JP5647809B2 - 履物用抗真菌組成物 - Google Patents
履物用抗真菌組成物 Download PDFInfo
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- JP5647809B2 JP5647809B2 JP2010084104A JP2010084104A JP5647809B2 JP 5647809 B2 JP5647809 B2 JP 5647809B2 JP 2010084104 A JP2010084104 A JP 2010084104A JP 2010084104 A JP2010084104 A JP 2010084104A JP 5647809 B2 JP5647809 B2 JP 5647809B2
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- antifungal
- footwear
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Landscapes
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Footwear And Its Accessory, Manufacturing Method And Apparatuses (AREA)
Description
上記履物用抗真菌組成物は、更にpH調整剤及び水を含有し、界面活性剤及び油類を含有しないことが好ましい。
このように、結晶粒子径が50μm以下(乾燥状態)の抗真菌成分を絶対量が多い状態で履物内に存在させると、足に存在する白癬菌の効率的な殺菌と併せて、履物の内側で増殖して再感染の原因となる白癬菌も殺菌されるため、患部への直接塗布と比較して、顕著な有効性が発揮されると推察される。
本発明において、乾燥状態における抗真菌成分の結晶粒子径は、顕微鏡(株式会社キーエンス製「デジタルマイクロスコープ VHX−1000」)で観察することにより、測定できる。
表1に示す組成にしたがって、実施例1〜12及び比較例1〜8の履物用抗真菌組成物を調製した。また、表2に示す組成にしたがって、実施例13〜21及び比較例9〜13の履物用抗真菌組成物を調製した。
表1に記載の組成物をトリガースプレーに充填し、ガラス板上に均一に噴霧した。組成物における溶剤が揮発した後(乾燥後)、抗真菌成分の状態を顕微鏡(株式会社キーエンス製「デジタルマイクロスコープ VHX−1000」)で観察し、乾燥状態における抗真菌成分の結晶粒子径を以下の判定基準で評価した。
○:結晶粒子径が50μm以下である
×:結晶粒子径が50μmを超えている
なお、「○」は、履物内側に噴霧し、溶剤揮発後(乾燥後)において、抗真菌成分が50μm以下の状態で均一に履物内に存在していることを示す。
実施例7及び比較例3の組成物について、観察された乾燥状態における写真を図1及び2に示した。
○:pH7以上
×:pH7未満
被験者は、ミコナゾール硝酸塩を1.0質量%含有する水虫治療剤を使用し、治療していたが改善することなく中止した人、又は治療して一度改善したが再び悪化した人(計12名)を対象とした。
被験者は、靴下(綿とポリエステルの混合)を履いて普段通りの生活を行いながら、トリガースプレーに充填した表2の組成物を、帰宅して脱いだ靴に毎日噴霧し(噴霧薬液量:約1.5g/回)、噴霧開始から2週間後、4週間後、8週間後の水虫治療効果を「水虫の自覚症状」及び「水虫改善度(臨床診断)」により判断した。
また、表2において、実施例の組成物は乾燥後の抗真菌成分の結晶粒子径が50μm以下のものであり、比較例の組成物は該粒子径が50μmを超えるものであった。
VAS(Visual Analogue Scale)法に基づいて、被験者の自覚症状を評価した。
具体的には、水虫の自覚症状について、試験開始時の症状を「10点」、症状を全く感じない場合を「1点」とするスケールを作成し、それぞれ被験者に自覚症状と合致する箇所に印をつけてもらった。数字が小さいほど改善されていることを示す。8週間後の平均点数を以下の判定基準で評価した。
○:平均点数5点未満
×:平均点数5点以上
被験者の水虫症状及び臨床的治療効果として、水虫改善度(臨床判断)を総合的に判断し、医師自身が著効、有効、やや有効、無効、判定不能の5段階で診断した。診断結果をもとに以下の判定基準で評価した。
○:「著効及び有効」の合計が70%以上
×:「著効及び有効」の合計が70%未満
靴を履いたときの不快感など、QOL(使い勝手)を患者自身が評価し、以下の判定基準で評価した。
○:「靴を履いたときの不快感などはない」との評価者数が70%以上
×:「靴を履いたときの不快感などはない」との評価者数が70%未満
表3に示す処方に従い、常法により、履物用抗真菌組成物(液剤)を調製した。また、調製した組成物と噴射剤(LPG)を適宜組み合わせ容器(エアゾール缶)に充填した(エアゾール剤)。これらの液剤及びエアゾール剤についても、乾燥状態における抗真菌成分の粒子径が50μm以下であり、水虫改善効果を有した。
Claims (5)
- 抗真菌成分を含有する履物用抗真菌組成物であって、
履物の内側に散布または塗布により使用され、かつ乾燥状態における前記抗真菌成分の粒子径が50μm以下であることを特徴とする履物用抗真菌組成物。 - 低級アルコールの含有量が5〜70質量%である請求項1記載の履物用抗真菌組成物。
- 前記抗真菌成分の含有量が0.1〜1.0質量%である請求項1又は2記載の履物用抗真菌組成物。
- 前記抗真菌成分が塩である請求項1〜3のいずれかに記載の履物用抗真菌組成物。
- 更にpH調整剤及び水を含有し、界面活性剤及び油類を含有しない請求項1〜4のいずれかに記載の履物用抗真菌組成物。
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