JP5671525B2 - 蛍光染料、合成方法及びその利用 - Google Patents

蛍光染料、合成方法及びその利用 Download PDF

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JP5671525B2
JP5671525B2 JP2012510098A JP2012510098A JP5671525B2 JP 5671525 B2 JP5671525 B2 JP 5671525B2 JP 2012510098 A JP2012510098 A JP 2012510098A JP 2012510098 A JP2012510098 A JP 2012510098A JP 5671525 B2 JP5671525 B2 JP 5671525B2
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compound
group
formula
reaction
fluorescent dye
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JP2012526862A5 (https=
JP2012526862A (ja
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孝▲軍▼ 彭
孝▲軍▼ 彭
▲トン▼ ▲呉▼
▲トン▼ ▲呉▼
江莉 樊
江莉 樊
世国 ▲孫▼
世国 ▲孫▼
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Dalian University of Technology
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    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
    • C09B23/02—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups
    • C09B23/06—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups three >CH- groups, e.g. carbocyanines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D421/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having selenium, tellurium, or halogen atoms as ring hetero atoms
    • C07D421/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having selenium, tellurium, or halogen atoms as ring hetero atoms containing two hetero rings
    • C07D421/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having selenium, tellurium, or halogen atoms as ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
    • C09K11/00—Luminescent materials, e.g. electroluminescent or chemiluminescent
    • C09K11/06—Luminescent materials, e.g. electroluminescent or chemiluminescent containing organic luminescent materials
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/52—Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper and including single- and multilayer analytical elements
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
    • C09K2211/00—Chemical nature of organic luminescent or tenebrescent compounds
    • C09K2211/10—Non-macromolecular compounds
    • C09K2211/1018—Heterocyclic compounds
    • C09K2211/1025—Heterocyclic compounds characterised by ligands
    • C09K2211/1029—Heterocyclic compounds characterised by ligands containing one nitrogen atom as the heteroatom
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
    • C09K2211/00—Chemical nature of organic luminescent or tenebrescent compounds
    • C09K2211/10—Non-macromolecular compounds
    • C09K2211/1018—Heterocyclic compounds
    • C09K2211/1025—Heterocyclic compounds characterised by ligands
    • C09K2211/1029—Heterocyclic compounds characterised by ligands containing one nitrogen atom as the heteroatom
    • C09K2211/1033—Heterocyclic compounds characterised by ligands containing one nitrogen atom as the heteroatom with oxygen
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
    • C09K2211/00—Chemical nature of organic luminescent or tenebrescent compounds
    • C09K2211/10—Non-macromolecular compounds
    • C09K2211/1018—Heterocyclic compounds
    • C09K2211/1025—Heterocyclic compounds characterised by ligands
    • C09K2211/1029—Heterocyclic compounds characterised by ligands containing one nitrogen atom as the heteroatom
    • C09K2211/1037—Heterocyclic compounds characterised by ligands containing one nitrogen atom as the heteroatom with sulfur
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
    • C09K2211/00—Chemical nature of organic luminescent or tenebrescent compounds
    • C09K2211/10—Non-macromolecular compounds
    • C09K2211/1018—Heterocyclic compounds
    • C09K2211/1025—Heterocyclic compounds characterised by ligands
    • C09K2211/1029—Heterocyclic compounds characterised by ligands containing one nitrogen atom as the heteroatom
    • C09K2211/104—Heterocyclic compounds characterised by ligands containing one nitrogen atom as the heteroatom with other heteroatoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Food Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Biotechnology (AREA)
  • Materials Engineering (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
JP2012510098A 2010-01-05 2010-04-30 蛍光染料、合成方法及びその利用 Active JP5671525B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN201010022414.6 2010-01-05
CN201010022414.6A CN102115610B (zh) 2010-01-05 2010-01-05 一类荧光染料、制备方法及其应用
PCT/CN2010/072378 WO2011082566A1 (zh) 2010-01-05 2010-04-30 一类荧光染料、制备方法及其应用

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JP2012526862A JP2012526862A (ja) 2012-11-01
JP2012526862A5 JP2012526862A5 (https=) 2013-11-28
JP5671525B2 true JP5671525B2 (ja) 2015-02-18

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US (1) US8298766B2 (https=)
JP (1) JP5671525B2 (https=)
CN (1) CN102115610B (https=)
WO (1) WO2011082566A1 (https=)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102618060A (zh) * 2012-03-17 2012-08-01 江南大学 一种不对称菁染料的制备及其用于牛血清白蛋白检测的方法
CN102766346B (zh) * 2012-07-30 2014-12-17 北京福罗泰科技有限责任公司 一种菁类荧光染料
CN104073019B (zh) * 2014-07-01 2016-01-06 浙江大学 一种不对称菁染料化合物及应用
KR102502117B1 (ko) * 2015-07-16 2023-02-22 에스에프씨 주식회사 염료 화합물
CN106675553A (zh) * 2016-12-30 2017-05-17 大连理工大学 菁类化合物在制备生物染色剂中的应用
JP2020066637A (ja) * 2017-02-27 2020-04-30 富士フイルム株式会社 病理診断用染色剤、細胞核染色方法、病理標本の製造方法、及び色素
CN109796781A (zh) * 2017-11-16 2019-05-24 上海生物芯片有限公司 双链dna结合荧光染料及其制备与应用
CN108485307A (zh) * 2018-05-14 2018-09-04 浙江工业大学 一种具有荧光开启性质的荧光染料、制备方法及其应用
ES2976491T3 (es) * 2018-05-24 2024-08-02 Philipps Univ Marburg Colorantes de cianina y su uso para la tinción in vivo de microorganismos
CN110330511B (zh) * 2018-12-31 2022-04-19 湖北大学 一种咪唑类配体的合成方法及生物检测应用
CN110006870B (zh) * 2019-04-29 2021-06-08 陕西科技大学 一种高效检测二乙胺的荧光传感器及其制备方法和应用
CN111518093A (zh) * 2020-04-20 2020-08-11 中铁十八局集团有限公司 一种检测硫化物的荧光探针及其制备和应用
JP7809329B2 (ja) * 2021-02-15 2026-02-02 国立大学法人大阪大学 ケージド化合物から化合物を放出させる方法
CN113686943B (zh) * 2021-08-03 2024-01-26 苏州优逸兰迪生物科技有限公司 一种多功能核酸染料及其制备方法与应用
CN113583467B (zh) * 2021-08-20 2022-04-26 四川大学 一种核酸荧光染料及其制备和应用
EP4137794B1 (en) 2021-08-20 2025-11-19 Philipps-Universität Marburg Cyanine dyes and their usage for in vivo staining of microorganisms and other living cells
CN114181204B (zh) * 2021-12-13 2023-07-11 洛兮医疗科技(杭州)有限公司 一种检测粘度的近红外荧光探针及其制备和应用
CN116143772B (zh) * 2023-02-20 2025-03-18 河南农业大学 一种基于苯并噻唑腙的光分子开关及其制备方法和应用
CN116239893B (zh) * 2023-03-21 2024-07-09 大连理工大学 一种季铵盐修饰的花菁类荧光染料及其合成方法和应用
CN118085600B (zh) * 2024-02-01 2025-10-21 大连理工大学 一类三甲川吡啶菁染料、其制备方法和应用
CN119039557B (zh) * 2024-08-29 2026-03-20 华南理工大学 一种具有防伪功能的荧光水性聚氨酯及其制备与应用

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JPS5747493A (en) * 1980-09-02 1982-03-18 Fuji Photo Film Co Ltd Method of determining a trace amount of enzyme
US5734058A (en) * 1995-11-09 1998-03-31 Biometric Imaging, Inc. Fluorescent DNA-Intercalating cyanine dyes including a positively charged benzothiazole substituent
US5658735A (en) * 1995-11-09 1997-08-19 Biometric Imaging, Inc. Cyclized fluorescent nucleic acid intercalating cyanine dyes and nucleic acid detection methods
FR2875130B1 (fr) * 2004-09-13 2006-12-15 Oreal Composition comprenant au moins un derive substitue de carbocyanine, procede de traitement des fibres keratiniques la mettant en oeuvre, dispositif et utilisation
CN101343420B (zh) * 2007-07-12 2013-10-16 大连理工大学 一类不对称菁类荧光染料
CN105440725A (zh) * 2008-01-04 2016-03-30 深圳迈瑞生物医疗电子股份有限公司 不对称菁类荧光染料，组合物及在生物样品染色中的用途
CN101555246B (zh) * 2008-04-11 2012-05-30 大连理工大学 含卤素不对称菁类化合物、制备方法及应用

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Publication number Publication date
WO2011082566A1 (zh) 2011-07-14
US8298766B2 (en) 2012-10-30
US20110262904A1 (en) 2011-10-27
CN102115610B (zh) 2014-07-02
JP2012526862A (ja) 2012-11-01
CN102115610A (zh) 2011-07-06

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