JP5671457B2 - 活性剤のためのポリマーデリバリーシステム - Google Patents

活性剤のためのポリマーデリバリーシステム Download PDF

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Publication number
JP5671457B2
JP5671457B2 JP2011515216A JP2011515216A JP5671457B2 JP 5671457 B2 JP5671457 B2 JP 5671457B2 JP 2011515216 A JP2011515216 A JP 2011515216A JP 2011515216 A JP2011515216 A JP 2011515216A JP 5671457 B2 JP5671457 B2 JP 5671457B2
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Prior art keywords
block
copolymer
oxazoline
active agent
composition according
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Japanese (ja)
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JP2011525514A (ja
JP2011525514A5 (cg-RX-API-DMAC10.html
Inventor
カバノフ，アレクサンダー・ブイ
ジョルダン，ライナー
ルクセンホファー，ロベルト
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Technical University of Munich
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Technical University of Munich
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • A01N25/08—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing solids as carriers or diluents
    • A01N25/10—Macromolecular compounds
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13—Cyclosporins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Inorganic Chemistry (AREA)
  • Dentistry (AREA)
  • Agronomy & Crop Science (AREA)
  • Dispersion Chemistry (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Dermatology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Hematology (AREA)
  • Environmental Sciences (AREA)
  • Zoology (AREA)
  • Urology & Nephrology (AREA)
  • Wood Science & Technology (AREA)
  • Plant Pathology (AREA)
  • Pest Control & Pesticides (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Food Science & Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Physics & Mathematics (AREA)
JP2011515216A 2008-06-26 2009-06-26 活性剤のためのポリマーデリバリーシステム Active JP5671457B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US13315408P 2008-06-26 2008-06-26
US61/133,154 2008-06-26
US13420908P 2008-07-08 2008-07-08
US61/134,209 2008-07-08
PCT/EP2009/004655 WO2009156180A2 (en) 2008-06-26 2009-06-26 Polymeric delivery systems for active agents

Publications (3)

Publication Number Publication Date
JP2011525514A JP2011525514A (ja) 2011-09-22
JP2011525514A5 JP2011525514A5 (cg-RX-API-DMAC10.html) 2012-07-19
JP5671457B2 true JP5671457B2 (ja) 2015-02-18

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ID=41137585

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JP2011515216A Active JP5671457B2 (ja) 2008-06-26 2009-06-26 活性剤のためのポリマーデリバリーシステム

Country Status (6)

Country Link
US (2) US20100041592A1 (cg-RX-API-DMAC10.html)
EP (1) EP2313115B1 (cg-RX-API-DMAC10.html)
JP (1) JP5671457B2 (cg-RX-API-DMAC10.html)
CN (1) CN102215874B (cg-RX-API-DMAC10.html)
RU (1) RU2523714C2 (cg-RX-API-DMAC10.html)
WO (1) WO2009156180A2 (cg-RX-API-DMAC10.html)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2009268528B2 (en) * 2008-07-09 2015-11-05 Board Of Regents Of The University Of Nebraska Functional micelles for hard tissue targeted delivery of chemicals
ES2409055T3 (es) 2009-06-29 2013-06-24 Bender Analytical Holding B.V. Sistema de suministro de fármacos que comprende polioxazolina y un agente bioactivo
US9974866B2 (en) 2010-04-07 2018-05-22 Board Of Regents Of The University Of Nebraska Protein-poly(2-oxazoline) conjugates for enhanced cellular delivery and transport across biological barriers
WO2013124867A1 (en) 2012-02-21 2013-08-29 Amrita Vishwa Vidyapeetham University Polymer - polymer or polymer - protein core - shell nano medicine loaded with multiple drug molecules
WO2013159092A1 (en) * 2012-04-20 2013-10-24 Board Of Regents Of The University Of Nebraska Tunable multimodal nanoparticles and methods of use thereof
CN103897181B (zh) * 2012-12-27 2017-02-08 张昊 聚合物、其制备方法和应用
WO2014141289A1 (en) 2013-03-12 2014-09-18 Amrita Vishwa Vidyapeetham University Photo - chemo composition on the basis of microcapsules with a core -shell structure
US11026418B2 (en) 2014-11-26 2021-06-08 Microban Products Company Surface disinfectant with residual biocidal property
US11033023B2 (en) 2014-11-26 2021-06-15 Microban Products Company Surface disinfectant with residual biocidal property
US10842147B2 (en) 2014-11-26 2020-11-24 Microban Products Company Surface disinfectant with residual biocidal property
US10925281B2 (en) 2014-11-26 2021-02-23 Microban Products Company Surface disinfectant with residual biocidal property
CA3005597A1 (en) * 2015-11-23 2017-06-01 Microban Products Company Surface disinfectant with residual biocidal property
CN108697082A (zh) * 2015-11-23 2018-10-23 美可帮产品公司 具有残余杀生物性质的表面杀菌剂
US11503824B2 (en) 2016-05-23 2022-11-22 Microban Products Company Touch screen cleaning and protectant composition
US11123433B2 (en) 2016-06-01 2021-09-21 Board Of Supervisors Of Louisiana State University Hydrophobically modified polypeptoids and uses thereof
EP3257921B1 (en) * 2016-06-14 2021-04-28 Infineum International Limited Lubricating oil additives
JP7036510B2 (ja) 2016-07-01 2022-03-15 ユニヴェルシテイト ヘント ポリ（環状イミノエーテル）
DE102017002454A1 (de) * 2017-03-14 2018-09-20 Friedrich-Schiller-Universität Jena Organische Polymerpartikel enthaltend Poly(oxazolin)-Stabilisatoren und Verwendung von Poly(oxazolinen) zur Stabilisierung von organischen Polymerpartikeln
EP3418317A1 (en) 2017-06-20 2018-12-26 Julius-Maximilians-Universität Würzburg Block-copolymers for the delivery of active agents
EP3764994A1 (en) * 2018-03-16 2021-01-20 Universiteit Gent Drug formulations comprising polyoxazolines as matrix excipient
US12187848B2 (en) * 2019-05-20 2025-01-07 The Regents Of The University Of California Compositions and methods for cellular delivery
CN112442180B (zh) * 2019-09-04 2022-04-01 北京化工大学 一种用于促进干细胞界面粘附生长的双亲性聚合物及其制备方法和用途

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5164477A (en) * 1989-02-28 1992-11-17 Shiro Kobayashi Polyfunctional polymerization initiator
JPH04128207A (ja) * 1990-09-19 1992-04-28 Kao Corp 可溶化型水性化粧料
US6916488B1 (en) * 1999-11-05 2005-07-12 Biocure, Inc. Amphiphilic polymeric vesicles
ATE427743T1 (de) * 1999-11-15 2009-04-15 Biocure Inc Auf aussere bedingungen ansprechende polymere hohle partikel
EP2155165A1 (en) * 2007-04-20 2010-02-24 BioCure, Inc. Drug delivery vehicle containing vesicles in a hydrogel base
RU2370261C2 (ru) * 2007-08-03 2009-10-20 Закрытое Акционерное Общество "Биокад" Стабильная эмульсия для парентерального введения плохо растворимых в воде соединений, обладающих противоопухолевой активностью, и способ ее получения

Also Published As

Publication number Publication date
US20110165258A1 (en) 2011-07-07
RU2011102780A (ru) 2012-08-10
EP2313115B1 (en) 2019-05-15
WO2009156180A2 (en) 2009-12-30
WO2009156180A3 (en) 2011-01-27
CN102215874A (zh) 2011-10-12
EP2313115A2 (en) 2011-04-27
JP2011525514A (ja) 2011-09-22
CN102215874B (zh) 2016-07-06
RU2523714C2 (ru) 2014-07-20
US20100041592A1 (en) 2010-02-18

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