CN102215874B - 活性剂的聚合物递送系统 - Google Patents

活性剂的聚合物递送系统 Download PDF

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Publication number
CN102215874B
CN102215874B CN200980123536.XA CN200980123536A CN102215874B CN 102215874 B CN102215874 B CN 102215874B CN 200980123536 A CN200980123536 A CN 200980123536A CN 102215874 B CN102215874 B CN 102215874B
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CN
China
Prior art keywords
block
formula
oxazoline
composition
copolymer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN200980123536.XA
Other languages
English (en)
Chinese (zh)
Other versions
CN102215874A (zh
Inventor
亚历山大·V·卡巴诺夫
瑞纳·乔丹
罗伯特·拉克森霍夫
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kabanov Alexander V.
Luxenhofer Robert
Rena Jordan
Original Assignee
University Nebraska Medical Ct
Technical University of Munich
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Filing date
Publication date
Application filed by University Nebraska Medical Ct, Technical University of Munich filed Critical University Nebraska Medical Ct
Publication of CN102215874A publication Critical patent/CN102215874A/zh
Application granted granted Critical
Publication of CN102215874B publication Critical patent/CN102215874B/zh
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • A01N25/08—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing solids as carriers or diluents
    • A01N25/10—Macromolecular compounds
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13—Cyclosporins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Inorganic Chemistry (AREA)
  • Dentistry (AREA)
  • Agronomy & Crop Science (AREA)
  • Dispersion Chemistry (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Dermatology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Hematology (AREA)
  • Environmental Sciences (AREA)
  • Zoology (AREA)
  • Urology & Nephrology (AREA)
  • Wood Science & Technology (AREA)
  • Plant Pathology (AREA)
  • Pest Control & Pesticides (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Food Science & Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Physics & Mathematics (AREA)
CN200980123536.XA 2008-06-26 2009-06-26 活性剂的聚合物递送系统 Expired - Fee Related CN102215874B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US13315408P 2008-06-26 2008-06-26
US61/133,154 2008-06-26
US13420908P 2008-07-08 2008-07-08
US61/134,209 2008-07-08
PCT/EP2009/004655 WO2009156180A2 (en) 2008-06-26 2009-06-26 Polymeric delivery systems for active agents

Publications (2)

Publication Number Publication Date
CN102215874A CN102215874A (zh) 2011-10-12
CN102215874B true CN102215874B (zh) 2016-07-06

Family

ID=41137585

Family Applications (1)

Application Number Title Priority Date Filing Date
CN200980123536.XA Expired - Fee Related CN102215874B (zh) 2008-06-26 2009-06-26 活性剂的聚合物递送系统

Country Status (6)

Country Link
US (2) US20100041592A1 (cg-RX-API-DMAC10.html)
EP (1) EP2313115B1 (cg-RX-API-DMAC10.html)
JP (1) JP5671457B2 (cg-RX-API-DMAC10.html)
CN (1) CN102215874B (cg-RX-API-DMAC10.html)
RU (1) RU2523714C2 (cg-RX-API-DMAC10.html)
WO (1) WO2009156180A2 (cg-RX-API-DMAC10.html)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2009268528B2 (en) * 2008-07-09 2015-11-05 Board Of Regents Of The University Of Nebraska Functional micelles for hard tissue targeted delivery of chemicals
ES2409055T3 (es) 2009-06-29 2013-06-24 Bender Analytical Holding B.V. Sistema de suministro de fármacos que comprende polioxazolina y un agente bioactivo
US9974866B2 (en) 2010-04-07 2018-05-22 Board Of Regents Of The University Of Nebraska Protein-poly(2-oxazoline) conjugates for enhanced cellular delivery and transport across biological barriers
WO2013124867A1 (en) 2012-02-21 2013-08-29 Amrita Vishwa Vidyapeetham University Polymer - polymer or polymer - protein core - shell nano medicine loaded with multiple drug molecules
WO2013159092A1 (en) * 2012-04-20 2013-10-24 Board Of Regents Of The University Of Nebraska Tunable multimodal nanoparticles and methods of use thereof
CN103897181B (zh) * 2012-12-27 2017-02-08 张昊 聚合物、其制备方法和应用
WO2014141289A1 (en) 2013-03-12 2014-09-18 Amrita Vishwa Vidyapeetham University Photo - chemo composition on the basis of microcapsules with a core -shell structure
US11026418B2 (en) 2014-11-26 2021-06-08 Microban Products Company Surface disinfectant with residual biocidal property
US11033023B2 (en) 2014-11-26 2021-06-15 Microban Products Company Surface disinfectant with residual biocidal property
US10842147B2 (en) 2014-11-26 2020-11-24 Microban Products Company Surface disinfectant with residual biocidal property
US10925281B2 (en) 2014-11-26 2021-02-23 Microban Products Company Surface disinfectant with residual biocidal property
CA3005597A1 (en) * 2015-11-23 2017-06-01 Microban Products Company Surface disinfectant with residual biocidal property
CN108697082A (zh) * 2015-11-23 2018-10-23 美可帮产品公司 具有残余杀生物性质的表面杀菌剂
US11503824B2 (en) 2016-05-23 2022-11-22 Microban Products Company Touch screen cleaning and protectant composition
US11123433B2 (en) 2016-06-01 2021-09-21 Board Of Supervisors Of Louisiana State University Hydrophobically modified polypeptoids and uses thereof
EP3257921B1 (en) * 2016-06-14 2021-04-28 Infineum International Limited Lubricating oil additives
JP7036510B2 (ja) 2016-07-01 2022-03-15 ユニヴェルシテイト ヘント ポリ（環状イミノエーテル）
DE102017002454A1 (de) * 2017-03-14 2018-09-20 Friedrich-Schiller-Universität Jena Organische Polymerpartikel enthaltend Poly(oxazolin)-Stabilisatoren und Verwendung von Poly(oxazolinen) zur Stabilisierung von organischen Polymerpartikeln
EP3418317A1 (en) 2017-06-20 2018-12-26 Julius-Maximilians-Universität Würzburg Block-copolymers for the delivery of active agents
EP3764994A1 (en) * 2018-03-16 2021-01-20 Universiteit Gent Drug formulations comprising polyoxazolines as matrix excipient
US12187848B2 (en) * 2019-05-20 2025-01-07 The Regents Of The University Of California Compositions and methods for cellular delivery
CN112442180B (zh) * 2019-09-04 2022-04-01 北京化工大学 一种用于促进干细胞界面粘附生长的双亲性聚合物及其制备方法和用途

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5164477A (en) * 1989-02-28 1992-11-17 Shiro Kobayashi Polyfunctional polymerization initiator
WO2008130641A1 (en) * 2007-04-20 2008-10-30 Biocure, Inc. Drug delivery vehicle containing vesicles in a hydrogel base

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH04128207A (ja) * 1990-09-19 1992-04-28 Kao Corp 可溶化型水性化粧料
US6916488B1 (en) * 1999-11-05 2005-07-12 Biocure, Inc. Amphiphilic polymeric vesicles
ATE427743T1 (de) * 1999-11-15 2009-04-15 Biocure Inc Auf aussere bedingungen ansprechende polymere hohle partikel
RU2370261C2 (ru) * 2007-08-03 2009-10-20 Закрытое Акционерное Общество "Биокад" Стабильная эмульсия для парентерального введения плохо растворимых в воде соединений, обладающих противоопухолевой активностью, и способ ее получения

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5164477A (en) * 1989-02-28 1992-11-17 Shiro Kobayashi Polyfunctional polymerization initiator
WO2008130641A1 (en) * 2007-04-20 2008-10-30 Biocure, Inc. Drug delivery vehicle containing vesicles in a hydrogel base

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
"Click chemistry with poly(2-oxazoline)s";Luxenhofer R. et al;《macromolecules》;20060425;第39卷(第10期);3509-3515 *
"Modulation of the lower critical solution temperature of 2-alkyl-2-oxazolin copolymers";Stephan Huber et al;《Colloid polym. Sci.》;20071114;第286卷(第4期);437-445 *
"Polymeric micelles of poly(2-ethyl -2-oxazoline)-block-poly(e-caprolactone) copolymer as a carrier for paclitaxel";Cheon Lee S et al;《Jouranl of controlled release》;20030520;第89卷(第3期);437-445 *

Also Published As

Publication number Publication date
JP5671457B2 (ja) 2015-02-18
US20110165258A1 (en) 2011-07-07
RU2011102780A (ru) 2012-08-10
EP2313115B1 (en) 2019-05-15
WO2009156180A2 (en) 2009-12-30
WO2009156180A3 (en) 2011-01-27
CN102215874A (zh) 2011-10-12
EP2313115A2 (en) 2011-04-27
JP2011525514A (ja) 2011-09-22
RU2523714C2 (ru) 2014-07-20
US20100041592A1 (en) 2010-02-18

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GR01 Patent grant
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Effective date of registration: 20180606

Address after: Fry, Germany

Co-patentee after: Luxenhofer Robert

Patentee after: Rena Jordan

Co-patentee after: Kabanov Alexander V.

Address before: Munich, Germany

Co-patentee before: University Nebraska Medical Ct

Patentee before: TECHNISCHE UNIVERSITAT MUNCHEN

TR01 Transfer of patent right
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20160706

CF01 Termination of patent right due to non-payment of annual fee