 9
- 229930007503 menthone Natural products 0.000 claims description 9
- 235000004347 Perilla Nutrition 0.000 claims description 6
- 239000000341 volatile oil Substances 0.000 claims description 6
- MOQGCGNUWBPGTQ-UHFFFAOYSA-N 2,6,6-trimethyl-1-cyclohexene-1-carboxaldehyde Chemical compound CC1=C(C=O)C(C)(C)CCC1 MOQGCGNUWBPGTQ-UHFFFAOYSA-N 0.000 claims description 4
- ULDHMXUKGWMISQ-UHFFFAOYSA-N carvone Chemical compound CC(=C)C1CC=C(C)C(=O)C1 ULDHMXUKGWMISQ-UHFFFAOYSA-N 0.000 claims description 4
- AZOCECCLWFDTAP-UHFFFAOYSA-N dihydrocarvone Chemical compound CC1CCC(C(C)=C)CC1=O AZOCECCLWFDTAP-UHFFFAOYSA-N 0.000 claims description 4
- 239000001525 mentha piperita l. herb oil Substances 0.000 claims description 4
- 235000019477 peppermint oil Nutrition 0.000 claims description 4
- SGAWOGXMMPSZPB-UHFFFAOYSA-N safranal Chemical compound CC1=C(C=O)C(C)(C)CC=C1 SGAWOGXMMPSZPB-UHFFFAOYSA-N 0.000 claims description 4
- NFLGAXVYCFJBMK-IUCAKERBSA-N (-)-isomenthone Chemical compound CC(C)[C@@H]1CC[C@H](C)CC1=O NFLGAXVYCFJBMK-IUCAKERBSA-N 0.000 claims description 2
- DSSYKIVIOFKYAU-XCBNKYQSSA-N (R)-camphor Chemical compound C1C[C@@]2(C)C(=O)C[C@@H]1C2(C)C DSSYKIVIOFKYAU-XCBNKYQSSA-N 0.000 claims description 2
- YSTPAHQEHQSRJD-UHFFFAOYSA-N 3-Carvomenthenone Chemical compound CC(C)C1CCC(C)=CC1=O YSTPAHQEHQSRJD-UHFFFAOYSA-N 0.000 claims description 2
- 239000005973 Carvone Substances 0.000 claims description 2
- 241000723346 Cinnamomum camphora Species 0.000 claims description 2
- 229930008380 camphor Natural products 0.000 claims description 2
- 229960000846 camphor Drugs 0.000 claims description 2
- 239000010624 camphor oil Substances 0.000 claims description 2
- 229960000411 camphor oil Drugs 0.000 claims description 2
- WPGPCDVQHXOMQP-UHFFFAOYSA-N carvotanacetone Natural products CC(C)C1CC=C(C)C(=O)C1 WPGPCDVQHXOMQP-UHFFFAOYSA-N 0.000 claims description 2
- KMPWYEUPVWOPIM-UHFFFAOYSA-N cinchonidine Natural products C1=CC=C2C(C(C3N4CCC(C(C4)C=C)C3)O)=CC=NC2=C1 KMPWYEUPVWOPIM-UHFFFAOYSA-N 0.000 claims description 2
- AZOCECCLWFDTAP-RKDXNWHRSA-N dihydrocarvone Natural products C[C@@H]1CC[C@@H](C(C)=C)CC1=O AZOCECCLWFDTAP-RKDXNWHRSA-N 0.000 claims description 2
- 229930006968 piperitone Natural products 0.000 claims description 2
- 235000017509 safranal Nutrition 0.000 claims description 2
- 239000010670 sage oil Substances 0.000 claims description 2
- 244000124853 Perilla frutescens Species 0.000 claims 1
- 239000002904 solvent Substances 0.000 description 11
- 235000013305 food Nutrition 0.000 description 8
- 238000002360 preparation method Methods 0.000 description 8
- 241000229722 Perilla <angiosperm> Species 0.000 description 5
- 235000006679 Mentha X verticillata Nutrition 0.000 description 4
- 235000002899 Mentha suaveolens Nutrition 0.000 description 4
- 235000001636 Mentha x rotundifolia Nutrition 0.000 description 4
- 239000007788 liquid Substances 0.000 description 4
- RUMOYJJNUMEFDD-UHFFFAOYSA-N perillyl aldehyde Chemical compound CC(=C)C1CCC(C=O)=CC1 RUMOYJJNUMEFDD-UHFFFAOYSA-N 0.000 description 4
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 238000011156 evaluation Methods 0.000 description 3
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 3
- 208000006386 Bone Resorption Diseases 0.000 description 2
- 208000001132 Osteoporosis Diseases 0.000 description 2
- 210000000988 bone and bone Anatomy 0.000 description 2
- 230000024279 bone resorption Effects 0.000 description 2
- 239000002775 capsule Substances 0.000 description 2
- 239000006071 cream Substances 0.000 description 2
- 238000002425 crystallisation Methods 0.000 description 2
- 230000008025 crystallization Effects 0.000 description 2
- 235000014113 dietary fatty acids Nutrition 0.000 description 2
- 235000020650 eye health related herbal supplements Nutrition 0.000 description 2
- 229930195729 fatty acid Natural products 0.000 description 2
- 239000000194 fatty acid Substances 0.000 description 2
- 239000008187 granular material Substances 0.000 description 2
- 235000015092 herbal tea Nutrition 0.000 description 2
- 235000015110 jellies Nutrition 0.000 description 2
- 239000008274 jelly Substances 0.000 description 2
- 239000006210 lotion Substances 0.000 description 2
- 150000004667 medium chain fatty acids Chemical class 0.000 description 2
- 239000002674 ointment Substances 0.000 description 2
- 239000002244 precipitate Substances 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- 239000007901 soft capsule Substances 0.000 description 2
- 235000014214 soft drink Nutrition 0.000 description 2
- 239000013589 supplement Substances 0.000 description 2
- 239000003826 tablet Substances 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 102000055006 Calcitonin Human genes 0.000 description 1
- 108060001064 Calcitonin Proteins 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- 239000004215 Carbon black (E152) Substances 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- YCKRFDGAMUMZLT-UHFFFAOYSA-N Fluorine atom Chemical compound [F] YCKRFDGAMUMZLT-UHFFFAOYSA-N 0.000 description 1
- 239000006096 absorbing agent Substances 0.000 description 1
- 239000003655 absorption accelerator Substances 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 239000010775 animal oil Substances 0.000 description 1
- 239000003945 anionic surfactant Substances 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- BBBFJLBPOGFECG-VJVYQDLKSA-N calcitonin Chemical compound N([C@H](C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(N)=O)C(C)C)C(=O)[C@@H]1CSSC[C@H](N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1 BBBFJLBPOGFECG-VJVYQDLKSA-N 0.000 description 1
- 229960004015 calcitonin Drugs 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 239000003093 cationic surfactant Substances 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 235000005687 corn oil Nutrition 0.000 description 1
- 239000002285 corn oil Substances 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 239000003925 fat Substances 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 229910052731 fluorine Inorganic materials 0.000 description 1
- 239000011737 fluorine Substances 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 229930195733 hydrocarbon Natural products 0.000 description 1
- 150000002430 hydrocarbons Chemical class 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 150000002767 monocyclic monoterpene derivatives Chemical class 0.000 description 1
- 239000002736 nonionic surfactant Substances 0.000 description 1
- 235000014593 oils and fats Nutrition 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 239000008213 purified water Substances 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 229920002545 silicone oil Polymers 0.000 description 1
- 230000003381 solubilizing effect Effects 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 150000005846 sugar alcohols Polymers 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
Landscapes
- Cosmetics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Medicinal Preparation (AREA)
Description
(1)イプリフラボンと、カルボニル基を有する環状モノテルペン誘導体を含有することを特徴とするイプリフラボン可溶化組成物、
(2)カルボニル基を有する環状式モノテルペン誘導体が、ペリルアルデヒド又はメントンであることを特徴とする(1)に記載のイプリフラボン可溶化組成物。
(3)カルボニル基を有する環状式モノテルペン誘導体を成分として含む精油を含有することを特徴とする、イプリフラボン可溶化組成物、
(4)精油がシソ油またはハッカ油であることを特徴とする(3)に記載のイプリフラボン可溶化組成物、
(5)化粧品用、医薬部外品用、医薬品用、食品用である(1)〜(4)のいずれかに記載のイプリフラボン可溶化組成物、
である。
(イプリフラボン可溶化組成物の調製)
表1に示す組成物に従い、所定量のシソ油、ハッカ油、メントンまたはペリルアルデヒドと溶剤(コーン油、中鎖脂肪酸トリグリセリドなど)とイプリフラボンを混合し、これを40〜80℃に加温して均一にし、イプリフラボン可溶化組成物とした。なお組成は質量部で示す。
(イプリフラボン可溶化組成物の評価)
調製したイプリフラボン可溶化組成物を一旦常温まで冷却した後、室温にて5日以上放置して、イプリフラボンの溶解状態を肉眼観察した。
(溶解性の評価基準)
○:全く析出物が見られない。
×:顕著な析出物が見られる、若しくは固化した。
評価結果を表1に示す。
Claims (3)
- イプリフラボンと、ペリルアルデヒド、メントン、カンファー、ピペリトン、カルボン、ジヒドロカルボン、イソメントン、プレゴン、ツヨン、シクロシトラール、及びサフラナールからなる群から選ばれる少なくとも1種のカルボニル基を有する環状モノテルペン誘導体を含有することを特徴とする、化粧品用、医薬部外品用又は医薬品用のイプリフラボン可溶化組成物。
- イプリフラボンと、シソ油、ハッカ油、セージ油、樟脳油、及びペパーミント油からなる群から選ばれる少なくとも1種のカルボニル基を有する環状モノテルペン誘導体を成分として含む精油を含有することを特徴とする、化粧品用、医薬部外品用又は医薬品用のイプリフラボン可溶化組成物。
- イプリフラボン1質量部に対して、環状モノテルペン誘導体が10質量部以上である、請求項1に記載のイプリフラボン可溶化組成物。
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2010205331A JP5672880B2 (ja) | 2010-09-14 | 2010-09-14 | イプリフラボン可溶化組成物 |
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JP2010205331A JP5672880B2 (ja) | 2010-09-14 | 2010-09-14 | イプリフラボン可溶化組成物 |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2012062248A JP2012062248A (ja) | 2012-03-29 |
JP5672880B2 true JP5672880B2 (ja) | 2015-02-18 |
Family
ID=46058345
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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JP2010205331A Active JP5672880B2 (ja) | 2010-09-14 | 2010-09-14 | イプリフラボン可溶化組成物 |
Country Status (1)
Country | Link |
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JP (1) | JP5672880B2 (ja) |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6726133B2 (en) * | 1997-07-18 | 2004-04-27 | Pulsewave Llc | Process for micronizing materials |
WO2000040220A1 (en) * | 1999-01-06 | 2000-07-13 | Korea Research Institute Of Chemical Technology | Method of preparing pharmaceutical active ingredient comprising water-insoluble drug and pharmaceutical composition for oral administration comprising the same |
WO2004073692A1 (ja) * | 2003-02-18 | 2004-09-02 | Yamashita, Shinji | 難水溶性薬物のハードカプセル剤 |
JP4596513B2 (ja) * | 2003-10-14 | 2010-12-08 | 雪印乳業株式会社 | 栄養組成物 |
-
2010
- 2010-09-14 JP JP2010205331A patent/JP5672880B2/ja active Active
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