CN102282157A - G蛋白偶联受体5(tgr5)调节剂及其使用方法 - Google Patents
G蛋白偶联受体5(tgr5)调节剂及其使用方法 Download PDFInfo
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Abstract
Description
Claims (13)
Priority Applications (1)
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CN201610680498.XA CN106380502A (zh) | 2008-11-19 | 2009-11-19 | G蛋白偶联受体5(tgr5)调节剂及其使用方法 |
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EP08169460 | 2008-11-19 | ||
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PCT/US2009/065199 WO2010059859A1 (en) | 2008-11-19 | 2009-11-19 | Tgr5 modulators and methods of use thereof |
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CN201610680498.XA Division CN106380502A (zh) | 2008-11-19 | 2009-11-19 | G蛋白偶联受体5(tgr5)调节剂及其使用方法 |
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CN102282157A true CN102282157A (zh) | 2011-12-14 |
CN102282157B CN102282157B (zh) | 2017-02-22 |
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CN200980154703.7A Expired - Fee Related CN102282157B (zh) | 2008-11-19 | 2009-11-19 | G蛋白偶联受体5(tgr5)调节剂及其使用方法 |
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US (1) | US8999964B2 (zh) |
EP (2) | EP2373673B1 (zh) |
JP (1) | JP5639073B2 (zh) |
CN (2) | CN106380502A (zh) |
AU (1) | AU2009316484B2 (zh) |
BR (1) | BRPI0921992B1 (zh) |
CA (1) | CA2744135C (zh) |
ES (2) | ES2592452T3 (zh) |
IL (1) | IL212970A (zh) |
WO (1) | WO2010059859A1 (zh) |
Cited By (10)
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CN104523703A (zh) * | 2014-12-24 | 2015-04-22 | 聂飚 | 一种游离脂肪酸转运蛋白小分子抑制物的应用 |
CN104672290A (zh) * | 2015-01-05 | 2015-06-03 | 北京普禄德医药科技有限公司 | 一种用于预防或治疗fxr-介导的疾病的药物及其制备方法和用途 |
CN105102425A (zh) * | 2012-10-26 | 2015-11-25 | 英特塞普特医药品公司 | 制备胆汁酸衍生物的方法 |
CN105348365A (zh) * | 2014-12-03 | 2016-02-24 | 四川百利药业有限责任公司 | 一种胆酸衍生物及其制备方法、药物组合物和用途 |
CN106854229A (zh) * | 2015-12-08 | 2017-06-16 | 陈剑 | 一类脂肪酸盐,其制备及其在医药上的应用 |
WO2018054300A1 (zh) * | 2016-09-20 | 2018-03-29 | 江苏豪森药业集团有限公司 | 胆酸衍生物游离碱,晶型及其制备方法和应用 |
TWI686401B (zh) * | 2014-11-19 | 2020-03-01 | 英商Nzp英國有限公司 | 化合物(三) |
TWI686400B (zh) * | 2014-11-19 | 2020-03-01 | 英商Nzp英國有限公司 | 化合物(二) |
TWI688571B (zh) * | 2014-11-19 | 2020-03-21 | 英商Nzp英國有限公司 | 化合物(四) |
TWI690536B (zh) * | 2014-11-19 | 2020-04-11 | 英商Nzp英國有限公司 | 化合物(一) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2013525489A (ja) | 2010-05-06 | 2013-06-20 | ブリストル−マイヤーズ スクイブ カンパニー | Gpr119修飾因子としての二環式ヘテロアリール類似体 |
US9062028B2 (en) | 2011-04-28 | 2015-06-23 | Bristol-Myers Squibb Company | Bicyclic nitrogen containing heteroaryl TGR5 receptor modulators |
EP2925328A1 (en) * | 2012-11-28 | 2015-10-07 | Intercept Pharmaceuticals, Inc. | Treatment of pulmonary disease |
CN105636984A (zh) | 2013-06-13 | 2016-06-01 | 法斯特弗沃德制药有限公司 | 用于治疗慢性炎症和预防胃肠道癌或纤维化的cd40信号转导抑制剂和其他化合物,该其他化合物是胆汁酸、胆汁酸衍生物、tgr5受体激动剂、fxr激动剂或其组合 |
PL3626725T3 (pl) * | 2014-05-29 | 2023-04-03 | Bar Pharmaceuticals S.R.L. | Pochodne cholanu do zastosowania w leczeniu i/lub zapobieganiu chorobom, w których pośredniczy fxr i tgr5/gpbar1 |
WO2016086169A1 (en) * | 2014-11-26 | 2016-06-02 | Enanta Pharmaceuticals, Inc. | Bile acid analogs as fxr/tgr5 agonists and methods of use thereof |
CN105330554B (zh) | 2015-02-15 | 2017-07-11 | 上海迪赛诺药业股份有限公司 | 手性环丙基乙炔基叔醇类化合物的合成方法 |
CN105985396A (zh) | 2015-02-16 | 2016-10-05 | 苏州泽璟生物制药有限公司 | 氘代鹅去氧胆酸衍生物以及包含该化合物的药物组合物 |
DK3310801T3 (da) * | 2015-06-19 | 2021-06-21 | Intercept Pharmaceuticals Inc | Tgr5-modulatorer og fremgangsmåder til anvendelse deraf |
GB201608777D0 (en) | 2016-05-18 | 2016-06-29 | Dextra Lab Ltd | Compounds |
GB201608776D0 (en) | 2016-05-18 | 2016-06-29 | Dextra Lab Ltd | Methods and compounds |
GB201812382D0 (en) | 2018-07-30 | 2018-09-12 | Nzp Uk Ltd | Compounds |
BR112022006546A2 (pt) | 2019-10-07 | 2022-08-30 | Kallyope Inc | Agonistas de gpr119 |
BR112022023359A2 (pt) | 2020-05-19 | 2023-04-18 | Kallyope Inc | Ativadores de ampk |
EP4172162A1 (en) | 2020-06-26 | 2023-05-03 | Kallyope, Inc. | Ampk activators |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
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FR2696934B1 (fr) | 1992-10-20 | 1995-06-02 | Conservatoire Nal Arts Metiers | Dérivés de stéroïdes naturels 3B hydroxyles ayant des propriétés de déclenchement et de stimulation de l'immunité, composition les contenant et procédé pour les obtenir. |
WO2004067008A1 (ja) | 2003-01-28 | 2004-08-12 | Takeda Pharmaceutical Company Limited | 受容体作動薬 |
MX2009007728A (es) * | 2007-01-19 | 2009-12-15 | Intercept Pharmaceuticals Inc | Acidos biliares 23-sustituidos como moduladores de tgr5 y metodos de uso de los mismos. |
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-
2011
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Cited By (12)
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CN105102425A (zh) * | 2012-10-26 | 2015-11-25 | 英特塞普特医药品公司 | 制备胆汁酸衍生物的方法 |
TWI686401B (zh) * | 2014-11-19 | 2020-03-01 | 英商Nzp英國有限公司 | 化合物(三) |
TWI686400B (zh) * | 2014-11-19 | 2020-03-01 | 英商Nzp英國有限公司 | 化合物(二) |
TWI688571B (zh) * | 2014-11-19 | 2020-03-21 | 英商Nzp英國有限公司 | 化合物(四) |
TWI690536B (zh) * | 2014-11-19 | 2020-04-11 | 英商Nzp英國有限公司 | 化合物(一) |
CN105348365A (zh) * | 2014-12-03 | 2016-02-24 | 四川百利药业有限责任公司 | 一种胆酸衍生物及其制备方法、药物组合物和用途 |
CN104523703A (zh) * | 2014-12-24 | 2015-04-22 | 聂飚 | 一种游离脂肪酸转运蛋白小分子抑制物的应用 |
CN104672290A (zh) * | 2015-01-05 | 2015-06-03 | 北京普禄德医药科技有限公司 | 一种用于预防或治疗fxr-介导的疾病的药物及其制备方法和用途 |
CN106854229A (zh) * | 2015-12-08 | 2017-06-16 | 陈剑 | 一类脂肪酸盐,其制备及其在医药上的应用 |
WO2018054300A1 (zh) * | 2016-09-20 | 2018-03-29 | 江苏豪森药业集团有限公司 | 胆酸衍生物游离碱,晶型及其制备方法和应用 |
CN109641934A (zh) * | 2016-09-20 | 2019-04-16 | 江苏豪森药业集团有限公司 | 胆酸衍生物游离碱,晶型及其制备方法和应用 |
CN109641934B (zh) * | 2016-09-20 | 2021-07-02 | 江苏豪森药业集团有限公司 | 胆酸衍生物游离碱,晶型及其制备方法和应用 |
Also Published As
Publication number | Publication date |
---|---|
EP3150620A1 (en) | 2017-04-05 |
CN106380502A (zh) | 2017-02-08 |
JP2012509349A (ja) | 2012-04-19 |
AU2009316484B2 (en) | 2015-04-16 |
CA2744135A1 (en) | 2010-05-27 |
IL212970A0 (en) | 2011-07-31 |
AU2009316484A1 (en) | 2010-05-27 |
US20110263555A1 (en) | 2011-10-27 |
ES2774368T3 (es) | 2020-07-20 |
CN102282157B (zh) | 2017-02-22 |
BRPI0921992B1 (pt) | 2021-12-14 |
IL212970A (en) | 2017-07-31 |
EP3150620B1 (en) | 2020-01-08 |
BRPI0921992A2 (pt) | 2018-06-05 |
EP2373673A1 (en) | 2011-10-12 |
CA2744135C (en) | 2017-07-04 |
ES2592452T3 (es) | 2016-11-30 |
EP2373673B1 (en) | 2016-07-27 |
WO2010059859A1 (en) | 2010-05-27 |
JP5639073B2 (ja) | 2014-12-10 |
US8999964B2 (en) | 2015-04-07 |
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