JP5639073B2 - Ｔｇｒ５モジュレーターおよびその使用方法 - Google Patents
Ｔｇｒ５モジュレーターおよびその使用方法 Download PDFInfo
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- JP5639073B2 JP5639073B2 JP2011537627A JP2011537627A JP5639073B2 JP 5639073 B2 JP5639073 B2 JP 5639073B2 JP 2011537627 A JP2011537627 A JP 2011537627A JP 2011537627 A JP2011537627 A JP 2011537627A JP 5639073 B2 JP5639073 B2 JP 5639073B2
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- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
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- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
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| EP08169460 | 2008-11-19 | ||
| EP08169460.6 | 2008-11-19 | ||
| PCT/US2009/065199 WO2010059859A1 (en) | 2008-11-19 | 2009-11-19 | Tgr5 modulators and methods of use thereof |
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| JP2012509349A JP2012509349A (ja) | 2012-04-19 |
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| MX2012012902A (es) | 2010-05-06 | 2012-12-17 | Bristol Myers Squibb Co | Analogos heteroarilo biciclicos como moduladores de receptor acoplado a la proteina g gpr119. |
| US9062028B2 (en) | 2011-04-28 | 2015-06-23 | Bristol-Myers Squibb Company | Bicyclic nitrogen containing heteroaryl TGR5 receptor modulators |
| SMT201700602T1 (it) * | 2012-10-26 | 2018-03-08 | Intercept Pharmaceuticals Inc | Processo per la preparazione di derivati dell’acido biliare |
| SG11201503697TA (en) * | 2012-11-28 | 2015-06-29 | Intercept Pharmaceuticals Inc | Treatment of pulmonary disease |
| AU2014278833A1 (en) | 2013-06-13 | 2016-01-07 | Fast Forward Pharmaceuticals B.V. | CD40 signalling inhibitor and a further compound, wherein the further compound is a bile acid, a bile acid derivative, an TGR5-receptor agonist, an FXR agonist or a combination thereof, for the treatment of chronic inflammation, and the prevention of gastrointestinal cancer or fibrosis. |
| LT3626725T (lt) | 2014-05-29 | 2023-03-10 | Bar Pharmaceuticals S.R.L. | Cholano dariniai skirti naudoti ligų, kurių atsiradimui tarpininkauja fxr ir tgr5/gpbar1, gydymui ir (arba) profilaktikai |
| KR102527821B1 (ko) * | 2014-11-19 | 2023-05-02 | 엔제트피 유케이 리미티드 | 스테로이드 FXR 조절인자를 제조하기 위한 중간체로서의 6α-알킬-6,7-다이온 스테로이드 |
| MX375863B (es) * | 2014-11-19 | 2025-03-07 | Nzp Uk Ltd | Esteroides de 6-alquil-7-hidroxi-4-en-3-ona como intermedios para la produccion de moduladores esteroideos del receptor x farnesoide (fxr) |
| WO2016079519A1 (en) * | 2014-11-19 | 2016-05-26 | Dextra Laboratories Limited | 6.alpha.-alkyl-3,7-dione steroids as intermediates for the production of steroidal fxr modulators |
| KR102526632B1 (ko) | 2014-11-19 | 2023-04-27 | 엔제트피 유케이 리미티드 | 스테로이드 FXR 조절인자를 제조하기 위한 중간체로서의 5β-6-알킬-7-하이드록시-3-온 스테로이드 |
| CN107231795A (zh) * | 2014-11-26 | 2017-10-03 | 英安塔制药有限公司 | 作为fxr/tgr5激动剂的胆汁酸类似物及其使用方法 |
| CN105348365A (zh) * | 2014-12-03 | 2016-02-24 | 四川百利药业有限责任公司 | 一种胆酸衍生物及其制备方法、药物组合物和用途 |
| CN104523703A (zh) * | 2014-12-24 | 2015-04-22 | 聂飚 | 一种游离脂肪酸转运蛋白小分子抑制物的应用 |
| CN104672290B (zh) * | 2015-01-05 | 2017-06-06 | 北京普禄德医药科技有限公司 | 一种用于预防或治疗fxr‑介导的疾病的药物及其制备方法和用途 |
| CN105330554B (zh) | 2015-02-15 | 2017-07-11 | 上海迪赛诺药业股份有限公司 | 手性环丙基乙炔基叔醇类化合物的合成方法 |
| CN105985396A (zh) | 2015-02-16 | 2016-10-05 | 苏州泽璟生物制药有限公司 | 氘代鹅去氧胆酸衍生物以及包含该化合物的药物组合物 |
| US10800807B2 (en) * | 2015-06-19 | 2020-10-13 | Intercept Pharmaceuticals, Inc. | TGR5 modulators and methods of use thereof |
| CN106854229A (zh) * | 2015-12-08 | 2017-06-16 | 陈剑 | 一类脂肪酸盐,其制备及其在医药上的应用 |
| GB201608777D0 (en) | 2016-05-18 | 2016-06-29 | Dextra Lab Ltd | Compounds |
| GB201608776D0 (en) | 2016-05-18 | 2016-06-29 | Dextra Lab Ltd | Methods and compounds |
| CN109641934B (zh) * | 2016-09-20 | 2021-07-02 | 江苏豪森药业集团有限公司 | 胆酸衍生物游离碱，晶型及其制备方法和应用 |
| GB201812382D0 (en) | 2018-07-30 | 2018-09-12 | Nzp Uk Ltd | Compounds |
| CA3156985A1 (en) | 2019-10-07 | 2021-04-15 | Kallyope, Inc. | Gpr119 agonists |
| JP7745559B2 (ja) | 2020-02-28 | 2025-09-29 | キャリーオペ，インク． | Ｇｐｒ４０アゴニスト |
| CA3178994A1 (en) | 2020-05-19 | 2021-11-25 | Iyassu Sebhat | Ampk activators |
| CN116390925A (zh) | 2020-06-26 | 2023-07-04 | 卡尔优普公司 | Ampk活化剂 |
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| FR2696934B1 (fr) | 1992-10-20 | 1995-06-02 | Conservatoire Nal Arts Metiers | Dérivés de stéroïdes naturels 3B hydroxyles ayant des propriétés de déclenchement et de stimulation de l'immunité, composition les contenant et procédé pour les obtenir. |
| WO2004067008A1 (ja) | 2003-01-28 | 2004-08-12 | Takeda Pharmaceutical Company Limited | 受容体作動薬 |
| EA017714B1 (ru) * | 2007-01-19 | 2013-02-28 | Интерсепт Фармасьютикалз, Инк. | Модуляторы tgr5 и способы их применения |
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- 2009-11-19 WO PCT/US2009/065199 patent/WO2010059859A1/en not_active Ceased
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- 2009-11-19 CN CN201610680498.XA patent/CN106380502A/zh active Pending
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|---|---|
| US20110263555A1 (en) | 2011-10-27 |
| IL212970A0 (en) | 2011-07-31 |
| BRPI0921992B1 (pt) | 2021-12-14 |
| US8999964B2 (en) | 2015-04-07 |
| WO2010059859A1 (en) | 2010-05-27 |
| CN106380502A (zh) | 2017-02-08 |
| ES2592452T3 (es) | 2016-11-30 |
| BRPI0921992A2 (pt) | 2018-06-05 |
| JP2012509349A (ja) | 2012-04-19 |
| CN102282157A (zh) | 2011-12-14 |
| AU2009316484A1 (en) | 2010-05-27 |
| EP2373673A1 (en) | 2011-10-12 |
| CA2744135C (en) | 2017-07-04 |
| AU2009316484B2 (en) | 2015-04-16 |
| EP3150620A1 (en) | 2017-04-05 |
| ES2774368T3 (es) | 2020-07-20 |
| CA2744135A1 (en) | 2010-05-27 |
| EP2373673B1 (en) | 2016-07-27 |
| IL212970A (en) | 2017-07-31 |
| EP3150620B1 (en) | 2020-01-08 |
| CN102282157B (zh) | 2017-02-22 |
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