JP5661738B2 - 患者をモニターするためのバイオマーカー - Google Patents
患者をモニターするためのバイオマーカー Download PDFInfo
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- JP5661738B2 JP5661738B2 JP2012505138A JP2012505138A JP5661738B2 JP 5661738 B2 JP5661738 B2 JP 5661738B2 JP 2012505138 A JP2012505138 A JP 2012505138A JP 2012505138 A JP2012505138 A JP 2012505138A JP 5661738 B2 JP5661738 B2 JP 5661738B2
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| US6638762B1 (en) | 1994-11-28 | 2003-10-28 | Genetic Therapy, Inc. | Tissue-vectors specific replication and gene expression |
| FR2727689A1 (fr) | 1994-12-01 | 1996-06-07 | Transgene Sa | Nouveau procede de preparation d'un vecteur viral |
| IL116816A (en) | 1995-01-20 | 2003-05-29 | Rhone Poulenc Rorer Sa | Cell for the production of a defective recombinant adenovirus or an adeno-associated virus and the various uses thereof |
| DE19520606B4 (de) | 1995-06-06 | 2004-04-08 | Roche Diagnostics Gmbh | Vorrichtung zur optischen Untersuchung von Oberflächen |
| DE69633565T3 (de) | 1995-06-15 | 2013-01-17 | Crucell Holland B.V. | Verpackungssysteme für humane, menschliche adenoviren, zur verwendung in die gentherapie |
| EP0954593A1 (en) | 1996-07-25 | 1999-11-10 | Therion Biologics Corporation | Recombinant pox virus for immunization against tumor-associated antigens |
| FR2751879B1 (fr) | 1996-07-30 | 1998-10-30 | Transgene Sa | Composition pharmaceutique contre les tumeurs et infections a papillomavirus |
| CA2282300C (en) | 1997-02-24 | 2011-08-02 | Therion Biologics Corporation | Recombinant pox virus for immunization against muc1 tumor-associated antigen |
| FR2766091A1 (fr) | 1997-07-18 | 1999-01-22 | Transgene Sa | Composition antitumorale a base de polypeptide immunogene de localisation cellulaire modifiee |
| WO2000046355A2 (en) | 1999-02-04 | 2000-08-10 | Geron Corporation | Telomerase reverse transcriptase transcriptional regulatory sequences |
| FR2773885B1 (fr) | 1998-01-16 | 2000-03-03 | Elf Antar France | Methode de caracterisation de la capacite de neutralisation d'un lubrifiant et dispositif pour la mise en oeuvre de cette methode |
| JP3119228B2 (ja) | 1998-01-20 | 2000-12-18 | 日本電気株式会社 | 液晶表示パネル及びその製造方法 |
| US6110929A (en) | 1998-07-28 | 2000-08-29 | 3M Innovative Properties Company | Oxazolo, thiazolo and selenazolo [4,5-c]-quinolin-4-amines and analogs thereof |
| US6900049B2 (en) | 1998-09-10 | 2005-05-31 | Cell Genesys, Inc. | Adenovirus vectors containing cell status-specific response elements and methods of use thereof |
| US20020037274A1 (en) | 1998-10-26 | 2002-03-28 | Angelica Williams | Single agent method for killing tumor and tumor associated endothelial cells using adenoviral mutants |
| FR2787465A1 (fr) | 1998-12-21 | 2000-06-23 | Transgene Sa | Procede d'inactivation des virus enveloppes dans une preparation virale de virus non enveloppes |
| CA2364934C (fr) | 1999-02-22 | 2011-10-18 | Transgene S.A. | Procede d'obtention d'une preparation virale purifiee |
| US6492169B1 (en) | 1999-05-18 | 2002-12-10 | Crucell Holland, B.V. | Complementing cell lines |
| US6331539B1 (en) | 1999-06-10 | 2001-12-18 | 3M Innovative Properties Company | Sulfonamide and sulfamide substituted imidazoquinolines |
| WO2001036650A2 (en) | 1999-11-15 | 2001-05-25 | Onyx Pharmaceuticals, Inc. | An oncolytic adenovirus |
| AUPQ520800A0 (en) | 2000-01-21 | 2000-02-17 | Alfred Hospital | Prime-boost vaccination strategy |
| HU230198B1 (hu) | 2000-11-23 | 2015-10-28 | Bavarian Nordic A/S | Módosított Vacciniavírus Ankara-variáns |
| FI116851B (fi) * | 2001-05-03 | 2006-03-15 | Fit Biotech Oyj Plc | Ilmentämisvektori, sen käyttöjä ja menetelmä sen valmistamiseksi sekä sitä sisältäviä tuotteita |
| GB0118532D0 (en) | 2001-07-30 | 2001-09-19 | Isis Innovation | Materials and methods relating to improved vaccination strategies |
| WO2004011082A1 (en) | 2002-07-26 | 2004-02-05 | Myomend, Inc. | Cardiac rhythm management system with intramural myocardial pacing leads and electrodes |
| NZ540098A (en) | 2002-10-29 | 2008-09-26 | Coley Pharmaceutical Group Ltd | Use of CPG oligonucleotides in the treatment of hepatitis C virus infection |
| FR2862648B1 (fr) | 2003-11-21 | 2006-02-03 | Biomerieux Sa | Nouveau peptide immunogene et nouveaux epitopes et utilisations notamment dans la preparation de compositions pharmaceutiques actives contre le virus de l 'hepatite c |
| PT2366400E (pt) * | 2005-06-28 | 2016-02-02 | Oncothyreon Inc | Método de tratamento de doentes com uma vacina à base de glicoproteína mucinosa (muc-1) |
| CA2668942A1 (en) * | 2006-12-05 | 2008-06-12 | Transgene S.A. | Means and method for raising improved immune response |
| RU2517719C2 (ru) * | 2008-05-29 | 2014-05-27 | Трансжене Са | Биомаркер для отбора пациентов и соответствующие способы |
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